Antibody therapy against coronavirus (COVID-19)

Resultado final

Opinion from EAB on the WP2 clinical work

Opinion from the Ethical Advisory Board AEB on the WP2 clinical work The AEB will revise Section 51 Ethics related to the phase I trial in WP2

Project website and logo

Project website including the description of the ATAC project and consortium, as well as news and links related to the project. The logo of the ATAC project will be included.

Publicaciones

Human genetic and immunological determinants of SARS-CoV-2 and Epstein–Barr virus diseases in childhood: Insightful contrasts

Autores: Qiang Pan-Hammarström, Jean-Laurent Casanova
Publicado en: Journal of Internal Medicine, 2023, ISSN 1613-6810
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1111/joim.13628

Humoral and cellular response before and after the fourth BNT162b2 vaccine dose in patients with solid tumors on active treatment

Autores: Lasagna A, Bergami F, Lilleri D, Percivalle E, Quaccini M, Comolli G, Sarasini A, Sammartino JC, Ferrari A, Arena F, Cicognini D, Schiavo R, Lo Cascio G, Baldanti F, Pedrazzoli P, Cassaniti I.
Publicado en: Annals of Oncology, 2022, Página(s) S0923-7534, ISSN 0923-7534
Editor: Oxford University Press
DOI: 10.1016/j.annonc.2022.07.012

SARS-CoV-2 specific T-cell immunity in COVID-19 convalescent patients and unexposed controls measured by ex vivo ELISpot assay

Autores: Irene Cassaniti, Elena Percivalle, Federica Bergami, Antonio Piralla, Giuditta Comolli, Raffaele Bruno, Marco Vecchia, Margherita Sambo, Marta Colaneri, Valentina Zuccaro, Marco Benazzo, Carlo Robotti, Anna Calastri, Eugenia Maiorano, Alessandro Ferrari, Giuseppe Cambiè, Fausto Baldanti
Publicado en: Clinical Microbiology and Infection, 2021, ISSN 1198-743X
Editor: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2021.03.010

Six-month humoral and cellular immune response to the third dose of BNT162b2 anti-SARS-CoV-2 vaccine in patients with solid tumors: a longitudinal cohort study with a focus on the variants of concern

Autores: Lasagna A, Bergami F, Lilleri D, Percivalle E, Quaccini M, Serra F, Comolli G, Sarasini A, Sammartino JC, Ferrari A, Arena F, Secondino S, Cicognini D, Schiavo R, Lo Cascio G, Cavanna L, Baldanti F, Pedrazzoli P, Cassaniti I
Publicado en: ESMO Open, Edición 7, 2022, Página(s) 100574, ISSN 2059-7029
Editor: Elsevier
DOI: 10.1016/j.esmoop.2022.100574

Characteristics and outcome of vaccinated and non-vaccinated patients hospitalized in a single Italian HUB for COVID-19 during the Delta and Omicron waves in Northern Italy

Autores: Francesca Rovida, Giuliana Lucia Esposito, Marco Rissone, Viola Novelli, Sara Cutti, Alba Muzzi, Claudia Rona, Emanuela Bertoli, Marinella Daglio, Antonio Piralla, Stefania Paolucci, Giulia Campanini, Guglielmo Ferrari, Federica Giardina, Federica Zavaglio, Daniele Lilleri, Anna Maria Grugnetti, Giuseppina Grugnetti, Anna Odone, Carlo Marena, Fausto Baldanti
Publicado en: International Journal of Infectious Diseases, Edición 122, 2022, Página(s) 420-426, ISSN 0022-1899
Editor: University of Chicago Press
DOI: 10.1016/j.ijid.2022.06.028

Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules

Autores: Matteo Stravalaci, Isabel Pagani, Elvezia Maria Paraboschi, Mattia Pedotti, Andrea Doni, Francesco Scavello, Sarah N. Mapelli, Marina Sironi, Chiara Perucchini, Luca Varani, Milos Matkovic, Andrea Cavalli, Daniela Cesana, Pierangela Gallina, Nicoletta Pedemonte, Valeria Capurro, Nicola Clementi, Nicasio Mancini, Pietro Invernizzi, Rafael Bayarri-Olmos, Peter Garred, Rino Rappuoli, Stefano Duga, Ba
Publicado en: Nature Immunology, Edición 23, 2022, Página(s) 275-286, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/s41590-021-01114-w

X-Linked TLR7 Deficiency Underlies Critical COVID-19 Pneumonia in a Male Patient with Ataxia-Telangiectasia

Autores: Hassan Abolhassani, Ahmad Vosughimotlagh, Takaki Asano, Nils Landegren, Bertrand Boisson, Samaneh Delavari, Paul Bastard, Maribel Aranda‑Guillén, Yating Wang, Fanglei Zuo, Fabian Sardh, Harold Marcotte, Likun Du, Shen‑Ying Zhang, Qian Zhang, Nima Rezaei, Olle Kämpe, Jean‑Laurent Casanova, Lennart Hammarström, Qiang Pan‑Hammarström
Publicado en: Journal of Clinical Immunology, 2021, ISSN 0271-9142
Editor: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10875-021-01151-y

MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination

Autores: Yeonsu Kim, Xiaoyan Zheng, Kathrin Eschke, M Zeeshan Chaudhry, Federico Bertoglio, Adriana Tomić, Astrid Krmpotić, Markus Hoffmann, Yotam Bar-On, Julia Boehme, Dunja Bruder, Thomas Ebensen , Linda Brunotte , Stephan Ludwig, Martin Messerle, Carlos Guzman, Ofer Mandelboim, Michael Hust, Stefan Pöhlmann, Stipan Jonjić, Luka Čičin-Šain
Publicado en: Cellular and Molecular Immunology, Edición 19, 2022, Página(s) 234-244, ISSN 1672-7681
Editor: Nature Publishing Group
DOI: 10.1038/s41423-021-00814-5

Evaluation of the Neutralizing Antibodies Response against 14 SARS-CoV-2 Variants in BNT162b2 Vaccinated Naïve and COVID-19 Positive Healthcare Workers from a Northern Italian Hospital

Autores: Josè Camilla Sammartino, Irene Cassaniti, Alessandro Ferrari, Federica Giardina, Guglielmo Ferrari, Federica Zavaglio, Stefania Paolucci, Daniele Lilleri, Antonio Piralla, Fausto Baldanti and Elena Percivalle
Publicado en: Vaccines, Edición 10, 2022, ISSN 2078-2489
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines10050703

A snapshot of the immunogenicity, efficacy and safety of a full course of BNT162b2 anti-SARS-CoV-2 vaccine in cancer patients treated with PD-1/PD-L1 inhibitors: a longitudinal cohort study

Autores: A. Lasagna, F. Agustoni, E. Percivalle, S. Borgetto, A. Paulet, G. Comolli, A. Sarasini, F. Bergami, J. C. Sammartino, A. Ferrari, F. Zavaglio, F. Arena, D. Lilleri, S. Secondino, M. Falzoni, R. Schiavo, C. Klersy, G. Lo Cascio, L. Cavanna, F. Baldanti, P. Pedrazzoli, I. Cassaniti
Publicado en: ESMO Open, Edición Volume 6, Edición 5, 2021, Página(s) 100272, ISSN 0923-7534
Editor: Oxford University Press
DOI: 10.1016/j.esmoop.2021.100272

SARS-CoV-2 infection in patients with inborn errors of immunity due to DNA repair defects

Autores: Yating Wang, Hassan Abolhassani, Lennart Hammarström, and Qiang Pan-Hammarström
Publicado en: Acta Biochimica et Biophysica Sinica,, Edición 54, 2022, Página(s) 836-846, ISSN 1672-9145
Editor: Institute of Biochemistry and Cell Biology
DOI: 10.3724/abbs.2022071

Inherited IFNAR1 Deficiency in a Child with Both Critical COVID-19 Pneumonia and Multisystem Inflammatory Syndrome

Autores: Hassan Abolhassani, Nils Landegren, Paul Bastard, Marie Materna, Mohammadreza Modaresi, Likun Du, Maribel Aranda Guillén, Fabian Sardh, Fanglei Zuo, Peng Zhang, Harold Marcotte, Nico Marr, Taushif Khan, Manar Ata, Fatima Al Ali, Remi Pescarmona, Alexandre Belot, Vivien Béziat, Qian Zhang, Jean Laurent Casanova, Olle Kämpe, Shen Ying Zhang, Lennart Hammarström, Qiang Pan Hammarström
Publicado en: Journal of Clinical Immunology, 2022, Página(s) 1-13, ISSN 0271-9142
Editor: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10875-022-01215-7

Heterologous inactivated virus/mRNA vaccination response to BF.7, BQ.1.1, and XBB.1

Autores: Fanglei Zuo, Rui Sun, Hassan Abolhassani, Likun Du, Yating Wang, Stelios Vlachiotis, Federico Bertoglio, Maren Schubert, Nima Rezaei, Zahra Chavoshzadeh, Concetta Guerra, Andrea Cavalli, Juni Andréll, Makiko Kumagai-Braesch, Yintong Xue, Yunlong Cao, Michael Hust, Davide F. Robbiani, Xiaoliang Sunney Xie, Lennart Hammarström, Harold Marcotte, and Qiang Pan-Hammarström
Publicado en: The Lancet Regional Health - Western Pacific, Edición 33, 2023, Página(s) 100762, ISSN 2666-6065
Editor: Elsevier Ltd.
DOI: 10.1016/j.lanwpc.2023.100762

SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface

Autores: Federico Bertoglio, Doris Meier, Nora Langreder, Stephan Steinke, Ulfert Rand, Luca Simonelli, Philip Alexander Heine, Rico Ballmann, Kai-Thomas Schneider, Kristian Daniel Ralph Roth, Maximilian Ruschig, Peggy Riese, Kathrin Eschke, Yeonsu Kim, Dorina Schäckermann, Mattia Pedotti, Philipp Kuhn, Susanne Zock-Emmenthal, Johannes Wöhrle, Normann Kilb, Tobias Herz, Marlies Becker, Martina Grasshoff,
Publicado en: Nature Communications, Edición 12/1, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-21609-2

Immunogenicity and safety after the third dose of BNT162b2 anti-SARS-CoV-2 vaccine in patients with solid tumors on active treatment: a prospective cohort study

Autores: A. Lasagna, F. Bergami, D. Lilleri, E. Percivalle, M. Quaccini, N. Alessio, G. Comolli, A. Sarasini, J. C. Sammartino, A. Ferrari, F. Arena, S. Secondino, D. Cicognini, R. Schiavo, G. Lo Cascio, L. Cavanna, F. Baldanti, P. Pedrazzoli, I. Cassaniti
Publicado en: ESMO Open, Edición 7, 2022, ISSN 0020-0255
Editor: Elsevier BV
DOI: 10.1016/j.esmoop.2022.100458

Baculovirus-Free SARS-CoV-2 Virus-like Particle Production in Insect Cells for Rapid Neutralization Assessment

Autores: by Marcel Jaron, Michael Lehky, Marta Zarà, Chris Nicole Zaydowicz, Aidin Lak, Rico Ballmann, Philip Alexander Heine, Esther Veronika Wenzel, Kai-Thomas Schneider, Federico Bertoglio, Susanne Kempter, Reinhard Wolfgang Köster, Silvia Stella Barbieri, Joop van den Heuvel, Michael Hust, Stefan Dübel and Maren Schubert
Publicado en: Viruses, Edición 14(10), 2022, Página(s) 1-16, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v14102087

Incidence of SARS-CoV-2 infection in health care workers from Northern Italy based on antibody status: immune protection from secondary infection- A retrospective observational case-controlled study

Autores: Francesca Rovida, Irene Cassaniti, Elena Percivalle, Antonella Sarasini, Stefania Paolucci, Catherine Klersy, Sara Cutti, Viola Novelli, Carlo Marena, Francesco Luzzaro, Giovanni De Vito, Roberta Schiavo, Giuliana Lo Cascio, Daniele Lilleri, Faust Baldanti
Publicado en: International Journal of Infectious Diseases, 2021, ISSN 1201-9712
Editor: Elsevier BV
DOI: 10.1016/j.ijid.2021.07.003

Analysis of the humoral and cellular immune response after a full course of BNT162b2 anti-SARS-CoV-2 vaccine in cancer patients treated with PD-1/PD-L1 inhibitors with or without chemotherapy: an update after 6 months of follow-up

Autores: Lasagna A, Lilleri D, Agustoni F, Percivalle E, Borgetto S, Alessio N, Comolli G, Sarasini A, Bergami F, Sammartino JC, Ferrari A, Zavaglio F, Arena F, Secondino S, Falzoni M, Schiavo R, Lo Cascio G, Cavanna L, Baldanti F, Pedrazzoli P, Cassaniti I.
Publicado en: ESMO Open, Edición 7, 2022, Página(s) 100359, ISSN 2059-7029
Editor: Elsevier B.V.
DOI: 10.1016/j.esmoop.2021.100359

Enhanced SARS-CoV-2 neutralization by dimeric IgA

Autores: Zijun Wang, Julio C. C. Lorenzi, Frauke Muecksch, Shlomo Finkin, Charlotte Viant, Christian Gaebler, Melissa Cipolla, Hans-Heinrich Hoffmann, Thiago Y. Oliveira, Deena A. Oren, Victor Ramos, Lilian Nogueira, Eleftherios Michailidis, Davide F. Robbiani, Anna Gazumyan, Charles M. Rice, Theodora Hatziioannou, Paul D. Bieniasz, Marina Caskey, Michel C. Nussenzweig
Publicado en: Science Translational Medicine, 2020, Página(s) eabf1555, ISSN 1946-6234
Editor: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.abf1555

Antibody therapy for COVID-19

Autores: Lennart Hammarstrom, Harold Marcotte, Antonio Piralla, Fausto Baldanti, Qiang Pan Hammarström
Publicado en: Current Opinion in Allergy Clinical Immunology, Edición 21, 2022, Página(s) 553-558, ISSN 1528-4050
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/aci.0000000000000787

Human serum from SARS-CoV-2-vaccinated and COVID-19 patients shows reduced binding to the RBD of SARS-CoV-2 Omicron variant

Autores: Maren Schubert; Federico Bertoglio; Stephan Steinke; Philip Alexander Heine; Mario Alberto Ynga-Durand; Henrike Maass; Josè Camilla Sammartino; Irene Cassaniti; Fanglei Zuo; Likun Du; Janin Korn; Marko Milošević; Esther Veronika Wenzel; Fran Krstanović; Saskia Polten; Marina Pribanić-Matešić; Ilija Brizić; Fausto Baldanti; Lennart Hammarström; Stefan Dübel; Alan Šustić; Harold Marcotte
Publicado en: BMC Biomedicine, Edición 20, 2022, Página(s) 102, ISSN 1741-7015
Editor: BioMed Central
DOI: 10.1186/s12916-022-02312-5

Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein

Autores: Filippo Bianchini, Virginia Crivelli, Morgan E. Abernathy, Concetta Guerra, Martin Palus,Jonathan Muri, Harold Marcotte, Antonio Piralla, Mattia Pedotti, Raoul De Gasparo, Luca Simonelli, Milos Matkovic, Chiara Toscano, Maira Biggiogero, Veronica Calvaruso, Pavel Svoboda, Tomás Cervantes Rincón, Tommaso Fava, Lucie Podešvová, Akanksha A. Shanbhag, Andrea Celoria, Jacopo Sgrignani, Michal St
Publicado en: Science Immunology, Edición eade0958, 2023, ISSN 2470-9468
Editor: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciimmunol.ade0958

Genetic and immunologic evaluation of children with inborn errors of immunity and severe or critical COVID-19

Autores: Hassan Abolhassani, Samaneh Delavari, Nils Landegren, Sima Shokri, Paul Bastard, Likun Du, Fanglei Zuo, Reza Hajebi, Farhad Abolnezhadian, Sara Iranparast, Mohammadreza Modaresi, Ahmad Vosughimotlagh, Fereshte Salami, Maribel Aranda-Guillen, Aurelie Cobat, Harold Marcotte, Shen-Ying Zhang, MD, Qian Zhang, Nima Rezaei, Jean-Laurent Casanova, Olle Kampe, Lennart Hammarstrom, and Qiang Pan-Hammarstro
Publicado en: The Journal of Allergy and Clinical Immunology, Edición 150 (5), 2022, Página(s) 1059-1073, ISSN 0091-6749
Editor: Mosby Inc.
DOI: 10.1016/j.jaci.2022.09.005

Impact of immunosuppressive treatment on the immunogenicity of mRNA COVID-19 vaccine in vulnerable patients with giant cell arteritis

Autores: Paolo Delvino, Alice Bartoletti, Irene Cassaniti, Federica Bergami, Daniele Lilleri, Fausto Baldanti, Emanuele Bozzalla Cassione, Alessandro Biglia, Carlomaurizio Montecucco, Sara Monti
Publicado en: Rheumatology, 2021, ISSN 1462-0324
Editor: Oxford University Press
DOI: 10.1093/rheumatology/keab776

19n01, a broadly neutralizing antibody against omicron BA.1, BA.2, BA.4/5, and other SARS-CoV-2 variants of concern

Autores: Melissa Garcıa-Vega, Edgar A. Melgoza-Gonzalez, Sofıa Hernandez-Valenzuela, Diana Hinojosa-Trujillo, Monica Resendiz-Sandoval, Mara Anais Llamas-Covarrubias, Martın Loza-Lopez,Olivia Valenzuela, Alan Soto-Gaxiola, Miguel A. Hernandez-Onate, Veronica Mata-Haro, Irene Cassaniti, Jose Camilla Sammartino, Alessandro Ferrari, Luca Simonelli, Mattia Pedotti, Rui Sun, Fanglei Zuo, Fausto Baldanti, Luc
Publicado en: iScience, Edición 26, 2023, Página(s) 10562, ISSN 2589-0042
Editor: Elsevier
DOI: 10.1016/j.isci.2023.106562

Limited cross-variant neutralization after primary Omicron infection: consideration for a variant-containing booster

Autores: Harold Marcotte, Qiang Pan-Hammarström, Lennart Hammarström
Publicado en: Signal Transduction and Targeted Therapy, Edición 7, 2022, Página(s) 294, ISSN 2095-9907
Editor: Springer Nature
DOI: 10.1038/s41392-022-01146-0

ReScan, a Multiplex Diagnostic Pipeline, Pans Human Sera for SARS-CoV-2 Antigens

Autores: Colin R. Zamecnik, Jayant V. Rajan, Kevin A. Yamauchi, Sabrina A. Mann, Rita P. Loudermilk, Gavin M. Sowa, Kelsey C. Zorn, Bonny D. Alvarenga, Christian Gaebler, Marina Caskey, Mars Stone, Philip J. Norris, Wei Gu, Charles Y. Chiu, Dianna Ng, James R. Byrnes, Xin X. Zhou, James A. Wells, Davide F. Robbiani, Michel C. Nussenzweig, Joseph L. DeRisi, Michael R. Wilson
Publicado en: Cell Reports Medicine, Edición 1/7, 2020, Página(s) 100123, ISSN 2666-3791
Editor: Cell press
DOI: 10.1016/j.xcrm.2020.100123

Spread of multiple SARS-CoV-2 lineages April-August 2020 anticipated the second pandemic wave in Lombardy (Italy)

