FIGHTING-OFF CORONAVIRUS (SARS-CoV-2) WITH BROAD-SPECTRUM ANTIVIRALS: ESTABLISHING ANIMAL VIRAL CHALLENGE MODEL

Deliverables

Identification of those compounds that most efficiently prevent infection and disease in small animal model. Choice of compound and dosing regimen to be used in NHP

Task 110 To evaluate the ability of candidate antivirals to prevent or minimise SARSCoV2infection and disease in mice month 130Objective To identify those antivirals that most effectively prevent SARSCoV2 infection and disease symptoms in mice

Dissemination activity and quality report
Determine tropism in airway epithelia (months 9) and antiviral activity (month 12-18), M12

Determine tropism in airway epithelia (month 9) and antiviral activity (month 12-18)

Detailed characterization (IC50, IC90) of the antiviral activity of each identified inhibitor against MA SARS-CoV-2 and Omicron

Task 19 To confirm the efficacy of developed antivirals against cellfree and cellcell infection of a mouse adapted SARSCoV2 strain and VOCs month 2430Objectives To establish an infection model with a mouse adapted SARSCoV2 strain and to evaluate the antiviral activity of most promising SARSCoV2 inhibitors developed in the consortium

Characterization of antiviral tweezers: Preclinical assessment and dose-efficacy
Characterization of antiviral tweezers: Preclinical assessment and dose-efficacy, M12

Characterization of antiviral tweezers: Preclinical assessment and dose-efficacy

Determine tropism in airway epithelia (months 9) and antiviral activity (month 12-18)

Determine tropism in airway epithelia (month 9) and antiviral activity (month 12-18)

Report on implementation of a non-human primate model for SARS-CoV-2 infection and disease

Report on implementation of a non-human primate model for SARS-CoV-2 infection and disease.

MTT-based SARS-CoV-2 assay established
Determination of ability for antiviral to prevent disease and choice of dosing regimen to be used in NHP

Task 26 Objective To evaluate the ability for antivirals to prevent or minimise SARSCoV2induced disease in hamster month 2630Expected results To identify if a clinically relevant dosing regimen that can prevent SARSCoV2induced disease Such a dosing regimen can be further evaluated in NHPs

Optimised hamster model of SARS-CoV-2 for evaluation of antivirals

Task 25 Objective To optimise a small animal wildtype disease model of SARSCoV2 month 2425Expected results To decide a dose of SARSCoV2 that leads to measurable clinical symptoms but not severe disease

Establishing SOPs for in vitro evaluation of antiviral activity against SARS-CoV-2
Report of treatment efficacy and safety measures after treatment of SARS-CoV-2 infected NHP.

Report of treatment efficacy and safety measures after treatment of SARSCoV2 infected NHP

Publication list of primary research articles in high impact journals (R, PU)

Publication of primary research articles in high impact journals

GLP toxicity studies in rats after systemic and intranasal administration
Publication list of primary research articles in high impact journals (R, PU), M24

Publication of primary research articles in high impact journals

Characterization of the antiviral compound ssON: Preclinical assessment and dose-efficacy
Characterization of additional antiviral compounds made available to the consortium after starting the project: Preclinical assessment and dose-efficacy

Characterization of additional antiviral compounds made available to the consortium after starting the project Preclinical assessment and doseefficacy

Characterization antiviral polymers: Preclinical assessment and dose-efficacy
Characterization antiviral polymers: Preclinical assessment and dose-efficacy, M12

Characterization antiviral polymers: Preclinical assessment and dose-efficacy

List Public communication to specialized and general audiences, M24

Public dissemination to specialized and general audiences

List Public communication to specialized and general audiences

Public dissemination to specialized and general audiences

Publications

BNT162b2 booster after heterologous prime-boost vaccination induces potent neutralizing antibodies and T cell reactivity against SARS-CoV-2 Omicron BA.1 in young adults.

