Risultati finali
CoroNAb website for dissemination of results, and for fostering broader protocol, reagent, and result sharing by the scientific community.
Formulation characteristics and physicochemical evaluation of antigen-adjuvant combinationsFormulation characteristics and physicochemical evaluation of antigen-adjuvant combinations.
Shared plasmid designWe will share out plasmid designs, right from the start of the project. Initially, this will be through our collaboration network, and subsequently this will be on the CoroNAb website.
Predicted antigen-specific antibody variants.Predicted antigenspecific antibody variants 1 month after receiving NGS data fromimmunized animal
Shared 2019-nCoV spike binding results for mAbsShared 2019-nCoV spike binding results for mAbs.
Shared nanobody sequences of confirmed binders, and data from NGS library sequencingShared nanobody sequences of confirmed binders, and data from NGS library sequencing.
Shared 2019-nCoV spike binding results for nanobodiesShared 2019-nCoV spike binding results for nanobodies.
Shared mAb sequences, including NGS dataD3.1 Shared mAb sequences, including NGS data.
Safety and immunogenicity data for each subunit/adjuvant combination. Selection of the best nCoV spike protein and adjuvant combination for immunizations of larger animals.
Scenarios will be developed for rollout of new antiviral therapy and a range of impacts will be examined in terms of impact on mortality and hospital bed usageModels of interventions and new forecasts will be published online.
Update of DMPThe draft management plan will be updated.
Neutralization results for isolated monoclonal antibodies and camelid nanobodies, as well as modified mAbsD4.2. Neutralization results for isolated monoclonal antibodies and camelid nanobodies (aims 2
Deliver an ongoing series of progressively optimized anti-nCoV mAbs to KI for neutralization screening.Deliver an ongoing series of progressively optimized antinCoV mAbs to KI for neutralization screening
Mathematical model will be released as open source R package. Model projections will be published online.
Shared plasmids.
Shared plasmids deposited with Addgene and shared directly where requested If a SARSCoV2 specific resource becomes available we will utilize this
Deliver lead candidate anti-nCoV mAbs (from hybridoma combinatorial library screens) to KI for neutralization screeningDeliver lead candidate antinCoV mAbs from hybridoma combinatorial library screens to KI for neutralization screening
At least one study will be published which examines the impact of widespread antiviral therapy on evolution of drug resistance and virulence of 2019nCoV
Shared expression resultsShared expression results, yields, and working protocols for all constructs. This will be ongoing throughout the project.
Pubblicazioni
Autori:
Pradeepa Pushparaj, Andrea Nicoletto, Daniel J. Sheward, Hrishikesh Das, Xaquin Castro Dopico, Laura Perez Vidakovics, Leo Hanke, Mark Chernyshev, Sanjana Narang, Sungyong Kim, Julian Fischbach, Simon Ekström, Gerald McInerney, B. Martin Hällberg, Ben Murrell. Martin Corcoran, Gunilla B. Karlsson Hedestam
Pubblicato in:
Immunity, 2022, ISSN 1097-4180
Editore:
Cell Press
DOI:
10.1016/j.immuni.2022.12.005
Autori:
Erik Volz, Swapnil Mishra, Meera Chand, Jeffrey C. Barrett, Robert Johnson, Lily Geidelberg, Wes R. Hinsley, Daniel J. Laydon, Gavin Dabrera, Áine O’Toole, Robert Amato, Manon Ragonnet-Cronin, Ian Harrison, Ben Jackson, Cristina V. Ariani, Olivia Boyd, Nicholas J. Loman, John T. McCrone, Sónia Gonçalves, David Jorgensen, Richard Myers, Verity Hill, David K. Jackson, Katy Gaythorpe, Natalie Gr