Autores: Monica Tallarita, Federica Giardina, Federica Novazzi, Stefano Gaiarsa, Gherard Batisti Biffignandi, Stefania Paolucci ,Francesca Rovida, Antonio Piralla, Fausto Baldanti
Publicado en: Pediatric Allergy and Immunology, Edición 33, 2022, Página(s) 89-92, ISSN 0905-6157
Editor: Blackwell Publishing Inc.
DOI: 10.1111/pai.13641

Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course

Autores: Jonathan Muri, Valentina Cecchinato, Andrea Cavalli, Akanksha A Shanbhag, Milos Matkovic, Maira Biggiogero, Pier Andrea Maida, Jacques Moritz, Chiara Toscano, Elaheh Ghovehoud , Raffaello Furlan, Franca Barbic, Antonio Voza, Guendalina De Nadai, Carlo Cervia, Yves Zurbuchen, Patrick Taeschler, Lilly A Murray, Gabriela Danelon-Sargenti, Simone Moro, Tao Gong, Pietro Piffaretti, Filippo Bianchini, V
Publicado en: Nature Immunology, Edición 24, 2023, Página(s) 604-611, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/s41590-023-01445-w

Developing Recombinant Antibodies by Phage Display Against Infectious Diseases and Toxins for Diagnostics and Therapy

Autores: Kristian Daniel Ralph Roth, Esther Veronika Wenzel, Maximilian Ruschig, Stephan Steinke, Nora Langreder, Philip Alexander Heine, Kai-Thomas Schneider, Rico Ballmann, Viola Fühner, Philipp Kuhn, Thomas Schirrmann, André Frenzel, Stefan Dübel, Maren Schubert, Gustavo Marçal Schmidt Garcia Moreira, Federico Bertoglio, Giulio Russo, Michael Hust
Publicado en: Frontiers in Cellular and Infection Microbiology, Edición 11, 2021, Página(s) 697876, ISSN 2235-2988
Editor: Frontiers Media S. A.
DOI: 10.3389/fcimb.2021.697876

The long term vaccine-induced anti-SARS-CoV-2 immune response is impaired in quantity and quality under TNFα blockade.

Autores: Geisen UM, Rose R, Neumann F, Ciripoi M, Vullriede L, Reid HM, Berner DK, Bertoglio F, Hoff P, Hust M, Longardt AC, Lorentz T, Martini GR, Saggau C, Schirmer JH, Schubert M, Sümbül M, Tran F, Voß M, Zeuner R, Morrison PJ, Bacher P, Fickenscher H, Gerdes S, Peipp M, Schreiber S, Krumbholz A, Hoyer BF
Publicado en: Journal of Medical Virology, 2022, ISSN 0146-6615
Editor: John Wiley & Sons Inc.
DOI: 10.1002/jmv.28063

Adapting Neutralizing Antibodies to Viral Variants by Structure-Guided Affinity Maturation Using Phage Display Technology

Autores: Frederik Peissert, Mattia Pedotti, Riccardo Corbellari, Luca Simonelli, Raoul De Gasparo, Elia Tamagnini, Louis Plüss, Abdullah Elsayed, Mattia Matasci, Roberto De Luca, Irene Cassaniti, Jose’ Camilla Sammartino, Antonio Piralla, Fausto Baldanti, Dario Neri, Luca Varani
Publicado en: Global Challenges, 2023, ISSN 2056-6646
Editor: Wiley-VCH GmbH
DOI: 10.1002/gch2.202300088

Assessing the Efficacy of Early Therapies against SARS-CoV-2 in Hematological Patients: A Real-Life Study from a COVID-19 Referral Centre in Northern Italy

Autores: Marta Colaneri,Teresa Chiara, Pieri,Silvia Roda, Alessandra Ricciardi, Manuel Gotti, Jacqueline Ferrari, Luca Arcaini, Sara Rattotti, Antonio Piralla, Federica Giardina, Guglielmo Ferrari, Paolo Sacchi, Valentina Zuccaro, Fausto Baldanti, and Raffaele Bruno
Publicado en: Journal of Clinical Medicine, Edición 11(24), 2022, Página(s) 1-12, ISSN 2077-0383
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm11247452

Mucosal IgA against SARS-CoV-2 Omicron Infection

Autores: Fanglei Zuo, Harold Marcotte, Lennart Hammarström, Qiang Pan-Hammarström
Publicado en: New England Journal Medecine, Edición 387, 2022, Página(s) e55, ISSN 0028-4793
Editor: Massachusetts Medical Society
DOI: 10.1056/nejmc2213153

Development of passive immunity against SARS-CoV-2 for management of immunodeficient patients—a perspective

Autores: Lennart Hammarström, Hassan Abolhassani, Fausto Baldanti, Harold Marcotte, Qiang Pan-Hammarström
Publicado en: Journal of Allergy and Clinical Immunology, 2020, ISSN 0091-6749
Editor: Mosby Inc.
DOI: 10.1016/j.jaci.2020.04.043

