Simulation of Cardiac Devices & Drugs for in-silico Testing and Certification

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Modelling & personalisation survey

Reports that gathers input from all partners in order to standardize models input & output.

Report on global standardisation

Specification document on the chosen formalism for standardized modelling and personalization.

Fluid simulations with optimised boundary conditions

Report on the personalized simulation of blood flows.

Report on the standardised models for LAAO devices

Description of the standardized simulation for the second use-case.

Description of biomarkers for drug safety, efficacy & cardiotoxicity

Reports on biomarkers used to evaluate drug safety, efficacy & cardiotoxicity.

Software API for pharmacokinetics

Specifications of the standardized interface for pharmacokinetics simulations for drugs specific to the project.

Report on the standardised models for interventional devices

Description of the standardized simulation for the first use-case.

Communication toolkits for physicians & patient organisations

First report on the exploitation strategy and market assessment for the project outcome.

Report on the standardised models for drugs

Description of the standardized models and simulations for the third use-case.

Dissemination and Communication strategy plan

Report on the communication and dissemination activities strategy for the project.

Report on the in-silico trial of pacing leads & catheters

Report on the results of the in-silico trials run for the first use-case.

Report on the in-silico trial of drug efficacy & cardiotoxicity

Report on the results of the in-silico trials run for the third use-case.

Cloud-based platform for pacing device simulation

Demonstration of the integration of the first use-case into the cloud platform.

Cloud-based platform for drugs simulation

Demonstration of the integration of the third use-case into the cloud platform.

Cloud-based platform for LAAO simulation

Demonstration of the integration of the second use-case into the cloud platform.

Demonstration of several catheters simulated and real ones

Demonstrator of catheter navigation within the simulator.

Demonstrator of simulation of drug effects in cellular and 3D models

Demonstration of simulation results for the third use-case.

Database of fluid simulations in virtual population

Demonstrator of computer models for device planning.

Database of virtual human cardiac models with drug interaction

Open-access database of detailed cardiac models for drug interaction simulation

Website and online presence

Project website and social media accounts online.

Publicaciones

Evaluation of cinematic volume rendering open-source and commercial solutions for the exploration of congenital heart data

Autores: Irum Baseer, Israel Valverde, Abdel H. Moustafa, Josep Blat, Oscar Camara
Publicado en: IEEE Visualization and Visual Analytics (VIS), 2023, ISSN 2331-8422
Editor: IEEE
DOI: 10.1109/vis54172.2023.00024

In-Silico Analysis of the Influence of Pulmonary Vein Configuration on Left Atrial Haemodynamics and Thrombus Formation in a Large Cohort

Autores: Jordi Mill, Josquin Harrison, Benoit Legghe, Andy L. Olivares, Xabier Morales, Jerome Noailly, Xavier Iriart, Hubert Cochet, Maxime Sermesant, Oscar Camara
Publicado en: International Conference on Functional Imaging and Modeling of the Heart, FIMH 2021, Edición Lecture Notes in Computer Science book series (LNIP, volume 12738), 2021, Página(s) 605-616, ISBN 978-3-030-78710-3
Editor: Springer, Cham
DOI: 10.1007/978-3-030-78710-3_58

Visual Analytics for Planning Left Atrial Appendage Occlusion: A Case Study on In-silico Hemodynamic Assessment

Autores: Nuhic, J., Albors, C., Mill, J., Olivares, A.L., Camara, O., Meuschke, M
Publicado en: EuroVis 2024 Conference, 2024
Editor: The Eurographics Association
DOI: 10.2312/evs.20241065

Exploring Chemotherapy-Induced Cardiotoxicity Combining A 3D Computational Model and Preclinical Cardiac Imaging Data. 15th International Workshop on Statistical Atlases and Computational Models of the Heart

Autores: Villar-Valero, J., Rodríguez Padilla, J.J., Buntheng, L., Gómez, J.F., Pop, M., Trenor, B., Sermesant, M.
Publicado en: STACOM 2024, 2024, Página(s) 64-74
Editor: Springer Cham

Role of Conduction Channels in Ventricular Arrhythmias: Insights from In Silico Simulation and Clinical Data

Autores: Villar-Valero, J., Gómez García, J.F., Soto-Iglesias, D., Penela, D., Berruezo, A., Trenor, B.
Publicado en: 8th Virtual Physiological Human Conference (VPH 2024)., 2024
Editor: VPH Institute

