Multifunctional nanocarriers for nonlinear microscopy: new tools for biology and medicine

Project Information

Micro4Nano

Grant agreement ID: 101007804

DOI

10.3030/101007804

EC signature date 5 November 2020

Start date 1 October 2021

End date 30 September 2026

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 795 800,00

EU contribution

€ 786 600,00

Coordinated by

UNIVERSITA DEGLI STUDI DI PARMA
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (3)

Second network wide event

The second Network-wide event will be organized at UNIPR at month 22, in concomitance with the mid-term meeting. Scientific training: microfluidics (ELV, UH, TUA) 2-photon microscopy (UNIPR) and ex vivo animal models for drug-delivery (UNIPR). Training on soft skills: entrepreneurship (ELV, NM) and preparation of a successful proposal (UNIPR).

First network-wide training event

The first kick-off meeting (KOM) will take place at ICHO PAN at M3 (should COVID-19 emergency hinder travels, KOM will be organized as a teleconference). Scientific training: functional dyes for 2PM (ICHO-PAN) and multifunctional nanocarriers for drug-delivery (UNIPR, CSIC, UNC). Training on soft skills: Ethics and Communication (ICHO PAN).

Eight ATM completed

8 out of 14 Advanced Training Modules (ATM) will be organized during the secondments of ER at the host Institutions. ATM will be open (and free of charges) to PhD students and researchers of the host Institutions. ATM will be recordered to make them accessible to all interested partners and (videos and slides will be uploaded in the private section of the website)

Websites, patent fillings, videos etc. (1)

Project website

Micro4Nano website will be most important communication tool, representing the primary communication platform at all levels (scientific & industrial community, general public, etc.). It will be created at the beginning of the project and regularly updated. The public section of the website will contain basic information about Micro4Nano explicitly referring to the support received from EU-Commission

Publications

Peer reviewed articles (33)

Integrated Microfluidic Chip for Neutrophil Extracellular Vesicle Analysis and Gastric Cancer Diagnosis

Author(s): Dan Yu, Jianmei Gu, Jiahui Zhang, Maoye Wang, Runbi Ji, Chunlai Feng, Hélder A. Santos, Hongbo Zhang, Xu Zhang
Published in: ACS Nano, Issue 19, 2025, Page(s) 10078-10092, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.4c16894

An efficient method for the synthesis of π-expanded phosphonium salts

Author(s): Krzysztof Górski, Łukasz W. Ciszewski, Antoni Wrzosek, Adam Szewczyk, Andrzej L. Sobolewski, Daniel T. Gryko
Published in: Organic Chemistry Frontiers, 2025, ISSN 2052-4129
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/d5qo00708a

Efficient Electron Transfer Driven by Excited-State Structural Relaxation in Corrole–Perylenedimiide Dyad

Author(s): Damian Kusy, Hongwei Song, Antoni Rząca, Marzena Banasiewicz, Cristina A. Barboza, Dongho Kim, Daniel T. Gryko
Published in: The Journal of Physical Chemistry Letters, Issue 15, 2024, Page(s) 5231-5238, ISSN 1948-7185
Publisher: American Chemical Society
DOI: 10.1021/acs.jpclett.4c00916

Strongly fluorescent indolizine-based coumarin analogs

Author(s): Jaqueline S. A. Badaro, Antoni Wrzosek, Olaf Morawski, Adam Szewczyk, Irena Deperasińska, Daniel T. Gryko
Published in: Organic Chemistry Frontiers, Issue 11, 2024, Page(s) 6627-6641, ISSN 2052-4129
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4qo01216j

Aggregates of Cyanine Dyes: When Molecular Vibrations and Electrostatic Screening Make the Difference

Author(s): Bertocchi, Francesco; Delledonne, Andrea; Vargas-Nadal, Guillem; Terenziani, Francesca; Painelli, Anna; Sissa, Cristina
Published in: Journal of Physical Chemistry C, Issue 127, 2023, ISSN 1932-7455
Publisher: Americal Chemical Society
DOI: 10.1021/acs.jpcc.3c01253