Prevalence of SARS-CoV-2 specific neutralising antibodies in blood donors from the Lodi Red Zone in Lombardy, Italy, as at 06 April 2020

Autores: Elena Percivalle, Giuseppe Cambiè, Irene Cassaniti, Edoardo Vecchio Nepita, Roberta Maserati, Alessandro Ferrari, Raffaella Di Martino, Paola Isernia, Francesco Mojoli, Raffaele Bruno, Marcello Tirani, Danilo Cereda, Carlo Nicora, Massimo Lombardo, Fausto Baldanti
Publicado en: Eurosurveillance, Edición 25/24, 2020, ISSN 1560-7917
Editor: European Centre for Disease Prevention and Control (ECDC)
DOI: 10.2807/1560-7917.es.2020.25.24.2001031

Convergent antibody responses to SARS-CoV-2 in convalescent individuals

Autores: Davide F. Robbiani, Christian Gaebler, Frauke Muecksch, Julio C. C. Lorenzi, Zijun Wang, Alice Cho, Marianna Agudelo, Christopher O. Barnes, Anna Gazumyan, Shlomo Finkin, Thomas Hägglöf, Thiago Y. Oliveira, Charlotte Viant, Arlene Hurley, Hans-Heinrich Hoffmann, Katrina G. Millard, Rhonda G. Kost, Melissa Cipolla, Kristie Gordon, Filippo Bianchini, Spencer T. Chen, Victor Ramos, Roshni Patel, Ju
Publicado en: Nature, 2020, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-020-2456-9

Residual SARS-CoV-2 RNA in nasal swabs of convalescent COVID-19 patients: Is prolonged quarantine always justified?

Autores: Antonio Piralla, Matteo Ricchi, Maria Grazia Cusi, Paola Prati, Nadia Vicari, Giada Scarsi, Claudia Gandolfo, Gabriele Anichini, Chiara Terrosi, Elena Percivalle, Edoardo Vecchio Nepita, Federica Bergami, Monica Tallarita, Raffaella Di Martino, Alessandro Ferrari, Francesca Rovida, Giovanna Lunghi, Roberta Schiavo, Fausto Baldanti
Publicado en: International Journal of Infectious Diseases, Edición 102, 2021, Página(s) 299-302, ISSN 1201-9712
Editor: Elsevier BV
DOI: 10.1016/j.ijid.2020.10.072

Evolution of antibody immunity to SARS-CoV-2

Autores: Christian Gaebler, Zijun Wang, Julio C. C. Lorenzi, Frauke Muecksch, Shlomo Finkin, Minami Tokuyama, Alice Cho, Mila Jankovic, Dennis Schaefer-Babajew, Thiago Y. Oliveira, Melissa Cipolla, Charlotte Viant, Christopher O. Barnes, Yaron Bram, Gaëlle Breton, Thomas Hägglöf, Pilar Mendoza, Arlene Hurley, Martina Turroja, Kristie Gordon, Katrina G. Millard, Victor Ramos, Fabian Schmidt, Yiska Weis
Publicado en: Nature, Edición 591/7851, 2021, Página(s) 639-644, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-021-03207-w

Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice

Autores: Raoul De Gasparo, Mattia Pedotti, Luca Simonelli, Petr Nickl, Frauke Muecksch, Irene Cassaniti, Elena Percivalle, Julio C. C. Lorenzi, Federica Mazzola, Davide Magrì, Tereza Michalcikova, Jan Haviernik, Vaclav Honig, Blanka Mrazkova, Natalie Polakova, Andrea Fortova, Jolana Tureckova, Veronika Iatsiuk, Salvatore Di Girolamo, Martin Palus, Dagmar Zudova, Petr Bednar, Ivana Bukova, Filippo Bianchin
Publicado en: Nature, 2021, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-021-03461-y

SARS-CoV-2 variants inactivation of plasma units using a riboflavin and ultraviolet light-based photochemical treatment

Autores: Alessandro Ferrari, Irene Cassanitia, Josè Camilla Sammartino, Cristina Mortellaro, Claudia Del Fante, Simona De Vitis Eugenio Barone, DanielaTroletti, Federica Prati, Fausto Baldanti, Elena Percivalle, Perotti Cesare
Publicado en: Transfusion and Apheresis Science, 2022, ISSN 0020-0255
Editor: Elsevier BV
DOI: 10.1016/j.transci.2022.103398

Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies

Autores: Allison J. Greaney, Tyler N. Starr, Christopher O. Barnes, Yiska Weisblum, Fabian Schmidt, Marina Caskey, Christian Gaebler, Alice Cho, Marianna Agudelo, Shlomo Finkin, Zijun Wang, Daniel Poston, Frauke Muecksch, Theodora Hatziioannou, Paul D. Bieniasz, Davide F. Robbiani, Michel C. Nussenzweig, Pamela J. Bjorkman, Jesse D. Bloom
Publicado en: Nature Communications, Edición 12/1, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-24435-8

Humoral and cell-mediated response against SARS-CoV-2 variants elicited by mRNA vaccine BNT162b2 in healthcare workers: a longitudinal observational study

