Modern approaches for developing antivirals against SARS-CoV 2

Informations projet

MAD-CoV 2

N° de convention de subvention: 101005026

DOI

10.3030/101005026

Projet clôturé

Date de signature de la CE 11 Août 2020

Date de début 1 Août 2020

Date de fin 31 Juillet 2025

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total

€ 6 405 168,75

Contribution de l’UE

€ 3 749 668,75

Coordonné par

STATENS VETERINAERMEDICINSKA ANSTALT
Sweden

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Open Research Data Pilot (2)

Draft of Data Management Plan

Description of datasets data sharing and archiving

Updated version of Data Management Plan

Websites, patent fillings, videos etc. (2)

Project website and communication pack

Project website and promotional tools for workshops and meetings

Consortium secured intranet

This tool will facilitate communication and establish the principles of work within the consortium

Documents, reports (1)

Communication and dissemination update

This report will provide an update on the implementation and impact of the communication and dissemination activities

Publications

Peer reviewed articles (31)

Natural Hydrogels Support Kidney Organoid Generation and Promote In Vitro Angiogenesis

Auteurs: Elena Garreta, Daniel Moya‐Rull, Andrés Marco, Gaia Amato, Asier Ullate‐Agote, Carolina Tarantino, Maria Gallo, David Esporrín‐Ubieto, Alberto Centeno, Amaia Vilas‐Zornoza, Rafael Mestre, María Kalil, Izar Gorroñogoitia, Ane Miren Zaldua, Samuel Sanchez, Laura Izquierdo Reyes, María Eugenia Fernández‐Santos, Felipe Prosper, Nuria Montserrat
Publié dans: Advanced Materials, Numéro 36, 2024, ISSN 0935-9648
Éditeur: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202400306

Human soluble ACE2 improves the effect of remdesivir in SARS‐CoV‐2 infection

Auteurs: Vanessa Monteil, Matheus Dyczynski, Volker M Lauschke, Hyesoo Kwon, Gerald Wirnsberger, Sonia Youhanna, Haibo Zhang, Arthur S Slutsky, Carmen Hurtado del Pozo, Moritz Horn, Nuria Montserrat, Josef M Penninger, Ali Mirazimi
Publié dans: EMBO Molecular Medicine, Numéro 13/1, 2021, Page(s) 13:e13426, ISSN 1757-4676
Éditeur: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202013426

Bat organoids reveal antiviral responses at epithelial surfaces

Auteurs: Max J. Kellner, Vanessa M. Monteil, Patrick Zelger, Gang Pei, Jie Jiao, Masahiro Onji, Komal Nayak, Matthias Zilbauer, Anne Balkema-Buschmann, Anca Dorhoi, Ali Mirazimi, Josef M. Penninger
Publié dans: Nature Immunology, Numéro 26, 2025, Page(s) 934-946, ISSN 1529-2908
Éditeur: Nature Publishing Group
DOI: 10.1038/s41590-025-02155-1

The Short- and Long-Range RNA-RNA Interactome of SARS-CoV-2

Auteurs: Omer Ziv, Jonathan Price, Lyudmila Shalamova, Tsveta Kamenova, Ian Goodfellow, Friedemann Weber, Eric A. Miska
Publié dans: Molecular Cell, Numéro 80, 2021, Page(s) 1067-1077.e5, ISSN 1097-2765
Éditeur: Cell Press
DOI: 10.1016/j.molcel.2020.11.004

Low-density lipoprotein receptor–related protein 1 (LRP1) as an auxiliary host factor for RNA viruses

Auteurs: Stephanie Devignot, Tim Wai Sha, Thomas R Burkard, Patrick Schmerer, Astrid Hagelkruys, Ali Mirazimi, Ulrich Elling, Josef M Penninger, Friedemann Weber
Publié dans: Life Science Alliance, Numéro 6, 2024, Page(s) e202302005, ISSN 2575-1077
Éditeur: Rockefeller University Press
DOI: 10.26508/lsa.202302005