Omecamtiv Mecarbil Improves Contraction Behaviour in a 3D Electromechanical Tissue Model of Heart Failure

Autores: Ilsbeth van Herck, Maria Teresa Mora, Jordi Llopis-Lorente, Henrik Finsberg, Cécile Daversin Catty , Javier Saiz, Beatriz Trenor, Hermenegild Arevalo, Samuel Wal
Publicado en: Computing in Cardiology 2022, Edición 49, 2022
Editor: IEEE
DOI: 10.22489/cinc.2022.033

In Silico Evaluation of New Approaches in Cardiac Resynchronization Therapy

Autores: Cristóbal R Ruiz, , Juan F Gómez, Eduardo Castellanos, Jesús Almendral, Beatriz Trenor
Publicado en: Computing in Cardiology 2022, 2022
Editor: IEEE
DOI: 10.22489/cinc.2022.102

Computer model of cardiac pacing devices

Autores: Coudière, Yves
Publicado en: Journées Math Bio Santé, 2024
Editor: CNRS RT Math Bio Santé et SMAI GT Mabiome

Determination of stimulation threshold in a 3D model of a pacemaker

Autores: Pannetier, Valentin and Leguèbe, Michael and Coudière, Yves and Faure, Guilhem and Feuerstein, Delphine
Publicado en: VPH Conference 2024 Data-Driven Simulation Technologies for Clinical Decision Making, 2024
Editor: VPH Institute

Left atrial wall dynamics in in-silico fluid simulations of atrial fibrillation patients

Autores: Carlos Albors, Nerea Arrarte Terreros, Josquin Harrison, Xabier Morales, Marta Saiz Vivó, Nils Planken, Joris R. de Groot, Maxime Sermesant, Oscar Camara
Publicado en: VPH Conference 2024 Data-Driven Simulation Technologies for Clinical Decision Making, 2024
Editor: VPH Institute

Simulation Study of the Protective Effect of Drugs in Acute Myocardial Ischemia

Autores: Ander Loidi, José M Ferrero
Publicado en: Computing in Cardiology 2022, 2022
Editor: IEEE
DOI: 10.22489/cinc.2022.044

Geometric Deep Learning for the Assessment of Thrombosis Risk in the Left Atrial Appendage

Autores: Xabier Morales, Jordi Mill, Guillem Simeon, Kristine A. Juhl, Ole De Backer, Rasmus R. Paulsen, Oscar Camara
Publicado en: International Conference on Functional Imaging and Modeling of the Heart, FIMH 2021, Edición Lecture Notes in Computer Science, vol 12738, 2021, Página(s) 639-649, ISBN 978-3-030-78710-3
Editor: Springer
DOI: 10.1007/978-3-030-78710-3_61

Estudio in silico de la influencia de la conductividad de los distintos órganos del torso sobre las derivaciones electrocardiográficas

Autores: Pérez-Herrero, S.,Trenor, B., Saiz, J.
Publicado en: XLII Congreso Anual de la Sociedad Española de Ingeniería Biomédica (CASEIB 2024), Edición XLII Congreso Anual de la Sociedad Española de Ingeniería Biomédica (CASEIB 2024)., 2024, Página(s) 541 - 544, ISBN 978-84-09-67332-2
Editor: CASEIB

The Role of Stellate Ganglion Induced Repolarization Heterogeneities in Post-Myocardial Infarction Arrhythmias: A Computational Approach

Autores: Lledo Nebot, Javier Villar Valero, Juan F Gomez, Bastiaan J.D Boukens, Beatriz Trenor
Publicado en: Computing in Cardiology Conference (CinC), 2024 Computing in Cardiology Conference (CinC), Edición 51, 2024
Editor: Computing in Cardiology
DOI: 10.22489/cinc.2024.428

Next generation cardiac care: SimCardioTest cloud-based platform

Autores: Alessia Baretta, Yves Coudière, Oscar Camara, Beatriz Trenor, Hermenegild Arevalo, Irene Balelli, Romano Setzu, Liesbet Geris, Sylvain Benito, Michele Barbier, Maxime Sermesant.
Publicado en: VPH Conference 2024 Data-Driven Simulation Technologies for Clinical Decision Making, 2024
Editor: VPH Institute

A Computer Model for In Silico Trials on Pacemaker Energy Efficiency

Autores: Yves Coudière, Michael Leguèbe, Irene Balelli, Alessia Baretta, Guilhem Fauré, Delphine Feuerstein
Publicado en: Computing in Cardiology Conference (CinC), 2024 Computing in Cardiology Conference (CinC), Edición 51, 2024
Editor: Computing in Cardiology
DOI: 10.22489/cinc.2024.235

