Project description
A novel DNA repair pathway
Interstrand crosslinks (ICLs) are a form of DNA damage in which the strands are chemically linked, preventing normal DNA replication and transcription. ICLs are conventionally recognised and repaired through a biochemical pathway known as the Fanconi anaemia DNA repair pathway. Scientists of the EU-funded XlinkRepair project have identified a novel pathway that repairs endogenous ICLs. For the duration of the project, they will investigate the molecular mechanism of this pathway and unveil key factors, mutagenic consequences and chromatin dynamics. Results will provide important insight into the maintenance of genome integrity and increase our understanding of the rare inherited condition Fanconi anaemia.
Fields of science
Programme(s)
Funding Scheme
ERC-COG - Consolidator Grant
Host institution
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
Net EU contribution
€ 2 000 000,00
Address
Kloveniersburgwal 29 Het Trippenhuis
1011 JV Amsterdam
Netherlands
1011 JV Amsterdam
Netherlands
See on map
Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Other
Other funding
€ 0,00
Beneficiaries (1)
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
Netherlands
Net EU contribution
€ 2 000 000,00
Address
Kloveniersburgwal 29 Het Trippenhuis
1011 JV Amsterdam
1011 JV Amsterdam
See on map
Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Other
Other funding
€ 0,00