CORDIS - EU research results
CORDIS

Modern approaches for developing antivirals against SARS-CoV 2

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Publications

Human soluble ACE2 improves the effect of remdesivir in SARS‐CoV‐2 infection

Author(s): Vanessa Monteil, Matheus Dyczynski, Volker M Lauschke, Hyesoo Kwon, Gerald Wirnsberger, Sonia Youhanna, Haibo Zhang, Arthur S Slutsky, Carmen Hurtado del Pozo, Moritz Horn, Nuria Montserrat, Josef M Penninger, Ali Mirazimi
Published in: EMBO Molecular Medicine, Issue 13/1, 2021, Page(s) 13:e13426, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202013426

The Short- and Long-Range RNA-RNA Interactome of SARS-CoV-2

Author(s): Omer Ziv, Jonathan Price, Lyudmila Shalamova, Tsveta Kamenova, Ian Goodfellow, Friedemann Weber, Eric A. Miska
Published in: Molecular Cell, Issue 80/6, 2020, Page(s) 1067-1077.e5, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2020.11.004

Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) is a host factor for RNA viruses including SARS-CoV-2

Author(s): Stephanie Devignot, Tim Wai Sha, Thomas Burkard, Patrick Schmerer, Astrid Hagelkruys, Ali Mirazimi, Ulrich Elling, Josef M. Penninger, Friedemann Weber
Published in: BioRxiv, 2022, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory, USA
DOI: 10.1101/2022.02.17.480904

ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology

Author(s): Gawish R, Starkl P, Pimenov L, Hladik A, Lakovits K, Oberndorfer F, Cronin SJ, Ohradanova-Repic A, Wirnsberger G, Agerer B, Endler L, Capraz T, Perthold JW, Cikes D, Koglgruber R, Hagelkruys A, Montserrat N, Mirazimi A, Boon L, Stockinger H, Bergthaler A, Oostenbrink C, Penninger JM, Knapp S.
Published in: Elife, 2022, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.74623

Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level.

Author(s): Zhu R, Canena D, Sikora M, Klausberger M, Seferovic H, Mehdipour AR, Hain L, Laurent E, Monteil V, Wirnsberger G, Wieneke R, Tampé R, Kienzl NF, Mach L, Mirazimi A, Oh YJ, Penninger JM, Hummer G, Hinterdorfer P.
Published in: Nat Commun., 2022, Page(s) 2022 Dec 24;13(1):7926., ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-35641-3

Angiotensin-converting enzyme 2-at the heart of the COVID-19 pandemic

Author(s): Oudit GY, Wang K, Viveiros A, Kellner MJ, Penninger JM.
Published in: Cell, 2023, Page(s) 2023 Mar 2;186(5):906-922., ISSN 1097-4172
Publisher: Elsevier
DOI: 10.1016/j.cell.2023.01.039

Identification of lectin receptors for conserved SARS-CoV-2 glycosylation sites

Author(s): Hoffmann D, Mereiter S, Jin Oh Y, Monteil V, Elder E, Zhu R, Canena D, Hain L, Laurent E, Grünwald-Gruber C, Klausberger M, Jonsson G, Kellner MJ, Novatchkova M, Ticevic M, Chabloz A, Wirnsberger G, Hagelkruys A, Altmann F, Mach L, Stadlmann J, Oostenbrink C, Mirazimi A, Hinterdorfer P, Penninger JM.
Published in: EMBO Journal, 2021, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2021108375

Assessing kidney development and disease using kidney organoids and CRISPR engineering

Author(s): Safi W; Marco A; Moya D; Prado P; Garreta E; Montserrat N
Published in: Frontiers In Cell And Developmental Biology, 2022, ISSN 2296-634X
Publisher: Frontiers Media Sa
DOI: 10.3389/fcell.2022.948395

Protocol for SARS-CoV-2 infection of kidney organoids derived from human pluripotent stem cells

Author(s): Garreta E, Moya-Rull D, Stanifer ML, Monteil V, Prado P, Marco A, Tarantino C, Gallo M, Jonsson G, Hagelkruys A, Mirazimi A, Boulant S, Penninger JM, Montserrat N.
Published in: Star Protocols, 2022, ISSN 2666-1667
Publisher: Cell Press
DOI: 10.1016/j.xpro.2022.101872

Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor

Author(s): Capraz T, Kienzl NF, Laurent E, Perthold JW, Föderl-Höbenreich E, Grünwald-Gruber C, Maresch D, Monteil V, Niederhöfer J, Wirnsberger G, Mirazimi A, Zatloukal K, Mach L, Penninger JM, Oostenbrink C, Stadlmann J.
Published in: Elife, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.73641

Human recombinant soluble ACE2 in severe COVID-19

Author(s): Alexander Zoufaly, Marko Poglitsch, Judith H Aberle, Wolfgang Hoepler, Tamara Seitz, Marianna Traugott, Alexander Grieb, Erich Pawelka, Hermann Laferl, Christoph Wenisch, Stephanie Neuhold, Doris Haider, Karin Stiasny, Andreas Bergthaler, Elisabeth Puchhammer-Stoeckl, Ali Mirazimi, Nuria Montserrat, Haibo Zhang, Arthur S Slutsky, Josef M Penninger
Published in: The Lancet Respiratory Medicine, Issue 8/11, 2020, Page(s) 1154-1158, ISSN 2213-2600
Publisher: Elsevier Limited
DOI: 10.1016/s2213-2600(20)30418-5

A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivo.

