Modern approaches for developing antivirals against SARS-CoV 2

Informazioni relative al progetto

MAD-CoV 2

ID dell’accordo di sovvenzione: 101005026

DOI

10.3030/101005026

Progetto chiuso

Data della firma CE 11 Agosto 2020

Data di avvio 1 Agosto 2020

Data di completamento 31 Luglio 2025

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 6 405 168,75

Contributo UE

€ 3 749 668,75

Coordinato da

STATENS VETERINAERMEDICINSKA ANSTALT
Sweden

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Open Research Data Pilot (2)

Draft of Data Management Plan

Description of datasets data sharing and archiving

Updated version of Data Management Plan

Websites, patent fillings, videos etc. (2)

Project website and communication pack

Project website and promotional tools for workshops and meetings

Consortium secured intranet

This tool will facilitate communication and establish the principles of work within the consortium

Documents, reports (1)

Communication and dissemination update

This report will provide an update on the implementation and impact of the communication and dissemination activities

Pubblicazioni

Peer reviewed articles (31)

Natural Hydrogels Support Kidney Organoid Generation and Promote In Vitro Angiogenesis

Autori: Elena Garreta, Daniel Moya‐Rull, Andrés Marco, Gaia Amato, Asier Ullate‐Agote, Carolina Tarantino, Maria Gallo, David Esporrín‐Ubieto, Alberto Centeno, Amaia Vilas‐Zornoza, Rafael Mestre, María Kalil, Izar Gorroñogoitia, Ane Miren Zaldua, Samuel Sanchez, Laura Izquierdo Reyes, María Eugenia Fernández‐Santos, Felipe Prosper, Nuria Montserrat
Pubblicato in: Advanced Materials, Numero 36, 2024, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202400306

Human soluble ACE2 improves the effect of remdesivir in SARS‐CoV‐2 infection

Autori: Vanessa Monteil, Matheus Dyczynski, Volker M Lauschke, Hyesoo Kwon, Gerald Wirnsberger, Sonia Youhanna, Haibo Zhang, Arthur S Slutsky, Carmen Hurtado del Pozo, Moritz Horn, Nuria Montserrat, Josef M Penninger, Ali Mirazimi
Pubblicato in: EMBO Molecular Medicine, Numero 13/1, 2021, Pagina/e 13:e13426, ISSN 1757-4676
Editore: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202013426

Bat organoids reveal antiviral responses at epithelial surfaces

Autori: Max J. Kellner, Vanessa M. Monteil, Patrick Zelger, Gang Pei, Jie Jiao, Masahiro Onji, Komal Nayak, Matthias Zilbauer, Anne Balkema-Buschmann, Anca Dorhoi, Ali Mirazimi, Josef M. Penninger
Pubblicato in: Nature Immunology, Numero 26, 2025, Pagina/e 934-946, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/s41590-025-02155-1

The Short- and Long-Range RNA-RNA Interactome of SARS-CoV-2

Autori: Omer Ziv, Jonathan Price, Lyudmila Shalamova, Tsveta Kamenova, Ian Goodfellow, Friedemann Weber, Eric A. Miska
Pubblicato in: Molecular Cell, Numero 80, 2021, Pagina/e 1067-1077.e5, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2020.11.004

Low-density lipoprotein receptor–related protein 1 (LRP1) as an auxiliary host factor for RNA viruses

Autori: Stephanie Devignot, Tim Wai Sha, Thomas R Burkard, Patrick Schmerer, Astrid Hagelkruys, Ali Mirazimi, Ulrich Elling, Josef M Penninger, Friedemann Weber
Pubblicato in: Life Science Alliance, Numero 6, 2024, Pagina/e e202302005, ISSN 2575-1077
Editore: Rockefeller University Press
DOI: 10.26508/lsa.202302005

The Short- and Long-Range RNA-RNA Interactome of SARS-CoV-2

Autori: Omer Ziv, Jonathan Price, Lyudmila Shalamova, Tsveta Kamenova, Ian Goodfellow, Friedemann Weber, Eric A. Miska
Pubblicato in: Molecular Cell, Numero 80/6, 2020, Pagina/e 1067-1077.e5, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2020.11.004

Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) is a host factor for RNA viruses including SARS-CoV-2

Autori: Stephanie Devignot, Tim Wai Sha, Thomas Burkard, Patrick Schmerer, Astrid Hagelkruys, Ali Mirazimi, Ulrich Elling, Josef M. Penninger, Friedemann Weber
Pubblicato in: BioRxiv, 2022, ISSN 2692-8205
Editore: Cold Spring Harbor Laboratory, USA
DOI: 10.1101/2022.02.17.480904

ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology

Autori: Gawish R, Starkl P, Pimenov L, Hladik A, Lakovits K, Oberndorfer F, Cronin SJ, Ohradanova-Repic A, Wirnsberger G, Agerer B, Endler L, Capraz T, Perthold JW, Cikes D, Koglgruber R, Hagelkruys A, Montserrat N, Mirazimi A, Boon L, Stockinger H, Bergthaler A, Oostenbrink C, Penninger JM, Knapp S.
Pubblicato in: Elife, 2022, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.74623

Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level.

Autori: Zhu R, Canena D, Sikora M, Klausberger M, Seferovic H, Mehdipour AR, Hain L, Laurent E, Monteil V, Wirnsberger G, Wieneke R, Tampé R, Kienzl NF, Mach L, Mirazimi A, Oh YJ, Penninger JM, Hummer G, Hinterdorfer P.
Pubblicato in: Nat Commun., 2022, Pagina/e 2022 Dec 24;13(1):7926., ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-35641-3

Angiotensin-converting enzyme 2-at the heart of the COVID-19 pandemic

Autori: Oudit GY, Wang K, Viveiros A, Kellner MJ, Penninger JM.
Pubblicato in: Cell, 2023, Pagina/e 2023 Mar 2;186(5):906-922., ISSN 1097-4172
Editore: Elsevier
DOI: 10.1016/j.cell.2023.01.039

Sequential multi-omics analysis identifies clinical phenotypes and predictive biomarkers for long COVID

Autori: Kaiming Wang, Mobin Khoramjoo, Karthik Srinivasan, Paul M.K. Gordon, Rupasri Mandal, Dana Jackson, Wendy Sligl, Maria B. Grant, Josef M. Penninger, Christoph H. Borchers, David S. Wishart, Vinay Prasad, Gavin Y. Oudit
Pubblicato in: Cell Reports Medicine, Numero 4, 2024, Pagina/e 101254, ISSN 2666-3791
Editore: Cell Press
DOI: 10.1016/j.xcrm.2023.101254

Crimean–Congo haemorrhagic fever virus uses LDLR to bind and enter host cells

Autori: Vanessa M. Monteil, Shane C. Wright, Matheus Dyczynski, Max J. Kellner, Sofia Appelberg, Sebastian W. Platzer, Ahmed Ibrahim, Hyesoo Kwon, Ioannis Pittarokoilis, Mattia Mirandola, Georg Michlits, Stephanie Devignot, Elizabeth Elder, Samir Abdurahman, Sándor Bereczky, Binnur Bagci, Sonia Youhanna, Teodor Aastrup, Volker M. Lauschke, Cristiano Salata, Nazif Elaldi, Friedemann Weber, Nuria Monserrat
Pubblicato in: Nature Microbiology, Numero 9, 2024, Pagina/e 1499-1512, ISSN 2058-5276
Editore: Nature Portfolio
DOI: 10.1038/s41564-024-01672-3

Identification of lectin receptors for conserved SARS-CoV-2 glycosylation sites

Autori: Hoffmann D, Mereiter S, Jin Oh Y, Monteil V, Elder E, Zhu R, Canena D, Hain L, Laurent E, Grünwald-Gruber C, Klausberger M, Jonsson G, Kellner MJ, Novatchkova M, Ticevic M, Chabloz A, Wirnsberger G, Hagelkruys A, Altmann F, Mach L, Stadlmann J, Oostenbrink C, Mirazimi A, Hinterdorfer P, Penninger JM.
Pubblicato in: EMBO Journal, 2021, ISSN 0261-4189
Editore: Nature Publishing Group
DOI: 10.15252/embj.2021108375