The Short- and Long-Range RNA-RNA Interactome of SARS-CoV-2

Auteurs: Omer Ziv, Jonathan Price, Lyudmila Shalamova, Tsveta Kamenova, Ian Goodfellow, Friedemann Weber, Eric A. Miska
Publié dans: Molecular Cell, Numéro 80/6, 2020, Page(s) 1067-1077.e5, ISSN 1097-2765
Éditeur: Cell Press
DOI: 10.1016/j.molcel.2020.11.004

Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) is a host factor for RNA viruses including SARS-CoV-2

Auteurs: Stephanie Devignot, Tim Wai Sha, Thomas Burkard, Patrick Schmerer, Astrid Hagelkruys, Ali Mirazimi, Ulrich Elling, Josef M. Penninger, Friedemann Weber
Publié dans: BioRxiv, 2022, ISSN 2692-8205
Éditeur: Cold Spring Harbor Laboratory, USA
DOI: 10.1101/2022.02.17.480904

ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology

Auteurs: Gawish R, Starkl P, Pimenov L, Hladik A, Lakovits K, Oberndorfer F, Cronin SJ, Ohradanova-Repic A, Wirnsberger G, Agerer B, Endler L, Capraz T, Perthold JW, Cikes D, Koglgruber R, Hagelkruys A, Montserrat N, Mirazimi A, Boon L, Stockinger H, Bergthaler A, Oostenbrink C, Penninger JM, Knapp S.
Publié dans: Elife, 2022, ISSN 2050-084X
Éditeur: eLife Sciences Publications
DOI: 10.7554/elife.74623

Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level.

Auteurs: Zhu R, Canena D, Sikora M, Klausberger M, Seferovic H, Mehdipour AR, Hain L, Laurent E, Monteil V, Wirnsberger G, Wieneke R, Tampé R, Kienzl NF, Mach L, Mirazimi A, Oh YJ, Penninger JM, Hummer G, Hinterdorfer P.
Publié dans: Nat Commun., 2022, Page(s) 2022 Dec 24;13(1):7926., ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-022-35641-3

Angiotensin-converting enzyme 2-at the heart of the COVID-19 pandemic

Auteurs: Oudit GY, Wang K, Viveiros A, Kellner MJ, Penninger JM.
Publié dans: Cell, 2023, Page(s) 2023 Mar 2;186(5):906-922., ISSN 1097-4172
Éditeur: Elsevier
DOI: 10.1016/j.cell.2023.01.039

Sequential multi-omics analysis identifies clinical phenotypes and predictive biomarkers for long COVID

Auteurs: Kaiming Wang, Mobin Khoramjoo, Karthik Srinivasan, Paul M.K. Gordon, Rupasri Mandal, Dana Jackson, Wendy Sligl, Maria B. Grant, Josef M. Penninger, Christoph H. Borchers, David S. Wishart, Vinay Prasad, Gavin Y. Oudit
Publié dans: Cell Reports Medicine, Numéro 4, 2024, Page(s) 101254, ISSN 2666-3791
Éditeur: Cell Press
DOI: 10.1016/j.xcrm.2023.101254

Crimean–Congo haemorrhagic fever virus uses LDLR to bind and enter host cells

Auteurs: Vanessa M. Monteil, Shane C. Wright, Matheus Dyczynski, Max J. Kellner, Sofia Appelberg, Sebastian W. Platzer, Ahmed Ibrahim, Hyesoo Kwon, Ioannis Pittarokoilis, Mattia Mirandola, Georg Michlits, Stephanie Devignot, Elizabeth Elder, Samir Abdurahman, Sándor Bereczky, Binnur Bagci, Sonia Youhanna, Teodor Aastrup, Volker M. Lauschke, Cristiano Salata, Nazif Elaldi, Friedemann Weber, Nuria Monserrat
Publié dans: Nature Microbiology, Numéro 9, 2024, Page(s) 1499-1512, ISSN 2058-5276
Éditeur: Nature Portfolio
DOI: 10.1038/s41564-024-01672-3

Identification of lectin receptors for conserved SARS-CoV-2 glycosylation sites

Auteurs: Hoffmann D, Mereiter S, Jin Oh Y, Monteil V, Elder E, Zhu R, Canena D, Hain L, Laurent E, Grünwald-Gruber C, Klausberger M, Jonsson G, Kellner MJ, Novatchkova M, Ticevic M, Chabloz A, Wirnsberger G, Hagelkruys A, Altmann F, Mach L, Stadlmann J, Oostenbrink C, Mirazimi A, Hinterdorfer P, Penninger JM.
Publié dans: EMBO Journal, 2021, ISSN 0261-4189
Éditeur: Nature Publishing Group
DOI: 10.15252/embj.2021108375

