Project description
Role of nuclear hotspots in the new gene expression paradigm
According to a new gene expression paradigm, genes and transcription factors cooperate to form specialised nuclear hotspots optimised for transcription. The EU-funded Hotspot project will investigate the hotspots that precede transcription during Zebrafish embryogenesis. The particular hotspots are large, isolated, long-lived, and their formation can be altered specifically. Initially, the research will determine the triggers of the hotspot formation, the components of hotspots and the order of the formation, followed by the study of the genes that come together. The researchers will develop an innovative method to visualise single-copy genes to reveal how stable gene expression programmes can emerge from the self-organising interactions between chromatin, transcription factors and the properties of transcribed sites.
Fields of science
Programme(s)
Funding Scheme
ERC-COG - Consolidator Grant
Host institution
1015 Lausanne
Switzerland
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Beneficiaries (1)
1015 Lausanne
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