Deliverables
CoroNAb website for dissemination of results, and for fostering broader protocol, reagent, and result sharing by the scientific community.
Formulation characteristics and physicochemical evaluation of antigen-adjuvant combinations.
We will share out plasmid designs, right from the start of the project. Initially, this will be through our collaboration network, and subsequently this will be on the CoroNAb website.
Predicted antigenspecific antibody variants 1 month after receiving NGS data fromimmunized animal
Shared 2019-nCoV spike binding results for mAbs.
Shared nanobody sequences of confirmed binders, and data from NGS library sequencing.
Shared 2019-nCoV spike binding results for nanobodies.
D3.1 Shared mAb sequences, including NGS data.
Safety and immunogenicity data for each subunit/adjuvant combination. Selection of the best nCoV spike protein and adjuvant combination for immunizations of larger animals.
Models of interventions and new forecasts will be published online.
The draft management plan will be updated.
D4.2. Neutralization results for isolated monoclonal antibodies and camelid nanobodies (aims 2
Deliver an ongoing series of progressively optimized antinCoV mAbs to KI for neutralization screening
Mathematical model will be released as open source R package. Model projections will be published online.
Deliver lead candidate antinCoV mAbs from hybridoma combinatorial library screens to KI for neutralization screening
Shared expression results, yields, and working protocols for all constructs. This will be ongoing throughout the project.
Searching for OpenAIRE data...
Publications
Author(s): Pradeepa Pushparaj, Andrea Nicoletto, Daniel J. Sheward, Hrishikesh Das, Xaquin Castro Dopico, Laura Perez Vidakovics, Leo Hanke, Mark Chernyshev, Sanjana Narang, Sungyong Kim, Julian Fischbach, Simon Ekström, Gerald McInerney, B. Martin Hällberg, Ben Murrell. Martin Corcoran, Gunilla B. Karlsson Hedestam
Published in: Immunity, 2022, ISSN 1097-4180
Publisher: Cell Press
DOI: 10.1016/j.immuni.2022.12.005
Author(s): Erik Volz, Swapnil Mishra, Meera Chand, Jeffrey C. Barrett, Robert Johnson, Lily Geidelberg, Wes R. Hinsley, Daniel J. Laydon, Gavin Dabrera, Áine O’Toole, Robert Amato, Manon Ragonnet-Cronin, Ian Harrison, Ben Jackson, Cristina V. Ariani, Olivia Boyd, Nicholas J. Loman, John T. McCrone, Sónia Gonçalves, David Jorgensen, Richard Myers, Verity Hill, David K. Jackson, Katy Gaythorpe, Natalie Gr
Published in: Nature, 593/7858, 2021, Page(s) 266-269, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-03470-x
Author(s): Inga Szurgot, Leo Hanke, Daniel J. Sheward, Laura Perez Vidakovics, Ben Murrell, Gerald M. McInerney, Peter Liljeström
Published in: Scientific Reports, 11/1, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-82498-5
Author(s): Marco Mandolesi, Daniel J. Sheward, Leo Hanke, Junjie Ma, Pradeepa Pushparaj, Laura Perez Vidakovics, Changil Kim, Monika Àdori, Klara Lenart, Karin Loré, Xaquin Castro Dopico, Jonathan M. Coquet, Gerald M. McInerney, Gunilla B. Karlsson Hedestam, Ben Murrell
Published in: Cell Reports Medicine, 2/4, 2021, Page(s) 100252, ISSN 2666-3791
Publisher: Cell Press
DOI: 10.1016/j.xcrm.2021.100252
Author(s): Sheward Dj, Kim C, Ehling Ra, Pankow A, Castro Dopico X, Dyrdak R, Martin Dp, Reddy St, Dillner J, Karlsson Hedestam Gb, Albert J, Murrell B
Published in: The Lancet. Infectious diseases, 2022, ISSN 1473-3099
Publisher: The Lancet Publishing Group
DOI: 10.1016/s1473-3099(22)00129-3
Author(s): Leo Hanke, Hrishikesh Das, Daniel J. Sheward, Laura Perez Vidakovics, Egon Urgard, Ainhoa Moliner-Morro, Changil Kim, Vivien Karl, Alec Pankow, Natalie L. Smith, Bartlomiej Porebski, Oscar Fernandez-Capetillo, Erdinc Sezgin, Gabriel K. Pedersen, Jonathan M. Coquet, B. Martin Hällberg, Ben Murrell & Gerald M. McInerney
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-27610-z
Author(s): Ehling, R.A., Weber, C.R., Mason, D.M., Friedensohn, S., Wagner, B., Bieberich, F., Kapetanovic, E., Vazquez-Lombardi, R., Di Roberto, R.B., Hong, K.-L., Wagner, C., Pataia, M., Overath, M.D., Sheward, D.J., Murrell, B., Yermanos, A., Cuny, A.P., Savic, M., Rudolf, F., Reddy, S.T.