Author(s): Seidel A, Zanoni M, Groß R, Krnavek D, Erdemci-Evin S, von Maltitz P, Albers DPJ, Conzelmann C, Liu S, Weil T, Mayer B, Hoffmann M, Pöhlmann S, Beil A, Kroschel J, Kirchhoff F, Münch J, Müller JA.
Published in: Frontiers Immunology, 2022, ISSN 1664-3224
Publisher: Frontiers Media S.A
DOI: 10.3389/fimmu.2022.882918

Plastic Antibodies Mimicking the ACE2 Receptor for Selective Binding of SARS-CoV-2 Spike

Author(s): Batista AD, Rajpal S, Keitel B, Dietl S, Fresco-Cala B, Dinc M, Groß R, Sobek H, Münch J, Mizaikoff B
Published in: Adv Mater Interfaces, 2022, ISSN 2196-7350
Publisher: Wiley
DOI: 10.1002/admi.202101925

Native and activated antithrombin inhibits TMPRSS2 activity and SARS-CoV-2 infection.

Author(s): Wettstein L, Immenschuh P, Weil T, Conzelmann C, Almeida-Hernández Y, Hoffmann M, Kempf A, Nehlmeier I, Lotke R, Petersen M, Stenger S, Kirchhoff F, Sauter D, Pöhlmann S, Sanchez-Garcia E, Münch J.
Published in: J Med Virol, 2022, ISSN 1096-9071
Publisher: Wiley
DOI: 10.1002/jmv.28124

Molecular Tweezers - a new class of potent broad-spectrum antivirals against enveloped viruses.

Author(s): E Taghuo K, M-H Le, T Schrader
Published in: Chemical Communications, 2022, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1cc06737k

Peptidomimetic inhibitors of TMPRSS2 block SARS-CoV-2 infection in cell culture

Author(s): Wettstein, L., Knaff, P.M., Kersten,C., Müller,P., Weil, T., Conzelmann, C., Müller, J., Brückner, M., Hoffmann, M., Pöhlmann, S., Schirmeister, T., Münch, J., Mailänder, V
Published in: Communications Biology, 2022, ISSN 2399-3642
Publisher: Nature
DOI: 10.1038/s42003-022-03613-4

SARS-CoV-2 Vaccination boosts Neutralizing Activity against Seasonal Human Coronaviruses.

Author(s): Lawrenz J, Xie Q, Zech F, Weil T, Seidel A, Krnavek D, van der Hoek L, Münch J, Müller JA, Kirchhoff F.
Published in: Clin Infect Dis, 2022, ISSN 1058-4838
Publisher: University of Chicago Press
DOI: 10.1093/cid/ciac057

Virucidal Efficacy of Different Oral Rinses Against Severe Acute Respiratory Syndrome Coronavirus 2

Author(s): Toni Luise Meister, Yannick Brüggemann, Daniel Todt, Carina Conzelmann, Janis A Müller, Rüdiger Groß, Jan Münch, Adalbert Krawczyk, Jörg Steinmann, Jochen Steinmann, Stephanie Pfaender, Eike Steinmann
Published in: The Journal of Infectious Diseases, Issue 222/8, 2020, Page(s) 1289-1292, ISSN 0022-1899
Publisher: University of Chicago Press
DOI: 10.1093/infdis/jiaa471

Detection of SARS-CoV-2 in human breastmilk

Author(s): Rüdiger Groß, Carina Conzelmann, Janis A Müller, Steffen Stenger, Karin Steinhart, Frank Kirchhoff, Jan Münch
Published in: The Lancet, Issue 395/10239, 2020, Page(s) 1757-1758, ISSN 0140-6736
Publisher: The Lancet Publishing Group
DOI: 10.1016/s0140-6736(20)31181-8

Macromolecular Viral Entry Inhibitors as Broad-Spectrum First-Line Antivirals with Activity against SARS-CoV-2

