Shaping Innovative Designs for Sustainable Tissue Engineering Products

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Preliminary in vivo and ex vivo

Report on the preliminary data collected in vivo and ex vivo using small animal models and porcine models. The data collected are needed to provide preclinical evidence that can push the process toward regulatory approval of the prototype.

Evaluation and validation of the in vitro functions of bioactive products

Report on the evaluation and validation of the in vitro functions of bioactive products. The evaluation and validation is performed using 3D tissue models.

Standardized protocols for natural compounds analysis

Report listing the the standardized protocols for natural compounds analysis defined by the project. The report includes a description of how the active natural molecules are conjugated and included in the release systems of each biopolymer used by the project.

Optimized fabrication parameters

Detailed description of the manufacturing techniques selected by the project and the optimal fabrication parameters chosen for each one.

Natural origin materials

Report on the natural origin materials polysaccharides proteins ceramics selected for the research The report will describe their different physicochemical properties different origin and their suitability for the development of multifunctional biomaterials fabrication

Training manifesto

Training manifesto for ESRs which includes the joint training program they will have to attend in person or remotely The Manifesto is prepared for Year 1 and subsequently updated each year with new training sessions

Biopolymers production at medical grade

Report on the Biopolymers produced at medical grade by the project, with an evaluation on their suitability as alternatives to commercially-available medical-grade products.

Report on natural sources

Report on natural polymers sources considered for research and their selection considering aspects like their sustainability quality assessment cost etc

Technology transfer

Report on Technology transfer pathways for the devices produced by the project and description of their commercialization patterns and models.

Commercial and route mapping

Report underlining the commercial potential of the products of the project. For each product a 'route mapping' describing the steps from lab to market and clinic will be provided.

Report on selected medicinal extracts

The report lists the medicinal extracts derived from Asian Traditional medicine researched by the project with a detailed description of the regenerative and healing potential

Project website

The Project website is the online portal of the project It will contain information about the research the Funding Agency the progress the events the partners of the project

Publications

Mussel-Inspired Hydrogels Incorporating Graphite Derivatives for Soft Tissue Regeneration

Author(s): Filipa Fernandes, Daniela Peixoto, Cátia Correia, Magda Silva, Maria C. Paiva, Natália M. Alves
Published in: Nanomaterials, Issue 15, 2025, Page(s) 276, ISSN 2079-4991
Publisher: MDPI AG
DOI: 10.3390/nano15040276

Biomedical applications of silk and its role for intervertebral disc repair

Author(s): Croft A. S.;Spessot E.;Bhattacharjee P.;Yang Y.;Motta A.;Woltje M.;Gantenbein B.
Published in: JOR SPINE, Issue 5, 2022, Page(s) 21, ISSN 2572-1143
Publisher: Wiley
DOI: 10.1002/jsp2.1225

Exploiting nano-in-micro-technologies to couple PLGA-hydroxyl-FK866 nanoparticles to a hydrogel network for local drug release

Author(s): Eugenia Spessot, Xue Bai, Daniel Moranduzzo, Chen Zhao, Sam Butterworth, Devid Maniglio, Annalisa Tirella
Published in: RSC Pharmaceutics, Issue 2, 2026, Page(s) 718-730, ISSN 2976-8713
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/d4pm00334a

Modeling a Dynamic Printability Window on Polysaccharide Blend Inks for Extrusion Bioprinting

Author(s): Francesca Perin, Eugenia Spessot, Anna Famà, Alessio Bucciarelli, Emanuela Callone, Carlos Mota, Antonella Motta, Devid Maniglio
Published in: ACS Biomaterials Science & Engineering, Issue 9, 2023, Page(s) 1320-1331, ISSN 2373-9878
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acsbiomaterials.2c01143

Physico-Chemical Characterizations of Composited Calcium-Ortho-Phosphate Porous Particles and Their Controlled Release Behavior of Clindamycin Phosphate and Amikacin Sulfate