A computational pipeline for fast surrogates of left atrial appendage occlusion fluid simulations

Autores: Marta Saiz Vivó, Carlos Albors Lucas, Angel Herrero Díaz, Jordi Mill Tena, Andy Luis Olivares, Benoit Legghe, Xavier Iriart, Gemma Piella, Maxime Sermesant, Oscar Camara
Publicado en: VPH Conference 2024 Data-Driven Simulation Technologies for Clinical Decision Making, 2024
Editor: VPH Institute

Using Computational Modelling to Define the Ideal Characteristics of Antiarrhythmic Drugs in Acute Ischemia

Autores: Ander Loidi, José M Ferrero
Publicado en: Computing in Cardiology 2022, Edición 49, 2022
Editor: IEEE
DOI: 10.22489/cinc.2022.062

In silicone and in silico: toward evaluation of pacemaker lead implantation based on soft robotics and computer simulation

Autores: Thomas Moupfouma, Quentin Peyron, Yinoussa Adagolodjo, Sylvain Caubet, Jean-François Ollivier, Christian Duriez
Publicado en: 2025 IEEE 8th International Conference on Soft Robotics (RoboSoft), 2025, Página(s) 1-8
Editor: IEEE
DOI: 10.1109/robosoft63089.2025.11020816

Análisis de la influencia electromecánica en la predicción del riesgo arritmogénico inducido por fármacos

Autores: Priego-Saiz, L., Llopis-Lorente, J., Mora, M.T., Daversin-Catty, C., van Herck, I., Finsberg, H., Arevalo, H., Saiz, J., Trenor, B.
Publicado en: XLII Congreso Anual de la Sociedad Española de Ingeniería Biomédica (CASEIB 2024)., Edición XLII Congreso Anual de la Sociedad Española de Ingeniería Biomédica (CASEIB 2024)., 2024, Página(s) 549-552, ISBN 978-84-09-67332-2
Editor: CASEIB

Examining flow dynamics after left atrial appendage occlusion using CFD simulations: Influence of device implant depth

Autores: Jordi Mill, Carlos Albors, Pedro Cepas-Guillen, Manal Barrouhou, Íñigo Anduaga, Laura Sanchis, Ana Laffond, Ignacio Cruz-Gonzalez, Xavier Freixa, Oscar Camara
Publicado en: VPH Conference 2024 Data-Driven Simulation Technologies for Clinical Decision Making, 2024
Editor: VPH Institute

Impact of Blood Rheological Strategies on the Optimization of Patient-Specific LAAO Configurations for Thrombus Assessment.

Autores: Albors, C., Olivares, A. L., Iriart, X., Cochet, H., Mill, J., & Camara, O
Publicado en: Lecture Notes in Computer Science, Edición 13958, 2023, ISBN 978-3-031-35302-4
Editor: SPRINGER LINK
DOI: 10.1007/978-3-031-35302-4_50

Sensitivity Analysis in a Rescaled 0D Pacemaker-Bimembrane Model

Autores: Valentin Pannetier, Michael Leguèbe, Yves Coudière, Gwladys Ravon, Delphine Feuerstein, Guilhem Fauré, Richard Walton
Publicado en: Computing in Cardiology Conference (CinC), 2024 Computing in Cardiology Conference (CinC), Edición 51, 2024
Editor: Computing in Cardiology
DOI: 10.22489/cinc.2024.317

Comparison of 4D flow magnetic resonance imaging with blood flow simulations before and after left atrial appendage occlusion

Autores: Paula Casademunt, Xabier Morales Ferez, Jordi Mill, Carlos Albors, Íñigo Anduaga, Pedro Cepas, Ada Doltra, Xavier Freixa, Oscar Camara
Publicado en: VPH Conference 2024 Data-Driven Simulation Technologies for Clinical Decision Making, 2024
Editor: VPH Institute

In-silico Analysis of Device-Related Thrombosis for Different Left Atrial Appendage Occluder Settings

Autores: Eric Planas, Jordi Mill, Andy L. Olivares, Xabier Morales, Maria Isabel Pons, Xavier Iriart, Hubert Cochet, Oscar Camara
Publicado en: International Workshop on Statistical Atlases and Computational Models of the Heart, STACOM 2021, Edición Lecture Notes in Computer Science book series (LNIP, volume 13131), 2022, Página(s) 160-168, ISBN 978-3-030-93722-5
Editor: Springer, Cham
DOI: 10.1007/978-3-030-93722-5_18

