Multifunctional nanocarriers for nonlinear microscopy: new tools for biology and medicine

Informations projet

Micro4Nano

N° de convention de subvention: 101007804

DOI

10.3030/101007804

Date de signature de la CE 5 Novembre 2020

Date de début 1 Octobre 2021

Date de fin 30 Septembre 2026

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total

€ 795 800,00

Contribution de l’UE

€ 786 600,00

Coordonné par

UNIVERSITA DEGLI STUDI DI PARMA
Italy

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (3)

Second network wide event

The second Network-wide event will be organized at UNIPR at month 22, in concomitance with the mid-term meeting. Scientific training: microfluidics (ELV, UH, TUA) 2-photon microscopy (UNIPR) and ex vivo animal models for drug-delivery (UNIPR). Training on soft skills: entrepreneurship (ELV, NM) and preparation of a successful proposal (UNIPR).

First network-wide training event

The first kick-off meeting (KOM) will take place at ICHO PAN at M3 (should COVID-19 emergency hinder travels, KOM will be organized as a teleconference). Scientific training: functional dyes for 2PM (ICHO-PAN) and multifunctional nanocarriers for drug-delivery (UNIPR, CSIC, UNC). Training on soft skills: Ethics and Communication (ICHO PAN).

Eight ATM completed

8 out of 14 Advanced Training Modules (ATM) will be organized during the secondments of ER at the host Institutions. ATM will be open (and free of charges) to PhD students and researchers of the host Institutions. ATM will be recordered to make them accessible to all interested partners and (videos and slides will be uploaded in the private section of the website)

Websites, patent fillings, videos etc. (1)

Project website

Micro4Nano website will be most important communication tool, representing the primary communication platform at all levels (scientific & industrial community, general public, etc.). It will be created at the beginning of the project and regularly updated. The public section of the website will contain basic information about Micro4Nano explicitly referring to the support received from EU-Commission

Publications

Peer reviewed articles (33)

Integrated Microfluidic Chip for Neutrophil Extracellular Vesicle Analysis and Gastric Cancer Diagnosis

Auteurs: Dan Yu, Jianmei Gu, Jiahui Zhang, Maoye Wang, Runbi Ji, Chunlai Feng, Hélder A. Santos, Hongbo Zhang, Xu Zhang
Publié dans: ACS Nano, Numéro 19, 2025, Page(s) 10078-10092, ISSN 1936-0851
Éditeur: American Chemical Society
DOI: 10.1021/acsnano.4c16894

An efficient method for the synthesis of π-expanded phosphonium salts

Auteurs: Krzysztof Górski, Łukasz W. Ciszewski, Antoni Wrzosek, Adam Szewczyk, Andrzej L. Sobolewski, Daniel T. Gryko
Publié dans: Organic Chemistry Frontiers, 2025, ISSN 2052-4129
Éditeur: Royal Society of Chemistry (RSC)
DOI: 10.1039/d5qo00708a

Efficient Electron Transfer Driven by Excited-State Structural Relaxation in Corrole–Perylenedimiide Dyad

Auteurs: Damian Kusy, Hongwei Song, Antoni Rząca, Marzena Banasiewicz, Cristina A. Barboza, Dongho Kim, Daniel T. Gryko
Publié dans: The Journal of Physical Chemistry Letters, Numéro 15, 2024, Page(s) 5231-5238, ISSN 1948-7185
Éditeur: American Chemical Society
DOI: 10.1021/acs.jpclett.4c00916

Strongly fluorescent indolizine-based coumarin analogs

Auteurs: Jaqueline S. A. Badaro, Antoni Wrzosek, Olaf Morawski, Adam Szewczyk, Irena Deperasińska, Daniel T. Gryko
Publié dans: Organic Chemistry Frontiers, Numéro 11, 2024, Page(s) 6627-6641, ISSN 2052-4129
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d4qo01216j

Aggregates of Cyanine Dyes: When Molecular Vibrations and Electrostatic Screening Make the Difference

