Project description DEENESFRITPL Natural materials help tissues create natural blood vessels in tissue engineering applications The regeneration of human tissues for therapeutic purposes is a treatment strategy that has received much attention thanks to its promising results. Partners of the EU-funded SHIFT project have designed several devices with bio-based polymers capable of promoting regeneration of skin, bone and cartilage during the implementation of MSCA-RISE REMIX (2017-2021). With SHIFT, the consortium aims to scale them up to a stage where they can be taken to clinical trials through the enhancement of angiogenetic capability (fundamental in ensuring tissue regeneration), process optimisation considering scalability, production of medical grade biopolymers and costs forecast. In doing so, SHIFT will apply green chemistry principles to reduce the negative environmental externalities of the research. Show the project objective Hide the project objective Objective Shaping Innovative Products for Sustainable Tissue Engineering Strategies - SHIFT is the follow up of MSCA-RISE REMIX (GA 778078). While REMIX researched and confirmed the potential of natural origin material such as silk proteins, collagen, keratin and marine organism-derived polymers for use in Tissue Engineering and Regenerative Medicine, SHIFT aims to take the research a step forward and design innovative natural-based, scalable constructs that enhance angiogenesis for the treatment of widespread chronic pathologies, such as large defect in bone and cartilage and the treatment of chronic wounds (ex. diabetic ulcer). Prototypes will be fabricated considering scalability, costs, regulatory issues.Multiple strategies will be used to achieve this aim:- pre-assessment of the regulative framework for TERM products and close collaboration with the industry; - fabrication in accordance with current GMP and ISO quality management Systems-requirements- standardization of the protocols for purification of raw materials from the waste of textile and food industry for the production of these prototypes, using medical-grade, commercially-available raw materials as benchmark. This may lead to the opening of a new opportunity for re-using industrial waste which is currently disposed of.- application of the principles of Green Chemistry to reduce the environmental impact of the research and production of the prototypes. An extensive training program will be offered to ESRs to set the best conditions for successful performance. The program will be offered through summer schools and online seminars and will cover a variety of topics related to TERM, technologies, regulations for product development. A special highlight will be devoted to product-development, spin-off, venture capitals, to provide junior researchers with knowledge and skills that may allow them to become profiles capable to successfully transfer ideas and innovations from academia to the industry. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesmedical biotechnologytissue engineeringnatural scienceschemical sciencespolymer sciencesengineering and technologymaterials engineeringtextilesmedical and health sciencesbasic medicinepathology Keywords Tissue Engineering Regenerative Medicine Product design Green Chemistry wound healing bench-to-bedside biotechnology bone cartilage Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.3. - Stimulating innovation by means of cross-fertilisation of knowledge Topic(s) MSCA-RISE-2020 - Research and Innovation Staff Exchange Call for proposal H2020-MSCA-RISE-2020 See other projects for this call Funding Scheme MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) Coordinator UNIVERSITA DEGLI STUDI DI TRENTO Net EU contribution € 391 000,00 Address VIA CALEPINA 14 38122 Trento Italy See on map Region Nord-Est Provincia Autonoma di Trento Trento Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 506 000,00 Participants (2) Sort alphabetically Sort by Net EU contribution Expand all Collapse all UNIVERSIDADE DO MINHO Portugal Net EU contribution € 262 200,00 Address LARGO DO PACO 4704 553 Braga See on map Region Continente Norte Cávado Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 312 800,00 THE UNIVERSITY OF BIRMINGHAM United Kingdom Net EU contribution € 257 600,00 Address Edgbaston B15 2TT Birmingham See on map Region West Midlands (England) West Midlands Birmingham Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 266 800,00 Partners (5) Sort alphabetically Sort by Net EU contribution Expand all Collapse all Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. UNIVERSITI KEBANGSAAN MALAYSIA Malaysia Net EU contribution € 0,00 Address UKM BANGI 43600 Selangor Darul Ehsan See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 124 200,00 Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. THE UNIVERSITY OF SYDNEY Australia Net EU contribution € 0,00 Address CAMPERDOWN CAMPUS ARUNDEL ST 71/79 2006 Sydney See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 82 800,00 Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. MONGOLIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY Mongolia Net EU contribution € 0,00 Address 8TH KHOROO, BAGA TOIRUU 141910005 Ulaanbaatar See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 69 000,00 Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. CHONBUK NATIONAL UNIVERSITY South Korea Net EU contribution € 0,00 Address BAEKJE DAERO 567 DEOKJIN GU JEONJU SI 561 756 JEOLLABUK DO See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 92 000,00 Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. CHULALONGKORN UNIVERSITY Thailand Net EU contribution € 0,00 Address PHYATHAI ROAD 254 PATHUMWAN 10330 Bangkok See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 253 000,00
