Periodic Reporting for period 1 - PhytoAPP (INNOVATIVE WATER-SOLUBLE PHYTOMATERIAL INHIBITORs FOR ALZHEIMERs AND PARKINSONs DISEASES PREVENTION)
Période du rapport: 2021-03-01 au 2024-02-29
The main objectives of the PHYTOAPP project are the design, development and delivery of innovative water-soluble Phytochemical Inhibitors for Alzheimer and Parkinson diseases prevention. To achieve this goal the PHYTOAPP project will explore the innovative nanotechnological solutions to overcome the challenge related to the phytochemical’s limitation related to their low water-solubility.
At the same time, the PHYTOAPP project aims to exploit the cross-sector potential of nanotechnologies and advanced materials to drive competitiveness, sustainability and well-being in the health-care system and industry.
At a research level, the PHYTOAPP project also aims to promote new skills acquisition, training opportunities for early-stage researches and to create long-standing collaboration between research partners internationally.
For the society, this project can be of great benefit specially if we consider the growing phenomena of the aging of population in the European Union member states. This comes with the challenge that countries have to improve their capacities to tackle diseases that are usually related to aging populations, as it is the case of Alzheimer’s and Parkinson. In this sense, the EU demographic change requires innovation to enhance healthcare delivery, quality of life and active ageing, to promote better health-care for this population, which is the goal of this project. Indeed, the development of the proposed solutions come as a significant opportunity for the industry as well considering the growing market.
At the same time, the PHYTOAPP project aims to exploit the cross-sector potential of nanotechnologies and advanced materials to drive competitiveness, sustainability and well-being in the health-care system and industry.
At a research level, the PHYTOAPP project also aims to promote new skills acquisition, training opportunities for early-stage researches and to create long-standing collaboration between research partners internationally.
For the society, this project can be of great benefit specially if we consider the growing phenomena of the aging of population in the European Union member states. This comes with the challenge that countries have to improve their capacities to tackle diseases that are usually related to aging populations, as it is the case of Alzheimer’s and Parkinson. In this sense, the EU demographic change requires innovation to enhance healthcare delivery, quality of life and active ageing, to promote better health-care for this population, which is the goal of this project. Indeed, the development of the proposed solutions come as a significant opportunity for the industry as well considering the growing market.
For the first steps of the project, partners are working on designing and optimizing reliable and reproducible lab scale synthesis of nano-enabled phytochemical water-soluble materials.
The second step it to develop comprehensive studies on inhibitions of amyloid fibrils formation, in order to elaborate solutions for water-soluble nano-enabled phytomaterials to be used in nanomedicine in the prevention of Alzheimer’s and Parkinson’s diseases.
The third step is the preclinical assessment of the previously elaborated nano-enabled phytomaterials for their permeability and their neuroprotective bioactivity. This assessment will be done through vitro testing and in vivo studies with rodent genetic models.
The fourth step is the scaling up and fabrication of product prototype of innovative materials. The goal is to demonstrate the increased degree of automation of phytocomplexes production lines, to lead to higher production volumes, improved reliability, and repeatability of the products fabrication, which in turn leads to lower productions costs.
The fifth step in the specification, certification for medical application and exploration of phytoproduct. Through dissemination activities, the goal is to transfer phytoapp project findings to innovative product fabrication recognized as nano-pharmaceuticals suitable for further clinical testing.
The sixth step is related to two categories of continuous work through the life-cycle of the project: dissemination and communication activities related to the project, and compliance with ethics requirements. Regarding dissemination activities, although this objective is central during the entire life-time of the project, and dissemination, communication and data management plan are delivered in the beginning of the project, this step is mostly relevant when approaching the conclusion of the project in order to communicate results of the project to promote further research and specially to promote the developed product in markets of nano pharmaceutical. And of course, for this is very important the compliance of ethic requirements to ensure product quality for the prospected consumer.
Since that the project at this time it is approaching its mid-term phase, main progresses have been made in the development of the technology and in its preclinical testing.
The second step it to develop comprehensive studies on inhibitions of amyloid fibrils formation, in order to elaborate solutions for water-soluble nano-enabled phytomaterials to be used in nanomedicine in the prevention of Alzheimer’s and Parkinson’s diseases.
The third step is the preclinical assessment of the previously elaborated nano-enabled phytomaterials for their permeability and their neuroprotective bioactivity. This assessment will be done through vitro testing and in vivo studies with rodent genetic models.
The fourth step is the scaling up and fabrication of product prototype of innovative materials. The goal is to demonstrate the increased degree of automation of phytocomplexes production lines, to lead to higher production volumes, improved reliability, and repeatability of the products fabrication, which in turn leads to lower productions costs.
The fifth step in the specification, certification for medical application and exploration of phytoproduct. Through dissemination activities, the goal is to transfer phytoapp project findings to innovative product fabrication recognized as nano-pharmaceuticals suitable for further clinical testing.
The sixth step is related to two categories of continuous work through the life-cycle of the project: dissemination and communication activities related to the project, and compliance with ethics requirements. Regarding dissemination activities, although this objective is central during the entire life-time of the project, and dissemination, communication and data management plan are delivered in the beginning of the project, this step is mostly relevant when approaching the conclusion of the project in order to communicate results of the project to promote further research and specially to promote the developed product in markets of nano pharmaceutical. And of course, for this is very important the compliance of ethic requirements to ensure product quality for the prospected consumer.
Since that the project at this time it is approaching its mid-term phase, main progresses have been made in the development of the technology and in its preclinical testing.
By the end of the project, it is expected that the partners can develop a product of innovative water-soluble Phytochemical Inhibitors for Alzheimer and Parkinson diseases prevention. After creating a prototype of the technology, developing preclinical trials and increasing the degree of automation of phytocomplexes production lines for increased reliability and decreased productions cost, the objective is to transfer its results to nanomedicine pharmaceuticals for the production of the product to the market. With this, the objective is to create wide societal impact by contributing in nanomedicine research, by providing a product that can be beneficial to an increasingly aging population in the EU, which can lead to an increase of Alzheimer’s and Parkinson’s diseases rates, which will rely on the development from scientific community of innovative ways to tackle the problem. Moreover, the project also aims to have societal impact in local economies, by promoting the creation of new job opportunities and in training scientist to new know how techniques.