Auteurs: Bertocchi, Francesco; Delledonne, Andrea; Vargas-Nadal, Guillem; Terenziani, Francesca; Painelli, Anna; Sissa, Cristina
Publié dans: Journal of Physical Chemistry C, Numéro 127, 2023, ISSN 1932-7455
Éditeur: Americal Chemical Society
DOI: 10.1021/acs.jpcc.3c01253

Nanothermometer Based on Polychlorinated Trityl Radicals Showing Two‐Photon Excitation and Emission in the Biological Transparency Window: Temperature Monitoring of Biological Tissues

Auteurs: Nerea Gonzalez‐Pato, Davide Blasi, Domna M. Nikolaidou, Francesco Bertocchi, Jesús Cerdá, Francesca Terenziani, Nora Ventosa, Juan Aragó, Andrea Lapini, Jaume Veciana, Imma Ratera
Publié dans: Small Methods, Numéro 8, 2024, ISSN 2366-9608
Éditeur: Wiley-VCH GmbH
DOI: 10.1002/smtd.202301060

Double helicene possessing B–N dative bonds built on 1,4-dihydropyrrolo[3,2-<i>b</i>]pyrrole core

Auteurs: Wojciech D. Petrykowski, Nicolas Vanthuyne, Carmelo Naim, Francesco Bertocchi, Yevgen M. Poronik, Arkadiusz Ciesielski, Michał K. Cyrański, Francesca Terenziani, Denis Jacquemin, Daniel T. Gryko
Publié dans: Chemical Science, Numéro 16, 2025, Page(s) 8338-8345, ISSN 2041-6520
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d5sc00540j

Conformation of the Ester Group Governs the Photophysics of Highly Polarized Benzo[g]coumarins

Auteurs: Kamil Szychta; Beata Koszarna; Marzena Banasiewicz; Andrzej Sobolewski; Omar O'Mari; John A. Clark; Valentine I. Vullev; Cristina A. Barboza; Daniel T. Gryko
Publié dans: JACS Au, Numéro 3, 7, 2023, Page(s) 1918–1930, ISSN 2691-3704
Éditeur: American Chemical Society
DOI: 10.1021/jacsau.3c00169

1,4-Dihydropyrrolo[3,2-<i>b</i>]pyrrole modified with dibenzoxazepine: a highly efficient core for charge-transfer-based OLED emitters

Auteurs: Krzysztof Górski, Steve Shelton, Jaijanarthanan Lingagouder, Przemyslaw Data, Denis Jacquemin, Daniel T. Gryko
Publié dans: Chemical Science, Numéro 16, 2025, Page(s) 5223-5233, ISSN 2041-6520
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d4sc04272g

Tuning the Optical Properties Through Hydrogen Bond‐assisted H‐aggregate Formation: The ODIN Case

Auteurs: Francesco Bertocchi, Danilo Marchetti, Sandra Doria, Mariangela di Donato, Cristina Sissa, Mauro Gemmi, Enrico Dalcanale, Roberta Pinalli, Andrea Lapini
Publié dans: Chemistry – A European Journal, Numéro 30, 2024, ISSN 0947-6539
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202302619

Ultrabright Föster Resonance Energy Transfer Nanovesicles: The Role of Dye Diffusion

Auteurs: Judit Morla-Folch; Guillem Vargas-Nadal; Edgar Fuentes; Sílvia Illa-Tuset; Mariana Köber; Cristina Sissa; Silvia Pujals; Anna Painelli; Jaume Veciana; Jordi Faraudo; Kevin D. Belfield; Lorenzo Albertazzi; Nora Ventosa
Publié dans: Chemistry of Materials, Numéro 34, 2022, Page(s) 8517-8527, ISSN 0897-4756
Éditeur: American Chemical Society
DOI: 10.1021/acs.chemmater.2c00384

Strongly Polarized -Extended 1,4-Dihydropyrrolo[3,2-<i>b</i>]pyrroles Fused with Tetrazolo[1,5-<i>a</i>]quinolines