Coagulation cascade systems modeling for oral anticoagulant monitorization in atrial fibrillation patients

Autores: Maria Segarra-Queralt, Marina Ribera, Andy L. Olivares, Oscar Camara
Publicado en: VPH Conference 2024 Data-Driven Simulation Technologies for Clinical Decision Making, 2024
Editor: VPH Institute

Unsupervised Machine Learning Exploration of Morphological and Haemodynamic Indices to Predict Thrombus Formation in the Left Atrial Appendage

Autores: Marta Saiz-Vivó, Jord Mill, Josquin Harrison, Guillermo Jimenez-Pérez, Benoit Legghe, Xavier Iriart, Hubert Cochet, Gemma Piella, Maxime Sermesant & Oscar Camara
Publicado en: Lecture Notes in Computer science, Edición 13593, 2023, ISSN 1611-3349
Editor: ACM DIGITAL LIBRARY
DOI: 10.1007/978-3-031-23443-9_19

Computational Study of Drug Effects on Different Atrial Fibrillation Stages

Autores: Violeta Puche-García, Lucía Romero, Javier Saiz
Publicado en: Computing in Cardiology 2023, Edición 50, 2023, ISSN 2325-887X
Editor: IEEE
DOI: 10.22489/cinc.2023.355

Réduire l’utilisation d’animaux avec des modèles in-silico : exemple de l’étude d’un pacemaker cardiaque

Autores: Coudière, Yves
Publicado en: Congrès de l'AFSTAL, 2024
Editor: AFSTAL

A causal discovery approach for streamline ion channels selection to improve drug-induced TdP risk assessment

Autores: Safaa Al-Ali, Jordi Llopis-Lorente, Maria Teresa Mora, Maxime Sermesant, Beatriz Trénor, Irene Balelli
Publicado en: 2023 Computing in Cardiology (CinC), Edición 50, 2023, Página(s) 1-4
Editor: IEEE
DOI: 10.22489/cinc.2023.009

Integrating soft robotics and computational models to study left atrial hemodynamics and device testing in sinus rhythm and atrial fibrillation

Autores: Ellen Roche, Manisha Singh, Keegan Mendez, Brian Ayers, Sophie Wang, Atsushi Takahashi, Debbie Teodorescu, Jordi Mill, Carlos Albors, Andreas Escher, Yiling Fan, Caglar Ozturk, Eve Sheridan, Emma Rutherford, Oscar Camara, Tarun Chakravarty
Publicado en: Nature Biomedical Engineering, 2025, ISSN 2157-846X
Editor: Nature Research
DOI: 10.21203/rs.3.rs-6283242/v1

Analysis of the response of human iPSC-derived cardiomyocyte tissue to ICaL block. A combined in vitro and in silico approach

Autores: Dasí, A., Hernández-Romero, I., Gomez, J. F., Climent, A. M., Ferrero, J. M., & Trenor, B.
Publicado en: Dasí, A., Hernández-Romero, I., Gomez, J. F., Climent, A. M., Ferrero, J. M., & Trenor, B., Edición Volume 137, October 2021, 104796, 2021, ISSN 0010-4825
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2021.104796

Arrhythmogenic Effects of Genetic Mutations Affecting Potassium Channels in Human Atrial Fibrillation: A Simulation Study

Autores: Belletti R., Romero L., Martinez-Mateu L., Cherry Elizabeth M., Fenton F. H., Saiz J.
Publicado en: Frontiers in Physiology,, Edición 12, 2021, ISSN 1664-042X
Editor: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.681943

Mapping the use of computational modelling and simulation in clinics: A survey

Autores: Lesage, Raphaëlle; Van Oudheusden, Michiel; Schievano, Silvia; Van Hoyweghen, Ine; Geris, Liesbet; Capelli, Claudio
Publicado en: Frontiers in Medical Technology, Edición 23, 2023, ISSN 2673-3129
Editor: Frontiers
DOI: 10.3389/fmedt.2023.1125524

Cardiomyopathy and thrombogenesis in cats through left atrial morphological and fluid dynamics analysis

