Meiotic crossing-over: from spatial distribution to in situ chromosomal architecture

Project Information

CrossOver

Grant agreement ID: 101002629

DOI

10.3030/101002629

EC signature date 24 March 2021

Start date 1 January 2022

End date 31 December 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 180,00

EU contribution

€ 1 999 180,00

Coordinated by

UNIVERSITAT WIEN
Austria

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (7)

FilamentID reveals the composition and function of metabolic enzyme polymers during gametogenesis

Author(s): Jannik Hugener, Jingwei Xu, Rahel Wettstein, Lydia Ioannidi, Daniel Velikov, Florian Wollweber, Adrian Henggeler, Joao Matos, Martin Pilhofer
Published in: Cell, Issue 187, 2024, Page(s) 3303-3318.e18, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2024.04.026

Distinct and overlapping roles of MutLγ, Mus81-Mms4, and STR in meiotic Holliday junction processing

Author(s): Lucija Orlić, Adrian Henggeler, Jázmin Nagy, Joao Matos
Published in: Nature Communications, Issue 17, 2026, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-026-73888-2

RPA directly stimulates Mer3 helicase processivity to ensure normal crossover formation in meiosis

Author(s): Veronika Altmannova, Lucija Orlić, Carolina Carrasco, Céline Adam, Clara Aicart-Ramos, Dario Guerrini, Petra Janning, Valérie Borde, Joao Matos, Fernando Moreno-Herrero, John R. Weir
Published in: Nature Communications, Issue 17, 2026, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-026-69985-x

The role of bivalent ions in the regulation of D-loop extension mediated by DMC1 during meiotic recombination

Author(s): Veronika Altmannova; Mario Spirek; Lucija Orlic; Atis Jēkabsons; Tereza Clarence; Adrian Henggeler; Jarmila Mlcouskova; Raphaël A.G. Chaleil; Joao Matos; Lumir Krejci
Published in: eScience, Issue 1, 2022, ISSN 2589-0042
Publisher: Elsevier
DOI: 10.25418/crick.21602961.v1

Waves of regulated protein expression and phosphorylation rewire the proteome to drive gametogenesis in budding yeast

Author(s): Rahel Wettstein, Jannik Hugener, Ludovic Gillet, Yi Hernández-Armenta, Adrian Henggeler, Jingwei Xu, Julian van Gerwen, Florian Wollweber, Meret Arter, Ruedi Aebersold, Pedro Beltrao, Martin Pilhofer, Joao Matos
Published in: Developmental Cell, Issue 59, 2024, Page(s) 1764-1782.e8, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2024.05.025

Synaptonemal complex SUMOylation is maintained by Nup60-dependent docking of Ulp1 at the nuclear periphery

Author(s): Rahel Wettstein, Grant A. King, Adrian Henggeler, Madison E. Walsh, Cyrus T. Ruediger, Elçin Ünal, Joao Matos
Published in: Cell Reports, Issue 45, 2026, Page(s) 117539, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2026.117539

Holliday junction–ZMM protein feedback enables meiotic crossover assurance

Author(s): Adrian Henggeler, Lucija Orlić, Daniel Velikov, Joao Matos
Published in: Nature, Issue 647, 2025, Page(s) 766-775, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-025-09559-x