Deliverables Documents, reports (20) Identification of those compounds that most efficiently prevent infection and disease in small animal model. Choice of compound and dosing regimen to be used in NHP Task 110 To evaluate the ability of candidate antivirals to prevent or minimise SARSCoV2infection and disease in mice month 130Objective To identify those antivirals that most effectively prevent SARSCoV2 infection and disease symptoms in mice Dissemination activity and quality report Determine tropism in airway epithelia (months 9) and antiviral activity (month 12-18), M12 Determine tropism in airway epithelia (month 9) and antiviral activity (month 12-18) Detailed characterization (IC50, IC90) of the antiviral activity of each identified inhibitor against MA SARS-CoV-2 and Omicron Task 19 To confirm the efficacy of developed antivirals against cellfree and cellcell infection of a mouse adapted SARSCoV2 strain and VOCs month 2430Objectives To establish an infection model with a mouse adapted SARSCoV2 strain and to evaluate the antiviral activity of most promising SARSCoV2 inhibitors developed in the consortium Characterization of antiviral tweezers: Preclinical assessment and dose-efficacy Characterization of antiviral tweezers: Preclinical assessment and dose-efficacy, M12 Characterization of antiviral tweezers: Preclinical assessment and dose-efficacy Determine tropism in airway epithelia (months 9) and antiviral activity (month 12-18) Determine tropism in airway epithelia (month 9) and antiviral activity (month 12-18) Report on implementation of a non-human primate model for SARS-CoV-2 infection and disease Report on implementation of a non-human primate model for SARS-CoV-2 infection and disease. MTT-based SARS-CoV-2 assay established Determination of ability for antiviral to prevent disease and choice of dosing regimen to be used in NHP Task 26 Objective To evaluate the ability for antivirals to prevent or minimise SARSCoV2induced disease in hamster month 2630Expected results To identify if a clinically relevant dosing regimen that can prevent SARSCoV2induced disease Such a dosing regimen can be further evaluated in NHPs Optimised hamster model of SARS-CoV-2 for evaluation of antivirals Task 25 Objective To optimise a small animal wildtype disease model of SARSCoV2 month 2425Expected results To decide a dose of SARSCoV2 that leads to measurable clinical symptoms but not severe disease Establishing SOPs for in vitro evaluation of antiviral activity against SARS-CoV-2 Report of treatment efficacy and safety measures after treatment of SARS-CoV-2 infected NHP. Report of treatment efficacy and safety measures after treatment of SARSCoV2 infected NHP Publication list of primary research articles in high impact journals (R, PU) Publication of primary research articles in high impact journals GLP toxicity studies in rats after systemic and intranasal administration Publication list of primary research articles in high impact journals (R, PU), M24 Publication of primary research articles in high impact journals Characterization of the antiviral compound ssON: Preclinical assessment and dose-efficacy Characterization of additional antiviral compounds made available to the consortium after starting the project: Preclinical assessment and dose-efficacy Characterization of additional antiviral compounds made available to the