Author(s): Groß R, Dias Loiola LM, Issmail L, Uhlig N, Eberlein V, Conzelmann C, Olari LR, Rauch L, Lawrenz J, Weil T, Müller JA, Cardoso MB, Gilg A, Larsson O, Höglund U, Pålsson SA, Tvilum AS, Løvschall KB, Kristensen MM, Spetz AL, Hontonnou F, Galloux M, Grunwald T, Zelikin AN*, Münch J*.
Published in: Adv. Sci., 2022, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.202201378

Broad‐Spectrum Antiviral Agents Based on Multivalent Inhibitors of Viral Infectivity

Author(s): Alexander N. Zelikin, Francesco Stellacci
Published in: Advanced Healthcare Materials, Issue 10/6, 2021, Page(s) 2001433, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202001433

Advanced Molecular Tweezers with Lipid Anchors against SARS-CoV-2 and Other Respiratory Viruses.

Author(s): Weil T, Kirupakaran A, Le MH, Rebmann P, Mieres-Perez J, Issmail L, Conzelmann C, Müller JA, Rauch L, Gilg A, Wettstein L, Groß R, Read C, Bergner T, Pålsson SA, Uhlig N, Eberlein V, Wöll H, Klärner FG, Stenger S, Kümmerer BM, Streeck H, Fois G, Frick M, Braubach P, Spetz AL, Grunwald T, Shorter J, Sanchez-Garcia E, Schrader T, Münch J.
Published in: JACS Au, 2022, ISSN 2691-3704
Publisher: ACS Publications
DOI: 10.1021/jacsau.2c00220

Inhibitors of Activin Receptor-like Kinase 5 Interfere with SARS-CoV-2 S-Protein Processing and Spike-Mediated Cell Fusion via Attenuation of Furin Expression.

Author(s): Mezger MC, Conzelmann C, Weil T, von Maltitz P, Albers DPJ, Münch J, Stamminger T, Schilling EM.
Published in: Viruses, 2022, Page(s) 1308, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v14061308

Single-Stranded Oligonucleotide-Mediated Inhibition of Respiratory Syncytial Virus Infection

Author(s): Sandra Axberg Pålsson, Aleksandra Dondalska, Joseph Bergenstråhle, Caroline Rolfes, Albin Björk, Laura Sedano, Ultan F. Power, Marie-Anne Rameix-Welti, Joakim Lundeberg, Marie Wahren-Herlenius, Peter Mastrangelo, Jean-Francois Eleouet, Ronan Le Goffic, Marie Galloux, Anna-Lena Spetz
Published in: Frontiers in Immunology, Issue 11, 2020, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2020.580547

Carrageenan-containing over-the-counter nasal and oral sprays inhibit SARS-CoV-2 infection of airway epithelial cultures

Author(s): Desiree Schütz, Carina Conzelmann, Giorgio Fois, Rüdiger Groß, Tatjana Weil, Lukas Wettstein, Steffen Stenger, Alexander Zelikin, Thomas K. Hoffmann, Manfred Frick, Janis A. Müller, Jan Münch
Published in: American Journal of Physiology-Lung Cellular and Molecular Physiology, Issue 320/5, 2021, Page(s) L750-L756, ISSN 1040-0605
Publisher: American Physiological Society
DOI: 10.1152/ajplung.00552.2020

Rapid, convenient and efficient kit-independent detection of SARS-CoV-2 RNA

Author(s): Detlef Michel, Karin M. Danzer, Rüdiger Groß, Carina Conzelmann, Janis A. Müller, Axel Freischmidt, Jochen H. Weishaupt, Sandra Heller, Jan Münch, Manuela Michel, Thomas Stamminger, Alexander Kleger, Markus Otto
Published in: Journal of Virological Methods, Issue 286, 2020, Page(s) 113965, ISSN 0166-0934
Publisher: Elsevier BV
DOI: 10.1016/j.jviromet.2020.113965

The Transmembrane Protease TMPRSS2 as a Therapeutic Target for COVID-19 Treatment

Author(s): Wettstein L, Kirchhoff F, Münch J.
Published in: Int J Mol Sci, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23031351

Nitric Oxide to Fight Viral Infections

Author(s): Fabio Lisi, Alexander N. Zelikin, Rona Chandrawati
Published in: Advanced Science, Issue 8/7, 2021, Page(s) 2003895, ISSN 2198-3844
Publisher: Wiley-VCH GmbH
DOI: 10.1002/advs.202003895

COVID-eVax, an electroporated plasmid DNA vaccine candidate encoding the SARS-CoV-2 Receptor Binding Domain, elicits protective immune responses in animal models of COVID-19.