Autores: Maria Isabel Pons, Andy L. Olivares, Jordi Mill, Jose Novo Matos, Patricia Garcia-Canadilla, Inma Cerrada, Anna Guy, Xabier Morales Ferez, J. Ciaran Hutchinson, Ian C. Simcock, Owen J. Arthurs, Andrew C. Cook, Virginia Luis Fuentes, Oscar Camara
Publicado en: Scientific Reports, Edición 15, 2025, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-025-96245-7

Automatic modeling of dynamic drug-hERG channel interactions using three voltage protocols and machine learning techniques: A simulation study

Autores: Fernando Escobar, Julio Gomis-Tena, Javier Saiz, Lucía Romero
Publicado en: Computer Methods and Programs in Biomedicine, Edición 226, 2022, ISSN 1872-7565
Editor: ELSEVIER
DOI: 10.1016/j.cmpb.2022.107148

Domain expert evaluation of advanced visual computing solutions and 3D printing for the planning of the left atrial appendage occluder interventions

Autores: Mill, J., Montoliu, H., Moustafa, A. H., Olivares, A. L., Albors, C., Aguado, A. M., ... & Camara, O
Publicado en: International journal of bioprinting, Edición 9, 2023, ISSN 2424-8002
Editor: AccScience Publishing
DOI: 10.18063/ijb.v9i1.640

Experimentally validated modeling of dynamic drug-hERG channel interactions reproducing the binding mechanisms and its importance in action potential duration

Autores: Fernando Escobar, Soren Friis, Nouran Adly, Nina Brinkwirth, Julio Gomis-Tena, Javier Saiz, Dan A. Klaerke, Sonja Stoelzle-Feix, Lucia Romero
Publicado en: Computer Methods and Programs in Biomedicine, 2024, ISSN 0169-2607
Editor: Elsevier BV
DOI: 10.1016/j.cmpb.2024.108293

Prediction of Drug-Induced Arrhythmogenic Risk Using In Silico Populations of Models

Autores: Jordi Llopis-Lorente, Beatriz Trénor, Javier Saiz
Publicado en: Computing in Cardiology (CinC), Edición Vol 48, 2021, Página(s) 1-4, ISSN 2169-3536
Editor: Institute of Electrical and Electronics Engineers Inc.
DOI: 10.23919/cinc53138.2021.9662679

The role of the pulmonary veins on left atrial flow patterns and thrombus formation

Autores: Jordi Mill, Josquin Harrison, Marta Saiz-Vivo, Carlos Albors, Xabier Morales, Andy L. Olivares, Xavier Iriart, Hubert Cochet, Jerome Noailly, Maxime Sermesant, Oscar Camara
Publicado en: Scientific Reports, Edición 14, 2024, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-024-56658-2

In silico estimation of thrombogenic risk after left atrial appendage excision: Towards digital twins in atrial fibrillation

Autores: Carlos Albors, Nerea Arrarte Terreros, Marta Saiz-Vivó, Pietro Zappala, Marc M. Terpstra, Andy L. Olivares, R. Nils Planken, WimJan P. van Boven, Antoine H.G. Driessen, Joris R. de Groot, Oscar Camara
Publicado en: Computers in Biology and Medicine, Edición 194, 2025, Página(s) 110483, ISSN 0010-4825
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2025.110483

VaMPy: An Automated and Objective Pipeline for Modeling Vascular Geometries

Autores: Henrik A. Kjeldsberg; Aslak W. Bergersen; Kristian Valen-Sendstad
Publicado en: Journal of Open Source Software, 2023, ISSN 2475-9066
Editor: Open Journals
DOI: 10.21105/joss.05278

Insights from electromechanical simulations to assess omecamtiv mecarbil efficacy in heart failure

Autores: Maria Teresa Mora, Ilse van Herck, Cécile Daversin‐Catty, Henrik Finsberg, Jordi Llopis‐Lorente, Javier Saiz, Hermenegild Arevalo, Samuel Wall, Beatriz Trenor
Publicado en: The Journal of Physiology, 2025, ISSN 0022-3751
Editor: Blackwell Publishing Inc.
DOI: 10.1113/jp288233

Integration of electrophysiological and mechanical biomarkers in cardiac risk assessment models

Autores: Lucia Priego, Maria Teresa Mora, Jordi Llopis-Lorente, Henrik Finsberg, Cecile Daversin-Catty, Ilsbeth Van Herck, Samuel Wall, Hermenegild Arevalo, Francisco Javier Saiz, Beatriz Trenor
Publicado en: Computer Methods and Programs in Biomedicine, Edición 269, 2025, Página(s) 108896, ISSN 0169-2607
Editor: Elsevier BV
DOI: 10.1016/j.cmpb.2025.108896