Pubblicato in:
Nature, Numero 593/7858, 2021, Pagina/e 266-269, ISSN 0028-0836
Editore:
Nature Publishing Group
DOI:
10.1038/s41586-021-03470-x
Autori:
Inga Szurgot, Leo Hanke, Daniel J. Sheward, Laura Perez Vidakovics, Ben Murrell, Gerald M. McInerney, Peter Liljeström
Pubblicato in:
Scientific Reports, Numero 11/1, 2021, ISSN 2045-2322
Editore:
Nature Publishing Group
DOI:
10.1038/s41598-021-82498-5
Autori:
Marco Mandolesi, Daniel J. Sheward, Leo Hanke, Junjie Ma, Pradeepa Pushparaj, Laura Perez Vidakovics, Changil Kim, Monika Àdori, Klara Lenart, Karin Loré, Xaquin Castro Dopico, Jonathan M. Coquet, Gerald M. McInerney, Gunilla B. Karlsson Hedestam, Ben Murrell
Pubblicato in:
Cell Reports Medicine, Numero 2/4, 2021, Pagina/e 100252, ISSN 2666-3791
Editore:
Cell Press
DOI:
10.1016/j.xcrm.2021.100252
Autori:
Joseph M Taft, Cédric R Weber, Beichen Gao, Roy A Ehling, Jiami Han, Lester Frei, Sean W Metcalfe, Max D Overath, Alexander Yermanos, William Kelton, Sai T Reddy
Pubblicato in:
Cell, 2022, ISSN 0092-8674
Editore:
Cell Press
DOI:
10.1016/j.cell.2022.08.024
Autori:
Sheward Dj, Kim C, Ehling Ra, Pankow A, Castro Dopico X, Dyrdak R, Martin Dp, Reddy St, Dillner J, Karlsson Hedestam Gb, Albert J, Murrell B
Pubblicato in:
The Lancet. Infectious diseases, 2022, ISSN 1473-3099
Editore:
The Lancet Publishing Group
DOI:
10.1016/s1473-3099(22)00129-3
Autori:
Daniel J Sheward, Changil Kim, Julian Fischbach, Sandra Muschiol, Roy A Ehling, Niklas K Björkström, Gunilla B Karlsson Hedestam, Sai T Reddy, Jan Albert, Thomas P Peacock, Ben Murrell
Pubblicato in:
The Lancet Infectious Diseases, 2022, ISSN 1473-3099
Editore:
The Lancet Publishing Group
DOI:
10.1016/s1473-3099(22)00524-2
Autori:
Leo Hanke, Hrishikesh Das, Daniel J. Sheward, Laura Perez Vidakovics, Egon Urgard, Ainhoa Moliner-Morro, Changil Kim, Vivien Karl, Alec Pankow, Natalie L. Smith, Bartlomiej Porebski, Oscar Fernandez-Capetillo, Erdinc Sezgin, Gabriel K. Pedersen, Jonathan M. Coquet, B. Martin Hällberg, Ben Murrell & Gerald M. McInerney
Pubblicato in:
Nature Communications, 2022, ISSN 2041-1723
Editore:
Nature Publishing Group
DOI:
10.1038/s41467-021-27610-z
Autori:
Ehling, R.A., Weber, C.R., Mason, D.M., Friedensohn, S., Wagner, B., Bieberich, F., Kapetanovic, E., Vazquez-Lombardi, R., Di Roberto, R.B., Hong, K.-L., Wagner, C., Pataia, M., Overath, M.D., Sheward, D.J., Murrell, B., Yermanos, A., Cuny, A.P., Savic, M., Rudolf, F., Reddy, S.T.
Pubblicato in:
Cell Reports, 2022, ISSN 2211-1247
Editore:
Cell Press
DOI:
10.1016/j.celrep.2021.110242
Autori:
Manon Ragonnet-Cronin, Olivia Boyd, Lily Geidelberg, David Jorgensen, Fabricia F. Nascimento, Igor Siveroni, Robert A. Johnson, Marc Baguelin, Zulma M. Cucunubá, Elita Jauneikaite, Swapnil Mishra, Oliver J. Watson, Neil Ferguson, Anne Cori, Christl A. Donnelly, Erik Volz
Pubblicato in:
Nature Communications, Numero 12/1, 2021, ISSN 2041-1723
Editore:
Nature Publishing Group
DOI:
10.1038/s41467-021-22366-y
Autori:
Jan Schlegel; Bartlomiej Porebski; Luca Andronico; Leo Hanke; Steven Edwards; Hjalmar Brismar; Ben Murrell; Gerald M. McInerney; Oscar Fernandez-Capetillo; Erdinc Sezgin
Pubblicato in:
Nano Letters, Numero 1, 2023, ISSN 1530-6984
Editore:
American Chemical Society
DOI:
10.1021/acs.nanolett.2c04884
Autori:
