Project description DEENESFRITPL Ultrasmall and multi-talented: Nanohybrid materials for diagnosis and therapy Nanoscale materials have gained a place in the spotlight as enablers of combination diagnostic-therapeutic technologies due to their tiny penetrating sizes and their unique functional properties. Nanohybrids that contain both organic and inorganic components, including metallic ones, offer tremendous opportunity for the functionalisation of biological or bioactive molecules. The EU-funded UNAT project will explore the capabilities of metal-carbon nanohybrids for multimodal in vivo imaging and therapy of tumours via electromagnetic radiation. The diagnosis and therapy of cancer will be evaluated through an ambitious campaign of preclinical in vitro and in vivo experiments. Show the project objective Hide the project objective Objective Nowadays, research focusing on control and use of nanomaterials in different areas including life sciences has become a key driver of innovation. UNAT project aims at a systematic interdisciplinary study of metal-carbon nanohybrides (NHs) for advanced theranostic application. Indeed, development of NHs based on organic & inorganic moieties can synergistically or antagonistically influence functional properties of engineered nanotheranostic medicines. UNAT will develop innovative approaches for synthesis and multi-functional application of ultra-small (<10 nm) carbon-based NHs functionalized with various metal atoms for diagnostics and therapy of cancer. In particular, carbon cores of NHs will be chemically synthesized from biomasses and bio-wastes. The combination of pre-clinical in-vitro & in-vivo experiments will allow to evaluate theranostic potential of the NHs.UNAT will associate an industrial partner from Greece (Bioemtech), a research and innovation center from Ukraine (Science Park) and 2 academic research groups from France (UCBL) and Italy (CNR). The uptake efficiency and specific localization of the NHs in biological cells depending on their intentionally designed surface chemistry will be studied in details. Extremely rich physico-chemical properties of the NHs will allow their application as universal multi-modal (MRI, PET, X-ray, Fluorescence, Photoacoustic) in-vivo bio-imaging agents. The multimodal imaging strategy will allow us to correlate the images obtained with the use of various imaging facilities to increase general reliability of visualization of the NHs localization in tumours. Various exciting electro-magnetic sources used for medical purposes will be simultaneously used for therapy of cancer tissues containing the incorporated NHs. Strongly complementary research experiences of the partners involved in UNAT and a high degree of cooperative integration between them will allow a deep scientific study of the theranostic potential of the NHs. Fields of science medical and health sciencesclinical medicineoncologyengineering and technologynanotechnologynano-materialsagricultural sciencesagricultural biotechnologybiomass Keywords nanohybrids bio-imaging nanomaterials for cancer therapy Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.3. - Stimulating innovation by means of cross-fertilisation of knowledge Topic(s) MSCA-RISE-2020 - Research and Innovation Staff Exchange Call for proposal H2020-MSCA-RISE-2020 See other projects for this call Funding Scheme MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) Coordinator UNIVERSITE LYON 1 CLAUDE BERNARD Net EU contribution € 142 600,00 Address BOULEVARD DU 11 NOVEMBRE 1918 NUM43 69622 Villeurbanne Cedex France See on map Region Auvergne-Rhône-Alpes Rhône-Alpes Rhône Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 142 600,00 Participants (4) Sort alphabetically Sort by Net EU contribution Expand all Collapse all CORPORATION SCIENCE PARK TARAS SHEVCHENKO UNIVERSITY OF KYIV Ukraine Net EU contribution € 400 200,00 Address VOLODYMYRSKA STR., 60 01033 Kyiv See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 400 200,00 CONSIGLIO NAZIONALE DELLE RICERCHE Italy Net EU contribution € 110 400,00 Address PIAZZALE ALDO MORO 7 00185 Roma See on map Region Centro (IT) Lazio Roma Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 110 400,00 BIOEMISSION TECHNOLOGY SOLUTIONS IKE Greece Net EU contribution € 151 800,00 Address L. MESOGEION 387 153 43 AGIA PARASKEVI (ATHINA) See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Αττική Aττική Βόρειος Τομέας Αθηνών Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 151 800,00 GLINCS France Net EU contribution € 27 600,00 Address 122 RUE SAINT GEORGES 69005 Lyon See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Auvergne-Rhône-Alpes Rhône-Alpes Rhône Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 27 600,00
