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Multifunctional nanocarriers for nonlinear microscopy: new tools for biology and medicine

Project description

Nanocarriers for 3D functional and structural bioimaging

Multiphoton microscopy enables the 3D visualisation of large sections of biological tissues to understand the relationship between their structure and function, leading to applications in biomedicine and drug delivery. The EU-funded Micro4Nano project aims to develop methods for 3D visualisation up to 1 mm in depth, combining hyperspectral imaging of autofluorescent species with structural information from second-harmonic generation signals and multifunctional fluorescent labels as well as chemical information from Raman microscopy. A new generation of multifunctional nanocarriers for two-photon microscopy and drug delivery will be designed for real-time monitoring of living cells and tissues. The network training programme offers career development opportunities for early-career scientists and fosters the interdisciplinary collaboration between participant organisations.

Objective

The direct 3D visualization of large sections of biological tissues, made possible by multiphoton microscopy, has the potential to revolutionize our understanding of the relation between the structure and function of biological tissues, opening the way to impressive applications in biomedicine and drug delivery, in phytotherapy, and agricultural and food industries. In an ambitious multidisciplinary effort, Micro4Nano will develop new approaches and methods towards the 3D visualization of biological tissues, up to 1 mm in depth, combining hyperspectral imaging of autofluorescent species, with structural information from second-harmonic generation signals, functional information from multifunctional fluorescent labels and chemical information from Raman microscopy. A new generation of multifunctional nanocarriers for two-photon microscopy and drug delivery will be designed and extensively exploited towards real-time monitoring of living cells and tissues. In an intersectoral endeavour, microscopy will be combined with microfluidics to investigate the tissue behaviour under controlled perfusion conditions. Micro4Nano promotes international and multidisciplinary collaborations between experts in complementary fields, including microscopy, drug delivery, spectroscopy, chemical synthesis, theoretical and computational chemistry. The collaboration is implemented through 50 secondments (173 person month) of early-stage and experienced researchers, the organization of three network-wide events and a rich and coherent program of training activities. The network promotes an effective integrate training of researchers, boosting their career development, and promotes enhanced collaboration schemes between participant organizations. The direct involvement of industrial partners guarantees the timely exploitation of original results from advanced research laboratories towards innovative products and services.

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Keywords

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Programme(s)

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Topic(s)

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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) H2020-MSCA-RISE-2020

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Coordinator

UNIVERSITA DEGLI STUDI DI PARMA
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 151 800,00
Address
VIA UNIVERSITA 12
43121 PARMA
Italy

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Region
Nord-Est Emilia-Romagna Parma
Activity type
Higher or Secondary Education Establishments
Links
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 224 342,00

Participants (10)

Partners (3)

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