A drug discovery platform for early human embryogenesis.

Información del proyecto

BLASTOID

Identificador del acuerdo de subvención: 101002317

DOI 10.3030/101002317

Fecha de la firma de la CE 25 Junio 2021

Fecha de inicio 1 Julio 2021

Fecha de finalización 30 Junio 2026

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total € 2 000 000,00

Aportación de la UE € 2 000 000,00

Coordinado por

INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH
Austria

Publicaciones

Peer reviewed articles (5)

A pendulum of induction between the epiblast and extra-embryonic endoderm supports post-implantation progression

Autores: Erik J. Vrij, Yvonne S. Scholte op Reimer, Laury Roa Fuentes, Isabel Misteli Guerreiro, Viktoria Holzmann, Javier Frias Aldeguer, Giovanni Sestini, Bon-Kyoung Koo, Jop Kind, Clemens A. van Blitterswijk, Nicolas C. Rivron
Publicado en: Development, 2022, ISSN 1477-9129
Editor: The company of biologists
DOI: 10.1242/dev.192310

Human blastoids model blastocyst development and implantation

Autores: Harunobu Kagawa, Alok Javali, Heidar Heidari Khoei, Theresa Maria Sommer, Giovanni Sestini, Maria Novatchkova, Yvonne Scholte op Reimer, Gaël Castel, Alexandre Bruneau, Nina Maenhoudt, Jenna Lammers, Sophie Loubersac, Thomas Freour, Hugo Vankelecom, Laurent David, Nicolas Rivron
Publicado en: Nature, 2021, ISSN 1476-4687
Editor: NPG
DOI: 10.1038/s41586-021-04267-8

Generating human blastoids modeling blastocyst-stage embryos and implantation.

Autores: Heidar Heidari Khoei, Alok Javali, Harunobu Kagawa, Theresa Maria Sommer, Giovanni Sestini, Laurent David, Jana Slovakova, Maria Novatchkova, Yvonne Scholte op Reimer, Nicolas Rivron
Publicado en: Nature protocol, 2023, ISSN 1750-2799
Editor: NPG
DOI: 10.1038/s41596-023-00802-1

Modeling human extraembryonic mesoderm cells using naive pluripotent stem cells

Autores: Thi Xuan Ai Pham, Amitesh Panda, Harunobu Kagawa, San Kit To, Cankat Ertekin, Grigorios Georgolopoulos, Sam S.F.A. van Knippenberg, Ryan Nicolaas Allsop, Alexandre Bruneau, Jonathan Sai-Hong Chui, Lotte Vanheer, Adrian Janiszewski, Joel Chappell, Michael Oberhuemer, Raissa Songwa Tchinda, Irene Talon, Sherif Khodeer, Janet Rossant, Frederic Lluis, Laurent David, Nicolas Rivron, Bradley Philip Bala
Publicado en: Cell Stem Cell, 2022, ISSN 1934-5909
Editor: Cell Press
DOI: 10.1016/j.stem.2022.08.001

Integrated multi-omics reveal polycomb repressive complex 2 restricts human trophoblast induction

Autores: Dick W. Zijlmans, Irene Talon, Sigrid Verhelst, Adam Bendall, Karlien Van Nerum, Alok Javali, Andrew A. Malcolm, Sam S. F. A. van Knippenberg, Laura Biggins, San Kit To, Adrian Janiszewski, Danielle Admiraal, Ruth Knops, Nikky Corthout, Bradley P. Balaton, Grigorios Georgolopoulos, Amitesh Panda, Natarajan V. Bhanu, Amanda J. Collier, Charlene Fabian, Ryan N. Allsop, Joel Chappell, Thi Xuan Ai Pha
Publicado en: Nature Cell Biology, 2022, ISSN 1476-4679
Editor: NPG
DOI: 10.1038/s41556-022-00932-w

Other (1)

In preprints: improving and interrogating embryo models

Autores: Antonio Scialdone, Nicolas Rivron
Publicado en: Development, 2022
Editor: The company of biologists
DOI: 10.1242/dev.201404

Derechos de propiedad intelectual

Patent (1)

BLASTOCYST-LIKE CELL AGGREGATE AND METHODS

Número de solicitud/publicación: 21 151455
Fecha: 2021-01-13