Assessing kidney development and disease using kidney organoids and CRISPR engineering

Auteurs: Safi W; Marco A; Moya D; Prado P; Garreta E; Montserrat N
Publié dans: Frontiers In Cell And Developmental Biology, 2022, ISSN 2296-634X
Éditeur: Frontiers Media Sa
DOI: 10.3389/fcell.2022.948395

Inhalation of ACE2 as a therapeutic target on sex-bias differences in SARS-CoV-2 infection and variant of concern

Auteurs: Yu Onodera, Jady Liang, Yuchong Li, Bryan Griffin, Thenuka Thanabalasingam, Cong Lu, JiaYi Zhu, Mingyao Liu, Theo Moraes, Wenhua Zheng, Jasmin Khateeb, Julie Khang, Yongbo Huang, Mirjana Jerkic, Masaki Nakane, Andrew Baker, Beverley Orser, Ya-Wen Chen, Gerald Wirnsberger, Josef M. Penninger, Ori D. Rotstein, Arthur S. Slutsky, Yimin Li, Samira Mubareka, Haibo Zhang
Publié dans: iScience, Numéro 26, 2024, Page(s) 107470, ISSN 2589-0042
Éditeur: Cell Press
DOI: 10.1016/j.isci.2023.107470

Protocol for SARS-CoV-2 infection of kidney organoids derived from human pluripotent stem cells

Auteurs: Garreta E, Moya-Rull D, Stanifer ML, Monteil V, Prado P, Marco A, Tarantino C, Gallo M, Jonsson G, Hagelkruys A, Mirazimi A, Boulant S, Penninger JM, Montserrat N.
Publié dans: Star Protocols, 2022, ISSN 2666-1667
Éditeur: Cell Press
DOI: 10.1016/j.xpro.2022.101872

Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor

Auteurs: Capraz T, Kienzl NF, Laurent E, Perthold JW, Föderl-Höbenreich E, Grünwald-Gruber C, Maresch D, Monteil V, Niederhöfer J, Wirnsberger G, Mirazimi A, Zatloukal K, Mach L, Penninger JM, Oostenbrink C, Stadlmann J.
Publié dans: Elife, 2021, ISSN 2050-084X
Éditeur: eLife Sciences Publications
DOI: 10.7554/elife.73641

Human recombinant soluble ACE2 in severe COVID-19

Auteurs: Alexander Zoufaly, Marko Poglitsch, Judith H Aberle, Wolfgang Hoepler, Tamara Seitz, Marianna Traugott, Alexander Grieb, Erich Pawelka, Hermann Laferl, Christoph Wenisch, Stephanie Neuhold, Doris Haider, Karin Stiasny, Andreas Bergthaler, Elisabeth Puchhammer-Stoeckl, Ali Mirazimi, Nuria Montserrat, Haibo Zhang, Arthur S Slutsky, Josef M Penninger
Publié dans: The Lancet Respiratory Medicine, Numéro 8/11, 2020, Page(s) 1154-1158, ISSN 2213-2600
Éditeur: Elsevier Limited
DOI: 10.1016/s2213-2600(20)30418-5

A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivo.

Auteurs: Chan JF, Oh YJ, Yuan S, Chu H, Yeung ML, Canena D, Chan CC, Poon VK, Chan CC, Zhang AJ, Cai JP, Ye ZW, Wen L, Yuen TT, Chik KK, Shuai H, Wang Y, Hou Y, Luo C, Chan WM, Qin Z, Sit KY, Au WK, Legendre M, Zhu R, Hain L, Seferovic H, Tampé R, To KK, Chan KH, Thomas DG, Klausberger M, Xu C, Moon JJ, Stadlmann J, Penninger JM, Oostenbrink C, Hinterdorfer P, Yuen KY, Markovitz DM.
Publié dans: Cell Rep Med, 2022, Page(s) 2022 Oct 18;3(10):100774., ISSN 2666-3791
Éditeur: Cell Press
DOI: 10.1016/j.xcrm.2022.100774