Impact of segregation scheme on performance of a strongly coupled cardiac electromechanical solver

Autores: Lena Myklebust, Hermenegild Arevalo, Cécile Daversin-Catty, Samuel T. Wall, Henrik N.T. Finsberg
Publicado en: Computer Methods in Applied Mechanics and Engineering, Edición 446, 2025, Página(s) 118270, ISSN 0045-7825
Editor: Elsevier BV
DOI: 10.1016/j.cma.2025.118270

simcardems: A FEniCS-based cardiac electro-mechanics solver

Autores: Henrik Nicolay Topnes Finsberg; Ilsbeth Gerarda Maria van Herck; Cécile Daversin-Catty; Hermenegild Arevalo; Samuel Wall
Publicado en: Journal of Open Source Software, 2023, ISSN 2475-9066
Editor: Open Journals
DOI: 10.21105/joss.04753

Uncertainty assessment of proarrhythmia predictions derived from multi‑level in silico models

Autores: Karolina Kopanska, Pablo Rodríguez‑Belenguer, Jordi Llopis‑Lorente, Beatriz Trenor, Javier Saiz, Manuel Pastor
Publicado en: Archives of Toxicology, Edición 97, 2023, ISSN 1432-0738
Editor: Springer
DOI: 10.1007/s00204-023-03557-6

Impact of occluder device configurations in in-silico left atrial hemodynamics for the analysis of device-related thrombus

Autores: Carlos Albors, Jordi Mill, Andy L. Olivares, Xavier Iriart, Hubert Cochet, Oscar Camara
Publicado en: PLOS Computational Biology, 2025, ISSN 1553-7358
Editor: San Francisco CA: Public Library of Science, 2005-
DOI: 10.1101/2024.01.11.575154

Left Atrial Thrombus-Are All Atria and Appendages Equal?

Autores: Cresti A, Camara O
Publicado en: Interventional Cardiology Clinics, 2022, ISSN 2211-7458
Editor: Elsevier BV
DOI: 10.1016/j.iccl.2021.11.005

On The Importance of Fundamental Computational Fluid Dynamics Towards a Robust and Reliable Model of Left Atrial Flows: Is There More Than Meets the Eye?

Autores: Khalili, Ehsan; Daversin-Catty, C'ecile; Olivares, Andy L.; Mill, Jordi; Camara, Oscar; Valen-Sendstad, Kristian
Publicado en: International Journal for Numerical Methods in Biomedical Engineering, 2023, ISSN 2040-7939
Editor: John Wiley & Sons Ltd.
DOI: 10.48550/arxiv.2302.01716

Analysis of vulnerability to reentry in acute myocardial ischemia using a realistic human heart model.

Autores: Carpio, E. F., Gomez, J. F., Rodríguez-Matas, J. F., Trenor, B., & Ferrero, J. M.
Publicado en: Computers in Biology and Medicine., Edición 141, 2021, ISSN 0010-4825
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2021.105038

Impact of left atrial wall motion assumptions in fluid simulations on proposed predictors of thrombus formation

Autores: Henrik A. Kjeldsberg, Carlos Albors, Jordi Mill, David Viladés Medel, Oscar Camara, Joakim Sundnes, Kristian Valen‐Sendstad
Publicado en: International Journal for Numerical Methods in Biomedical Engineering, Edición 40, 2024, ISSN 2040-7939
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/cnm.3825

Digital twin integrating clinical, morphological and hemodynamic data to identify stroke risk factors

Autores: Marta Saiz-Vivó, Jordi Mill, Xavier Iriart, Hubert Cochet, Gemma Piella, Maxime Sermesant, Oscar Camara
Publicado en: npj Digital Medicine, Edición 8, 2025, ISSN 2398-6352
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41746-025-01676-1

Insights from an electro-mechanical heart failure cell model: Role of SERCA enhancement on arrhythmogenesis and myocyte contraction

Autores: Maria Teresa Mora, Antonio Zaza, Beatriz Trenor
Publicado en: Computer Methods and Programs in Biomedicine, Edición 230, 2023, ISSN 2666-9900
Editor: ELSEVIER
DOI: 10.1016/j.cmpb.2023.107350

A verified and validated moving domain CFD solver with applications to cardiovascular flows