Published in: Cell Reports, 2022, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.110242
Author(s): Manon Ragonnet-Cronin, Olivia Boyd, Lily Geidelberg, David Jorgensen, Fabricia F. Nascimento, Igor Siveroni, Robert A. Johnson, Marc Baguelin, Zulma M. Cucunubá, Elita Jauneikaite, Swapnil Mishra, Oliver J. Watson, Neil Ferguson, Anne Cori, Christl A. Donnelly, Erik Volz
Published in: Nature Communications, 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-22366-y
Author(s): Ainhoa Moliner-Morro, Daniel J. Sheward, Vivien Karl, Laura Perez Vidakovics, Ben Murrell, Gerald M. McInerney, Leo Hanke
Published in: Biomolecules, 10/12, 2020, Page(s) 1661, ISSN 2218-273X
Publisher: MDPI
DOI: 10.3390/biom10121661
Author(s): Tânia F. Custódio, Hrishikesh Das, Daniel J. Sheward, Leo Hanke, Samuel Pazicky, Joanna Pieprzyk, Michèle Sorgenfrei, Martin A. Schroer, Andrey Yu. Gruzinov, Cy M. Jeffries, Melissa A. Graewert, Dmitri I. Svergun, Nikolay Dobrev, Kim Remans, Markus A. Seeger, Gerald M. McInerney, Ben Murrell, B. Martin Hällberg, Christian Löw
Published in: Nature Communications, 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-19204-y
Author(s): Paul-Albert Koenig, Hrishikesh Das, Hejun Liu, Beate M. Kümmerer, Florian N. Gohr, Lea-Marie Jenster, Lisa D. J. Schiffelers, Yonas M. Tesfamariam, Miki Uchima, Jennifer D. Wuerth, Karl Gatterdam, Natalia Ruetalo, Maria H. Christensen, Caroline I. Fandrey, Sabine Normann, Jan M. P. Tödtmann, Steffen Pritzl, Leo Hanke, Jannik Boos, Meng Yuan, Xueyong Zhu, Jonathan L. Schmid-Burgk, Hiroki Kato, Mi
Published in: Science, 371/6530, 2021, Page(s) eabe6230, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abe6230
Author(s): X. Castro Dopico, S. Muschiol, M. Christian, L. Hanke, D. J. Sheward, N. F. Grinberg, J. Rorbach, G. Bogdanovic, G. M. Mcinerney, T. Allander, C. Wallace, B. Murrell, J. Albert, G. B. Karlsson Hedestam
Published in: Journal of Internal Medicine, 2021, ISSN 0954-6820
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/joim.13304
Author(s): Leo Hanke, Laura Vidakovics Perez, Daniel J. Sheward, Hrishikesh Das, Tim Schulte, Ainhoa Moliner-Morro, Martin Corcoran, Adnane Achour, Gunilla B. Karlsson Hedestam, B. Martin Hällberg, Ben Murrell, Gerald M. McInerney
Published in: Nature Communications, 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-18174-5
Author(s): Katharina Wørzner, Daniel J. Sheward, Signe Tandrup Schmidt, Leo Hanke, Julie Zimmermann, Gerald McInerney, Gunilla B. Karlsson Hedestam, Ben Murrell, Dennis Christensen, Gabriel Kristian Pedersen
Published in: EBioMedicine, 63, 2021, Page(s) 103197, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2020.103197
Author(s): Lydia Scharf, Hannes Axelsson, Aikaterini Emmanouilidi, Nimitha R. Mathew, Daniel J. Sheward, Susannah Leach, Pauline Isakson, Ilya V. Smirnov, Emelie Marklund, Nicolae Miron, Lars-Magnus Andersson, Magnus Gisslén, Ben Murrell, Anna Lundgren, Mats Bemark, and Davide Angeletti