Author(s): Namfon Khamkaew, Sorada Kanokpanont, Jirun Apinun, Chalika Wangdee, Antonella Motta, Siriporn Damrongsakkul
Published in: Polymers, Issue 16, 2025, Page(s) 3144, ISSN 2073-4360
Publisher: MDPI AG
DOI: 10.3390/polym16223144

Quercetin-Embedded Gelastin Injectable Hydrogel as Provisional Biotemplate for Future Cutaneous Application: Optimization and In Vitro Evaluation

Author(s): Mazlan Zawani, Manira Maarof, Yasuhiko Tabata, Antonella Motta, Mh Busra Fauzi
Published in: Gels, Issue 8, 2025, Page(s) 623, ISSN 2310-2861
Publisher: MDPI AG
DOI: 10.3390/gels8100623

Bioprinting vascularized skin analogs: a stepwise approach

Author(s): Linyang Liu, Eugenia Spessot, Khoon S Lim, Ziyu Wang, Suzanne M Mithieux, Devid Maniglio, Antonella Motta, Anthony S Weiss
Published in: Burns & Trauma, Issue 13, 2025, ISSN 2321-3876
Publisher: Oxford University Press (OUP)
DOI: 10.1093/burnst/tkaf018

Advanced therapy medicinal products: Emerging therapeutic frontiers and evolving regulatory landscapes

Author(s): Alessio Bucciarelli, Antonella Motta
Published in: Precision Medicine and Engineering, Issue 3, 2026, Page(s) 100063, ISSN 2950-4821
Publisher: Elsevier BV
DOI: 10.1016/j.preme.2026.100063

Plasma-Polymerised Antibacterial Coating of Ovine Tendon Collagen Type I (OTC) Crosslinked with Genipin (GNP) and Dehydrothermal-Crosslinked (DHT) as a Cutaneous Substitute for Wound Healing

Author(s): Ibrahim N. Amirrah, Izzat Zulkiflee, M. F. Mohd Razip Wee, Asad Masood, Kim S. Siow, Antonella Motta, Mh Busra Fauzi
Published in: Materials, Issue 16, 2025, Page(s) 2739, ISSN 1996-1944
Publisher: MDPI Open Access Publishing
DOI: 10.3390/ma16072739

Nanocomposite Methacrylated Silk Fibroin-Based Scaffolds for Bone Tissue Engineering

Author(s): Eugenia Spessot, Serena Passuello, Lekha Vinod Shah, Devid Maniglio, Antonella Motta
Published in: Biomimetics, Issue 9, 2025, Page(s) 218, ISSN 2313-7673
Publisher: MDPI AG
DOI: 10.3390/biomimetics9040218

Antibacterial properties of photo-crosslinked chitosan/methacrylated hyaluronic acid nanoparticles loaded with bacitracin

Author(s): Raquel R. Gonçalves, Daniela Peixoto, Rui R. Costa, Albina R. Franco, Vânia I.B. Castro, Ricardo A. Pires, Rui L. Reis, Iva Pashkuleva, Devid Maniglio, Annalisa Tirella, Antonella Motta, Natália M. Alves
Published in: International Journal of Biological Macromolecules, Issue 277, 2026, Page(s) 134250, ISSN 0141-8130
Publisher: Elsevier BV
DOI: 10.1016/j.ijbiomac.2024.134250

Multifunctional Hyaluronic Acid/Graphite Nanoplatelet Hydrogels as Tools for Spinal Cord Regeneration

Author(s): Cátia Correia, Daniela Cruz-Moreira, Fábio S. Gonçalves, Vanessa F. Cardoso, Maria C. Paiva, Rui L. Reis, Iva Pashkuleva, Daniela Peixoto, Natália M. Alves
Published in: ACS Applied Materials & Interfaces, Issue 17, 2026, Page(s) 69196-69208, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.5c20777

Tropoelastin enhances vascularization in printable protein hydrogels

Author(s): Linyang Liu, Nannan Xue, Ziyu Wang, Eugenia Spessot, Miao Zhang, Suzanne M. Mithieux, Iman Roohani, Jelena Rnjak-Kovacina, Antonella Motta, Yiwei Wang, Anthony S. Weiss
Published in: Communications Materials, 2026, ISSN 2662-4443
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s43246-026-01288-6