Autores: Kjeldsberg, Henrik A.; Sundnes, Joakim; Valen-Sendstad, Kristian
Publicado en: International Journal for Numerical Methods in Biomedical Engineering, 2023, ISSN 2040-7939
Editor: John Wiley & Sons Ltd.
DOI: 10.48550/arxiv.2305.15539

Left atrial haemodynamic evaluation using 4D flow cardiac magnetic resonance imaging: application to hypertension and hypertrophic cardiomyopathy

Autores: X Morales Ferez, A Elsayed, D Zhao, F Loncaric, G Quill, K Gilbert, R Dunphy, M Ramos, A Doltra, M Sitges, B Lowe, A Young, M Nash, O Camara, B Bijnens
Publicado en: European Heart Journal, Edición 44, 2023, ISSN 0195-668X
Editor: Oxford University Press
DOI: 10.1093/eurheartj/ehad655.240

Application of Machine Learning to improve the efficiency of electrophysiological simulations used for the prediction of drug-induced ventricular arrhythmia

Autores: Pablo Rodriguez-Berenguer, Karolina Kopanska, Jordi Llopis-Lorente , Beatriz Trenor , Javier Saiz , Manuel Pastor.
Publicado en: Computer Methods and Programs in Biomedicine, Edición 230, 2023, ISSN 2666-9900
Editor: ELSEVIER
DOI: 10.1016/j.cmpb.2023.107345

Considering population variability of electrophysiological models improves the assessment of drug-induced torsadogenic risk

Autores: Llopis-Lorente, J., Trenor, B., & Saiz, J.
Publicado en: Computer Methods and Programs in Biomedicine, Edición Vol 221C June 2022, 2022, Página(s) 106934, ISSN 0169-2607
Editor: Elsevier BV
DOI: 10.1016/j.cmpb.2022.106934

Deep Learning Framework for Real-Time Estimation of in-silico Thrombotic Risk Indices in the Left Atrial Appendage

Autores: Xabier Morales Ferez; Jordi Mill; Kristine Aavild Juhl; Cesar Acebes; Xavier Iriart; Benoit Legghe; Hubert Cochet; Ole De Backer; Rasmus Reinhold Paulsen; Oscar Camara
Publicado en: Frontiers in Physiology, 2021, ISSN 1664-042X
Editor: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.694945

A simulation study of the impact of drug-IKr binding mechanisms on biomarkers of proarrhythmic risk reveals a crucial role in reverse use-dependence of action potential duration and a marked influence on the vulnerable window

Autores: Julio Gomis-Tena, Fernando Escobar, Lucia Romero
Publicado en: Computer Methods and Programs in Biomedicine, Edición 260, 2025, Página(s) 108566, ISSN 0169-2607
Editor: Elsevier BV
DOI: 10.1016/j.cmpb.2024.108566

Sensitivity Analysis of In Silico Fluid Simulations to Predict Thrombus Formation after Left Atrial Appendage Occlusion

Autores: Mill J, Agudelo V, Olivares AL, Pons MI, Silva E, Nuñez-Garcia M, Morales X, Arzamendi D, Freixa X, Noailly J, Camara O
Publicado en: Mathematics, 2022, ISSN 2227-7390
Editor: MDPI
DOI: 10.3390/math9182304

Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibility

Autores: Flora T. Musuamba, Ine Skottheim Rusten, Raphaëlle Lesage, Giulia Russo, Roberta Bursi, Luca Emili, Gaby Wangorsch,Efthymios Manolis, Kristin E. Karlsson, Alexander Kulesza, Eulalie Courcelles, Jean- Pierre Boissel, Cécile F. Rousseau,Emmanuelle M. Voisin,Rossana Alessandrello, Nuno Curado, Enrico Dall’ara, Blanca Rodriguez, Francesco Pappalardo, Liesbet Geris
Publicado en: CPT Pharmacometrics Syst Pharmacol., Edición 2021, 8 June, 2021, Página(s) 804-825, ISSN 2163-8306
Editor: Nature Publishing Group
DOI: 10.1002/psp4.12669

Modeling Cardiac Stimulation by a Pacemaker, with Accurate Tissue-Electrode Interface

Autores: Pannetier, Valentin and Leguèbe, Michael and Coudière, Yves and Walton, Richard and Dhiver, Philippe and Feuerstein, Delphine and Amaro, Diego
Publicado en: Functional Imaging and Modeling of the Heart, 2023, Página(s) 194 - 203, ISBN 978-3-031-35302-4
Editor: Springer Nature Switzerland
DOI: 10.1007/978-3-031-35302-4_20