Published in: JCI Insight, 2022, ISSN 2379-3708
Publisher: American Society for Clinical Investigation (ASCI)
DOI: 10.1172/jci.insight.165299
Author(s): Ann-Sofie Rudberg, Sebastian Havervall, Anna Månberg, August Jernbom Falk, Katherina Aguilera, Henry Ng, Lena Gabrielsson, Ann-Christin Salomonsson, Leo Hanke, Ben Murrell, Gerald McInerney, Jennie Olofsson, Eni Andersson, Cecilia Hellström, Shaghayegh Bayati, Sofia Bergström, Elisa Pin, Ronald Sjöberg, Hanna Tegel, My Hedhammar, Mia Phillipson, Peter Nilsson, Sophia Hober, Charlotte Thålin
Published in: Nature Communications, 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-18848-0
Author(s): Erik Volz, Verity Hill, John T. McCrone, Anna Price, David Jorgensen, Áine O’Toole, Joel Southgate, Robert Johnson, Ben Jackson, Fabricia F. Nascimento, Sara M. Rey, Samuel M. Nicholls, Rachel M. Colquhoun, Ana da Silva Filipe, James Shepherd, David J. Pascall, Rajiv Shah, Natasha Jesudason, Kathy Li, Ruth Jarrett, Nicole Pacchiarini, Matthew Bull, Lily Geidelberg, Igor Siveroni, Ian Goodfellow
Published in: Cell, 184/1, 2021, Page(s) 64-75.e11, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.11.020
Author(s): Niclas Roxhed; Annika Bendes; Matilda Dale; Cecilia Mattsson; Leo Hanke; Tea Dodig-Crnković; Murray Christian; Birthe Meineke; Birthe Meineke; Simon J. Elsässer; Simon J. Elsässer; Juni Andréll; Sebastian Havervall; Charlotte Thålin; Carina Eklund; Joakim Dillner; Olof Beck; Cecilia Engel Thomas; Gerald M. McInerney; Mun-Gwan Hong; Ben Murrell; Claudia Fredolini; Jochen M. Schwenk
Published in: Nature Communications, 1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-23893-4
Author(s): Hanke, L., Sheward, D.J., Pankow, A., Vidakovics, L.P., Karl, V., Kim, C., Urgard, E., Smith, N.L., Astorga-Wells, J., Ekström, S., Coquet, J.M., McInerney, G.M., Murrell, B
Published in: Science Advances, 2022, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abm0220
Author(s): Xaquin Castro Dopico; Sandra Muschiol; Nastasiya F Grinberg; Soo Aleman; Daniel J Sheward; Leo Hanke; Marcus Ahl; Linnea Vikström; Mattias Forsell; Jonathan M Coquet; Gerald McInerney; Joakim Dillner; Gordana Bogdanovic; Ben Murrell; Jan Albert; Chris Wallace; Gunilla B Karlsson Hedestam
Published in: Clinical & Translational Immunology, 1, 2022, ISSN 2050-0068
Publisher: Wiley
DOI: 10.1002/cti2.1379
Author(s): Ainhoa Moliner-Morro, Gerald M McInerney, Leo Hanke
Published in: Journal of General Virology, 2022, ISSN 1743-422X
Publisher: BioMed Central
DOI: 10.1099/jgv.0.001731
Author(s): Sheward Dj, Mandolesi M, Urgard E, Kim C, Hanke L, Perez Vidakovics L, Pankow A, Smith Nl, Castro Dopico X, Mcinerney Gm, Coquet Jm, Karlsson Hedestam Gb, Murrell B
Published in: Cell Reports Medicine, 2021, ISSN 2666-3791
Publisher: Cell Press
DOI: 10.1016/j.xcrm.2021.100450