consortium after starting the project Preclinical assessment and doseefficacy Characterization antiviral polymers: Preclinical assessment and dose-efficacy Characterization antiviral polymers: Preclinical assessment and dose-efficacy, M12 Characterization antiviral polymers: Preclinical assessment and dose-efficacy Websites, patent fillings, videos etc. (2) List Public communication to specialized and general audiences, M24 Public dissemination to specialized and general audiences List Public communication to specialized and general audiences Public dissemination to specialized and general audiences Publications Peer reviewed articles (42) BNT162b2 booster after heterologous prime-boost vaccination induces potent neutralizing antibodies and T cell reactivity against SARS-CoV-2 Omicron BA.1 in young adults. Author(s): Seidel A, Zanoni M, Groß R, Krnavek D, Erdemci-Evin S, von Maltitz P, Albers DPJ, Conzelmann C, Liu S, Weil T, Mayer B, Hoffmann M, Pöhlmann S, Beil A, Kroschel J, Kirchhoff F, Münch J, Müller JA. Published in: Frontiers Immunology, 2022, ISSN 1664-3224 Publisher: Frontiers Media S.A DOI: 10.3389/fimmu.2022.882918 Plastic Antibodies Mimicking the ACE2 Receptor for Selective Binding of SARS-CoV-2 Spike Author(s): Batista AD, Rajpal S, Keitel B, Dietl S, Fresco-Cala B, Dinc M, Groß R, Sobek H, Münch J, Mizaikoff B Published in: Adv Mater Interfaces, 2022, ISSN 2196-7350 Publisher: Wiley DOI: 10.1002/admi.202101925 Native and activated antithrombin inhibits TMPRSS2 activity and SARS-CoV-2 infection. Author(s): Wettstein L, Immenschuh P, Weil T, Conzelmann C, Almeida-Hernández Y, Hoffmann M, Kempf A, Nehlmeier I, Lotke R, Petersen M, Stenger S, Kirchhoff F, Sauter D, Pöhlmann S, Sanchez-Garcia E, Münch J. Published in: J Med Virol, 2022, ISSN 1096-9071 Publisher: Wiley DOI: 10.1002/jmv.28124 Molecular Tweezers - a new class of potent broad-spectrum antivirals against enveloped viruses. Author(s): E Taghuo K, M-H Le, T Schrader Published in: Chemical Communications, 2022, ISSN 1359-7345 Publisher: Royal Society of Chemistry DOI: 10.1039/d1cc06737k Peptidomimetic inhibitors of TMPRSS2 block SARS-CoV-2 infection in cell culture Author(s): Wettstein, L., Knaff, P.M., Kersten,C., Müller,P., Weil, T., Conzelmann, C., Müller, J., Brückner, M., Hoffmann, M., Pöhlmann, S., Schirmeister, T., Münch, J., Mailänder, V Published in: Communications Biology, 2022, ISSN 2399-3642 Publisher: Nature DOI: 10.1038/s42003-022-03613-4 SARS-CoV-2 Vaccination boosts Neutralizing Activity against Seasonal Human Coronaviruses. Author(s): Lawrenz J, Xie Q, Zech F, Weil T, Seidel A, Krnavek D, van der Hoek L, Münch J, Müller JA, Kirchhoff F. Published in: Clin Infect Dis, 2022, ISSN 1058-4838 Publisher: University of Chicago Press DOI: 10.1093/cid/ciac057 Virucidal Efficacy of Different Oral Rinses Against Severe Acute Respiratory Syndrome Coronavirus 2 Author(s): Toni Luise Meister, Yannick Brüggemann, Daniel Todt, Carina Conzelmann, Janis A Müller, Rüdiger Groß, Jan Münch, Adalbert Krawczyk, Jörg Steinmann, Jochen Steinmann, Stephanie Pfaender, Eike Steinmann Published in: The Journal of Infectious Diseases, Issue 222/8, 2020, Page(s) 1289-1292, ISSN 0022-1899 Publisher: University of Chicago Press DOI: 10.1093/infdis/jiaa471 Detection of SARS-CoV-2 in human breastmilk Author(s): Rüdiger Groß, Carina Conzelmann, Janis A Müller, Steffen