For the first steps of the project, partners are working on designing and optimizing reliable and reproducible lab scale synthesis of nano-enabled phytochemical water-soluble materials.
The second step it to develop comprehensive studies on inhibitions of amyloid fibrils formation, in order to elaborate solutions for water-soluble nano-enabled phytomaterials to be used in nanomedicine in the prevention of Alzheimer’s and Parkinson’s diseases.
The third step is the preclinical assessment of the previously elaborated nano-enabled phytomaterials for their permeability and their neuroprotective bioactivity. This assessment will be done through vitro testing and in vivo studies with rodent genetic models.
The fourth step is the scaling up and fabrication of product prototype of innovative materials. The goal is to demonstrate the increased degree of automation of phytocomplexes production lines, to lead to higher production volumes, improved reliability, and repeatability of the products fabrication, which in turn leads to lower productions costs.
The fifth step in the specification, certification for medical application and exploration of phytoproduct. Through dissemination activities, the goal is to transfer phytoapp project findings to innovative product fabrication recognized as nano-pharmaceuticals suitable for further clinical testing.
The sixth step is related to two categories of continuous work through the life-cycle of the project: dissemination and communication activities related to the project, and compliance with ethics requirements. Regarding dissemination activities, although this objective is central during the entire life-time of the project, and dissemination, communication and data management plan are delivered in the beginning of the project, this step is mostly relevant when approaching the conclusion of the project in order to communicate results of the project to promote further research and specially to promote the developed product in markets of nano pharmaceutical. And of course, for this is very important the compliance of ethic requirements to ensure product quality for the prospected consumer.
Since that the project at this time it is approaching its mid-term phase, main progresses have been made in the development of the technology and in its preclinical testing.
