Descrizione del progetto
Piccolissimi e poliedrici: i materiali nanoibridi per la diagnosi e la terapia
I materiali in scala nanometrica hanno guadagnato un posto sotto i riflettori come abilitatori di tecnologie combinate diagnostico-terapeutiche in virtù delle loro piccole dimensioni penetranti e delle loro proprietà funzionali uniche. I nanoibridi che contengono sia componenti organici che inorganici, compresi quelli metallici, offrono enormi opportunità per la funzionalizzazione di molecole biologiche o bioattive. Il progetto UNAT, finanziato dall’UE, esplorerà le capacità dei nanoibridi metallo-carbonio per l’imaging multimodale in vivo e la terapia dei tumori attraverso la radiazione elettromagnetica. La diagnosi e la terapia del cancro saranno valutate attraverso un’ambiziosa campagna di esperimenti preclinici in vitro e in vivo.
Obiettivo
Nowadays, research focusing on control and use of nanomaterials in different areas including life sciences has become a key driver of innovation. UNAT project aims at a systematic interdisciplinary study of metal-carbon nanohybrides (NHs) for advanced theranostic application. Indeed, development of NHs based on organic & inorganic moieties can synergistically or antagonistically influence functional properties of engineered nanotheranostic medicines. UNAT will develop innovative approaches for synthesis and multi-functional application of ultra-small (<10 nm) carbon-based NHs functionalized with various metal atoms for diagnostics and therapy of cancer. In particular, carbon cores of NHs will be chemically synthesized from biomasses and bio-wastes. The combination of pre-clinical in-vitro & in-vivo experiments will allow to evaluate theranostic potential of the NHs.
UNAT will associate an industrial partner from Greece (Bioemtech), a research and innovation center from Ukraine (Science Park) and 2 academic research groups from France (UCBL) and Italy (CNR). The uptake efficiency and specific localization of the NHs in biological cells depending on their intentionally designed surface chemistry will be studied in details. Extremely rich physico-chemical properties of the NHs will allow their application as universal multi-modal (MRI, PET, X-ray, Fluorescence, Photoacoustic) in-vivo bio-imaging agents. The multimodal imaging strategy will allow us to correlate the images obtained with the use of various imaging facilities to increase general reliability of visualization of the NHs localization in tumours. Various exciting electro-magnetic sources used for medical purposes will be simultaneously used for therapy of cancer tissues containing the incorporated NHs. Strongly complementary research experiences of the partners involved in UNAT and a high degree of cooperative integration between them will allow a deep scientific study of the theranostic potential of the NHs.
Campo scientifico
Parole chiave
Programma(i)
Meccanismo di finanziamento
MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)Coordinatore
69622 Villeurbanne Cedex
Francia