Nanothermometer Based on Polychlorinated Trityl Radicals Showing Two‐Photon Excitation and Emission in the Biological Transparency Window: Temperature Monitoring of Biological Tissues

Author(s): Nerea Gonzalez‐Pato, Davide Blasi, Domna M. Nikolaidou, Francesco Bertocchi, Jesús Cerdá, Francesca Terenziani, Nora Ventosa, Juan Aragó, Andrea Lapini, Jaume Veciana, Imma Ratera
Published in: Small Methods, Issue 8, 2024, ISSN 2366-9608
Publisher: Wiley-VCH GmbH
DOI: 10.1002/smtd.202301060

Double helicene possessing B–N dative bonds built on 1,4-dihydropyrrolo[3,2-<i>b</i>]pyrrole core

Author(s): Wojciech D. Petrykowski, Nicolas Vanthuyne, Carmelo Naim, Francesco Bertocchi, Yevgen M. Poronik, Arkadiusz Ciesielski, Michał K. Cyrański, Francesca Terenziani, Denis Jacquemin, Daniel T. Gryko
Published in: Chemical Science, Issue 16, 2025, Page(s) 8338-8345, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d5sc00540j

Conformation of the Ester Group Governs the Photophysics of Highly Polarized Benzo[g]coumarins

Author(s): Kamil Szychta; Beata Koszarna; Marzena Banasiewicz; Andrzej Sobolewski; Omar O'Mari; John A. Clark; Valentine I. Vullev; Cristina A. Barboza; Daniel T. Gryko
Published in: JACS Au, Issue 3, 7, 2023, Page(s) 1918–1930, ISSN 2691-3704
Publisher: American Chemical Society
DOI: 10.1021/jacsau.3c00169

1,4-Dihydropyrrolo[3,2-<i>b</i>]pyrrole modified with dibenzoxazepine: a highly efficient core for charge-transfer-based OLED emitters

Author(s): Krzysztof Górski, Steve Shelton, Jaijanarthanan Lingagouder, Przemyslaw Data, Denis Jacquemin, Daniel T. Gryko
Published in: Chemical Science, Issue 16, 2025, Page(s) 5223-5233, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4sc04272g

Tuning the Optical Properties Through Hydrogen Bond‐assisted H‐aggregate Formation: The ODIN Case

Author(s): Francesco Bertocchi, Danilo Marchetti, Sandra Doria, Mariangela di Donato, Cristina Sissa, Mauro Gemmi, Enrico Dalcanale, Roberta Pinalli, Andrea Lapini
Published in: Chemistry – A European Journal, Issue 30, 2024, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202302619

Ultrabright Föster Resonance Energy Transfer Nanovesicles: The Role of Dye Diffusion

Author(s): Judit Morla-Folch; Guillem Vargas-Nadal; Edgar Fuentes; Sílvia Illa-Tuset; Mariana Köber; Cristina Sissa; Silvia Pujals; Anna Painelli; Jaume Veciana; Jordi Faraudo; Kevin D. Belfield; Lorenzo Albertazzi; Nora Ventosa
Published in: Chemistry of Materials, Issue 34, 2022, Page(s) 8517-8527, ISSN 0897-4756
Publisher: American Chemical Society
DOI: 10.1021/acs.chemmater.2c00384

Strongly Polarized -Extended 1,4-Dihydropyrrolo[3,2-<i>b</i>]pyrroles Fused with Tetrazolo[1,5-<i>a</i>]quinolines

Author(s): Mohammad B. Teimouri, Irena Deperasiska, Matt Rammo, Marzena Banasiewicz, Charles W. Stark, ukasz Dobrzycki, Micha K. Cyraski, Aleksander Rebane, Daniel T. Gryko
Published in: The Journal of Organic Chemistry, Issue 89, 2024, Page(s) 4657-4672, ISSN 0022-3263
Publisher: American Chemical Society
DOI: 10.1021/acs.joc.3c02916

