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Antibody therapy against coronavirus (COVID-19)

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Publications

SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies

Author(s): Christopher O. Barnes, Claudia A. Jette, Morgan E. Abernathy, Kim-Marie A. Dam, Shannon R. Esswein, Harry B. Gristick, Andrey G. Malyutin, Naima G. Sharaf, Kathryn E. Huey-Tubman, Yu E. Lee, Davide F. Robbiani, Michel C. Nussenzweig, Anthony P. West, Pamela J. Bjorkman
Published in: Nature, 2020, ISSN 0028-0836
DOI: 10.1038/s41586-020-2852-1

Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo

Author(s): Alexandra Schäfer, Frauke Muecksch, Julio C.C. Lorenzi, Sarah R. Leist, Melissa Cipolla, Stylianos Bournazos, Fabian Schmidt, Rachel M. Maison, Anna Gazumyan, David R. Martinez, Ralph S. Baric, Davide F. Robbiani, Theodora Hatziioannou, Jeffrey V. Ravetch, Paul D. Bieniasz, Richard A. Bowen, Michel C. Nussenzweig, Timothy P. Sheahan
Published in: Journal of Experimental Medicine, Issue 218/3, 2021, ISSN 0022-1007
DOI: 10.1084/jem.20201993

ReScan, a Multiplex Diagnostic Pipeline, Pans Human Sera for SARS-CoV-2 Antigens

Author(s): Colin R. Zamecnik, Jayant V. Rajan, Kevin A. Yamauchi, Sabrina A. Mann, Rita P. Loudermilk, Gavin M. Sowa, Kelsey C. Zorn, Bonny D. Alvarenga, Christian Gaebler, Marina Caskey, Mars Stone, Philip J. Norris, Wei Gu, Charles Y. Chiu, Dianna Ng, James R. Byrnes, Xin X. Zhou, James A. Wells, Davide F. Robbiani, Michel C. Nussenzweig, Joseph L. DeRisi, Michael R. Wilson
Published in: Cell Reports Medicine, Issue 1/7, 2020, Page(s) 100123, ISSN 2666-3791
DOI: 10.1016/j.xcrm.2020.100123

Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies

Author(s): Christopher O. Barnes, Anthony P. West, Kathryn E. Huey-Tubman, Magnus A.G. Hoffmann, Naima G. Sharaf, Pauline R. Hoffman, Nicholas Koranda, Harry B. Gristick, Christian Gaebler, Frauke Muecksch, Julio C. Cetrulo Lorenzi, Shlomo Finkin, Thomas Hägglöf, Arlene Hurley, Katrina G. Millard, Yiska Weisblum, Fabian Schmidt, Theodora Hatziioannou, Paul D. Bieniasz, Marina Caskey, Davide F. Robbiani, Mi
Published in: Cell, Issue 182/4, 2020, Page(s) 828-842.e16, ISSN 0092-8674
DOI: 10.1016/j.cell.2020.06.025

Development of passive immunity against SARS-CoV-2 for management of immunodeficient patients—a perspective

Author(s): Lennart Hammarström, Hassan Abolhassani, Fausto Baldanti, Harold Marcotte, Qiang Pan-Hammarström
Published in: Journal of Allergy and Clinical Immunology, 2020, ISSN 0091-6749
DOI: 10.1016/j.jaci.2020.04.043

Prevalence of SARS-CoV-2 specific neutralising antibodies in blood donors from the Lodi Red Zone in Lombardy, Italy, as at 06 April 2020

Author(s): Elena Percivalle, Giuseppe Cambiè, Irene Cassaniti, Edoardo Vecchio Nepita, Roberta Maserati, Alessandro Ferrari, Raffaella Di Martino, Paola Isernia, Francesco Mojoli, Raffaele Bruno, Marcello Tirani, Danilo Cereda, Carlo Nicora, Massimo Lombardo, Fausto Baldanti
Published in: Eurosurveillance, Issue 25/24, 2020, ISSN 1560-7917
DOI: 10.2807/1560-7917.es.2020.25.24.2001031

Convergent antibody responses to SARS-CoV-2 in convalescent individuals

Author(s): Davide F. Robbiani, Christian Gaebler, Frauke Muecksch, Julio C. C. Lorenzi, Zijun Wang, Alice Cho, Marianna Agudelo, Christopher O. Barnes, Anna Gazumyan, Shlomo Finkin, Thomas Hägglöf, Thiago Y. Oliveira, Charlotte Viant, Arlene Hurley, Hans-Heinrich Hoffmann, Katrina G. Millard, Rhonda G. Kost, Melissa Cipolla, Kristie Gordon, Filippo Bianchini, Spencer T. Chen, Victor Ramos, Roshni Patel, Ju
Published in: Nature, 2020, ISSN 0028-0836
DOI: 10.1038/s41586-020-2456-9

Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses

Author(s): Fabian Schmidt, Yiska Weisblum, Frauke Muecksch, Hans-Heinrich Hoffmann, Eleftherios Michailidis, Julio C.C. Lorenzi, Pilar Mendoza, Magdalena Rutkowska, Eva Bednarski, Christian Gaebler, Marianna Agudelo, Alice Cho, Zijun Wang, Anna Gazumyan, Melissa Cipolla, Marina Caskey, Davide F. Robbiani, Michel C. Nussenzweig, Charles M. Rice, Theodora Hatziioannou, Paul D. Bieniasz
Published in: Journal of Experimental Medicine, Issue 217/11, 2020, ISSN 0022-1007
DOI: 10.1084/jem.20201181¨

Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants

Author(s): Weisblum Y, Schmidt F, Zhang F, DaSilva J, Poston D, Lorenzi JC, Muecksch F, Rutkowska M, Hoffmann HH, Michailidis E, Gaebler C, Agudelo M, Cho A, Wang Z, Gazumyan A, Cipolla M, Luchsinger L, Hillyer CD, Caskey M, Robbiani DF, Rice CM, Nussenzweig MC, Hatziioannou T, Bieniasz PD.
Published in: Elife, 2020, ISSN 2050-084X
DOI: 10.7554/elife.61312

Mortality reduction in 46 severe Covid-19 patients treated with hyperimmune plasma. A proof of concept single arm multicenter trial

Author(s): Cesare Perotti, Fausto Baldanti, Raffaele Bruno, Claudia Del Fante, Elena Seminari, Salvatore Casari, Elena Percivalle, Claudia Glingani, Valeria Musella, Mirko Belliato, Martina Garuti, Federica Meloni, Marilena Frigato, Antonio Di Sabatino, Catherine Klersy, Giuseppe De Donno, Massimo Franchini
Published in: Haematologica, 2020, Page(s) haematol.2020.261784, ISSN 0390-6078
DOI: 10.3324/haematol.2020.261784