Author(s): Conforti A, Marra E, Palombo F, Roscilli G, Ravà M, Fumagalli V, Muzi A, Maffei M, Luberto L, Lione L, Salvatori E, Compagnone M, Pinto E, Pavoni E, Bucci F, Vitagliano G, Stoppoloni D, Pacello ML, Cappelletti M, Ferrara FF, D'Acunto E, Chiarini V, Arriga R, Nyska A, Di Lucia P, Marotta D, Bono E, Giustini L, Sala E, Perucchini C, Paterson J, Ryan KA, Challis AR, Matusali G, Colavita F, Caselli G
Published in: Mol Ther, 2021, ISSN 1525-0016
Publisher: Nature Publishing Group
DOI: 10.1016/j.ymthe.2021.09.011

Immunodetection assays for the quantification of seasonal common cold coronaviruses OC43, NL63, or 229E infection confirm nirmatrelvir as broad coronavirus inhibitor.

Author(s): Weil T, Lawrenz J, Seidel A, Münch J, Müller JA
Published in: Antiviral Res, 2022, ISSN 0166-3542
Publisher: Elsevier BV
DOI: 10.1016/j.antiviral.2022.105343

Drug Inhibition of SARS-CoV-2 Replication in Human Pluripotent Stem Cell–Derived Intestinal Organoids

Author(s): Jana Krüger, Rüdiger Groß, Carina Conzelmann, Janis A. Müller, Lennart Koepke, Konstantin M.J. Sparrer, Tatjana Weil, Desiree Schütz, Thomas Seufferlein, Thomas F.E. Barth, Steffen Stenger, Sandra Heller, Jan Münch, Alexander Kleger
Published in: Cellular and Molecular Gastroenterology and Hepatology, Issue 11/4, 2021, Page(s) 935-948, ISSN 2352-345X
Publisher: Elsevier Inc.
DOI: 10.1016/j.jcmgh.2020.11.003

Towards the direct detection of viral materials at the surface of protective face masks via infrared spectroscopy.

Author(s): Schorer V, Haas J, Stach R, Kokoric V, Groß R, Münch J, Hummel T, Sobek H, Mennig J, Mizaikoff B.
Published in: Sci Rep, 2022, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-06335-z

Robust and durable serological response following pediatric SARS-CoV-2 infection

Author(s): Renk H, Dulovic A, Seidel A, Becker M, Fabricius D, Zernickel M, Junker D, Groß R, Müller J, Hilger A, Bode SFN, Fritsch L, Frieh P, Haddad A, Görne T, Remppis J, Ganzemueller T, Dietz A, Huzly D, Hengel H, Kaier K, Weber S, Jacobsen EM, Kaiser PD, Traenkle B, Rothbauer U, Stich M, Tönshoff B, Hoffmann GF, Müller B, Ludwig C, Jahrsdörfer B, Schrezenmeier H, Peter A, Hörber S, Iftner T, Mün
Published in: Nat Commun, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-27595-9

SARS-CoV-2 Is Restricted by Zinc Finger Antiviral Protein despite Preadaptation to the Low-CpG Environment in Humans

Author(s): Rayhane Nchioua, Dorota Kmiec, Janis A. Müller, Carina Conzelmann, Rüdiger Groß, Chad M. Swanson, Stuart J. D. Neil, Steffen Stenger, Daniel Sauter, Jan Münch, Konstantin M. J. Sparrer, Frank Kirchhoff
Published in: mBio, Issue 11/5, 2020, ISSN 2150-7511
Publisher: American Society for Microbiology
DOI: 10.1128/mbio.01930-20