Polyelectrolyte Complex Dry Powder Formulations of Tobramycin with Hyaluronic Acid and Sodium Hyaluronate for Inhalation Therapy in Cystic Fibrosis-Associated Infections

Author(s): Yanina de Lafuente, Eride Quarta, María S. Magi, Ana L. Apas, Joaquín Pagani, María C. Palena, Paulina L. Páez, Fabio Sonvico, Alvaro F. Jimenez-Kairuz
Published in: Antibiotics, Issue 14, 2025, Page(s) 169, ISSN 2079-6382
Publisher: MDPI AG
DOI: 10.3390/antibiotics14020169

From symmetry breaking to symmetry swapping: is Kasha's rule violated in multibranched phenyleneethynylenes?

Author(s): K. Swathi; Meleppatt Sujith; P. S. Divya; Merin Varghese P; Andrea Delledonne; D. K. Andrea Phan Huu; Francesco Di Maiolo; Francesca Terenziani; Andrea Lapini; Anna Painelli; Cristina Sissa; K. George Thomas
Published in: Chemical Science, Issue 14, 2023, ISSN 2041-6539
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2sc05206g

Fluorescent Multifunctional Organic Nanoparticles for Drug Delivery and Bioimaging: A Tutorial Review

Author(s): Vargas-Nadal, Guillem; Köber, Mariana; Nsamela, Audrey; Terenziani, Francesca; Sissa, Cristina; Pescina, Silvia; Sonvico, Fabio; Gazzali, Amirah Mohd; Wahab, Habibah A.; Grisanti, Luca; Olivera, María Eugenia; Palena, María Celeste; Guzman, María Laura; Luciani-Giacobbe, Laura Carolina; Jimenez-Kairuz, Alvaro; Ventosa, Nora; Ratera, Imma; Belfield, Kevin D.; Maoz, Ben M.
Published in: Pharmaceutics, Issue 14(11), 2022, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14112498

Synthesis and Chiroptical Activity of π‐Expanded Electron‐Rich Heterohelicenes Based on the 1,4‐Dihydropyrrolo[3,2‐<i>b</i>]pyrrole Core

Author(s): Damian Kusy, Krzysztof Górski, Francesco Bertocchi, Matteo Galli, Nicolas Vanthuyne, Francesca Terenziani, Daniel T. Gryko
Published in: Chemistry – A European Journal, Issue 31, 2025, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202404632

Ratiometric Nanothermometer Based on a Radical Excimer for In Vivo Sensing

Author(s): Davide Blasi; Nerea Gonzalez-Pato; Xavier Rodriguez Rodriguez; Iñigo Diez-Zabala; Sumithra Yasaswini Srinivasan; Núria Camarero; Oriol Esquivias; Mònica Roldán; Judith Guasch; Anna Laromaine; Pau Gorostiza; Jaume Veciana; Imma Ratera
Published in: Small, Issue 19 (32), 2023, ISSN 1613-6829
Publisher: Wiley
DOI: 10.1002/smll.202207806

Quatsomes Loaded with Squaraine Dye as an Effective Photosensitizer for Photodynamic Therapy

Author(s): Nicolò Bordignon; Mariana Köber; Giorgia Chinigò; Carlotta Pontremoli; Ettore Sansone; Guillem Vargas-Nadal; Maria Jesus Moran Plata; Alessandra Fiorio Pla; Nadia Barbero; Judit Morla-Folch; Nora Ventosa
Published in: Pharmaceutics, Issue 15(3), 2023, Page(s) 902, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15030902

Nanostructured Lipid Carriers for Enhanced Transscleral Delivery of Dexamethasone Acetate: Development, Ex Vivo Characterization and Multiphoton Microscopy Studies

