Resultado final
CoroNAb website for dissemination of results, and for fostering broader protocol, reagent, and result sharing by the scientific community.
Formulation characteristics and physicochemical evaluation of antigen-adjuvant combinationsFormulation characteristics and physicochemical evaluation of antigen-adjuvant combinations.
Shared plasmid designWe will share out plasmid designs, right from the start of the project. Initially, this will be through our collaboration network, and subsequently this will be on the CoroNAb website.
Predicted antigen-specific antibody variants.Predicted antigenspecific antibody variants 1 month after receiving NGS data fromimmunized animal
Shared 2019-nCoV spike binding results for mAbsShared 2019-nCoV spike binding results for mAbs.
Shared nanobody sequences of confirmed binders, and data from NGS library sequencingShared nanobody sequences of confirmed binders, and data from NGS library sequencing.
Shared 2019-nCoV spike binding results for nanobodiesShared 2019-nCoV spike binding results for nanobodies.
Shared mAb sequences, including NGS dataD3.1 Shared mAb sequences, including NGS data.
Shared mAb expression plasmids (AddGene).
Shared nanobody expression plasmids of confirmed binders (AddGene) and libraries (by request)Shared nanobody expression plasmids of confirmed binders (AddGene) and libraries (by request).
2019-nCoV neutralization assay SOP, and dissemination of relevant plasmids.Shared plasmids.
Shared plasmids deposited with Addgene and shared directly where requested If a SARSCoV2 specific resource becomes available we will utilize this
Deliver lead candidate anti-nCoV mAbs (from hybridoma combinatorial library screens) to KI for neutralization screeningDeliver lead candidate antinCoV mAbs from hybridoma combinatorial library screens to KI for neutralization screening
Safety and immunogenicity data for each subunit/adjuvant combination. Selection of the best nCoV spike protein and adjuvant combination for immunizations of larger animals.
Scenarios will be developed for rollout of new antiviral therapy and a range of impacts will be examined in terms of impact on mortality and hospital bed usageModels of interventions and new forecasts will be published online.
Update of DMPThe draft management plan will be updated.
Neutralization results for isolated monoclonal antibodies and camelid nanobodies, as well as modified mAbsD4.2. Neutralization results for isolated monoclonal antibodies and camelid nanobodies (aims 2
Deliver an ongoing series of progressively optimized anti-nCoV mAbs to KI for neutralization screening.Deliver an ongoing series of progressively optimized antinCoV mAbs to KI for neutralization screening
Mathematical model will be released as open source R package. Model projections will be published online.
At least one study will be published which examines the impact of widespread antiviral therapy on evolution of drug resistance and virulence of 2019nCoV
Shared expression resultsShared expression results, yields, and working protocols for all constructs. This will be ongoing throughout the project.
Publicaciones
Autores:
Pradeepa Pushparaj, Andrea Nicoletto, Daniel J. Sheward, Hrishikesh Das, Xaquin Castro Dopico, Laura Perez Vidakovics, Leo Hanke, Mark Chernyshev, Sanjana Narang, Sungyong Kim, Julian Fischbach, Simon Ekström, Gerald McInerney, B. Martin Hällberg, Ben Murrell. Martin Corcoran, Gunilla B. Karlsson Hedestam
Publicado en:
Immunity, 2022, ISSN 1097-4180
Editor:
Cell Press
DOI:
10.1016/j.immuni.2022.12.005