Autores: Irene Cassaniti, Federica Bergami, Elena Percivalle, Elisa Gabanti, Josè Camilla Sammartino, Alessandro Ferrari, Kodjo Messan Guy Adzasehoun, Federica Zavaglio, Paola Zelini, Giuditta Comolli, Antonella Sarasini, Antonio Piralla, Alessandra Ricciardi, Valentina Zuccaro, Fabrizio Maggi, Federica Novazzi, Luca Simonelli, Luca Varani, Daniele Lilleri, Fausto Baldanti
Publicado en: Clinical Microbiology and Infection, 2022, Página(s) 301.e1-301.e8, ISSN 1469-0691
Editor: Elsevier
DOI: 10.1016/j.cmi.2021.09.016

SARS-CoV-2–specific B- and T-cell immunity in a population-based study of young Swedish adults

Autores: Sophia Bjorkander, Likun Du, Fanglei Zuo, Sandra Ekstrom, Yating Wang, Hui Wan, Natalia Sherina, Lisanne Schoutens, Juni Andrell, Niklas Andersson, Antonios Georgelis, Anna Bergstrom, Harold Marcotte, Inger Kull, Lennart Hammarstrom, Erik Melen, and Qiang Pan-Hammarstrom, for the BAMSECOVID-19 study group
Publicado en: The Journal of Allergy and Clinical Immunology, Edición 149, 2022, Página(s) 65-75.e8, ISSN 0091-6749
Editor: Mosby Inc.
DOI: 10.1016/j.jaci.2021.10.014

Immune Response to BNT162b2 in Solid Organ Transplant Recipients: Negative Impact of Mycophenolate and High Responsiveness of SARS-CoV-2 Recovered Subjects against Delta Variant

Autores: Irene Cassaniti, Federica Bergami, Francesca Arena, Jose Camilla Sammartino, Alessandro Ferrari, Federica Zavaglio, Irene Curti, Elena Percivalle, Federica Meloni, Laura Pandolfi, Carlo Pellegrini, Annalisa Turco, Elena Seminari, Eleonora Francesca Pattonieri, Marilena Gregorini, Teresa Rampino, Antonella Sarasini, Daniele Lilleri, and Fausto Baldanti
Publicado en: Microorganisms, Edición 9, 2021, Página(s) 2622, ISSN 2076-2607
Editor: MDPI
DOI: 10.3390/microorganisms9122622

Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses

Autores: Fabian Schmidt, Yiska Weisblum, Frauke Muecksch, Hans-Heinrich Hoffmann, Eleftherios Michailidis, Julio C.C. Lorenzi, Pilar Mendoza, Magdalena Rutkowska, Eva Bednarski, Christian Gaebler, Marianna Agudelo, Alice Cho, Zijun Wang, Anna Gazumyan, Melissa Cipolla, Marina Caskey, Davide F. Robbiani, Michel C. Nussenzweig, Charles M. Rice, Theodora Hatziioannou, Paul D. Bieniasz
Publicado en: Journal of Experimental Medicine, Edición 217/11, 2020, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/jem.20201181¨

ORFeome Phage Display Reveals a Major Immunogenic Epitope on the S2 Subdomain of SARS-CoV-2 Spike Protein

Autores: Rico Ballmann, Sven-Kevin Hotop, Federico Bertoglio, Stephan Steinke, Philip Alexander Heine, M. Zeeshan Chaudhry, Dieter Jahn, Boas Pucker, Fausto Baldanti, Antonio Piralla, Maren Schubert, Luka Ciˇcin-Šain, Mark Brönstrup, Michael Hust, and Stefan Dübel
Publicado en: Viruses, Edición 14, 2022, Página(s) 1326, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v14061326

Impact of Viral Decontamination Method on Cytokine Profile of COVID-19 Patients

Autores: Anna Navarro, Federica Bergami, Elena Percivalle, Alessandro Ferrari, Teresa Lettieri, Luigi Calzolai, Antonio Piralla, Fausto Baldanti and Sabrina Gioria
Publicado en: Biomedicines, Edición 9, 2021, Página(s) 1287, ISSN 2227-9059
Editor: MDPI AG
DOI: 10.3390/biomedicines9101287

A SARS-CoV-2 neutralizing antibody selected from COVID-19 patients binds to the ACE2-RBD interface and is tolerant to most known RBD mutations

Autores: Federico Bertoglio, Viola Fühner, Maximilian Ruschig, Philip Alexander Heine, Leila Abassi, Thomas Klünemann, Ulfert Rand, Doris Meier, Nora Langreder, Stephan Steinke, Rico Ballmann , Kai-Thomas Schneider, Kristian Daniel Ralph Roth, Philipp Kuhn, Peggy Riese, Dorina Schäckermann, Janin Korn, Allan Koch, M Zeeshan Chaudhry, Kathrin Eschke, Yeonsu Kim, Susanne Zock-Emmenthal, Marlies Becker, Ma
Publicado en: Cell Report, Edición 36, 2021, Página(s) 109433, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2021.109433