Auteurs: Mohammad B. Teimouri, Irena Deperasiska, Matt Rammo, Marzena Banasiewicz, Charles W. Stark, ukasz Dobrzycki, Micha K. Cyraski, Aleksander Rebane, Daniel T. Gryko
Publié dans: The Journal of Organic Chemistry, Numéro 89, 2024, Page(s) 4657-4672, ISSN 0022-3263
Éditeur: American Chemical Society
DOI: 10.1021/acs.joc.3c02916

Polyelectrolyte Complex Dry Powder Formulations of Tobramycin with Hyaluronic Acid and Sodium Hyaluronate for Inhalation Therapy in Cystic Fibrosis-Associated Infections

Auteurs: Yanina de Lafuente, Eride Quarta, María S. Magi, Ana L. Apas, Joaquín Pagani, María C. Palena, Paulina L. Páez, Fabio Sonvico, Alvaro F. Jimenez-Kairuz
Publié dans: Antibiotics, Numéro 14, 2025, Page(s) 169, ISSN 2079-6382
Éditeur: MDPI AG
DOI: 10.3390/antibiotics14020169

From symmetry breaking to symmetry swapping: is Kasha's rule violated in multibranched phenyleneethynylenes?

Auteurs: K. Swathi; Meleppatt Sujith; P. S. Divya; Merin Varghese P; Andrea Delledonne; D. K. Andrea Phan Huu; Francesco Di Maiolo; Francesca Terenziani; Andrea Lapini; Anna Painelli; Cristina Sissa; K. George Thomas
Publié dans: Chemical Science, Numéro 14, 2023, ISSN 2041-6539
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d2sc05206g

Fluorescent Multifunctional Organic Nanoparticles for Drug Delivery and Bioimaging: A Tutorial Review

Auteurs: Vargas-Nadal, Guillem; Köber, Mariana; Nsamela, Audrey; Terenziani, Francesca; Sissa, Cristina; Pescina, Silvia; Sonvico, Fabio; Gazzali, Amirah Mohd; Wahab, Habibah A.; Grisanti, Luca; Olivera, María Eugenia; Palena, María Celeste; Guzman, María Laura; Luciani-Giacobbe, Laura Carolina; Jimenez-Kairuz, Alvaro; Ventosa, Nora; Ratera, Imma; Belfield, Kevin D.; Maoz, Ben M.
Publié dans: Pharmaceutics, Numéro 14(11), 2022, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14112498

Synthesis and Chiroptical Activity of π‐Expanded Electron‐Rich Heterohelicenes Based on the 1,4‐Dihydropyrrolo[3,2‐<i>b</i>]pyrrole Core

Auteurs: Damian Kusy, Krzysztof Górski, Francesco Bertocchi, Matteo Galli, Nicolas Vanthuyne, Francesca Terenziani, Daniel T. Gryko
Publié dans: Chemistry – A European Journal, Numéro 31, 2025, ISSN 0947-6539
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202404632

Ratiometric Nanothermometer Based on a Radical Excimer for In Vivo Sensing

Auteurs: Davide Blasi; Nerea Gonzalez-Pato; Xavier Rodriguez Rodriguez; Iñigo Diez-Zabala; Sumithra Yasaswini Srinivasan; Núria Camarero; Oriol Esquivias; Mònica Roldán; Judith Guasch; Anna Laromaine; Pau Gorostiza; Jaume Veciana; Imma Ratera
Publié dans: Small, Numéro 19 (32), 2023, ISSN 1613-6829
Éditeur: Wiley
DOI: 10.1002/smll.202207806

Quatsomes Loaded with Squaraine Dye as an Effective Photosensitizer for Photodynamic Therapy

Auteurs: Nicolò Bordignon; Mariana Köber; Giorgia Chinigò; Carlotta Pontremoli; Ettore Sansone; Guillem Vargas-Nadal; Maria Jesus Moran Plata; Alessandra Fiorio Pla; Nadia Barbero; Judit Morla-Folch; Nora Ventosa
Publié dans: Pharmaceutics, Numéro 15(3), 2023, Page(s) 902, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15030902

Nanostructured Lipid Carriers for Enhanced Transscleral Delivery of Dexamethasone Acetate: Development, Ex Vivo Characterization and Multiphoton Microscopy Studies