Autores:
Erik Volz, Swapnil Mishra, Meera Chand, Jeffrey C. Barrett, Robert Johnson, Lily Geidelberg, Wes R. Hinsley, Daniel J. Laydon, Gavin Dabrera, Áine O’Toole, Robert Amato, Manon Ragonnet-Cronin, Ian Harrison, Ben Jackson, Cristina V. Ariani, Olivia Boyd, Nicholas J. Loman, John T. McCrone, Sónia Gonçalves, David Jorgensen, Richard Myers, Verity Hill, David K. Jackson, Katy Gaythorpe, Natalie Gr
Publicado en:
Nature, Edición 593/7858, 2021, Página(s) 266-269, ISSN 0028-0836
Editor:
Nature Publishing Group
DOI:
10.1038/s41586-021-03470-x
Autores:
Inga Szurgot, Leo Hanke, Daniel J. Sheward, Laura Perez Vidakovics, Ben Murrell, Gerald M. McInerney, Peter Liljeström
Publicado en:
Scientific Reports, Edición 11/1, 2021, ISSN 2045-2322
Editor:
Nature Publishing Group
DOI:
10.1038/s41598-021-82498-5
Autores:
Marco Mandolesi, Daniel J. Sheward, Leo Hanke, Junjie Ma, Pradeepa Pushparaj, Laura Perez Vidakovics, Changil Kim, Monika Àdori, Klara Lenart, Karin Loré, Xaquin Castro Dopico, Jonathan M. Coquet, Gerald M. McInerney, Gunilla B. Karlsson Hedestam, Ben Murrell
Publicado en:
Cell Reports Medicine, Edición 2/4, 2021, Página(s) 100252, ISSN 2666-3791
Editor:
Cell Press
DOI:
10.1016/j.xcrm.2021.100252
Autores:
Joseph M Taft, Cédric R Weber, Beichen Gao, Roy A Ehling, Jiami Han, Lester Frei, Sean W Metcalfe, Max D Overath, Alexander Yermanos, William Kelton, Sai T Reddy
Publicado en:
Cell, 2022, ISSN 0092-8674
Editor:
Cell Press
DOI:
10.1016/j.cell.2022.08.024
Autores:
Sheward Dj, Kim C, Ehling Ra, Pankow A, Castro Dopico X, Dyrdak R, Martin Dp, Reddy St, Dillner J, Karlsson Hedestam Gb, Albert J, Murrell B
Publicado en:
The Lancet. Infectious diseases, 2022, ISSN 1473-3099
Editor:
The Lancet Publishing Group
DOI:
10.1016/s1473-3099(22)00129-3
Autores:
Daniel J Sheward, Changil Kim, Julian Fischbach, Sandra Muschiol, Roy A Ehling, Niklas K Björkström, Gunilla B Karlsson Hedestam, Sai T Reddy, Jan Albert, Thomas P Peacock, Ben Murrell
Publicado en:
The Lancet Infectious Diseases, 2022, ISSN 1473-3099
Editor:
The Lancet Publishing Group
DOI:
10.1016/s1473-3099(22)00524-2
Autores:
Leo Hanke, Hrishikesh Das, Daniel J. Sheward, Laura Perez Vidakovics, Egon Urgard, Ainhoa Moliner-Morro, Changil Kim, Vivien Karl, Alec Pankow, Natalie L. Smith, Bartlomiej Porebski, Oscar Fernandez-Capetillo, Erdinc Sezgin, Gabriel K. Pedersen, Jonathan M. Coquet, B. Martin Hällberg, Ben Murrell & Gerald M. McInerney
Publicado en:
Nature Communications, 2022, ISSN 2041-1723
Editor:
Nature Publishing Group
DOI:
10.1038/s41467-021-27610-z
Autores:
Ehling, R.A., Weber, C.R., Mason, D.M., Friedensohn, S., Wagner, B., Bieberich, F., Kapetanovic, E., Vazquez-Lombardi, R., Di Roberto, R.B., Hong, K.-L., Wagner, C., Pataia, M., Overath, M.D., Sheward, D.J., Murrell, B., Yermanos, A., Cuny, A.P., Savic, M., Rudolf, F., Reddy, S.T.
Publicado en:
Cell Reports, 2022, ISSN 2211-1247
Editor:
Cell Press
DOI:
10.1016/j.celrep.2021.110242
Autores:
Manon Ragonnet-Cronin, Olivia Boyd, Lily Geidelberg, David Jorgensen, Fabricia F. Nascimento, Igor Siveroni, Robert A. Johnson, Marc Baguelin, Zulma M. Cucunubá, Elita Jauneikaite, Swapnil Mishra, Oliver J. Watson, Neil Ferguson, Anne Cori, Christl A. Donnelly, Erik Volz
Publicado en:
Nature Communications, Edición 12/1, 2021, ISSN 2041-1723
Editor:
Nature Publishing Group
DOI:
10.1038/s41467-021-22366-y
Autores:
Jan Schlegel; Bartlomiej Porebski; Luca Andronico; Leo Hanke; Steven Edwards; Hjalmar Brismar; Ben Murrell; Gerald M. McInerney; Oscar Fernandez-Capetillo; Erdinc Sezgin
