Mechano-Regulation of Proteins at Low Forces: Paving the Way for Therapeutic Interventions

Project Information

ProForce

Grant agreement ID: 101002656

DOI

10.3030/101002656

EC signature date 30 November 2021

Start date 1 March 2022

End date 28 February 2027

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 991 760,00

EU contribution

€ 1 991 760,00

Coordinated by

UNIVERSITAET AUGSBURG
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (9)

The effects of DMSO on DNA conformations and mechanics

Author(s): Koen R. Storm, Caroline Körösy, Enrico Skoruppa, Stefanie D. Pritzl, Pauline J. Kolbeck, Willem Vanderlinden, Helmut Schiessel, Jan Lipfert
Published in: Biophysical Journal, Issue 124, 2025, Page(s) 2639-2654, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2025.06.041

Optical Control of Membrane Viscosity Modulates ER-to-Golgi Trafficking

Author(s): Noemi Jiménez-Rojo, Suihan Feng, Johannes Morstein, Stefanie D. Pritzl, Antonino Asaro, Sergio López, Yun Xu, Takeshi Harayama, Nynke A. Vepřek, Christopher J. Arp, Martin Reynders, Alexander J. E.
Published in: ACS Central Science, Issue 11, 2025, Page(s) 1736-1752, ISSN 2374-7943
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acscentsci.5c00606

Labelizer: systematic selection of protein residues for covalent fluorophore labeling

Author(s): Christian Gebhardt, Pascal Bawidamann, Anna-Katharina Spring, Robin Schenk, Konstantin Schütze, Gabriel G. Moya Muñoz, Nicolas D. Wendler, Douglas A. Griffith, Jan Lipfert, Thorben Cordes
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-025-58602-y

Accurate drift-invariant single-molecule force calibration using the Hadamard variance

Author(s): Stefanie D. Pritzl, Alptuğ Ulugöl, Caroline Körösy, Laura Filion, Jan Lipfert
Published in: Biophysical Journal, 2024, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2024.10.008

Photoswitchable phospholipids for the optical control of membrane processes, protein function, and drug delivery

Author(s): Stefanie D. Pritzl, Johannes Morstein, Nikolaj A. Pritzl, Jan Lipfert, Theobald Lohmüller, Dirk H. Trauner
Published in: Communications Materials, Issue 6, 2025, ISSN 2662-4443
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s43246-025-00773-8

Single-molecule force stability of the SARS-CoV-2–ACE2 interface in variants-of-concern

Author(s): Magnus S. Bauer, Sophia Gruber, Adina Hausch, Marcelo C. R. Melo, Priscila S. F. C. Gomes, Thomas Nicolaus, Lukas F. Milles, Hermann E. Gaub, Rafael C. Bernardi, Jan Lipfert
Published in: Nature Nanotechnology, Issue 19, 2024, Page(s) 399-405, ISSN 1748-3387
Publisher: Nature Publishing Group
DOI: 10.1038/s41565-023-01536-7

Pixelated High-<i>Q</i> Metasurfaces for in Situ Biospectroscopy and Artificial Intelligence-Enabled Classification of Lipid Membrane Photoswitching Dynamics

Author(s): Martin Barkey, Rebecca Büchner, Alwin Wester, Stefanie D. Pritzl, Maksim Makarenko, Qizhou Wang, Thomas Weber, Dirk Trauner, Stefan A. Maier, Andrea Fratalocchi, Theobald Lohmüller, Andreas Tittl
Published in: ACS Nano, Issue 18, 2024, Page(s) 11644-11654, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.3c09798

DNA fluctuations reveal the size and dynamics of topological domains

Author(s): Willem Vanderlinden; Enrico Skoruppa; Pauline J Kolbeck; Enrico Carlon; Jan Lipfert
Published in: PNAS Nexus, 2022, ISSN 2752-6542
Publisher: Oxford University Press
DOI: 10.1093/pnasnexus/pgac268

Supercoiling-dependent DNA binding: quantitative modeling and applications to bulk and single-molecule experiments

Author(s): Pauline J Kolbeck, Miloš Tišma, Brian T Analikwu, Willem Vanderlinden, Cees Dekker, Jan Lipfert
Published in: Nucleic Acids Research, Issue 52, 2024, Page(s) 59-72, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkad1055

Other (1)

Determination of Absolute Intramolecular Distances in Proteins by Anomalous X-ray Scattering Interferometry

Author(s): Samuel Stubhan, Anna V. Baptist, Caroline Körösy, Alessandra Narducci, Gustavo Gabriel Moya Muñoz, Nicolas Wendler, Aidin Lak, Michael Sztucki, Thorben Cordes, Jan Lipfert
Published in: 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.02.09.579681