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Understanding DNA interstrand crosslink repair – the Fanconi anemia pathway and beyond

Project description

A novel DNA repair pathway

Interstrand crosslinks (ICLs) are a form of DNA damage in which the strands are chemically linked, preventing normal DNA replication and transcription. ICLs are conventionally recognised and repaired through a biochemical pathway known as the Fanconi anaemia DNA repair pathway. Scientists of the EU-funded XlinkRepair project have identified a novel pathway that repairs endogenous ICLs. For the duration of the project, they will investigate the molecular mechanism of this pathway and unveil key factors, mutagenic consequences and chromatin dynamics. Results will provide important insight into the maintenance of genome integrity and increase our understanding of the rare inherited condition Fanconi anaemia.

Call for proposal

ERC-2020-COG
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Host institution

KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
Address
Kloveniersburgwal 29 Het Trippenhuis
1011 JV Amsterdam
Netherlands
Activity type
Other
EU contribution
€ 2 000 000

Beneficiaries (1)

KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
Netherlands
EU contribution
€ 2 000 000
Address
Kloveniersburgwal 29 Het Trippenhuis
1011 JV Amsterdam
Activity type
Other