Ainhoa Moliner-Morro, Daniel J. Sheward, Vivien Karl, Laura Perez Vidakovics, Ben Murrell, Gerald M. McInerney, Leo Hanke
Pubblicato in:
Biomolecules, Numero 10/12, 2020, Pagina/e 1661, ISSN 2218-273X
Editore:
MDPI
DOI:
10.3390/biom10121661
Autori:
Tânia F. Custódio, Hrishikesh Das, Daniel J. Sheward, Leo Hanke, Samuel Pazicky, Joanna Pieprzyk, Michèle Sorgenfrei, Martin A. Schroer, Andrey Yu. Gruzinov, Cy M. Jeffries, Melissa A. Graewert, Dmitri I. Svergun, Nikolay Dobrev, Kim Remans, Markus A. Seeger, Gerald M. McInerney, Ben Murrell, B. Martin Hällberg, Christian Löw
Pubblicato in:
Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore:
Nature Publishing Group
DOI:
10.1038/s41467-020-19204-y
Autori:
Paul-Albert Koenig, Hrishikesh Das, Hejun Liu, Beate M. Kümmerer, Florian N. Gohr, Lea-Marie Jenster, Lisa D. J. Schiffelers, Yonas M. Tesfamariam, Miki Uchima, Jennifer D. Wuerth, Karl Gatterdam, Natalia Ruetalo, Maria H. Christensen, Caroline I. Fandrey, Sabine Normann, Jan M. P. Tödtmann, Steffen Pritzl, Leo Hanke, Jannik Boos, Meng Yuan, Xueyong Zhu, Jonathan L. Schmid-Burgk, Hiroki Kato, Mi
Pubblicato in:
Science, Numero 371/6530, 2021, Pagina/e eabe6230, ISSN 0036-8075
Editore:
American Association for the Advancement of Science
DOI:
10.1126/science.abe6230
Autori:
X. Castro Dopico, S. Muschiol, M. Christian, L. Hanke, D. J. Sheward, N. F. Grinberg, J. Rorbach, G. Bogdanovic, G. M. Mcinerney, T. Allander, C. Wallace, B. Murrell, J. Albert, G. B. Karlsson Hedestam
Pubblicato in:
Journal of Internal Medicine, 2021, ISSN 0954-6820
Editore:
Blackwell Publishing Inc.
DOI:
10.1111/joim.13304
Autori:
Leo Hanke, Laura Vidakovics Perez, Daniel J. Sheward, Hrishikesh Das, Tim Schulte, Ainhoa Moliner-Morro, Martin Corcoran, Adnane Achour, Gunilla B. Karlsson Hedestam, B. Martin Hällberg, Ben Murrell, Gerald M. McInerney
Pubblicato in:
Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore:
Nature Publishing Group
DOI:
10.1038/s41467-020-18174-5
Autori:
Anouschka Akerman
Vanessa Milogiannakis
Tyra Jean
Camille Esneau
Mariana Ruiz Silva
Timothy Ison
Christina Fichter
Joseph A. Lopez
Deborah Chandra
Zin Naing
Joanna Caguicla
Daiyang Li
Gregory Walker
Supavadee Amatayakul-Chantler
Nathan Roth
Sandro Manni
Thomas Hauser
Thomas Barnes
Anna Condylios
Malinna Yeang
Maureen Wong
Charles S.P. Foster
Kenta Sato
Sharon Lee
Yang Song
Lijun Mao
Allison Sigmun
Pubblicato in:
EBioMedicine, 2023, ISSN 2352-3964
Editore:
Elsevier BV
DOI:
10.1016/j.ebiom.2023.104545
Autori:
Katharina Wørzner, Daniel J. Sheward, Signe Tandrup Schmidt, Leo Hanke, Julie Zimmermann, Gerald McInerney, Gunilla B. Karlsson Hedestam, Ben Murrell, Dennis Christensen, Gabriel Kristian Pedersen
Pubblicato in:
EBioMedicine, Numero 63, 2021, Pagina/e 103197, ISSN 2352-3964
Editore:
Elsevier BV
DOI:
10.1016/j.ebiom.2020.103197
Autori:
Lydia Scharf, Hannes Axelsson, Aikaterini Emmanouilidi, Nimitha R. Mathew, Daniel J. Sheward, Susannah Leach, Pauline Isakson, Ilya V. Smirnov, Emelie Marklund, Nicolae Miron, Lars-Magnus Andersson, Magnus Gisslén, Ben Murrell, Anna Lundgren, Mats Bemark, and Davide Angeletti
Pubblicato in:
JCI Insight, 2022, ISSN 2379-3708
Editore:
American Society for Clinical Investigation (ASCI)
DOI:
10.1172/jci.insight.165299
Autori:
Ann-Sofie Rudberg, Sebastian Havervall, Anna Månberg, August Jernbom Falk, Katherina Aguilera, Henry Ng, Lena Gabrielsson, Ann-Christin Salomonsson, Leo Hanke, Ben Murrell, Gerald McInerney, Jennie Olofsson, Eni Andersson, Cecilia Hellström, Shaghayegh Bayati, Sofia Bergström, Elisa Pin, Ronald Sjöberg, Hanna Tegel, My Hedhammar, Mia Phillipson, Peter Nilsson, Sophia Hober, Charlotte Thålin