Stenger, Karin Steinhart, Frank Kirchhoff, Jan Münch Published in: The Lancet, Issue 395/10239, 2020, Page(s) 1757-1758, ISSN 0140-6736 Publisher: The Lancet Publishing Group DOI: 10.1016/s0140-6736(20)31181-8 Macromolecular Viral Entry Inhibitors as Broad-Spectrum First-Line Antivirals with Activity against SARS-CoV-2 Author(s): Groß R, Dias Loiola LM, Issmail L, Uhlig N, Eberlein V, Conzelmann C, Olari LR, Rauch L, Lawrenz J, Weil T, Müller JA, Cardoso MB, Gilg A, Larsson O, Höglund U, Pålsson SA, Tvilum AS, Løvschall KB, Kristensen MM, Spetz AL, Hontonnou F, Galloux M, Grunwald T, Zelikin AN*, Münch J*. Published in: Adv. Sci., 2022, ISSN 2198-3844 Publisher: Wiley DOI: 10.1002/advs.202201378 Broad‐Spectrum Antiviral Agents Based on Multivalent Inhibitors of Viral Infectivity Author(s): Alexander N. Zelikin, Francesco Stellacci Published in: Advanced Healthcare Materials, Issue 10/6, 2021, Page(s) 2001433, ISSN 2192-2640 Publisher: John Wiley and Sons Ltd DOI: 10.1002/adhm.202001433 Advanced Molecular Tweezers with Lipid Anchors against SARS-CoV-2 and Other Respiratory Viruses. Author(s): Weil T, Kirupakaran A, Le MH, Rebmann P, Mieres-Perez J, Issmail L, Conzelmann C, Müller JA, Rauch L, Gilg A, Wettstein L, Groß R, Read C, Bergner T, Pålsson SA, Uhlig N, Eberlein V, Wöll H, Klärner FG, Stenger S, Kümmerer BM, Streeck H, Fois G, Frick M, Braubach P, Spetz AL, Grunwald T, Shorter J, Sanchez-Garcia E, Schrader T, Münch J. Published in: JACS Au, 2022, ISSN 2691-3704 Publisher: ACS Publications DOI: 10.1021/jacsau.2c00220 Inhibitors of Activin Receptor-like Kinase 5 Interfere with SARS-CoV-2 S-Protein Processing and Spike-Mediated Cell Fusion via Attenuation of Furin Expression. Author(s): Mezger MC, Conzelmann C, Weil T, von Maltitz P, Albers DPJ, Münch J, Stamminger T, Schilling EM. Published in: Viruses, 2022, Page(s) 1308, ISSN 1999-4915 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/v14061308 Single-Stranded Oligonucleotide-Mediated Inhibition of Respiratory Syncytial Virus Infection Author(s): Sandra Axberg Pålsson, Aleksandra Dondalska, Joseph Bergenstråhle, Caroline Rolfes, Albin Björk, Laura Sedano, Ultan F. Power, Marie-Anne Rameix-Welti, Joakim Lundeberg, Marie Wahren-Herlenius, Peter Mastrangelo, Jean-Francois Eleouet, Ronan Le Goffic, Marie Galloux, Anna-Lena Spetz Published in: Frontiers in Immunology, Issue 11, 2020, ISSN 1664-3224 Publisher: Frontiers DOI: 10.3389/fimmu.2020.580547 Carrageenan-containing over-the-counter nasal and oral sprays inhibit SARS-CoV-2 infection of airway epithelial cultures Author(s): Desiree Schütz, Carina Conzelmann, Giorgio Fois, Rüdiger Groß, Tatjana Weil, Lukas Wettstein, Steffen Stenger, Alexander Zelikin, Thomas K. Hoffmann, Manfred Frick, Janis A. Müller, Jan Münch Published in: American Journal of Physiology-Lung Cellular and Molecular Physiology, Issue 320/5, 2021, Page(s) L750-L756, ISSN 1040-0605 Publisher: American Physiological Society DOI: 10.1152/ajplung.00552.2020 Rapid, convenient and efficient kit-independent detection of SARS-CoV-2 RNA Author(s): Detlef Michel, Karin M. Danzer, Rüdiger Groß, Carina Conzelmann, Janis A. Müller, Axel Freischmidt, Jochen H. Weishaupt, Sandra Heller, Jan Münch, Manuela Michel, Thomas Stamminger, Alexander Kleger, Markus Otto Published in: Journal of Virological Methods, Issue 286, 2020, Page(s) 113965, ISSN 0166-0934 