Author(s): Felipe M. González-Fernández, Andrea Delledonne, Sara Nicoli,Paolo Gasco, Cristina Padula, Patrizia Santi, Cristina Sissa, Silvia Pescina
Published in: Pharmaceutics, Issue 407, 2023, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15020407

A new plant-based drug delivery platform based on alkyl polyglucosides and β-sitosterol nanovesicles for topical delivery

Author(s): Marta Alcaina-Hernando, Ivana Malvacio, Ilaria Ferraboschi, Cristián Huck-Iriart, Annalisa Bianchera, Santi Sala, Jan Skov Pedersen, Lidia Ferrer-Tasies, Silvia Pescina, Cristina Sissa, Nora Ventosa, Alba Córdoba
Published in: Applied Materials Today, Issue 41, 2024, Page(s) 102467, ISSN 2352-9407
Publisher: Elsevier BV
DOI: 10.1016/j.apmt.2024.102467

Novel Method for the Synthesis of Merocyanines: New Photophysical Possibilities for a Known Class of Fluorophores

Author(s): Brunella Bardi; Katerina V. Vygranenko; Beata Koszarna; Olena Vakuliuk; Łukasz Dobrzycki; Daniel T. Gryko; Francesca Terenziani; Anna Painelli
Published in: Chemistry- A European Journal, Issue 29 (45), 2023, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202300979

Neutral rhodol-based dyes expressing localization in mitochondria

Author(s): Ilaria Ferraboschi, Juraj Ovčar, Kateryna V. Vygranenko, Shupei Yu, Alfonso Minervino, Antoni Wrzosek, Adam Szewczyk, Riccardo Rozza, Alessandra Magistrato, Kevin D. Belfield, Daniel T. Gryko, Luca Grisanti, Cristina Sissa
Published in: Organic &amp; Biomolecular Chemistry, Issue 22, 2024, Page(s) 5886-5890, ISSN 1477-0520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4ob00252k

A sterilizable platform based on crosslinked xanthan gum for controlled-release of polymeric micelles: Ocular application for the delivery of neuroprotective compounds to the posterior eye segment

Author(s): Sara Signorini, Andrea Delledonne, Silvia Pescina, Annalisa Bianchera, Cristina Sissa, Maria Vivero-Lopez, Carmen Alvarez-Lorenzo, Patrizia Santi, Cristina Padula, Sara Nicoli
Published in: International Journal of Pharmaceutics, Issue 657, 2024, Page(s) 124141, ISSN 0378-5173
Publisher: Elsevier BV
DOI: 10.1016/j.ijpharm.2024.124141

MultiSensor Origami Platform: A Customizable System for Obtaining Spatiotemporally Precise Functional Readouts in 3D Models

Author(s): Noam Rahav, Denise Marrero, Adi Soffer, Emma Glickman, Megane BeldjilaliLabro, Yakey Yaffe, Keshet Tadmor, Yael LeichtmannBardoogo, Uri Ashery, Ben M. Maoz
Published in: Advanced Science, Issue 11, 2024, ISSN 2198-3844
Publisher: Wiley-VCH GmbH
DOI: 10.1002/advs.202305555

Multifunctional Heteropentalenes: From Synthesis to Optoelectronic Applications

Author(s): Sebastian Stecko; Daniel T. Gryko
Published in: JACS Au, Issue 2, 2022, Page(s) 1290-1305, ISSN 2691-3704
Publisher: American Chemical Society
DOI: 10.1021/jacsau.2c00147

Hierarchical Quatsome-RGD Nanoarchitectonic Surfaces for Enhanced Integrin-Mediated Cell Adhesion