Pubblicato in:
Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore:
Nature Publishing Group
DOI:
10.1038/s41467-020-18848-0
Autori:
Erik Volz, Verity Hill, John T. McCrone, Anna Price, David Jorgensen, Áine O’Toole, Joel Southgate, Robert Johnson, Ben Jackson, Fabricia F. Nascimento, Sara M. Rey, Samuel M. Nicholls, Rachel M. Colquhoun, Ana da Silva Filipe, James Shepherd, David J. Pascall, Rajiv Shah, Natasha Jesudason, Kathy Li, Ruth Jarrett, Nicole Pacchiarini, Matthew Bull, Lily Geidelberg, Igor Siveroni, Ian Goodfellow
Pubblicato in:
Cell, Numero 184/1, 2021, Pagina/e 64-75.e11, ISSN 0092-8674
Editore:
Cell Press
DOI:
10.1016/j.cell.2020.11.020
Autori:
Niclas Roxhed; Annika Bendes; Matilda Dale; Cecilia Mattsson; Leo Hanke; Tea Dodig-Crnković; Murray Christian; Birthe Meineke; Birthe Meineke; Simon J. Elsässer; Simon J. Elsässer; Juni Andréll; Sebastian Havervall; Charlotte Thålin; Carina Eklund; Joakim Dillner; Olof Beck; Cecilia Engel Thomas; Gerald M. McInerney; Mun-Gwan Hong; Ben Murrell; Claudia Fredolini; Jochen M. Schwenk
Pubblicato in:
Nature Communications, Numero 1, 2021, ISSN 2041-1723
Editore:
Nature Publishing Group
DOI:
10.1038/s41467-021-23893-4
Autori:
Dennis Christensen, Charlotta Polacek, Daniel J Sheward, Leo Hanke, Ainhoa Moliner-Morro, Gerald McInerney, Ben Murrell, Katrine Top Hartmann, Henrik Elvang Jensen, Gregers Jungersen, Kristin Illigen, Louise Krag Isling, Rune Fledelius Jensen, Julia Sid Hansen, Ida Rosenkrands, Carlota Fernandez-Antunez, Santseharay Ramirez, Frank Follmann, Jens Bukh, Gabriel Kristian Pedersen
Pubblicato in:
EBioMedicine, 2022, ISSN 2352-3964
Editore:
Elsevier BV
DOI:
10.1016/j.ebiom.2022.104248
Autori:
Hanke, L., Sheward, D.J., Pankow, A., Vidakovics, L.P., Karl, V., Kim, C., Urgard, E., Smith, N.L., Astorga-Wells, J., Ekström, S., Coquet, J.M., McInerney, G.M., Murrell, B
Pubblicato in:
Science Advances, 2022, ISSN 2375-2548
Editore:
American Association for the Advancement of Science
DOI:
10.1126/sciadv.abm0220
Autori:
Xaquin Castro Dopico; Sandra Muschiol; Nastasiya F Grinberg; Soo Aleman; Daniel J Sheward; Leo Hanke; Marcus Ahl; Linnea Vikström; Mattias Forsell; Jonathan M Coquet; Gerald McInerney; Joakim Dillner; Gordana Bogdanovic; Ben Murrell; Jan Albert; Chris Wallace; Gunilla B Karlsson Hedestam
Pubblicato in:
Clinical & Translational Immunology, Numero 1, 2022, ISSN 2050-0068
Editore:
Wiley
DOI:
10.1002/cti2.1379
Autori:
Ainhoa Moliner-Morro, Gerald M McInerney, Leo Hanke
Pubblicato in:
Journal of General Virology, 2022, ISSN 1743-422X
Editore:
BioMed Central
DOI:
10.1099/jgv.0.001731
Autori:
Sheward Dj, Mandolesi M, Urgard E, Kim C, Hanke L, Perez Vidakovics L, Pankow A, Smith Nl, Castro Dopico X, Mcinerney Gm, Coquet Jm, Karlsson Hedestam Gb, Murrell B
Pubblicato in:
Cell Reports Medicine, 2021, ISSN 2666-3791
Editore:
Cell Press
DOI:
10.1016/j.xcrm.2021.100450
Autori:
Daniel J Sheward, Changil Kim, Julian Fischbach, Sandra Muschiol, Roy A Ehling, Niklas K Björkström, Gunilla B Karlsson Hedestam, Sai T Reddy, Jan Albert, Thomas P Peacock, Ben Murrell
Pubblicato in:
The Lancet Infectious Diseases, 2022, ISSN 1473-3099
Editore:
The Lancet Publishing Group
DOI:
10.1016/s1473-3099(22)00663-6
È in corso la ricerca di dati su OpenAIRE...
Si è verificato un errore durante la ricerca dei dati su OpenAIRE
Nessun risultato disponibile