How antibodies and complement orchestrate protective immune responses against bacteria

Informazioni relative al progetto

ACCENT

ID dell’accordo di sovvenzione: 101001937

DOI

10.3030/101001937

Data della firma CE 16 Febbraio 2021

Data di avvio 1 Gennaio 2022

Data di completamento 31 Dicembre 2026

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 000 000,00

Contributo UE

€ 2 000 000,00

Coordinato da

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Open Research Data Pilot (1)

Data Management Plan

A DMP will be written taking into account the most recent templates available The DMP will be updated when necessary and submitted together with periodic reports

Pubblicazioni

Peer reviewed articles (8)

Klebsiella LPS O1-antigen prevents complement-mediated killing by inhibiting C9 polymerization

Autori: Frerich M Masson, Salvör Káradóttir, Sjors PA van der Lans, Dennis J Doorduijn, Carla JC de Haas, Suzan HM Rooijakkers, Bart W Bardoel
Pubblicato in: Scientific Reports, 2024, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.21203/rs.3.rs-3934642/v1

Human anti-C1q autoantibodies bind specifically to solid-phase C1q and enhance phagocytosis but not complement activation

Autori: Douwe J. Dijkstra, Fleur S. van de Bovenkamp, Leoni Abendstein, Rob Zuijderduijn, Jos Pool, Cynthia S. M. Kramer, Linda M. Slot, Jan W. Drijfhout, Lisanne de Vor, Kyra A. Gelderman, Suzan H. M. Rooijakkers, Arnaud Zaldumbide, Gestur Vidarsson, Thomas H. Sharp, Paul W. H. I. Parren, Leendert A. Trouw
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 120, 2023, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2310666120

Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria

Autori: Stian Foss, Siri A. Sakya, Leire Aguinagalde, Marta Lustig, Jutamas Shaughnessy, Ana Rita Cruz, Lisette Scheepmaker, Line Mathiesen, Fulgencio Ruso-Julve, Aina Karen Anthi, Torleif Tollefsrud Gjølberg, Simone Mester, Malin Bern, Mitchell Evers, Diane B. Bratlie, Terje E. Michaelsen, Tilman Schlothauer, Devin Sok, Jayanta Bhattacharya, Jeanette Leusen, Thomas Valerius, Sanjay Ram, Suzan H. M. Rooi
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-46321-9

Inhibition of cleavage of human complement component C5 and the R885H C5 variant by two distinct high affinity anti-C5 nanobodies

Autori: Eva M. Struijf, Karla I De la O Becerra, Maartje Ruyken, Fleur van Oosterom, Danique Y. Siere, Dani A. C. Heesterbeek, Edward Dolk, Raimond Heukers, Bart W. Bardoel, Piet Gros, Suzan H.M. Rooijakkers
Pubblicato in: Journal of Biological Chemistry, 2023, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2023.104956

Artificial surface labelling of Escherichia coli with StrepTagII antigen to study how monoclonal antibodies drive complement-mediated killing

Autori: Remy M. Muts, Maurits A. den Boer, Bart W. Bardoel, Piet C. Aerts, Carla J. C. de Haas, Albert J. R. Heck, Suzan H. M. Rooijakkers, Dani A. C. Heesterbeek
Pubblicato in: Scientific Reports, Numero 13, 2023, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-023-46026-x

Single-cell Sequencing of Circulating Human Plasmablasts during <i>Staphylococcus aureus</i> Bacteremia

Autori: Priscilla F. Kerkman, Lisanne de Vor, Thomas W. van der Vaart, Thijs ten Doesschate, Remy M. Muts, Jamie S. Depelteau, Lisette M. Scheepmaker, Maartje Ruyken, Carla J. C. de Haas, Piet C. Aerts, Renoud J. Marijnissen, Janine Schuurman, Frank J. Beurskens, Andrea Gorlani, Bart W. Bardoel, Suzan H. M. Rooijakkers
Pubblicato in: The Journal of Immunology, 2024, ISSN 0022-1767
Editore: American Association of Immunologists
DOI: 10.4049/jimmunol.2300858

Promoting Fc-Fc interactions between anti-capsular antibodies provides strong immune protection against <i>Streptococcus pneumoniae</i>

Autori: Aguinagalde Salazar, Leire; den Boer, Maurits A; Castenmiller, Suzanne M; Zwarthoff, Seline A; de Haas, Carla; Aerts, Piet C; Beurskens, Frank J; Schuurman, Janine; Heck, Albert J R; van Kessel, Kok; Rooijakkers, Suzan H M; Afd Biomol.Mass Spect. and Proteomics; Sub Biomol.Mass Spectrometry & Proteom.; Biomolecular Mass Spectrometry and Proteomics; Biomolecular Mass Spectrometry and Proteomics
Pubblicato in: eLife, 12. eLife Sciences Publications, Numero 2, 2023, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.80669

Agnostic B cell selection approach identifies antibodies against K. pneumoniae that synergistically drive complement activation

Autori: Sjors P. A. van der Lans, Bart W. Bardoel, Maartje Ruyken, Carla J. C. de Haas, Stan Baijens, Remy M. Muts, Lisette M. Scheepmaker, Piet C. Aerts, Marije F. L. van ’t Wout, Johannes Preiner, Renoud J. Marijnissen, Janine Schuurman, Frank J. Beurskens, Priscilla F. Kerkman, Suzan H. M. Rooijakkers
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-52372-9