Engineering Extracellular Vesicle Production Through Magnetic Ion Channel Activation for Bone Regeneration

Author(s): Afeesh Rajan Unnithan, Kenny Man, null Kritika, Lee A. Gethings, Christopher J. Hughes, Alicia Keenan, Liam Heaney, Sophie C. Cox, Owen G. Davies, Alicia J. El Haj
Published in: Advanced Healthcare Materials, Issue 15, 2026, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202504542

Development and in vitro assessment of injectable, adhesive, and self-healing chitosan-based hydrogels for treatment of spinal cord injury

Author(s): Cátia Correia, Daniela Peixoto, Diana Soares da Costa, Rui L. Reis, Iva Pashkuleva, Natália M. Alves
Published in: Biomaterials Advances, Issue 167, 2024, Page(s) 214090, ISSN 2772-9508
Publisher: Elsevier BV
DOI: 10.1016/j.bioadv.2024.214090

Silk fibroin-based inks for in situ 3D printing using a double crosslinking process

Author(s): Francesca Agostinacchio, Vincent Fitzpatrick, Sandra Dirè, David L. Kaplan, Antonella Motta
Published in: Bioactive Materials, Issue 35, 2024, Page(s) 122-134, ISSN 2452-199X
Publisher: Elsevier BV
DOI: 10.1016/j.bioactmat.2024.01.015

Data-Driven Sustainable <i>In Vitro</i> Campaigns to Decipher Invasive Breast Cancer Features

Author(s): Lekha Shah, Valentina Breschi, Annalisa Tirella
Published in: ACS Biomaterials Science & Engineering, Issue 11, 2025, Page(s) 5107-5121, ISSN 2373-9878
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acsbiomaterials.5c00731

Harnessing de novo designed ultrashort self-assembling peptides and silk fibroin as pre-gels for extrusion-based bioprinting

Author(s): Eugenia Spessot, Mohamed A.N. Soliman, Daniele Campoli, Abdulwahhab Khedr, Gaia Pascolo, Antonella Motta, Devid Maniglio, Mohamed A. Elsawy, Annalisa Tirella
Published in: Next Materials, Issue 12, 2026, Page(s) 102095, ISSN 2949-8228
Publisher: Elsevier BV
DOI: 10.1016/j.nxmate.2026.102095

A Comprehensive Review on Collagen Type I Development of Biomaterials for Tissue Engineering: From Biosynthesis to Bioscaffold

Author(s): Ibrahim N. Amirrah, Yogeswaran Lokanathan, Izzat Zulkiflee, M. F. Mohd Razip Wee, Antonella Motta, Mh Busra Fauzi
Published in: Biomedicines, 2022, ISSN 2227-9059
Publisher: MDPI
DOI: 10.3390/biomedicines10092307

Localized growth factor delivery from microparticles modulates osteogenic and chondrogenic gene expression in a growth factor-dependent manner in an ex vivo chick embryonic bone model

Author(s): Hassan Rashidi, Helen C. Cox, Omar Qutachi, Dale Moulding, Lisa J. White, Emma L. Smith, Janos M. Kanczler, Luis Rojo, Michael Rotherham, James R. Henstock, Molly M. Stevens, Alicia J. El Haj, Richard O.C. Oreffo, Kevin M. Shakesheff, Felicity R.A.J. Rose
Published in: Acta Biomaterialia, Issue 204, 2026, Page(s) 558-567, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2025.08.028

Structuring of gellan hydrogel enables the production of inherently antifibrotic, lubricating eye drops

Author(s): Samuel R. Moxon, Rachel C. Vincent, A. Taylor, B. Cassidy, Richard J.A. Moakes, Gibran F. Butt, Graham R. Wallace, Anthony D. Metcalfe, Richard L. Williams, Nicholas M. Barnes, Ann Logan, Saaeha Rauz, Liam M. Grover
Published in: Acta Biomaterialia, Issue 205, 2026, Page(s) 260-269, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2025.08.039

