Project description DEENESFRITPL New platform for an accurate diagnosis and staging of cancer with 'liquid biopsy' Conventional cancer biopsies rely on invasive methods to take samples from a tumour's tissues. The sample is used for histological analysis for the clinical diagnosis, and for identification of prognostic and therapeutic targets. Circulating cell-free ribonucleic acids (ccfRNAs) have opened the door to a non-invasive alternative – liquid biopsy. However, despite extensive academic and clinical research, ccfRNAs have not yet entered the field of clinical diagnostics. This is in part because the current analytical methods are unsatisfactory, meaning that ccfRNA detection remains challenging, costly, and based on elaborate multi-step sample preparations. The EU-funded diaRNAgnosis project brings together a pan-European, multidisciplinary and intersectoral team to deliver a new platform for the direct quantitative measurement of ccfRNA signatures that are specifically and overexpressed in testicular germ cell tumour and prostate cancer. Show the project objective Hide the project objective Objective Circulating cell-free ribonucleic acids (ccfRNAs) represent an emerging and important class of molecules, able to provide significant clinical relevance as novel screening, prognostic and therapy monitoring biomarkers in cancer. Through analysing specific ccfRNAs, different cancers can be accurately correlated for type and stage. Sadly, despite extensive academic and clinical research identifying and validating in limited clinical trials, ccfRNAs have not yet entered the field of clinical diagnostics. This is amongst others because the current analytical methods remain less than satisfactory, and until now ccfRNA detection remains therefore challenging, costly, and requires elaborate multi-step sample preparations. Prompted by these current analytical limitations, two innovative EU companies, DESTINA Genomica SL (Spain) and OPTOELETTRONICA ITALIA SRL (Italy) have developed the “ODG Platform” for direct quantitative measurement of circulating RNA molecules. The diaRNAgnosis project objective is to complete development of the ODG platform, delivering reliable and robust detection of novel ccfRNA signatures that could be linked to specific cancer types. To ensure timely delivery and success of the diaRNAgnosis project, DESTINA and OPTOI have considered and invited partners who they believe will add real value to the consortium. These are the Spanish company NanoGetic SL (specializing in nanotechnologies); three key academic research groups from the Universities of Trento and Catania (Italy), Granada (Spain); as well as the Princess Máxima Center (The Netherlands). This new pan-European, multidisciplinary and intersectoral team will develop a reliable and innovative method and platform to identify cancer biomarkers in liquid biopsies. The research collaboration will address the need to perform high sensitivity/high specificity analysis of ccfRNAs that are specifically and overexpressed in testicular germ cell tumour (TGCT) and prostate cancer (PCa) respectively. Fields of science medical and health sciencesclinical medicineoncologyprostate cancerengineering and technologynanotechnologynatural sciencesbiological sciencesgeneticsRNA Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.3. - Stimulating innovation by means of cross-fertilisation of knowledge Topic(s) MSCA-RISE-2020 - Research and Innovation Staff Exchange Call for proposal H2020-MSCA-RISE-2020 See other projects for this call Funding Scheme MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) Coordinator DESTINA GENOMICA SLNE Net EU contribution € 230 000,00 Address Avenida de la innoaci0n 1 edificio bic 18100 Granada Spain See on map Region Sur Andalucía Granada Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (6) Sort alphabetically Sort by Net EU contribution Expand all Collapse all OPTOELETTRONICA ITALIA SRL Italy Net EU contribution € 41 400,00 Address Via vienna 8 38121 Trento See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Nord-Est Provincia Autonoma di Trento Trento Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITA DEGLI STUDI DI CATANIA Italy Net EU contribution € 110 400,00 Address Piazza universita 2 95131 Catania See on map Region Isole Sicilia Catania Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITA DEGLI STUDI DI TRENTO Italy Net EU contribution € 124 200,00 Address Via calepina 14 38122 Trento See on map Region Nord-Est Provincia Autonoma di Trento Trento Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV Netherlands Net EU contribution € 124 200,00 Address Heidelberglaan 25 3584CS Utrecht See on map Region West-Nederland Utrecht Utrecht Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSIDAD DE GRANADA Spain Net EU contribution € 87 400,00 Address Cuesta del hospicio sn 18071 Granada See on map Region Sur Andalucía Granada Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 NANOGETIC SOCIEDAD LIMITADA Spain Net EU contribution € 41 400,00 Address Calle marques de los velez 2 6 c 18005 Granada See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Sur Andalucía Granada Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