Hydroxychloroquine use against SARS-CoV-2 infection in non-human primates

Author(s): Pauline Maisonnasse, Jérémie Guedj, Vanessa Contreras, Sylvie Behillil, Caroline Solas, Romain Marlin, Thibaut Naninck, Andres Pizzorno, Julien Lemaitre, Antonio Gonçalves, Nidhal Kahlaoui, Olivier Terrier, Raphael Ho Tsong Fang, Vincent Enouf, Nathalie Dereuddre-Bosquet, Angela Brisebarre, Franck Touret, Catherine Chapon, Bruno Hoen, Bruno Lina, Manuel Rosa Calatrava, Sylvie van der Werf, Xavi
Published in: Nature, Issue 585/7826, 2020, Page(s) 584-587, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2558-4

Supramolecular Mechanism of Viral Envelope Disruption by Molecular Tweezers

Author(s): Tatjana Weil, Rüdiger Groß, Annika Röcker, Kenny Bravo-Rodriguez, Christian Heid, Andrea Sowislok, My-Hue Le, Nelli Erwin, Mridula Dwivedi, Stephen M. Bart, Paul Bates, Lukas Wettstein, Janis A. Müller, Mirja Harms, Konstantin Sparrer, Yasser B. Ruiz-Blanco, Christina M. Stürzel, Jens von Einem, Sina Lippold, Clarissa Read, Paul Walther, Marco Hebel, Florian Kreppel, Frank-Gerrit Klärner, Ga
Published in: Journal of the American Chemical Society, Issue 142/40, 2020, Page(s) 17024-17038, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.0c06400

An enzyme-based immunodetection assay to quantify SARS-CoV-2 infection

Author(s): Carina Conzelmann, Andrea Gilg, Rüdiger Groß, Desiree Schütz, Nico Preising, Ludger Ständker, Bernd Jahrsdörfer, Hubert Schrezenmeier, Konstantin M.J. Sparrer, Thomas Stamminger, Steffen Stenger, Jan Münch, Janis A. Müller
Published in: Antiviral Research, Issue 181, 2020, Page(s) 104882, ISSN 0166-3542
Publisher: Elsevier BV
DOI: 10.1016/j.antiviral.2020.104882

SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies

Author(s): Markus Hoffmann, Prerna Arora, Rüdiger Groß, Alina Seidel, Bojan F. Hörnich, Alexander S. Hahn, Nadine Krüger, Luise Graichen, Heike Hofmann-Winkler, Amy Kempf, Martin S. Winkler, Sebastian Schulz, Hans-Martin Jäck, Bernd Jahrsdörfer, Hubert Schrezenmeier, Martin Müller, Alexander Kleger, Jan Münch, Stefan Pöhlmann
Published in: Cell, Issue 184/9, 2021, Page(s) 2384-2393.e12, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2021.03.036

Antibody-mediated procoagulant platelets in SARS-CoV-2- vaccination associated immune thrombotic thrombocytopenia.

Author(s): Althaus K, Möller P, Uzun G, Singh A, Beck A, Bettag M, Bösmüller H, Guthoff M, Dorn F, Petzold GC, Henkes H, Heyne N, Jumaa H, Kreiser K, Limpach C, Luz B, Maschke M, Müller JA, Münch J, Nagel S, Pötzsch B, Müller J, Schlegel C, Viardot A, Bäzner H, Wolf M, Pelzl L, Warm V, Willinek WA, Steiner J, Schneiderhan-Marra N, Vollherbst D, Sachs UJ, Fend F, Bakchoul T.
Published in: Haematologica, 2021, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2021.279000

Characterization of the SARS-CoV-2 Neutralization Potential of COVID-19-Convalescent Donors