Publicado en:
Nano Letters, Edición 1, 2023, ISSN 1530-6984
Editor:
American Chemical Society
DOI:
10.1021/acs.nanolett.2c04884
Autores:
Ainhoa Moliner-Morro, Daniel J. Sheward, Vivien Karl, Laura Perez Vidakovics, Ben Murrell, Gerald M. McInerney, Leo Hanke
Publicado en:
Biomolecules, Edición 10/12, 2020, Página(s) 1661, ISSN 2218-273X
Editor:
MDPI
DOI:
10.3390/biom10121661
Autores:
Tânia F. Custódio, Hrishikesh Das, Daniel J. Sheward, Leo Hanke, Samuel Pazicky, Joanna Pieprzyk, Michèle Sorgenfrei, Martin A. Schroer, Andrey Yu. Gruzinov, Cy M. Jeffries, Melissa A. Graewert, Dmitri I. Svergun, Nikolay Dobrev, Kim Remans, Markus A. Seeger, Gerald M. McInerney, Ben Murrell, B. Martin Hällberg, Christian Löw
Publicado en:
Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor:
Nature Publishing Group
DOI:
10.1038/s41467-020-19204-y
Autores:
Paul-Albert Koenig, Hrishikesh Das, Hejun Liu, Beate M. Kümmerer, Florian N. Gohr, Lea-Marie Jenster, Lisa D. J. Schiffelers, Yonas M. Tesfamariam, Miki Uchima, Jennifer D. Wuerth, Karl Gatterdam, Natalia Ruetalo, Maria H. Christensen, Caroline I. Fandrey, Sabine Normann, Jan M. P. Tödtmann, Steffen Pritzl, Leo Hanke, Jannik Boos, Meng Yuan, Xueyong Zhu, Jonathan L. Schmid-Burgk, Hiroki Kato, Mi
Publicado en:
Science, Edición 371/6530, 2021, Página(s) eabe6230, ISSN 0036-8075
Editor:
American Association for the Advancement of Science
DOI:
10.1126/science.abe6230
Autores:
X. Castro Dopico, S. Muschiol, M. Christian, L. Hanke, D. J. Sheward, N. F. Grinberg, J. Rorbach, G. Bogdanovic, G. M. Mcinerney, T. Allander, C. Wallace, B. Murrell, J. Albert, G. B. Karlsson Hedestam
Publicado en:
Journal of Internal Medicine, 2021, ISSN 0954-6820
Editor:
Blackwell Publishing Inc.
DOI:
10.1111/joim.13304
Autores:
Leo Hanke, Laura Vidakovics Perez, Daniel J. Sheward, Hrishikesh Das, Tim Schulte, Ainhoa Moliner-Morro, Martin Corcoran, Adnane Achour, Gunilla B. Karlsson Hedestam, B. Martin Hällberg, Ben Murrell, Gerald M. McInerney
Publicado en:
Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor:
Nature Publishing Group
DOI:
10.1038/s41467-020-18174-5
Autores:
Anouschka Akerman
Vanessa Milogiannakis
Tyra Jean
Camille Esneau
Mariana Ruiz Silva
Timothy Ison
Christina Fichter
Joseph A. Lopez
Deborah Chandra
Zin Naing
Joanna Caguicla
Daiyang Li
Gregory Walker
Supavadee Amatayakul-Chantler
Nathan Roth
Sandro Manni
Thomas Hauser
Thomas Barnes
Anna Condylios
Malinna Yeang
Maureen Wong
Charles S.P. Foster
Kenta Sato
Sharon Lee
Yang Song
Lijun Mao
Allison Sigmun
Publicado en:
EBioMedicine, 2023, ISSN 2352-3964
Editor:
Elsevier BV
DOI:
10.1016/j.ebiom.2023.104545
Autores:
Katharina Wørzner, Daniel J. Sheward, Signe Tandrup Schmidt, Leo Hanke, Julie Zimmermann, Gerald McInerney, Gunilla B. Karlsson Hedestam, Ben Murrell, Dennis Christensen, Gabriel Kristian Pedersen
Publicado en:
EBioMedicine, Edición 63, 2021, Página(s) 103197, ISSN 2352-3964
Editor:
Elsevier BV
DOI:
10.1016/j.ebiom.2020.103197
Autores:
Lydia Scharf, Hannes Axelsson, Aikaterini Emmanouilidi, Nimitha R. Mathew, Daniel J. Sheward, Susannah Leach, Pauline Isakson, Ilya V. Smirnov, Emelie Marklund, Nicolae Miron, Lars-Magnus Andersson, Magnus Gisslén, Ben Murrell, Anna Lundgren, Mats Bemark, and Davide Angeletti
Publicado en:
JCI Insight, 2022, ISSN 2379-3708
Editor:
American Society for Clinical Investigation (ASCI)
DOI:
10.1172/jci.insight.165299
Autores:
Ann-Sofie Rudberg, Sebastian Havervall, Anna Månberg, August Jernbom Falk, Katherina Aguilera, Henry Ng, Lena Gabrielsson, Ann-Christin Salomonsson, Leo Hanke, Ben Murrell, Gerald McInerney, Jennie Olofsson, Eni Andersson, Cecilia Hellström, Shaghayegh Bayati, Sofia Bergström, Elisa Pin, Ronald Sjöberg, Hanna Tegel, My Hedhammar, Mia Phillipson, Peter Nilsson, Sophia Hober, Charlotte Thålin
Publicado en:
Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor:
Nature Publishing Group
DOI:
10.1038/s41467-020-18848-0
Autores:
Erik Volz, Verity Hill, John T. McCrone, Anna Price, David Jorgensen, Áine O’Toole, Joel Southgate, Robert Johnson, Ben Jackson, Fabricia F. Nascimento, Sara M. Rey, Samuel M. Nicholls, Rachel M. Colquhoun, Ana da Silva Filipe, James Shepherd, David J. Pascall, Rajiv Shah, Natasha Jesudason, Kathy Li, Ruth Jarrett, Nicole Pacchiarini, Matthew Bull, Lily Geidelberg, Igor Siveroni, Ian Goodfellow
Publicado en:
Cell, Edición 184/1, 2021, Página(s) 64-75.e11, ISSN 0092-8674
Editor:
Cell Press
DOI:
10.1016/j.cell.2020.11.020
Autores:
Niclas Roxhed; Annika Bendes; Matilda Dale; Cecilia Mattsson; Leo Hanke; Tea Dodig-Crnković; Murray Christian; Birthe Meineke; Birthe Meineke; Simon J. Elsässer; Simon J. Elsässer; Juni Andréll; Sebastian Havervall; Charlotte Thålin; Carina Eklund; Joakim Dillner; Olof Beck; Cecilia Engel Thomas; Gerald M. McInerney; Mun-Gwan Hong; Ben Murrell; Claudia Fredolini; Jochen M. Schwenk
Publicado en:
Nature Communications, Edición 1, 2021, ISSN 2041-1723
Editor:
Nature Publishing Group
DOI:
10.1038/s41467-021-23893-4
Autores:
Dennis Christensen, Charlotta Polacek, Daniel J Sheward, Leo Hanke, Ainhoa Moliner-Morro, Gerald McInerney, Ben Murrell, Katrine Top Hartmann, Henrik Elvang Jensen, Gregers Jungersen, Kristin Illigen, Louise Krag Isling, Rune Fledelius Jensen, Julia Sid Hansen, Ida Rosenkrands, Carlota Fernandez-Antunez, Santseharay Ramirez, Frank Follmann, Jens Bukh, Gabriel Kristian Pedersen
Publicado en:
EBioMedicine, 2022, ISSN 2352-3964
Editor:
Elsevier BV
DOI:
10.1016/j.ebiom.2022.104248
Autores:
Hanke, L., Sheward, D.J., Pankow, A., Vidakovics, L.P., Karl, V., Kim, C., Urgard, E., Smith, N.L., Astorga-Wells, J., Ekström, S., Coquet, J.M., McInerney, G.M., Murrell, B
Publicado en:
Science Advances, 2022, ISSN 2375-2548
Editor:
American Association for the Advancement of Science
DOI:
10.1126/sciadv.abm0220
Autores:
Xaquin Castro Dopico; Sandra Muschiol; Nastasiya F Grinberg; Soo Aleman; Daniel J Sheward; Leo Hanke; Marcus Ahl; Linnea Vikström; Mattias Forsell; Jonathan M Coquet; Gerald McInerney; Joakim Dillner; Gordana Bogdanovic; Ben Murrell; Jan Albert; Chris Wallace; Gunilla B Karlsson Hedestam
Publicado en:
Clinical & Translational Immunology, Edición 1, 2022, ISSN 2050-0068
Editor:
Wiley
DOI:
10.1002/cti2.1379
Autores:
Ainhoa Moliner-Morro, Gerald M McInerney, Leo Hanke
Publicado en:
Journal of General Virology, 2022, ISSN 1743-422X
Editor:
BioMed Central
DOI:
10.1099/jgv.0.001731
Autores:
Sheward Dj, Mandolesi M, Urgard E, Kim C, Hanke L, Perez Vidakovics L, Pankow A, Smith Nl, Castro Dopico X, Mcinerney Gm, Coquet Jm, Karlsson Hedestam Gb, Murrell B
Publicado en:
Cell Reports Medicine, 2021, ISSN 2666-3791
Editor:
Cell Press
DOI:
10.1016/j.xcrm.2021.100450
Autores:
Daniel J Sheward, Changil Kim, Julian Fischbach, Sandra Muschiol, Roy A Ehling, Niklas K Björkström, Gunilla B Karlsson Hedestam, Sai T Reddy, Jan Albert, Thomas P Peacock, Ben Murrell
Publicado en:
The Lancet Infectious Diseases, 2022, ISSN 1473-3099
Editor:
The Lancet Publishing Group
DOI:
10.1016/s1473-3099(22)00663-6
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