A novel DNA repair pathway
Interstrand crosslinks (ICLs) are a form of DNA damage in which the strands are chemically linked, preventing normal DNA replication and transcription. ICLs are conventionally recognised and repaired through a biochemical pathway known as the Fanconi anaemia DNA repair pathway. Scientists of the EU-funded XlinkRepair project have identified a novel pathway that repairs endogenous ICLs. For the duration of the project, they will investigate the molecular mechanism of this pathway and unveil key factors, mutagenic consequences and chromatin dynamics. Results will provide important insight into the maintenance of genome integrity and increase our understanding of the rare inherited condition Fanconi anaemia.
Fields of science
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