Assessing kidney development and disease using kidney organoids and CRISPR engineering

Autori: Safi W; Marco A; Moya D; Prado P; Garreta E; Montserrat N
Pubblicato in: Frontiers In Cell And Developmental Biology, 2022, ISSN 2296-634X
Editore: Frontiers Media Sa
DOI: 10.3389/fcell.2022.948395

Inhalation of ACE2 as a therapeutic target on sex-bias differences in SARS-CoV-2 infection and variant of concern

Autori: Yu Onodera, Jady Liang, Yuchong Li, Bryan Griffin, Thenuka Thanabalasingam, Cong Lu, JiaYi Zhu, Mingyao Liu, Theo Moraes, Wenhua Zheng, Jasmin Khateeb, Julie Khang, Yongbo Huang, Mirjana Jerkic, Masaki Nakane, Andrew Baker, Beverley Orser, Ya-Wen Chen, Gerald Wirnsberger, Josef M. Penninger, Ori D. Rotstein, Arthur S. Slutsky, Yimin Li, Samira Mubareka, Haibo Zhang
Pubblicato in: iScience, Numero 26, 2024, Pagina/e 107470, ISSN 2589-0042
Editore: Cell Press
DOI: 10.1016/j.isci.2023.107470

Protocol for SARS-CoV-2 infection of kidney organoids derived from human pluripotent stem cells

Autori: Garreta E, Moya-Rull D, Stanifer ML, Monteil V, Prado P, Marco A, Tarantino C, Gallo M, Jonsson G, Hagelkruys A, Mirazimi A, Boulant S, Penninger JM, Montserrat N.
Pubblicato in: Star Protocols, 2022, ISSN 2666-1667
Editore: Cell Press
DOI: 10.1016/j.xpro.2022.101872

Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor

Autori: Capraz T, Kienzl NF, Laurent E, Perthold JW, Föderl-Höbenreich E, Grünwald-Gruber C, Maresch D, Monteil V, Niederhöfer J, Wirnsberger G, Mirazimi A, Zatloukal K, Mach L, Penninger JM, Oostenbrink C, Stadlmann J.
Pubblicato in: Elife, 2021, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.73641

Human recombinant soluble ACE2 in severe COVID-19

Autori: Alexander Zoufaly, Marko Poglitsch, Judith H Aberle, Wolfgang Hoepler, Tamara Seitz, Marianna Traugott, Alexander Grieb, Erich Pawelka, Hermann Laferl, Christoph Wenisch, Stephanie Neuhold, Doris Haider, Karin Stiasny, Andreas Bergthaler, Elisabeth Puchhammer-Stoeckl, Ali Mirazimi, Nuria Montserrat, Haibo Zhang, Arthur S Slutsky, Josef M Penninger
Pubblicato in: The Lancet Respiratory Medicine, Numero 8/11, 2020, Pagina/e 1154-1158, ISSN 2213-2600
Editore: Elsevier Limited
DOI: 10.1016/s2213-2600(20)30418-5

A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivo.

Autori: Chan JF, Oh YJ, Yuan S, Chu H, Yeung ML, Canena D, Chan CC, Poon VK, Chan CC, Zhang AJ, Cai JP, Ye ZW, Wen L, Yuen TT, Chik KK, Shuai H, Wang Y, Hou Y, Luo C, Chan WM, Qin Z, Sit KY, Au WK, Legendre M, Zhu R, Hain L, Seferovic H, Tampé R, To KK, Chan KH, Thomas DG, Klausberger M, Xu C, Moon JJ, Stadlmann J, Penninger JM, Oostenbrink C, Hinterdorfer P, Yuen KY, Markovitz DM.
Pubblicato in: Cell Rep Med, 2022, Pagina/e 2022 Oct 18;3(10):100774., ISSN 2666-3791
Editore: Cell Press
DOI: 10.1016/j.xcrm.2022.100774