Publisher: Elsevier BV DOI: 10.1016/j.jviromet.2020.113965 The Transmembrane Protease TMPRSS2 as a Therapeutic Target for COVID-19 Treatment Author(s): Wettstein L, Kirchhoff F, Münch J. Published in: Int J Mol Sci, 2022, ISSN 1422-0067 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms23031351 Nitric Oxide to Fight Viral Infections Author(s): Fabio Lisi, Alexander N. Zelikin, Rona Chandrawati Published in: Advanced Science, Issue 8/7, 2021, Page(s) 2003895, ISSN 2198-3844 Publisher: Wiley-VCH GmbH DOI: 10.1002/advs.202003895 COVID-eVax, an electroporated plasmid DNA vaccine candidate encoding the SARS-CoV-2 Receptor Binding Domain, elicits protective immune responses in animal models of COVID-19. Author(s): Conforti A, Marra E, Palombo F, Roscilli G, Ravà M, Fumagalli V, Muzi A, Maffei M, Luberto L, Lione L, Salvatori E, Compagnone M, Pinto E, Pavoni E, Bucci F, Vitagliano G, Stoppoloni D, Pacello ML, Cappelletti M, Ferrara FF, D'Acunto E, Chiarini V, Arriga R, Nyska A, Di Lucia P, Marotta D, Bono E, Giustini L, Sala E, Perucchini C, Paterson J, Ryan KA, Challis AR, Matusali G, Colavita F, Caselli G Published in: Mol Ther, 2021, ISSN 1525-0016 Publisher: Nature Publishing Group DOI: 10.1016/j.ymthe.2021.09.011 Immunodetection assays for the quantification of seasonal common cold coronaviruses OC43, NL63, or 229E infection confirm nirmatrelvir as broad coronavirus inhibitor. Author(s): Weil T, Lawrenz J, Seidel A, Münch J, Müller JA Published in: Antiviral Res, 2022, ISSN 0166-3542 Publisher: Elsevier BV DOI: 10.1016/j.antiviral.2022.105343 Drug Inhibition of SARS-CoV-2 Replication in Human Pluripotent Stem Cell–Derived Intestinal Organoids Author(s): Jana Krüger, Rüdiger Groß, Carina Conzelmann, Janis A. Müller, Lennart Koepke, Konstantin M.J. Sparrer, Tatjana Weil, Desiree Schütz, Thomas Seufferlein, Thomas F.E. Barth, Steffen Stenger, Sandra Heller, Jan Münch, Alexander Kleger Published in: Cellular and Molecular Gastroenterology and Hepatology, Issue 11/4, 2021, Page(s) 935-948, ISSN 2352-345X Publisher: Elsevier Inc. DOI: 10.1016/j.jcmgh.2020.11.003 Towards the direct detection of viral materials at the surface of protective face masks via infrared spectroscopy. Author(s): Schorer V, Haas J, Stach R, Kokoric V, Groß R, Münch J, Hummel T, Sobek H, Mennig J, Mizaikoff B. Published in: Sci Rep, 2022, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/s41598-022-06335-z Robust and durable serological response following pediatric SARS-CoV-2 infection Author(s): Renk H, Dulovic A, Seidel A, Becker M, Fabricius D, Zernickel M, Junker D, Groß R, Müller J, Hilger A, Bode SFN, Fritsch L, Frieh P, Haddad A, Görne T, Remppis J, Ganzemueller T, Dietz A, Huzly D, Hengel H, Kaier K, Weber S, Jacobsen EM, Kaiser PD, Traenkle B, Rothbauer U, Stich M, Tönshoff B, Hoffmann GF, Müller B, Ludwig C, Jahrsdörfer B, Schrezenmeier H, Peter A, Hörber S, Iftner T, Mün Published in: Nat Commun, 2022, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-021-27595-9 SARS-CoV-2 Is Restricted by Zinc Finger Antiviral Protein despite Preadaptation to the Low-CpG Environment in Humans Author(s): Rayhane Nchioua, Dorota Kmiec, Janis A. Müller, Carina Conzelmann, Rüdiger Groß, Chad M. Swanson, Stuart J. D. Neil, Steffen Stenger, Daniel Sauter, Jan Münch, Konstantin M. J. Sparrer, Frank Kirchhoff Published in: mBio, Issue 11/5, 2020, ISSN 