Identification of CCZ1 as an essential lysosomal trafficking regulator in Marburg and Ebola virus infections

Auteurs: Vanessa Monteil, Hyesoo Kwon, Lijo John, Cristiano Salata, Gustav Jonsson, Sabine U. Vorrink, Sofia Appelberg, Sonia Youhanna, Matheus Dyczynski, Alexandra Leopoldi, Nicole Leeb, Jennifer Volz, Astrid Hagelkruys, Max J. Kellner, Stéphanie Devignot, Georg Michlits, Michelle Foong-Sobis, Friedemann Weber, Volker M. Lauschke, Moritz Horn, Heinz Feldmann, Ulrich Elling, Josef M. Penninger, Ali Mirazi
Publié dans: Nature Communications, Numéro 14, 2023, Page(s) 2023 Oct 25;14(1):6785, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-023-42526-6

Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants

Auteurs: Monteil V, Eaton B, Postnikova E, Murphy M, Braunsfeld B, Crozier I, Kricek F, Niederhöfer J, Schwarzböck A, Breid H, Devignot S, Klingström J, Thålin C, Kellner MJ, Christ W, Havervall S, Mereiter S, Knapp S, Sanchez Jimenez A, Bugajska-Schretter A, Dohnal A, Ruf C, Gugenberger R, Hagelkruys A, Montserrat N, Kozieradzki I, Hasan Ali O, Stadlmann J, Holbrook MR, Schmaljohn C, Oostenbrink C, Sh
Publié dans: EMBO Mol Med., 2022, ISSN 1757-4676
Éditeur: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202115230

Generation of complex bone marrow organoids from human induced pluripotent stem cells

Auteurs: Stephanie Frenz-Wiessner, Savannah D. Fairley, Maximilian Buser, Isabel Goek, Kirill Salewskij, Gustav Jonsson, David Illig, Benedicta zu Putlitz, Daniel Petersheim, Yue Li, Pin-Hsuan Chen, Martina Kalauz, Raffaele Conca, Michael Sterr, Johanna Geuder, Yoko Mizoguchi, Remco T. A. Megens, Monika I. Linder, Daniel Kotlarz, Martina Rudelius, Josef M. Penninger, Carsten Marr, Christoph Klein
Publié dans: Nature Methods, Numéro 21, 2024, Page(s) 868-881, ISSN 1548-7091
Éditeur: Nature Publishing Group
DOI: 10.1038/s41592-024-02172-2

Development of an aerosol intervention for COVID-19 disease: Tolerability of soluble ACE2 (APN01) administered via nebulizer.

Auteurs: Shoemaker RH, Panettieri RA Jr, Libutti SK, Hochster HS, Watts NR, Wingfield PT, Starkl P, Pimenov L, Gawish R, Hladik A, Knapp S, Boring D, White JM, Lawrence Q, Boone J, Marshall JD, Matthews RL, Cholewa BD, Richig JW, Chen BT, McCormick DL, Gugensberger R, Höller S, Penninger JM, Wirnsberger G.
Publié dans: PLoS One, 2022, Page(s) 2022 Jul 11;17(7):e0271066. , ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0271066

Identification of SARS-CoV-2–induced pathways reveals drug repurposing strategies

Auteurs: Namshik Han, Woochang Hwang, Konstantinos Tzelepis, Patrick Schmerer, Eliza Yankova, Méabh MacMahon, Winnie Lei, Nicholas M. Katritsis, Anika Liu, Ulrike Felgenhauer, Alison Schuldt, Rebecca Harris, Kathryn Chapman, Frank McCaughan, Friedemann Weber, Tony Kouzarides
Publié dans: Science Advances, Numéro 7, 2024, ISSN 2375-2548
Éditeur: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciadv.abh3032

Omicron variant of SARS-CoV-2 exhibits an increased resilience to the antiviral type I interferon response