Mechanochemical synthesis and cold sintering of mussel shell-derived hydroxyapatite nano-powders for bone tissue regeneration

Author(s): Anna Galotta, Francesca Agostinacchio, Antonella Motta, Sandra Dire'. Vincenzo Sglavo
Published in: Journal of the European Ceramic Society, Issue 43, 2022, Page(s) 8, ISSN 0955-2219
Publisher: Elsevier BV
DOI: 10.1016/j.jeurceramsoc.2022.09.024

Discovery of bioactive peptides as therapeutic agents for skin wound repair

Author(s): Nur Izzah Md Fadilah, Nurul Aqilah Shahabudin, Raniya Adiba Mohd Razif, Arka Sanyal, Anushikha Ghosh, Khairul Idzwan Baharin, Haslina Ahmad, Manira Maarof, Antonella Motta, Mh Busra Fauzi
Published in: Journal of Tissue Engineering, Issue 15, 2026, ISSN 2041-7314
Publisher: SAGE Publications
DOI: 10.1177/20417314241280359

Self‐Delivering Microstructured Iota Carrageenan Spray Inhibits Fibrosis at Multiple Length Scales

Author(s): Thomas E. Robinson, Mathieu Y. Brunet, Iain Chapple, Adrian H. M. Heagerty, Anthony D. Metcalfe, Liam M. Grover
Published in: Advanced NanoBiomed Research, Issue 3, 2025, ISSN 2699-9307
Publisher: Wiley
DOI: 10.1002/anbr.202300048

Bioadhesive Hyaluronic Acid-Based Hydrogels for Spinal Cord Injury

Author(s): Diogo Duarte, Cátia Correia, Rui L. Reis, Iva Pashkuleva, Daniela Peixoto, Natália M. Alves
Published in: Biomacromolecules, Issue 25, 2024, Page(s) 1592-1601, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.3c01186

Enhanced chondrogenic potential in GelMA-based 3D cartilage model via Wnt3a surface immobilization

Author(s): Angela Imere, Nicola C. Foster, Hadi Hajiali, Kerime Ebrar Okur, Abigail L. Wright, Ines A. Barroso, Alicia J. El Haj
Published in: Scientific Reports, Issue 14, 2024, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-024-65970-w

Functionalised-biomatrix for wound healing and cutaneous regeneration: future impactful medical products in clinical translation and precision medicine

Author(s): Nur Izzah Md Fadilah, Shaima Maliha Riha, Zawani Mazlan, Adzim Poh Yuen Wen, Looi Qi Hao, Blessy Joseph, Manira Maarof, Sabu Thomas, Antonella Motta, Mh Busra Fauzi
Published in: Frontiers in Bioengineering and Biotechnology, Issue 11, 2023, ISSN 2296-4185
Publisher: Frontiers Media SA
DOI: 10.3389/fbioe.2023.1160577

Microfluidics Enabling the Controlled Manufacturing of Peptide and Protein Micro and Nano Biomaterials for Biomedical Applications

Author(s): Gaia Pascolo, Bekzod Bekchanov, Mohamed A. N. Soliman, Eugenia Spessot, Hafiz Ali, Omar Qutachi, Meisam Abdi, Annalisa Tirella, Mohamed A. Elsawy
Published in: Biomacromolecules, Issue 26, 2025, Page(s) 3903-3928, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.4c01712

Engineered-Skin of Single Dermal Layer Containing Printed Hybrid Gelatin-Polyvinyl Alcohol Bioink via 3D-Bioprinting: In Vitro Assessment under Submerged vs. Air-Lifting Models

Author(s): Syafira Masri, Faraheda Amilia Mohd Fauzi,Sarah Batrisyia Hasnizam, Aizzaty Sulha Azhari, Juliana Edora Amin Lim, Looi Qi Hao, Manira Maarof, Antonella Motta, Mh Busra Fauzi
Published in: Pharmaceuticals, 2022, ISSN 1424-8247
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph15111328

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