Author(s): Jahrsdörfer B, Groß R, Seidel A, Wettstein L, Ludwig C, Schwarz T, Körper S, Rojewski M, Lotfi R, Weinstock C, Seifried E, Corman VM, Drosten C, Münch J, Schrezenmeier H.
Published in: J Immunol, 2021, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.2100036

Immune responses against SARS-CoV-2 variants after heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination

Author(s): Barros-Martins J, Hammerschmidt SI, Cossmann A, Odak I, Stankov MV, Morillas Ramos G, Dopfer-Jablonka A, Heidemann A, Ritter C, Friedrichsen M, Schultze-Florey C, Ravens I, Willenzon S, Bubke A, Ristenpart J, Janssen A, Ssebyatika G, Bernhardt G, Münch J, Hoffmann M, Pöhlmann S, Krey T, Bošnjak B, Förster R, Behrens GMN.
Published in: Nat Med, 2021, ISSN 1546-170X
Publisher: Springer Nature
DOI: 10.1038/s41591-021-01449-9

Inhibition of Respiratory Syncytial Virus Infection by Small Non-Coding RNA Fragments

Author(s): Pålsson SA, Sekar V, Kutter C, Friedländer MR, Spetz AL
Published in: Int. J. Mol. Sci., 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23115990

Pasteurization Inactivates SARS-CoV-2–Spiked Breast Milk

Author(s): Carina Conzelmann, Rüdiger Groß, Toni Luise Meister, Daniel Todt, Adalbert Krawczyk, Ulf Dittmer, Steffen Stenger, Jan Münch, Eike Steinmann, Janis A. Müller, Stephanie Pfaender
Published in: Pediatrics, Issue 147/1, 2021, Page(s) e2020031690, ISSN 0031-4005
Publisher: American Academy of Pediatrics
DOI: 10.1542/peds.2020-031690

SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas

Author(s): Janis A. Müller, Rüdiger Groß, Carina Conzelmann, Jana Krüger, Uta Merle, Johannes Steinhart, Tatjana Weil, Lennart Koepke, Caterina Prelli Bozzo, Clarissa Read, Giorgio Fois, Tim Eiseler, Julia Gehrmann, Joanne van Vuuren, Isabel M. Wessbecher, Manfred Frick, Ivan G. Costa, Markus Breunig, Beate Grüner, Lynn Peters, Michael Schuster, Stefan Liebau, Thomas Seufferlein, Steffen Stenger, Albrec
Published in: Nature Metabolism, Issue 3/2, 2021, Page(s) 149-165, ISSN 2522-5812
Publisher: Springer Nature
DOI: 10.1038/s42255-021-00347-1

Salivary extracellular vesicles inhibit Zika virus but not SARS‐CoV‐2 infection

Author(s): Carina Conzelmann, Rüdiger Groß, Min Zou, Franziska Krüger, André Görgens, Manuela O Gustafsson, Samir El Andaloussi, Jan Münch, Janis A. Müller
Published in: Journal of Extracellular Vesicles, Issue 9/1, 2020, Page(s) 1808281, ISSN 2001-3078
Publisher: Taylor and Francis Online
DOI: 10.1080/20013078.2020.1808281

Structural and functional basis for pan-CoV fusion inhibitors against SARS-CoV-2 and its variants with preclinical evaluation

Author(s): Xia S, Lan Q, Zhu Y, Wang C, Xu W, Li Y, Wang L, Jiao F, Zhou J, Hua C, Wang Q, Cai X, Wu Y, Gao J, Liu H, Sun G, Münch J, Kirchhoff F, Yuan Z, Xie Y, Sun F, Jiang S, Lu L.
Published in: Signal Transduct Target Ther., 2021, ISSN 2059-3635
Publisher: Springer Nature
DOI: 10.1038/s41392-021-00712-2

Is There a Role for Immunoregulatory and Antiviral Oligonucleotides Acting in the Extracellular Space? A Review and Hypothesis

Author(s): Dondalska A, Axberg Pålsson S, Spetz AL
Published in: Int J Mol Sci, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms232314593

Heterologous ChAdOx1 nCoV-19 and BNT162b2 prime-boost vaccination elicits potent neutralizing antibody responses and T cell reactivity against prevalent SARS-CoV-2 variants.

