A drug discovery platform for early human embryogenesis.

Project Information

BLASTOID

Grant agreement ID: 101002317

DOI

10.3030/101002317

EC signature date 25 June 2021

Start date 1 July 2021

End date 30 June 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 000 000,00

EU contribution

€ 2 000 000,00

Coordinated by

INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH
Austria

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (5)

A pendulum of induction between the epiblast and extra-embryonic endoderm supports post-implantation progression

Author(s): Erik J. Vrij, Yvonne S. Scholte op Reimer, Laury Roa Fuentes, Isabel Misteli Guerreiro, Viktoria Holzmann, Javier Frias Aldeguer, Giovanni Sestini, Bon-Kyoung Koo, Jop Kind, Clemens A. van Blitterswijk, Nicolas C. Rivron
Published in: Development, 2022, ISSN 1477-9129
Publisher: The company of biologists
DOI: 10.1242/dev.192310

Human blastoids model blastocyst development and implantation

Author(s): Harunobu Kagawa, Alok Javali, Heidar Heidari Khoei, Theresa Maria Sommer, Giovanni Sestini, Maria Novatchkova, Yvonne Scholte op Reimer, Gaël Castel, Alexandre Bruneau, Nina Maenhoudt, Jenna Lammers, Sophie Loubersac, Thomas Freour, Hugo Vankelecom, Laurent David, Nicolas Rivron
Published in: Nature, 2021, ISSN 1476-4687
Publisher: NPG
DOI: 10.1038/s41586-021-04267-8

Generating human blastoids modeling blastocyst-stage embryos and implantation.

Author(s): Heidar Heidari Khoei, Alok Javali, Harunobu Kagawa, Theresa Maria Sommer, Giovanni Sestini, Laurent David, Jana Slovakova, Maria Novatchkova, Yvonne Scholte op Reimer, Nicolas Rivron
Published in: Nature protocol, 2023, ISSN 1750-2799
Publisher: NPG
DOI: 10.1038/s41596-023-00802-1

Modeling human extraembryonic mesoderm cells using naive pluripotent stem cells

Author(s): Thi Xuan Ai Pham, Amitesh Panda, Harunobu Kagawa, San Kit To, Cankat Ertekin, Grigorios Georgolopoulos, Sam S.F.A. van Knippenberg, Ryan Nicolaas Allsop, Alexandre Bruneau, Jonathan Sai-Hong Chui, Lotte Vanheer, Adrian Janiszewski, Joel Chappell, Michael Oberhuemer, Raissa Songwa Tchinda, Irene Talon, Sherif Khodeer, Janet Rossant, Frederic Lluis, Laurent David, Nicolas Rivron, Bradley Philip Bala
Published in: Cell Stem Cell, 2022, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2022.08.001

Integrated multi-omics reveal polycomb repressive complex 2 restricts human trophoblast induction

Author(s): Dick W. Zijlmans, Irene Talon, Sigrid Verhelst, Adam Bendall, Karlien Van Nerum, Alok Javali, Andrew A. Malcolm, Sam S. F. A. van Knippenberg, Laura Biggins, San Kit To, Adrian Janiszewski, Danielle Admiraal, Ruth Knops, Nikky Corthout, Bradley P. Balaton, Grigorios Georgolopoulos, Amitesh Panda, Natarajan V. Bhanu, Amanda J. Collier, Charlene Fabian, Ryan N. Allsop, Joel Chappell, Thi Xuan Ai Pha
Published in: Nature Cell Biology, 2022, ISSN 1476-4679
Publisher: NPG
DOI: 10.1038/s41556-022-00932-w

Other (1)

In preprints: improving and interrogating embryo models

Author(s): Antonio Scialdone, Nicolas Rivron
Published in: Development, 2022
Publisher: The company of biologists
DOI: 10.1242/dev.201404

Intellectual Property Rights

Patent (1)

BLASTOCYST-LIKE CELL AGGREGATE AND METHODS

Application/Publication number: 21 151455
Date: 2021-01-13
Applicant(s): INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH