Modern approaches for developing antivirals against SARS-CoV 2

Deliverables

Open Research Data Pilot (2)

Draft of Data Management Plan

Description of datasets data sharing and archiving

Updated version of Data Management Plan

Websites, patent fillings, videos etc. (2)

Project website and communication pack

Project website and promotional tools for workshops and meetings

Consortium secured intranet

This tool will facilitate communication and establish the principles of work within the consortium

Publications

Peer reviewed articles (11)

Human soluble ACE2 improves the effect of remdesivir in SARS‐CoV‐2 infection

Author(s): Vanessa Monteil, Matheus Dyczynski, Volker M Lauschke, Hyesoo Kwon, Gerald Wirnsberger, Sonia Youhanna, Haibo Zhang, Arthur S Slutsky, Carmen Hurtado del Pozo, Moritz Horn, Nuria Montserrat, Josef M Penninger, Ali Mirazimi
Published in: EMBO Molecular Medicine, 13/1, 2021, Page(s) 13:e13426, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202013426

The Short- and Long-Range RNA-RNA Interactome of SARS-CoV-2

Author(s): Omer Ziv, Jonathan Price, Lyudmila Shalamova, Tsveta Kamenova, Ian Goodfellow, Friedemann Weber, Eric A. Miska
Published in: Molecular Cell, 80/6, 2020, Page(s) 1067-1077.e5, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2020.11.004

Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) is a host factor for RNA viruses including SARS-CoV-2

Author(s): Stephanie Devignot, Tim Wai Sha, Thomas Burkard, Patrick Schmerer, Astrid Hagelkruys, Ali Mirazimi, Ulrich Elling, Josef M. Penninger, Friedemann Weber
Published in: BioRxiv, 2022, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory, USA
DOI: 10.1101/2022.02.17.480904

ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology

Author(s): Gawish R, Starkl P, Pimenov L, Hladik A, Lakovits K, Oberndorfer F, Cronin SJ, Ohradanova-Repic A, Wirnsberger G, Agerer B, Endler L, Capraz T, Perthold JW, Cikes D, Koglgruber R, Hagelkruys A, Montserrat N, Mirazimi A, Boon L, Stockinger H, Bergthaler A, Oostenbrink C, Penninger JM, Knapp S.
Published in: Elife, 2022, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.74623

Identification of SARS-CoV-2–induced pathways reveals drug repurposing strategies

Author(s): Namshik Han, Woochang Hwang, Konstantinos Tzelepis, Patrick Schmerer, Eliza Yankova, Méabh MacMahon, Winnie Lei, Nicholas M. Katritsis, Anika Liu, Ulrike Felgenhauer, Alison Schuldt, Rebecca Harris, Kathryn Chapman, Frank McCaughan, Friedemann Weber, Tony Kouzarides
Published in: Science Advances, 7/27, 2021, Page(s) eabh3032, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.abh3032

Identification of lectin receptors for conserved SARS-CoV-2 glycosylation sites

Author(s): Hoffmann D, Mereiter S, Jin Oh Y, Monteil V, Elder E, Zhu R, Canena D, Hain L, Laurent E, Grünwald-Gruber C, Klausberger M, Jonsson G, Kellner MJ, Novatchkova M, Ticevic M, Chabloz A, Wirnsberger G, Hagelkruys A, Altmann F, Mach L, Stadlmann J, Oostenbrink C, Mirazimi A, Hinterdorfer P, Penninger JM.
Published in: EMBO Journal, 2021, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2021108375

Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor

Author(s): Capraz T, Kienzl NF, Laurent E, Perthold JW, Föderl-Höbenreich E, Grünwald-Gruber C, Maresch D, Monteil V, Niederhöfer J, Wirnsberger G, Mirazimi A, Zatloukal K, Mach L, Penninger JM, Oostenbrink C, Stadlmann J.
Published in: Elife, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.73641

Human recombinant soluble ACE2 in severe COVID-19

Author(s): Alexander Zoufaly, Marko Poglitsch, Judith H Aberle, Wolfgang Hoepler, Tamara Seitz, Marianna Traugott, Alexander Grieb, Erich Pawelka, Hermann Laferl, Christoph Wenisch, Stephanie Neuhold, Doris Haider, Karin Stiasny, Andreas Bergthaler, Elisabeth Puchhammer-Stoeckl, Ali Mirazimi, Nuria Montserrat, Haibo Zhang, Arthur S Slutsky, Josef M Penninger
Published in: The Lancet Respiratory Medicine, 8/11, 2020, Page(s) 1154-1158, ISSN 2213-2600
Publisher: Elsevier Limited
DOI: 10.1016/s2213-2600(20)30418-5

Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants

Author(s): Monteil V, Eaton B, Postnikova E, Murphy M, Braunsfeld B, Crozier I, Kricek F, Niederhöfer J, Schwarzböck A, Breid H, Devignot S, Klingström J, Thålin C, Kellner MJ, Christ W, Havervall S, Mereiter S, Knapp S, Sanchez Jimenez A, Bugajska-Schretter A, Dohnal A, Ruf C, Gugenberger R, Hagelkruys A, Montserrat N, Kozieradzki I, Hasan Ali O, Stadlmann J, Holbrook MR, Schmaljohn C, Oostenbrink C, Sh
Published in: EMBO Mol Med., 17574676, 2022, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202115230

Omicron variant of SARS-CoV-2 exhibits an increased resilience to the antiviral type I interferon response

Author(s): Lyudmila Shalamova, Ulrike Felgenhauer, Jochen Wilhelm, Andreas R Schaubmar, Kathrin Büttner, Andreas Schoen, Marek Widera, Sandra Ciesek, Friedemann Weber
Published in: PNAS Nexus, 2022, ISSN 2752-6542
Publisher: Oxford University Press
DOI: 10.1093/pnasnexus/pgac067

A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells

Author(s): Garreta E, Prado P, Stanifer ML, Monteil V, Marco A, Ullate-Agote A, Moya-Rull D, Vilas-Zornoza A, Tarantino C, Romero JP, Jonsson G, Oria R, Leopoldi A, Hagelkruys A, Gallo M, González F, Domingo-Pedrol P, Gavaldà A, Del Pozo CH, Hasan Ali O, Ventura-Aguiar P, Campistol JM, Prosper F, Mirazimi A, Boulant S, Penninger JM, Montserrat N.
Published in: Cell Metab., 2022, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2022.04.009