Understanding DNA interstrand crosslink repair – the Fanconi anemia pathway and beyond

Project Information

XlinkRepair

Grant agreement ID: 101003210

DOI

10.3030/101003210

Project closed

EC signature date 27 January 2021

Start date 1 May 2021

End date 30 April 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 000 000,00

EU contribution

€ 2 000 000,00

Coordinated by

KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
Netherlands

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (7)

BRCA2-HSF2BP oligomeric ring disassembly by BRME1 promotes homologous recombination

Author(s): Rania Ghouil, Simona Miron, Koichi Sato, Dejan Ristic, Sari E. van Rossum-Fikkert, Pierre Legrand, Malika Ouldali, Jean-Marie Winter, Virginie Ropars, Gabriel David, Ana-Andreea Arteni, Claire Wyman, Puck Knipscheer, Roland Kanaar, Alex N. Zelensky, Sophie Zinn-Justin
Published in: Science Advances, Issue 9, 2024, ISSN 2375-2548
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciadv.adi7352

Efficient Synthesis of DNA Duplexes Containing Reduced Acetaldehyde Interstrand Cross-Links

Author(s): Sally B. Morton; L. David Finger; Roxanne van der Sluijs; William D. Mulcrone; Michael Hodskinson; Christopher L. Millington; Christina Vanhinsbergh; Ketan J. Patel; Mark J. Dickman; Puck Knipscheer; Jane A. Grasby; David M. Williams
Published in: Journal of the American Chemical Society, Issue 2, 2023, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.2c10070

CAF-1 deposits newly synthesized histones during DNA replication using distinct mechanisms on the leading and lagging strands

Author(s): Rouillon C, Eckhardt BV, Kollenstart L, Gruss F, Verkennis AEE, Rondeel I, Krijger PHL, Ricci G, Biran A, van Laar T, Delvaux de Fenffe CM, Luppens G, Albanese P, Sato K, Scheltema RA, de Laat W, Knipscheer P, Dekker NH, Groth A, Mattiroli F.
Published in: Nucleic acid research, 2023, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkad171

FANCD2–FANCI surveys DNA and recognizes double- to single-stranded junctions

Author(s): Pablo Alcón, Artur P. Kaczmarczyk, Korak Kumar Ray, Themistoklis Liolios, Guillaume Guilbaud, Tamara Sijacki, Yichao Shen, Stephen H. McLaughlin, Julian E. Sale, Puck Knipscheer, David S. Rueda, Lori A. Passmore
Published in: Nature, Issue 632, 2025, Page(s) 1165-1173, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-024-07770-w

FAN1-mediated translesion synthesis and POLQ/HELQ-mediated end joining generate interstrand crosslink-induced mutations

Author(s): Jip Verschuren, Robin van Schendel, Ivo van Bostelen, Alex E. E. Verkennis, Puck Knipscheer, Marcel Tijsterman
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-025-57764-z

DNA polymerase kappa is the primary translesion synthesis polymerase for aldehyde ICLs

Author(s): Roxanne V van der Sluijs, Alexander E E Verkennis, Michael R Hodskinson, Jamie Barnett, Victoria M Cruz, Miguel Hernandez-Quiles, Themistoklis Liolios, Sally B Morton, Aiko Hendrikx, Collin Bos, Harm Post, Christopher L Millington, Clément Rouillon, Giulia Ricci, Francesca Mattiroli, David M Williams, Maarten Altelaar, Michiel Vermeulen, K J Patel, Puck Knipscheer
Published in: Nucleic Acids Research, Issue 53, 2025, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkaf875

Tissue-specific mutagenesis from endogenous guanine damage is suppressed by Polκ and DNA repair

Author(s): Yang Jiang, Moritz Przybilla, Linda Bakker, Foster C. Jacobs, Dylan Mckeon, Roxanne van der Sluijs, Koichi Sato, Juliëtte Wezenbeek, Joeri van Strien, Jeroen Willems, Alexander E. E. Verkennis, Jamie Barnett, Adrian Baez Ortega, Federico Abascal, Peter W. Villalta, Puck Knipscheer, Inigo Martincorena, Silvia Balbo, Juan Garaycoechea
Published in: Nature Communications, Issue 17, 2026, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-025-67072-1