Project description DEENESFRITPL Towards the development of low-risk insecticides Insecticides are substances that help eliminate insects and mites that cause human diseases such as malaria. While there are benefits to their use, they can also pose a serious threat to both wildlife and humans, for example through toxic residues in food and water. This issue has encouraged research into the creation of low-risk insecticides. One area research has explored is the role of the enzyme cytochrome P450 (CYP) in the sensitivity to insecticides. The EU-funded CypTox project will exploit the CYP metabolic/detoxification pathway of target and non-target organisms in order to develop insecticides that are highly selective and safe. The project’s work will also lead to state-of-the-art biotechnology platforms. Show the project objective Hide the project objective Objective Some of the most acute challenges that the world faces are caused by insects and mites that seriously threaten human health and food security. Their control is primarily achieved by the use of insecticides: e.g. malaria prevalence has halved since 2000, saving 660 million lives, with 80% of the reduction being attributable to the use of insecticides. However, both limited availability of low risk insecticides (“insecticides that only fight the bad bugs’) and insecticide resistance represent major threats. So, there is an urgent need to develop novel, safe insecticides. Earlier research pointed to a discriminatory role for the enzyme cytochrome P450 (CYP) in the sensitivity to insecticides. CypTox will exploit the CYP metabolic/detoxification pathway of target and non-target organisms, to develop insecticides, efficient against selected insect & mite major pests and vectors, but highly selective and safe for mammals, pollinators and the environment. Outcomes will also include significantly beyond the state of the art biotechnology platforms (high-throughput cell/enzyme- screening assays and in silico pipelines), that will advance research capabilities for future developments of low risk insecticides. CypTox will provide excellent research training within a creative and flexible environment that actively promotes the integration of academic rigor and commercial pragmatism through mobility between sectors and focused training events. The size and balance of a highly motivated consortium (6 AC/6 industrial–of which 3 SME & 3 TC; 300 well distributed secondments), the involvement of experienced PIs in Horizon2020 and ERC projects and the modern communication, dissemination and exploitation approaches will ensure efficient implementation and impact, at several levels. Enhanced career perspectives for scientists and researchers will be achieved by building a sustainable multidisciplinary and inter-sectoral network, integrating world leading researchers and stakeholders. Fields of science medical and health scienceshealth sciencesinfectious diseasesmalariamedical and health scienceshealth sciencesnutritionnatural sciencesbiological scienceszoologyentomologynatural sciencesbiological scienceszoologymammalogynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Keywords malaria vector borne disease Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.3. - Stimulating innovation by means of cross-fertilisation of knowledge Topic(s) MSCA-RISE-2020 - Research and Innovation Staff Exchange Call for proposal H2020-MSCA-RISE-2020 See other projects for this call Funding Scheme MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) Coordinator IDRYMA TECHNOLOGIAS KAI EREVNAS Net EU contribution € 464 600,00 Address N PLASTIRA STR 100 70013 Irakleio Greece See on map Region Νησιά Αιγαίου Κρήτη Ηράκλειο Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 464 600,00 Participants (14) Sort alphabetically Sort by Net EU contribution Expand all Collapse all GEOPONIKO PANEPISTIMION ATHINON Greece Net EU contribution € 193 200,00 Address IERA ODOS 75 11855 Athina See on map Region Αττική Aττική Κεντρικός Τομέας Αθηνών Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 193 200,00 ENDURA SPA Italy Net EU contribution € 27 600,00 Address Viale Pietramellara 5 40121 Bologna See on map Region Nord-Est Emilia-Romagna Bologna Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 27 600,00 MAGMA - AGRO ANONYMI EMPORIKI KAI BIOMICHANIKI ETAIREIA Greece Net EU contribution € 27 600,00 Address LEOFOROU KIFISIAS 256 152 31 CHALANDRI See on map Region Αττική Aττική Βόρειος Τομέας Αθηνών Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 27 600,00 UNIVERSITAT DE VALENCIA Spain Net EU contribution € 69 000,00 Address AVENIDA BLASCO IBANEZ 13 46010 Valencia See on map Region Este Comunitat Valenciana Valencia/València Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 69 000,00 CYPEX LTD United Kingdom Net EU contribution € 18 400,00 Address 30 34 REFORM STREET DD1 1RJ Dundee See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Scotland Eastern Scotland Angus and Dundee City Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 18 400,00 UNIVERSITEIT GENT Belgium Net EU contribution € 82 800,00 Address SINT PIETERSNIEUWSTRAAT 25 9000 Gent See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 82 800,00 THE UNIVERSITY OF EXETER United Kingdom Net EU contribution € 41 400,00 Address THE QUEEN'S DRIVE NORTHCOTE HOUSE EX4 4QJ Exeter See on map Region South West (England) Devon Devon CC Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 41 400,00 ENZYQUEST PRIVATE COMPANY Greece Net EU contribution € 13 800,00 Address SCIENCE AND TECHNOLOGY PARK OF CRETE NIKOLAOU PLASTIRA 100 VASSILIKA VOUTON 70013 HERAKLION See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Νησιά Αιγαίου Κρήτη Ηράκλειο Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 13 800,00 UNIVERSITAT AUTONOMA DE BARCELONA Spain Net EU contribution € 105 800,00 Address EDIF A CAMPUS DE LA UAB BELLATERRA CERDANYOLA V 08193 Cerdanyola Del Valles See on map Region Este Cataluña Barcelona Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 105 800,00 BIONOS BIOTECH SL Spain Net EU contribution € 18 400,00 Address BULEV SUR S/N - BIOPOLO LA FE EDIFICIO TORRE A HO 46029 Valencia See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Este Comunitat Valenciana Valencia/València Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 18 400,00 DEVGEN NV Belgium Net EU contribution € 41 400,00 Address TECHNOLOGIEPARK 30 9052 Zwijnaarde - Gent See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 41 400,00 SYNGENTA CROP PROTECTION AG Switzerland Net EU contribution € 124 200,00 Address ROSENTALSTRASSE 67 4058 BASEL See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 124 200,00 SYNGENTA LIMITED United Kingdom Net EU contribution € 96 600,00 Address SYNGENTA JEALOTTS HILL INTERNATIONAL RESERCH CENTR RG42 6EY Bracknell Berkshire See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Berkshire Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 96 600,00 THE INTERNATIONAL CENTRE OF INSECT PHYSIOLOGY AND ECOLOGY LBG Kenya Net EU contribution € 55 200,00 Address OFF THIKA ROAD DUDUVILLE CAMPUS 0100 Nairobi See on map Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 55 200,00 Partners (3) Sort alphabetically Sort by Net EU contribution Expand all Collapse all Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. UNIVERSITE DES SCIENCES DES TECHNIQUES ET DES TECHNOLOGIES DE BAMAKO Mali Net EU contribution € 0,00 Address QUARTIER ACI 2000 RUE 405 PORTE 359 BP1805 Bamako See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 69 000,00 Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. UNIVERSITY OF KENTUCKY United States Net EU contribution € 0,00 Address 410 Administration Drive 40506 Lexington See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. JOHNS HOPKINS UNIVERSITY United States Net EU contribution € 0,00 Address NORTH CHARLES STREET 3400 21218 Baltimore See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data