Identification of CCZ1 as an essential lysosomal trafficking regulator in Marburg and Ebola virus infections

Autori: Vanessa Monteil, Hyesoo Kwon, Lijo John, Cristiano Salata, Gustav Jonsson, Sabine U. Vorrink, Sofia Appelberg, Sonia Youhanna, Matheus Dyczynski, Alexandra Leopoldi, Nicole Leeb, Jennifer Volz, Astrid Hagelkruys, Max J. Kellner, Stéphanie Devignot, Georg Michlits, Michelle Foong-Sobis, Friedemann Weber, Volker M. Lauschke, Moritz Horn, Heinz Feldmann, Ulrich Elling, Josef M. Penninger, Ali Mirazi
Pubblicato in: Nature Communications, Numero 14, 2023, Pagina/e 2023 Oct 25;14(1):6785, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-42526-6

Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants

Autori: Monteil V, Eaton B, Postnikova E, Murphy M, Braunsfeld B, Crozier I, Kricek F, Niederhöfer J, Schwarzböck A, Breid H, Devignot S, Klingström J, Thålin C, Kellner MJ, Christ W, Havervall S, Mereiter S, Knapp S, Sanchez Jimenez A, Bugajska-Schretter A, Dohnal A, Ruf C, Gugenberger R, Hagelkruys A, Montserrat N, Kozieradzki I, Hasan Ali O, Stadlmann J, Holbrook MR, Schmaljohn C, Oostenbrink C, Sh
Pubblicato in: EMBO Mol Med., 2022, ISSN 1757-4676
Editore: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202115230

Generation of complex bone marrow organoids from human induced pluripotent stem cells

Autori: Stephanie Frenz-Wiessner, Savannah D. Fairley, Maximilian Buser, Isabel Goek, Kirill Salewskij, Gustav Jonsson, David Illig, Benedicta zu Putlitz, Daniel Petersheim, Yue Li, Pin-Hsuan Chen, Martina Kalauz, Raffaele Conca, Michael Sterr, Johanna Geuder, Yoko Mizoguchi, Remco T. A. Megens, Monika I. Linder, Daniel Kotlarz, Martina Rudelius, Josef M. Penninger, Carsten Marr, Christoph Klein
Pubblicato in: Nature Methods, Numero 21, 2024, Pagina/e 868-881, ISSN 1548-7091
Editore: Nature Publishing Group
DOI: 10.1038/s41592-024-02172-2

Development of an aerosol intervention for COVID-19 disease: Tolerability of soluble ACE2 (APN01) administered via nebulizer.

Autori: Shoemaker RH, Panettieri RA Jr, Libutti SK, Hochster HS, Watts NR, Wingfield PT, Starkl P, Pimenov L, Gawish R, Hladik A, Knapp S, Boring D, White JM, Lawrence Q, Boone J, Marshall JD, Matthews RL, Cholewa BD, Richig JW, Chen BT, McCormick DL, Gugensberger R, Höller S, Penninger JM, Wirnsberger G.
Pubblicato in: PLoS One, 2022, Pagina/e 2022 Jul 11;17(7):e0271066. , ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0271066

Identification of SARS-CoV-2–induced pathways reveals drug repurposing strategies

Autori: Namshik Han, Woochang Hwang, Konstantinos Tzelepis, Patrick Schmerer, Eliza Yankova, Méabh MacMahon, Winnie Lei, Nicholas M. Katritsis, Anika Liu, Ulrike Felgenhauer, Alison Schuldt, Rebecca Harris, Kathryn Chapman, Frank McCaughan, Friedemann Weber, Tony Kouzarides
Pubblicato in: Science Advances, Numero 7, 2024, ISSN 2375-2548
Editore: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciadv.abh3032

Omicron variant of SARS-CoV-2 exhibits an increased resilience to the antiviral type I interferon response