Auteurs: Lyudmila Shalamova, Ulrike Felgenhauer, Jochen Wilhelm, Andreas R Schaubmar, Kathrin Büttner, Andreas Schoen, Marek Widera, Sandra Ciesek, Friedemann Weber
Publié dans: PNAS Nexus, 2022, ISSN 2752-6542
Éditeur: Oxford University Press
DOI: 10.1093/pnasnexus/pgac067

Engineering physiological environments to advance kidney organoid models from human pluripotent stem cells

Auteurs: Anisha Pahuja, Iphigénie Goux Corredera, Daniel Moya-Rull, Elena Garreta, Nuria Montserrat
Publié dans: Current Opinion in Cell Biology, Numéro 86, 2024, Page(s) 102306, ISSN 0955-0674
Éditeur: Elsevier BV
DOI: 10.1016/j.ceb.2023.102306

A lyophilized open-source RT-LAMP assay for molecular diagnostics in resource-limited settings

Auteurs: Martin Matl, Max J Kellner, Felix Ansah, Irina Grishkovskaya, Dominik Handler, Robert Heinen, Benedikt Bauer, Luis Menéndez-Arias, Thomas O Auer, Lucia L Prieto-Godino, Josef M Penninger, null null, Gordon A Awandare, Julius Brennecke, Andrea Pauli
Publié dans: Life Science Alliance, Numéro 8, 2025, Page(s) e202403167, ISSN 2575-1077
Éditeur: Life Science Alliance, LLC
DOI: 10.26508/lsa.202403167

A microfluidic platform integrating functional vascularized organoids-on-chip

Auteurs: Clément Quintard, Emily Tubbs, Gustav Jonsson, Jie Jiao, Jun Wang, Nicolas Werschler, Camille Laporte, Amandine Pitaval, Thierno-Sidy Bah, Gideon Pomeranz, Caroline Bissardon, Joris Kaal, Alexandra Leopoldi, David A. Long, Pierre Blandin, Jean-Luc Achard, Christophe Battail, Astrid Hagelkruys, Fabrice Navarro, Yves Fouillet, Josef M. Penninger, Xavier Gidrol
Publié dans: Nature Communications, Numéro 15, 2024, Page(s) 2024 Jun;9(6):1499-1512, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-024-45710-4

Non-targeted N-glycome profiling reveals multiple layers of organ-specific diversity in mice

Auteurs: Johannes Helm, Stefan Mereiter, Tiago Oliveira, Anna Gattinger, David M. Markovitz, Josef M. Penninger, Friedrich Altmann, Johannes Stadlmann
Publié dans: Nature Communications, Numéro 15, 2024, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-024-54134-z

A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells

Auteurs: Garreta E, Prado P, Stanifer ML, Monteil V, Marco A, Ullate-Agote A, Moya-Rull D, Vilas-Zornoza A, Tarantino C, Romero JP, Jonsson G, Oria R, Leopoldi A, Hagelkruys A, Gallo M, González F, Domingo-Pedrol P, Gavaldà A, Del Pozo CH, Hasan Ali O, Ventura-Aguiar P, Campistol JM, Prosper F, Mirazimi A, Boulant S, Penninger JM, Montserrat N.
Publié dans: Cell Metab., 2022, ISSN 1550-4131
Éditeur: Cell Press
DOI: 10.1016/j.cmet.2022.04.009

Pulmonary Surfactant Proteins Are Inhibited by Immunoglobulin A Autoantibodies in Severe COVID-19.

Auteurs: Sinnberg T, Lichtensteiger C, Ali OH, Pop OT, Jochum AK, Risch L, Brugger SD, Velic A, Bomze D, Kohler P, Vernazza P, Albrich WC, Kahlert CR, Abdou MT, Wyss N, Hofmeister K, Niessner H, Zinner C, Gilardi M, Tzankov A, Röcken M, Dulovic A, Shambat SM, Ruetalo N, Buehler PK, Scheier TC, Jochum W, Kern L, Henz S, Schneider T, Kuster GM, Lampart M, Siegemund M, Bingisser R, Schindler M, Schneiderhan-
Publié dans: Am J Respir Crit Care Med, 2023, Page(s) 2023 Jan 1;207(1):38-49., ISSN 1097-4172
Éditeur: the American Thoracic Society
DOI: 10.1164/rccm.202201-0011oc