Author(s): Groß R, Zanoni M, Seidel A, Conzelmann C, Gilg A, Krnavek D, Erdemci-Evin S, Mayer B, Hoffmann M, Pöhlmann S, Liu W, Hahn BH, Beil A, Kroschel J, Jahrsdörfer B, Schrezenmeier H, Kirchhoff F, Münch J, Müller JA.
Published in: EBioMedicine, 2022, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2021.103761

High antibody levels and reduced cellular response in children up to one year after SARS-CoV-2 infection.

Author(s): Jacobsen EM, Fabricius D, Class M, Topfstedt F, Lorenzetti R, Janowska I, Schmidt F, Staniek J, Zernickel M, Stamminger T, Dietz AN, Zellmer A, Hecht M, Rauch P, Blum C, Ludwig C, Jahrsdörfer B, Schrezenmeier H, Heeg M, Mayer B, Seidel A, Groß R, Münch J, Kirchhoff F, Bode SFN, Strauss G, Renk H, Elling R, Stich M, Voll RE, Tönshof B, Franz AR, Henneke P, Debatin KM, Rizzi M, Janda A.
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-35055-1

The molecular tweezer CLR01 inhibits antibody-resistant cell-to-cell spread of human cytomegalovirus

Author(s): S. Brenner, B. Braun, C. Read, T. Weil, P. Walther, T. Schrader, J. Münch, J. von Einem
Published in: Viruses, 2021, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13091685

Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection

Author(s): Lukas Wettstein, Tatjana Weil, Carina Conzelmann, Janis A. Müller, Rüdiger Groß, Maximilian Hirschenberger, Alina Seidel, Susanne Klute, Fabian Zech, Caterina Prelli Bozzo, Nico Preising, Giorgio Fois, Robin Lochbaum, Philip Maximilian Knaff, Volker Mailänder, Ludger Ständker, Dietmar Rudolf Thal, Christian Schumann, Steffen Stenger, Alexander Kleger, Günter Lochnit, Benjamin Mayer, Yasser B
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-21972-0

Inhaled and systemic heparin as a repurposed direct antiviral drug for prevention and treatment of COVID-19

Author(s): Carina Conzelmann, Janis A Müller, Lukas Perkhofer, Konstantin MJ Sparrer, Alexander N Zelikin, Jan Münch, Alexander Kleger
Published in: Clinical Medicine, Issue 20/6, 2020, Page(s) e218-e221, ISSN 1470-2118
Publisher: Royal College of Physicians
DOI: 10.7861/clinmed.2020-0351

IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro.

Author(s): Prelli Bozzo C, Nchioua R, Volcic M, Koepke L, Krüger J, Schütz D, Heller S, Stürzel CM, Kmiec D, Conzelmann C, Müller J, Zech F, Braun E, Groß R, Wettstein L, Weil T, Weiß J, Diofano F, Rodríguez Alfonso AA, Wiese S, Sauter D, Münch J, Goffinet C, Catanese A, Schön M, Boeckers TM, Stenger S, Sato K, Just S, Kleger A, Sparrer KMJ, Kirchhoff F.
Published in: Nat Comm, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-24817-y

Intellectual Property Rights

SINGLE STRANDED OLIGONUCLEOTIDES INHIBITING ENDOCYTOSIS

Application/Publication number: 20 18074032
Date: 2018-09-06

NEW MOLECULAR TWEEZERS AGAINST NEUROLOGICAL DISORDERS AND VIRAL INFECTIONS

Application/Publication number: 19 824953
Date: 2019-06-28

SINGLE-STRANDED OLIGONUCLEOTIDES FOR USE IN THE MEDICAL TREATMENT AND/OR PROPHYLAXIS OF VIRUS INFECTIONS

Application/Publication number: 20 22061404
Date: 2022-04-28

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