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Uncovering Protein Mechanics in Physiology and Disease

Project description

Exploring the perturbations of titin mechanics

Playing a central role in cellular processes, proteins are now being engineered. What is known is that protein mechanics contribute to the function of biological systems. The question is how and whether alteration of protein mechanics can trigger disease, particularly in mechanical conditions such as cardiomyopathies. The ERC-funded ProtMechanics-Live project will build on unique expertise in protein mechanics and engineering, biophysics, biochemistry and cardiovascular biology. Its aim is to enable investigation of mechanical proteins in their functionally relevant, physiological context. Specifically, the project will apply first-of-their-kind tools to titin, the largest protein known. It will explore how perturbations of titin mechanics result in altered cardiomyocyte force generation, mechanosensing, mechanotransduction, differentiation and proliferation.

Call for proposal

ERC-2020-COG
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Host institution

CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)
Address
Calle Melchor Fernandez Almagro 3
28029 Madrid
Spain
Activity type
Research Organisations
EU contribution
€ 2 000 000

Beneficiaries (1)

CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)
Spain
EU contribution
€ 2 000 000
Address
Calle Melchor Fernandez Almagro 3
28029 Madrid
Activity type
Research Organisations