Quantitative Comparison of Blood Flow Patterns from in Silico Simulations and 4D Flow Data Before and After Left Atrial Occlusion

Autores: Paula Casademunt, Xabier Morales, Pedro Cepas-Guillén, Ada Doltra, Jordi Mill, Marta Saiz-Vivó, Eduardo Flores-Umanzor, Laura Sanchis, Xavier Freixa, Oscar Camara
Publicado en: Lecture Notes in Computer Science, Statistical Atlases and Computational Models of the Heart. Workshop, CMRxRecon and MBAS Challenge Papers., 2025, Página(s) 75-86
Editor: Springer Nature Switzerland
DOI: 10.1007/978-3-031-87756-8_8

Sensitivity Analysis of Left Atrial Wall Modeling Approaches and Inlet/Outlet Boundary Conditions in Fluid Simulations to Predict Thrombus Formation

Autores: Albors, C., Mill, J., Kjeldsberg, H. A., Viladés Medel, D., Olivares, A. L., Valen-Sendstad, K., & Camara, O
Publicado en: Lecture Notes in Computer Science, Edición 13593, 2023, ISSN 0302-9743
Editor: SPRINGER LINK
DOI: 10.1007/978-3-031-23443-9_17

Automatic Identification of Optimal Transseptal Puncture Localization and Device Configuration with Patient-Specific Haemodynamic Modelling in Patients Undergoing Left Atrial Appendage Occlusion

Autores: Marta Saiz-Vivó, Jordi Mill, Ainhoa M. Aguado, Nahomy Rochelle, Anna Barredo, Carlos Albors, Mònica Font, Pedro Cepas-Guillén, Xavier Freixa, Manuel Barreiro-Perez, Oscar Camara
Publicado en: Lecture Notes in Computer Science, Functional Imaging and Modeling of the Heart, 2025, Página(s) 330-340
Editor: Springer Nature Switzerland
DOI: 10.1007/978-3-031-94562-5_30

Towards Validation of Two Computational Models of Artificial Pacemakers

Autores: Valentin Pannetier, Michael Leguèbe, Yves Coudière, Richard Walton, Guilhem Fauré, Romano Setzu
Publicado en: Lecture Notes in Computer Science, Functional Imaging and Modeling of the Heart, 2025, Página(s) 127-137
Editor: Springer Nature Switzerland
DOI: 10.1007/978-3-031-94559-5_12

Chapter 7 - Machine learning and biophysical models: how to benefit each other?

Autores: Nicolas Duchateau, Oscar Camara
Publicado en: Reduced Order Models for the Biomechanics of Living Organs Edited by: Francisco Chinesta, Elías Cueto, ... Jacques Ohayon, 2023, Página(s) 147-164, ISBN 978-0-323-89967-3
Editor: ELSEVIER
DOI: 10.1016/b978-0-32-389967-3.00009-3

Multi-therapeutic Modelling for Stroke Prevention in Atrial Fibrillation: Impact of the Pulmonary Ridge

Autores: Maria Segarra-Queralt, Manal Barrouhou-Berrouhou, Marc Molla, Marina Ribera, Carlos Albors, Andy L. Olivares, Gabriel Bernardino, Jordi Mill, Oscar Camara
Publicado en: Lecture Notes in Computer Science, Functional Imaging and Modeling of the Heart, 2025, Página(s) 197-205
Editor: Springer Nature Switzerland
DOI: 10.1007/978-3-031-94559-5_18

An Experimental Setup for the Analysis of Patient-Specific Left Atrial Appendage with Particle Image Velocimetry Investigation

Autores: Emanuele Gasparotti, Emanuele Vignali, Rachele Marangoni, Jordi Mill, Andy L. Olivares, Carlos Albors, Manal Barrouhou-Berrouhou, Oscar Camara, Simona Celi
Publicado en: Lecture Notes in Computer Science, Functional Imaging and Modeling of the Heart, 2025, Página(s) 186-196
Editor: Springer Nature Switzerland
DOI: 10.1007/978-3-031-94559-5_17

Towards Real-Time Optimization of Left Atrial Appendage Occlusion Device Placement Through Physics-Informed Neural Networks.

Autores: Morales, X., Albors, C., Mill, J., & Camara, O.
Publicado en: Lecture Notes in Computer Science, Edición 13593, 2022, ISSN 1611-3349
Editor: Springer
DOI: 10.1007/978-3-031-23443-9_4

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