Auteurs: Felipe M. González-Fernández, Andrea Delledonne, Sara Nicoli,Paolo Gasco, Cristina Padula, Patrizia Santi, Cristina Sissa, Silvia Pescina
Publié dans: Pharmaceutics, Numéro 407, 2023, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15020407

A new plant-based drug delivery platform based on alkyl polyglucosides and β-sitosterol nanovesicles for topical delivery

Auteurs: Marta Alcaina-Hernando, Ivana Malvacio, Ilaria Ferraboschi, Cristián Huck-Iriart, Annalisa Bianchera, Santi Sala, Jan Skov Pedersen, Lidia Ferrer-Tasies, Silvia Pescina, Cristina Sissa, Nora Ventosa, Alba Córdoba
Publié dans: Applied Materials Today, Numéro 41, 2024, Page(s) 102467, ISSN 2352-9407
Éditeur: Elsevier BV
DOI: 10.1016/j.apmt.2024.102467

Novel Method for the Synthesis of Merocyanines: New Photophysical Possibilities for a Known Class of Fluorophores

Auteurs: Brunella Bardi; Katerina V. Vygranenko; Beata Koszarna; Olena Vakuliuk; Łukasz Dobrzycki; Daniel T. Gryko; Francesca Terenziani; Anna Painelli
Publié dans: Chemistry- A European Journal, Numéro 29 (45), 2023, ISSN 0947-6539
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202300979

Neutral rhodol-based dyes expressing localization in mitochondria

Auteurs: Ilaria Ferraboschi, Juraj Ovčar, Kateryna V. Vygranenko, Shupei Yu, Alfonso Minervino, Antoni Wrzosek, Adam Szewczyk, Riccardo Rozza, Alessandra Magistrato, Kevin D. Belfield, Daniel T. Gryko, Luca Grisanti, Cristina Sissa
Publié dans: Organic &amp; Biomolecular Chemistry, Numéro 22, 2024, Page(s) 5886-5890, ISSN 1477-0520
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d4ob00252k

A sterilizable platform based on crosslinked xanthan gum for controlled-release of polymeric micelles: Ocular application for the delivery of neuroprotective compounds to the posterior eye segment

Auteurs: Sara Signorini, Andrea Delledonne, Silvia Pescina, Annalisa Bianchera, Cristina Sissa, Maria Vivero-Lopez, Carmen Alvarez-Lorenzo, Patrizia Santi, Cristina Padula, Sara Nicoli
Publié dans: International Journal of Pharmaceutics, Numéro 657, 2024, Page(s) 124141, ISSN 0378-5173
Éditeur: Elsevier BV
DOI: 10.1016/j.ijpharm.2024.124141

MultiSensor Origami Platform: A Customizable System for Obtaining Spatiotemporally Precise Functional Readouts in 3D Models

Auteurs: Noam Rahav, Denise Marrero, Adi Soffer, Emma Glickman, Megane BeldjilaliLabro, Yakey Yaffe, Keshet Tadmor, Yael LeichtmannBardoogo, Uri Ashery, Ben M. Maoz
Publié dans: Advanced Science, Numéro 11, 2024, ISSN 2198-3844
Éditeur: Wiley-VCH GmbH
DOI: 10.1002/advs.202305555

Multifunctional Heteropentalenes: From Synthesis to Optoelectronic Applications

Auteurs: Sebastian Stecko; Daniel T. Gryko
Publié dans: JACS Au, Numéro 2, 2022, Page(s) 1290-1305, ISSN 2691-3704
Éditeur: American Chemical Society
DOI: 10.1021/jacsau.2c00147

Hierarchical Quatsome-RGD Nanoarchitectonic Surfaces for Enhanced Integrin-Mediated Cell Adhesion