A retrospective study assessing the characteristics of COVID‐19 convalescent plasma donors and donations

Autores: Claudia Del Fante, Massimo Franchini, Fausto Baldanti, Elena Percivalle, Claudia Glingani, Giuseppe Marano, Carlo Mengoli, Cristina Mortellaro, Gianluca Viarengo, Cesare Perotti, Giancarlo Maria Liumbruno
Publicado en: Transfusion, Edición 61/3, 2021, Página(s) 830-838, ISSN 0041-1132
Editor: Blackwell Publishing Inc.
DOI: 10.1111/trf.16208

Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants

Autores: Weisblum Y, Schmidt F, Zhang F, DaSilva J, Poston D, Lorenzi JC, Muecksch F, Rutkowska M, Hoffmann HH, Michailidis E, Gaebler C, Agudelo M, Cho A, Wang Z, Gazumyan A, Cipolla M, Luchsinger L, Hillyer CD, Caskey M, Robbiani DF, Rice CM, Nussenzweig MC, Hatziioannou T, Bieniasz PD.
Publicado en: Elife, 2020, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.61312

Seroprevalence of SARS-CoV-2 in blood donors from the Lodi Red Zone and adjacent Lodi metropolitan and suburban area

Autores: Irene Cassaniti, Elena Percivalle, Antonella Sarasini, Giuseppe Cambiè, Edoardo Vecchio Nepita, Roberta Maserati, Alessandro Ferrari, Alfonso Corcione, Raffaella Di Martino, Alice Bonetti, Annapia Di Napoli, Guglielmo Ferrari, Fausto Baldanti
Publicado en: Clinical Microbiology and Infection, 2021, ISSN 1198-743X
Editor: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2021.01.030

Persistence of SARS-CoV-2-specific B and T cell responses in convalescent COVID-19 patients 6–8 months after the infection

Autores: Natalia Sherina, Antonio Piralla, Likun Du, Hui Wan, Makiko Kumagai-Braesch, Juni Andréll, Sten Braesch-Andersen, Irene Cassaniti, Elena Percivalle, Antonella Sarasini, Federica Bergami, Raffaella Di Martino, Marta Colaneri, Marco Vecchia, Margherita Sambo, Valentina Zuccaro, Raffaele Bruno, Michele Sachs, Tiberio Oggionni, Federica Meloni, Hassan Abolhassani, Federico Bertoglio, Maren Schubert,
Publicado en: Med, Edición 2/3, 2021, Página(s) 281-295.e4, ISSN 2666-6340
Editor: Cell pres
DOI: 10.1016/j.medj.2021.02.001

Heterologous immunization with inactivated vaccine followed by mRNA-booster elicits strong immunity against SARS-CoV-2 Omicron variant.

Autores: Fanglei Zuo, Hassan Abolhassani, Likun Du, Antonio Piralla, Federico Bertoglio, Leire de Campos-Mata, Hui Wan, Maren Schubert, Irene Cassaniti, Yating Wang, Josè Camilla Sammartino, Rui Sun, Stelios Vlachiotis, Federica Bergami, Makiko Kumagai-Braesch, Juni Andréll, Zhaoxia Zhang, Yintong Xue, Esther Veronika Wenzel, Luigi Calzolai, Luca Varani, Nima Rezaei, Zahra Chavoshzadeh, Fausto Baldanti,
Publicado en: Nature Communications, Edición 13, 2022, Página(s) 2670, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-30340-5

Differential Kinetics of Effector and Memory Responses Induced by Three Doses of SARS-CoV-2 mRNA Vaccine in a Cohort of Healthcare Workers

Autores: Federica Bergami; Francesca Arena; Josè Camilla Sammartino; Alessandro Ferrari; Federica Zavaglio; Paola Zelini; Stefania Paolucci; Giuditta Comolli; Elena Percivalle; Daniele Lilleri; Irene Cassaniti; Fausto Baldanti
Publicado en: Vaccines; Volume 10; Edición 11; Pages: 1809, Edición 10, 2022, Página(s) 1-11, ISSN 2076-393X
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines10111809

Reply to: Hultström et al., Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19. Mannose-binding lectin genetics in COVID-19

Autores: Rosanna Asselta, Elvezia Maria Paraboschi, Matteo Stravalaci, Pietro Invernizzi , Paolo Bonfanti, Andrea Biondi, Isabel Pagani, Mattia Pedotti, Andrea Doni, Francesco Scavello, Sarah N. Mapelli, Marina Sironi, Chiara Perucchini, Luca Varani , Milos Matkovic, Andrea Cavalli, Daniela Cesana, Pierangela Gallina, Nicoletta Pedemonte, Valeria Capurro, Nicola Clementi, Nicasio Mancini, Rafael Bayarr
Publicado en: Nature Immunology, Edición 23, 2022, Página(s) 865-867, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/s41590-022-01227-w

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