Exploring the perturbations of titin mechanics
Playing a central role in cellular processes, proteins are now being engineered. What is known is that protein mechanics contribute to the function of biological systems. The question is how and whether alteration of protein mechanics can trigger disease, particularly in mechanical conditions such as cardiomyopathies. The ERC-funded ProtMechanics-Live project will build on unique expertise in protein mechanics and engineering, biophysics, biochemistry and cardiovascular biology. Its aim is to enable investigation of mechanical proteins in their functionally relevant, physiological context. Specifically, the project will apply first-of-their-kind tools to titin, the largest protein known. It will explore how perturbations of titin mechanics result in altered cardiomyocyte force generation, mechanosensing, mechanotransduction, differentiation and proliferation.
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