Auteurs: Marc Martínez-Miguel; Miquel Castellote-Borrell; Mariana Köber; Adriana R. Kyvik; Judit Tomsen-Melero; Guillem Vargas-Nadal; Jose Muñoz; Daniel Pulido; Edgar Cristóbal-Lecina; Solène Passemard; Miriam Royo; Marta Mas-Torrent; Jaume Veciana; Marina I. Giannotti; Judith Guasch; Nora Ventosa; Imma Ratera
Publié dans: Applied Materials & Interfaces, Numéro 3, 2022, ISSN 1944-8252
Éditeur: American Chemical Society
DOI: 10.1021/acsami.2c10497

Shedding new light on quadrupolar 1,4-dihydropyrrolo[3,2-<i>b</i>]pyrroles: impact of electron-deficient scaffolds over emission

Auteurs: Bartosz Szymański, Smruti Ranjan Sahoo, Olena Vakuliuk, Rashid Valiev, Ruslan Ramazanov, Piotr Łaski, Katarzyna N. Jarzembska, Radosław Kamiński, Mohammad B. Teimouri, Glib Baryshnikov, Daniel T. Gryko
Publié dans: Chemical Science, Numéro 16, 2025, Page(s) 2170-2179, ISSN 2041-6520
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d4sc07275h

Buccal Permeation of Polysaccharide High Molecular Weight Compounds: Effect of Chemical Permeation Enhancers

Auteurs: Adriana Fantini; Luca Giulio; Andrea Delledonne; Silvia Pescina; Cristina Sissa; Sara Nicoli; Patrizia Santi; Cristina Padula
Publié dans: Pharmaceutics, Numéro 15(1), 2023, Page(s) 129, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15010129

Quadrupolar, Highly Polarized Dyes: Emission Dependence on Viscosity and Selective Mitochondria Staining

Auteurs: Mariusz Tasior, Olena Vakuliuk, Antoni Wrzosek, Valentine I. Vullev, Adam Szewczyk, Denis Jacquemin, Daniel T. Gryko
Publié dans: ACS Organic &amp; Inorganic Au, Numéro 4, 2024, Page(s) 248-257, ISSN 2694-247X
Éditeur: ACS Publications
DOI: 10.1021/acsorginorgau.3c00035

Amphiphilic Fluorinated Unimer Micelles as Nanocarriers of Fluorescent Probes for Bioimaging

Auteurs: Delledonne, Andrea; Guazzelli, Elisa; Pescina, Silvia; Bianchera, Annalisa; Galli, Giancarlo; Martinelli, Elisa; Sissa, Cristina
Publié dans: ACS Applied Nanomaterials, Numéro 6, 2023, ISSN 2574-0970
Éditeur: American Chemical Society
DOI: 10.1021/acsanm.3c02300

Cyclosporine-loaded micelles for ocular delivery: investigating the penetration mechanisms

Auteurs: Ghezzi, Martina; Ferraboschi, Ilaria; Delledonne, Andrea; Pescina, Silvia; Padula, Cristina; Santi, Patrizia; Sissa, Cristina; Terenziani, Francesca; Nicoli, Sara
Publié dans: Journal of Controlled Release, Numéro 349, 2022, Page(s) 744-755, ISSN 0168-3659
Éditeur: Elsevier BV
DOI: 10.1016/j.jconrel.2022.07.019

Novel Dry Hyaluronic AcidVancomycin Complex Powder for Inhalation, Useful in Pulmonary Infections Associated with Cystic Fibrosis

Auteurs: Mara S. Magi, Yanina de Lafuente, Eride Quarta, Mara C. Palena, Perla del R. Ardiles, Paulina L. Pez, Fabio Sonvico, Francesca Buttini, Alvaro F. Jimenez-Kairuz
Publié dans: Pharmaceutics, Numéro 16, 2024, Page(s) 436, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics16040436

Engineered chitosan-derived nanocarrier for efficient siRNA delivery to peripheral and central neurons

Auteurs: Ana P. Spencer, Adriana Vilaça, Miguel Xavier, Rafael Santos, Ariel Ionescu, María Lázaro, Victoria Leiro, Eran Perlson, Sofia C. Guimarães, Ben M. Maoz, Ana P. Pêgo
Publié dans: Advanced Healtcare Materials, 2025, ISSN 2192-2659
Éditeur: World Scientific
DOI: 10.1101/2024.09.05.611434