2150-7511 Publisher: American Society for Microbiology DOI: 10.1128/mbio.01930-20 Hydroxychloroquine use against SARS-CoV-2 infection in non-human primates Author(s): Pauline Maisonnasse, Jérémie Guedj, Vanessa Contreras, Sylvie Behillil, Caroline Solas, Romain Marlin, Thibaut Naninck, Andres Pizzorno, Julien Lemaitre, Antonio Gonçalves, Nidhal Kahlaoui, Olivier Terrier, Raphael Ho Tsong Fang, Vincent Enouf, Nathalie Dereuddre-Bosquet, Angela Brisebarre, Franck Touret, Catherine Chapon, Bruno Hoen, Bruno Lina, Manuel Rosa Calatrava, Sylvie van der Werf, Xavi Published in: Nature, Issue 585/7826, 2020, Page(s) 584-587, ISSN 0028-0836 Publisher: Nature Publishing Group DOI: 10.1038/s41586-020-2558-4 Supramolecular Mechanism of Viral Envelope Disruption by Molecular Tweezers Author(s): Tatjana Weil, Rüdiger Groß, Annika Röcker, Kenny Bravo-Rodriguez, Christian Heid, Andrea Sowislok, My-Hue Le, Nelli Erwin, Mridula Dwivedi, Stephen M. Bart, Paul Bates, Lukas Wettstein, Janis A. Müller, Mirja Harms, Konstantin Sparrer, Yasser B. Ruiz-Blanco, Christina M. Stürzel, Jens von Einem, Sina Lippold, Clarissa Read, Paul Walther, Marco Hebel, Florian Kreppel, Frank-Gerrit Klärner, Ga Published in: Journal of the American Chemical Society, Issue 142/40, 2020, Page(s) 17024-17038, ISSN 0002-7863 Publisher: American Chemical Society DOI: 10.1021/jacs.0c06400 An enzyme-based immunodetection assay to quantify SARS-CoV-2 infection Author(s): Carina Conzelmann, Andrea Gilg, Rüdiger Groß, Desiree Schütz, Nico Preising, Ludger Ständker, Bernd Jahrsdörfer, Hubert Schrezenmeier, Konstantin M.J. Sparrer, Thomas Stamminger, Steffen Stenger, Jan Münch, Janis A. Müller Published in: Antiviral Research, Issue 181, 2020, Page(s) 104882, ISSN 0166-3542 Publisher: Elsevier BV DOI: 10.1016/j.antiviral.2020.104882 SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies Author(s): Markus Hoffmann, Prerna Arora, Rüdiger Groß, Alina Seidel, Bojan F. Hörnich, Alexander S. Hahn, Nadine Krüger, Luise Graichen, Heike Hofmann-Winkler, Amy Kempf, Martin S. Winkler, Sebastian Schulz, Hans-Martin Jäck, Bernd Jahrsdörfer, Hubert Schrezenmeier, Martin Müller, Alexander Kleger, Jan Münch, Stefan Pöhlmann Published in: Cell, Issue 184/9, 2021, Page(s) 2384-2393.e12, ISSN 0092-8674 Publisher: Cell Press DOI: 10.1016/j.cell.2021.03.036 Antibody-mediated procoagulant platelets in SARS-CoV-2- vaccination associated immune thrombotic thrombocytopenia. Author(s): Althaus K, Möller P, Uzun G, Singh A, Beck A, Bettag M, Bösmüller H, Guthoff M, Dorn F, Petzold GC, Henkes H, Heyne N, Jumaa H, Kreiser K, Limpach C, Luz B, Maschke M, Müller JA, Münch J, Nagel S, Pötzsch B, Müller J, Schlegel C, Viardot A, Bäzner H, Wolf M, Pelzl L, Warm V, Willinek WA, Steiner J, Schneiderhan-Marra N, Vollherbst D, Sachs UJ, Fend F, Bakchoul T. Published in: Haematologica, 2021, ISSN 0390-6078 Publisher: Ferrata Storti Foundation DOI: 10.3324/haematol.2021.279000 Characterization of the SARS-CoV-2 Neutralization Potential of COVID-19-Convalescent Donors Author(s): Jahrsdörfer B, Groß R, Seidel A, Wettstein L, Ludwig C, Schwarz T, Körper S, Rojewski M, Lotfi R, Weinstock C, Seifried E, Corman VM, Drosten C, Münch J, Schrezenmeier H. Published in: J Immunol, 2021, ISSN 0022-1767 Publisher: American Association of Immunologists DOI: 10.4049/jimmunol.2100036 Immune responses against SARS-CoV-2 variants after heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination Author(s): Barros-Martins J, Hammerschmidt SI, Cossmann A, Odak I, Stankov MV, Morillas Ramos G, Dopfer-Jablonka A, Heidemann A, Ritter C, Friedrichsen M, Schultze-Florey C, Ravens I, Willenzon S, Bubke A, Ristenpart J, Janssen A, Ssebyatika G, Bernhardt G, Münch J, Hoffmann M, Pöhlmann S, Krey T, Bošnjak B, Förster R, Behrens GMN. Published in: Nat Med, 2021, ISSN 1546-170X Publisher: Springer Nature DOI: 10.1038/s41591-021-01449-9 Inhibition of Respiratory Syncytial Virus Infection by Small Non-Coding RNA Fragments Author(s): Pålsson SA, Sekar V, Kutter C, Friedländer MR, Spetz AL Published in: Int. J. Mol. Sci., 2022, ISSN 1422-0067 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms23115990 Pasteurization Inactivates SARS-CoV-2–Spiked Breast Milk Author(s): Carina Conzelmann, Rüdiger Groß, Toni Luise Meister, Daniel Todt, Adalbert Krawczyk, Ulf Dittmer, Steffen Stenger, Jan Münch, Eike Steinmann, Janis A. Müller, Stephanie Pfaender Published in: Pediatrics, Issue 147/1, 2021, Page(s) e2020031690, ISSN 0031-4005 Publisher: American Academy of Pediatrics DOI: 10.1542/peds.2020-031690 SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas Author(s): Janis A. Müller, Rüdiger Groß, Carina Conzelmann, Jana Krüger, Uta Merle, Johannes Steinhart, Tatjana Weil, Lennart Koepke, Caterina Prelli Bozzo, Clarissa Read, Giorgio Fois, Tim Eiseler, Julia Gehrmann, Joanne van Vuuren, Isabel M. Wessbecher, Manfred Frick, Ivan G. Costa, Markus Breunig, Beate Grüner, Lynn Peters, Michael Schuster, Stefan Liebau, Thomas Seufferlein, Steffen Stenger, Albrec Published in: Nature Metabolism, Issue 3/2, 2021, Page(s) 149-165, ISSN 2522-5812 Publisher: Springer Nature DOI: 10.1038/s42255-021-00347-1 Salivary extracellular vesicles inhibit Zika virus but not SARS‐CoV‐2 infection Author(s): Carina Conzelmann, Rüdiger Groß, Min Zou, Franziska Krüger, André Görgens, Manuela O Gustafsson, Samir El Andaloussi, Jan Münch, Janis A. Müller Published in: Journal of Extracellular Vesicles, Issue 9/1, 2020, Page(s) 1808281, ISSN 2001-3078 Publisher: Taylor and Francis Online DOI: 10.1080/20013078.2020.1808281 Structural and functional basis for pan-CoV fusion inhibitors against SARS-CoV-2 and its variants with preclinical evaluation Author(s): Xia S, Lan Q, Zhu Y, Wang C, Xu W, Li Y, Wang L, Jiao F, Zhou J, Hua C, Wang Q, Cai X, Wu Y, Gao J, Liu H, Sun G, Münch J, Kirchhoff F, Yuan Z, Xie Y, Sun F, Jiang S, Lu L. Published in: Signal Transduct Target Ther., 2021, ISSN 2059-3635 Publisher: Springer Nature DOI: 10.1038/s41392-021-00712-2 Is There a Role for Immunoregulatory and Antiviral Oligonucleotides Acting in the Extracellular Space? A Review and Hypothesis Author(s): Dondalska A, Axberg Pålsson S, Spetz AL Published in: Int J Mol Sci, 2022, ISSN 1422-0067 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms232314593 Heterologous ChAdOx1 nCoV-19 and BNT162b2 prime-boost vaccination elicits potent neutralizing antibody responses and T cell reactivity against prevalent SARS-CoV-2 variants. Author(s): Groß R, Zanoni M, Seidel A, Conzelmann C, Gilg A, Krnavek D, Erdemci-Evin S, Mayer B, Hoffmann M, Pöhlmann S, Liu W, Hahn BH, Beil A, Kroschel J, Jahrsdörfer B, Schrezenmeier H, Kirchhoff F, Münch J, Müller JA. Published in: EBioMedicine, 2022, ISSN 2352-3964 Publisher: Elsevier