Author(s): Marc Martínez-Miguel; Miquel Castellote-Borrell; Mariana Köber; Adriana R. Kyvik; Judit Tomsen-Melero; Guillem Vargas-Nadal; Jose Muñoz; Daniel Pulido; Edgar Cristóbal-Lecina; Solène Passemard; Miriam Royo; Marta Mas-Torrent; Jaume Veciana; Marina I. Giannotti; Judith Guasch; Nora Ventosa; Imma Ratera
Published in: Applied Materials & Interfaces, Issue 3, 2022, ISSN 1944-8252
Publisher: American Chemical Society
DOI: 10.1021/acsami.2c10497

Shedding new light on quadrupolar 1,4-dihydropyrrolo[3,2-<i>b</i>]pyrroles: impact of electron-deficient scaffolds over emission

Author(s): Bartosz Szymański, Smruti Ranjan Sahoo, Olena Vakuliuk, Rashid Valiev, Ruslan Ramazanov, Piotr Łaski, Katarzyna N. Jarzembska, Radosław Kamiński, Mohammad B. Teimouri, Glib Baryshnikov, Daniel T. Gryko
Published in: Chemical Science, Issue 16, 2025, Page(s) 2170-2179, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4sc07275h

Buccal Permeation of Polysaccharide High Molecular Weight Compounds: Effect of Chemical Permeation Enhancers

Author(s): Adriana Fantini; Luca Giulio; Andrea Delledonne; Silvia Pescina; Cristina Sissa; Sara Nicoli; Patrizia Santi; Cristina Padula
Published in: Pharmaceutics, Issue 15(1), 2023, Page(s) 129, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15010129

Quadrupolar, Highly Polarized Dyes: Emission Dependence on Viscosity and Selective Mitochondria Staining

Author(s): Mariusz Tasior, Olena Vakuliuk, Antoni Wrzosek, Valentine I. Vullev, Adam Szewczyk, Denis Jacquemin, Daniel T. Gryko
Published in: ACS Organic &amp; Inorganic Au, Issue 4, 2024, Page(s) 248-257, ISSN 2694-247X
Publisher: ACS Publications
DOI: 10.1021/acsorginorgau.3c00035

Amphiphilic Fluorinated Unimer Micelles as Nanocarriers of Fluorescent Probes for Bioimaging

Author(s): Delledonne, Andrea; Guazzelli, Elisa; Pescina, Silvia; Bianchera, Annalisa; Galli, Giancarlo; Martinelli, Elisa; Sissa, Cristina
Published in: ACS Applied Nanomaterials, Issue 6, 2023, ISSN 2574-0970
Publisher: American Chemical Society
DOI: 10.1021/acsanm.3c02300

Cyclosporine-loaded micelles for ocular delivery: investigating the penetration mechanisms

Author(s): Ghezzi, Martina; Ferraboschi, Ilaria; Delledonne, Andrea; Pescina, Silvia; Padula, Cristina; Santi, Patrizia; Sissa, Cristina; Terenziani, Francesca; Nicoli, Sara
Published in: Journal of Controlled Release, Issue 349, 2022, Page(s) 744-755, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2022.07.019

Novel Dry Hyaluronic AcidVancomycin Complex Powder for Inhalation, Useful in Pulmonary Infections Associated with Cystic Fibrosis

Author(s): Mara S. Magi, Yanina de Lafuente, Eride Quarta, Mara C. Palena, Perla del R. Ardiles, Paulina L. Pez, Fabio Sonvico, Francesca Buttini, Alvaro F. Jimenez-Kairuz
Published in: Pharmaceutics, Issue 16, 2024, Page(s) 436, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics16040436

Engineered chitosan-derived nanocarrier for efficient siRNA delivery to peripheral and central neurons

Author(s): Ana P. Spencer, Adriana Vilaça, Miguel Xavier, Rafael Santos, Ariel Ionescu, María Lázaro, Victoria Leiro, Eran Perlson, Sofia C. Guimarães, Ben M. Maoz, Ana P. Pêgo
Published in: Advanced Healtcare Materials, 2025, ISSN 2192-2659
Publisher: World Scientific
DOI: 10.1101/2024.09.05.611434