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Understanding gene regulation in nuclear space

Project description

Role of nuclear hotspots in the new gene expression paradigm

According to a new gene expression paradigm, genes and transcription factors cooperate to form specialised nuclear hotspots optimised for transcription. The EU-funded Hotspot project will investigate the hotspots that precede transcription during Zebrafish embryogenesis. The particular hotspots are large, isolated, long-lived, and their formation can be altered specifically. Initially, the research will determine the triggers of the hotspot formation, the components of hotspots and the order of the formation, followed by the study of the genes that come together. The researchers will develop an innovative method to visualise single-copy genes to reveal how stable gene expression programmes can emerge from the self-organising interactions between chromatin, transcription factors and the properties of transcribed sites.

Host institution

UNIVERSITE DE LAUSANNE
Net EU contribution
€ 1 994 500,00
Address
Quartier Unil-centre Bâtiment Unicentre
1015 Lausanne
Switzerland

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Region
Schweiz/Suisse/Svizzera Région lémanique Vaud
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Beneficiaries (1)

UNIVERSITE DE LAUSANNE
Switzerland
Net EU contribution
€ 1 994 500,00
Address
Quartier Unil-centre Bâtiment Unicentre
1015 Lausanne

See on map

Region
Schweiz/Suisse/Svizzera Région lémanique Vaud
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00