Author(s): Chan JF, Oh YJ, Yuan S, Chu H, Yeung ML, Canena D, Chan CC, Poon VK, Chan CC, Zhang AJ, Cai JP, Ye ZW, Wen L, Yuen TT, Chik KK, Shuai H, Wang Y, Hou Y, Luo C, Chan WM, Qin Z, Sit KY, Au WK, Legendre M, Zhu R, Hain L, Seferovic H, Tampé R, To KK, Chan KH, Thomas DG, Klausberger M, Xu C, Moon JJ, Stadlmann J, Penninger JM, Oostenbrink C, Hinterdorfer P, Yuen KY, Markovitz DM.
Published in: Cell Rep Med, 2022, Page(s) 2022 Oct 18;3(10):100774., ISSN 2666-3791
Publisher: Cell Press
DOI: 10.1016/j.xcrm.2022.100774

Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants

Author(s): Monteil V, Eaton B, Postnikova E, Murphy M, Braunsfeld B, Crozier I, Kricek F, Niederhöfer J, Schwarzböck A, Breid H, Devignot S, Klingström J, Thålin C, Kellner MJ, Christ W, Havervall S, Mereiter S, Knapp S, Sanchez Jimenez A, Bugajska-Schretter A, Dohnal A, Ruf C, Gugenberger R, Hagelkruys A, Montserrat N, Kozieradzki I, Hasan Ali O, Stadlmann J, Holbrook MR, Schmaljohn C, Oostenbrink C, Sh
Published in: EMBO Mol Med., Issue 17574676, 2022, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202115230

Development of an aerosol intervention for COVID-19 disease: Tolerability of soluble ACE2 (APN01) administered via nebulizer.

Author(s): Shoemaker RH, Panettieri RA Jr, Libutti SK, Hochster HS, Watts NR, Wingfield PT, Starkl P, Pimenov L, Gawish R, Hladik A, Knapp S, Boring D, White JM, Lawrence Q, Boone J, Marshall JD, Matthews RL, Cholewa BD, Richig JW, Chen BT, McCormick DL, Gugensberger R, Höller S, Penninger JM, Wirnsberger G.
Published in: PLoS One, 2022, Page(s) 2022 Jul 11;17(7):e0271066. , ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0271066

Omicron variant of SARS-CoV-2 exhibits an increased resilience to the antiviral type I interferon response

Author(s): Lyudmila Shalamova, Ulrike Felgenhauer, Jochen Wilhelm, Andreas R Schaubmar, Kathrin Büttner, Andreas Schoen, Marek Widera, Sandra Ciesek, Friedemann Weber
Published in: PNAS Nexus, 2022, ISSN 2752-6542
Publisher: Oxford University Press
DOI: 10.1093/pnasnexus/pgac067

A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells

Author(s): Garreta E, Prado P, Stanifer ML, Monteil V, Marco A, Ullate-Agote A, Moya-Rull D, Vilas-Zornoza A, Tarantino C, Romero JP, Jonsson G, Oria R, Leopoldi A, Hagelkruys A, Gallo M, González F, Domingo-Pedrol P, Gavaldà A, Del Pozo CH, Hasan Ali O, Ventura-Aguiar P, Campistol JM, Prosper F, Mirazimi A, Boulant S, Penninger JM, Montserrat N.
Published in: Cell Metab., 2022, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2022.04.009

Pulmonary Surfactant Proteins Are Inhibited by Immunoglobulin A Autoantibodies in Severe COVID-19.

Author(s): Sinnberg T, Lichtensteiger C, Ali OH, Pop OT, Jochum AK, Risch L, Brugger SD, Velic A, Bomze D, Kohler P, Vernazza P, Albrich WC, Kahlert CR, Abdou MT, Wyss N, Hofmeister K, Niessner H, Zinner C, Gilardi M, Tzankov A, Röcken M, Dulovic A, Shambat SM, Ruetalo N, Buehler PK, Scheier TC, Jochum W, Kern L, Henz S, Schneider T, Kuster GM, Lampart M, Siegemund M, Bingisser R, Schindler M, Schneiderhan-
Published in: Am J Respir Crit Care Med, 2023, Page(s) 2023 Jan 1;207(1):38-49., ISSN 1097-4172
Publisher: the American Thoracic Society
DOI: 10.1164/rccm.202201-0011oc

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