Uncovering Protein Mechanics in Physiology and Disease

Project Information

ProtMechanics-Live

Grant agreement ID: 101002927

DOI

10.3030/101002927

Project closed

EC signature date 16 February 2021

Start date 1 June 2021

End date 31 August 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 000 000,00

EU contribution

€ 2 000 000,00

Coordinated by

CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (5)

Mechanically knocking out titin reveals protein tension loss as a trigger of muscle disease

Author(s): Roberto Silva-Rojas, Natalia Vicente, Manuel Gavilán-Herrera, Verónica Labrador-Cantarero, Jon Sicilia, Olga Giménez-Sáez, Andra C. Dumitru, Mateo I. Sánchez, Mara Gato-Vilaseca, Diana Velázquez-Carreras, Juan Antonio López, Jesús Vázquez, Elías Herrero-Galán, Miguel A. López-Unzu, Maria Rosaria Pricolo, Jorge Alegre-Cebollada
Published in: Nature Biomedical Engineering, Issue 9, 2025, Page(s) 1758-1774, ISSN 2157-846X
Publisher: Springer Nature
DOI: 10.1038/s41551-025-01403-x

Titin cleavage in living cardiomyocytes induces sarcomere disassembly but does not trigger cell proliferation

Author(s): Maria Rosaria Pricolo, Miguel A. López-Unzu, Natalia Vicente, Cristina Morales-López, Carla Huerta-López, Wendy Pérez-Franco, Andra C. Dumitru, Jorge Peña-Peña, Francisco M. Espinosa, Mateo I. Sanchez, Ricardo Garcia, Roberto Silva-Rojas, Miguel Torres, Elías Herrero-Galán, Jorge Alegre-Cebollada
Published in: Journal of Biological Chemistry, Issue 302, 2026, Page(s) 113167, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2026.113167

Cell response to extracellular matrix viscous energy dissipation outweighs high-rigidity sensing

Author(s): Carla Huerta-López, Alejandro Clemente-Manteca, Diana Velázquez-Carreras, Francisco M. Espinosa, Juan G. Sanchez, Álvaro Martínez-del-Pozo, María García-García, Sara Martín-Colomo, Andrea Rodríguez-Blanco, Ricardo Esteban-González, Francisco M. Martín-Zamora, Luis I. Gutierrez-Rus, Ricardo Garcia, Pere Roca-Cusachs, Alberto Elosegui-Artola, Miguel A. del Pozo, Elías Herrero-Galán, Pab
Published in: Science Advances, Issue 10, 2024, Page(s) eadf9758, ISSN 2375-2548
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciadv.adf9758

Protein nanomechanics in biological context

Author(s): Alegre-Cebollada, Jorge
Published in: Biophysical Reviews, Issue 1, 2021, ISSN 1867-2450
Publisher: Springer Verlag
DOI: 10.1007/s12551-021-00822-9

Mavacamten shows broad benefit in human and mouse models of MYBPC3-related hypertrophic cardiomyopathy

Author(s): Laura Sen-Martín, Ángel Fernández-Trasancos, Miguel Á. López-Unzu, Agata Bak, Magdalena Zafra-Castellano, Rajiven Srikantharajah, Divya Pathak, Annika Klotz, Michel N. Kuehn, Alessia Ferrarini, Verónica Labrador-Cantarero, David Sánchez-Ortiz, María Rosaria Pricolo, Natalia Vicente, Diana Velázquez-Carreras, Lucía Sánchez-García, Jon Sicilia, José Ángel Nicolás-Ávila, María Sánch
Published in: Nature Cardiovascular Research, Issue 5, 2026, Page(s) 638-657, ISSN 2731-0590
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s44161-026-00833-3