BV DOI: 10.1016/j.ebiom.2021.103761 High antibody levels and reduced cellular response in children up to one year after SARS-CoV-2 infection. Author(s): Jacobsen EM, Fabricius D, Class M, Topfstedt F, Lorenzetti R, Janowska I, Schmidt F, Staniek J, Zernickel M, Stamminger T, Dietz AN, Zellmer A, Hecht M, Rauch P, Blum C, Ludwig C, Jahrsdörfer B, Schrezenmeier H, Heeg M, Mayer B, Seidel A, Groß R, Münch J, Kirchhoff F, Bode SFN, Strauss G, Renk H, Elling R, Stich M, Voll RE, Tönshof B, Franz AR, Henneke P, Debatin KM, Rizzi M, Janda A. Published in: Nature Communications, 2022, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-022-35055-1 The molecular tweezer CLR01 inhibits antibody-resistant cell-to-cell spread of human cytomegalovirus Author(s): S. Brenner, B. Braun, C. Read, T. Weil, P. Walther, T. Schrader, J. Münch, J. von Einem Published in: Viruses, 2021, ISSN 1999-4915 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/v13091685 Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection Author(s): Lukas Wettstein, Tatjana Weil, Carina Conzelmann, Janis A. Müller, Rüdiger Groß, Maximilian Hirschenberger, Alina Seidel, Susanne Klute, Fabian Zech, Caterina Prelli Bozzo, Nico Preising, Giorgio Fois, Robin Lochbaum, Philip Maximilian Knaff, Volker Mailänder, Ludger Ständker, Dietmar Rudolf Thal, Christian Schumann, Steffen Stenger, Alexander Kleger, Günter Lochnit, Benjamin Mayer, Yasser B Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-021-21972-0 Inhaled and systemic heparin as a repurposed direct antiviral drug for prevention and treatment of COVID-19 Author(s): Carina Conzelmann, Janis A Müller, Lukas Perkhofer, Konstantin MJ Sparrer, Alexander N Zelikin, Jan Münch, Alexander Kleger Published in: Clinical Medicine, Issue 20/6, 2020, Page(s) e218-e221, ISSN 1470-2118 Publisher: Royal College of Physicians DOI: 10.7861/clinmed.2020-0351 IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro. Author(s): Prelli Bozzo C, Nchioua R, Volcic M, Koepke L, Krüger J, Schütz D, Heller S, Stürzel CM, Kmiec D, Conzelmann C, Müller J, Zech F, Braun E, Groß R, Wettstein L, Weil T, Weiß J, Diofano F, Rodríguez Alfonso AA, Wiese S, Sauter D, Münch J, Goffinet C, Catanese A, Schön M, Boeckers TM, Stenger S, Sato K, Just S, Kleger A, Sparrer KMJ, Kirchhoff F. Published in: Nat Comm, 2021, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-021-24817-y Intellectual Property Rights Patent (6) SINGLE STRANDED OLIGONUCLEOTIDES INHIBITING ENDOCYTOSIS Application/Publication number: 20 18074032 Date: 2018-09-06 SINGLE STRANDED OLIGONUCLEOTIDES INHIBITING ENDOCYTOSIS Application/Publication number: 20 18074032 Date: 2018-09-06 NEW MOLECULAR TWEEZERS AGAINST NEUROLOGICAL DISORDERS AND VIRAL INFECTIONS Application/Publication number: 19 824953 Date: 2019-06-28 Applicant(s): UNIVERSITAET DUISBURG-ESSEN SINGLE STRANDED OLIGONUCLEOTIDES INHIBITING ENDOCYTOSIS Application/Publication number: 20 18074032 Date: 2018-09-06 NEW MOLECULAR TWEEZERS AGAINST NEUROLOGICAL DISORDERS AND VIRAL INFECTIONS Application/Publication number: 19 824953 Date: 2019-06-28 Applicant(s): UNIVERSITAET DUISBURG-ESSEN NEW MOLECULAR TWEEZERS AGAINST NEUROLOGICAL DISORDERS AND VIRAL INFECTIONS Application/Publication number: 19 824953 Date: 2019-06-28 Applicant(s): UNIVERSITAET DUISBURG-ESSEN Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available