Autori: Lyudmila Shalamova, Ulrike Felgenhauer, Jochen Wilhelm, Andreas R Schaubmar, Kathrin Büttner, Andreas Schoen, Marek Widera, Sandra Ciesek, Friedemann Weber
Pubblicato in: PNAS Nexus, 2022, ISSN 2752-6542
Editore: Oxford University Press
DOI: 10.1093/pnasnexus/pgac067

Engineering physiological environments to advance kidney organoid models from human pluripotent stem cells

Autori: Anisha Pahuja, Iphigénie Goux Corredera, Daniel Moya-Rull, Elena Garreta, Nuria Montserrat
Pubblicato in: Current Opinion in Cell Biology, Numero 86, 2024, Pagina/e 102306, ISSN 0955-0674
Editore: Elsevier BV
DOI: 10.1016/j.ceb.2023.102306

A lyophilized open-source RT-LAMP assay for molecular diagnostics in resource-limited settings

Autori: Martin Matl, Max J Kellner, Felix Ansah, Irina Grishkovskaya, Dominik Handler, Robert Heinen, Benedikt Bauer, Luis Menéndez-Arias, Thomas O Auer, Lucia L Prieto-Godino, Josef M Penninger, null null, Gordon A Awandare, Julius Brennecke, Andrea Pauli
Pubblicato in: Life Science Alliance, Numero 8, 2025, Pagina/e e202403167, ISSN 2575-1077
Editore: Life Science Alliance, LLC
DOI: 10.26508/lsa.202403167

A microfluidic platform integrating functional vascularized organoids-on-chip

Autori: Clément Quintard, Emily Tubbs, Gustav Jonsson, Jie Jiao, Jun Wang, Nicolas Werschler, Camille Laporte, Amandine Pitaval, Thierno-Sidy Bah, Gideon Pomeranz, Caroline Bissardon, Joris Kaal, Alexandra Leopoldi, David A. Long, Pierre Blandin, Jean-Luc Achard, Christophe Battail, Astrid Hagelkruys, Fabrice Navarro, Yves Fouillet, Josef M. Penninger, Xavier Gidrol
Pubblicato in: Nature Communications, Numero 15, 2024, Pagina/e 2024 Jun;9(6):1499-1512, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-45710-4

Non-targeted N-glycome profiling reveals multiple layers of organ-specific diversity in mice

Autori: Johannes Helm, Stefan Mereiter, Tiago Oliveira, Anna Gattinger, David M. Markovitz, Josef M. Penninger, Friedrich Altmann, Johannes Stadlmann
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-54134-z

A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells

Autori: Garreta E, Prado P, Stanifer ML, Monteil V, Marco A, Ullate-Agote A, Moya-Rull D, Vilas-Zornoza A, Tarantino C, Romero JP, Jonsson G, Oria R, Leopoldi A, Hagelkruys A, Gallo M, González F, Domingo-Pedrol P, Gavaldà A, Del Pozo CH, Hasan Ali O, Ventura-Aguiar P, Campistol JM, Prosper F, Mirazimi A, Boulant S, Penninger JM, Montserrat N.
Pubblicato in: Cell Metab., 2022, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2022.04.009

Pulmonary Surfactant Proteins Are Inhibited by Immunoglobulin A Autoantibodies in Severe COVID-19.

Autori: Sinnberg T, Lichtensteiger C, Ali OH, Pop OT, Jochum AK, Risch L, Brugger SD, Velic A, Bomze D, Kohler P, Vernazza P, Albrich WC, Kahlert CR, Abdou MT, Wyss N, Hofmeister K, Niessner H, Zinner C, Gilardi M, Tzankov A, Röcken M, Dulovic A, Shambat SM, Ruetalo N, Buehler PK, Scheier TC, Jochum W, Kern L, Henz S, Schneider T, Kuster GM, Lampart M, Siegemund M, Bingisser R, Schindler M, Schneiderhan-
Pubblicato in: Am J Respir Crit Care Med, 2023, Pagina/e 2023 Jan 1;207(1):38-49., ISSN 1097-4172
Editore: the American Thoracic Society
DOI: 10.1164/rccm.202201-0011oc