Artificial Intelligence-driven, Decentralized Production for Advanced Therapies in the Hospital

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Stakeholder centric design principles ensuring trust and acceptance
Results dissemination campaign plan
Societal Guide for implementing Smart Manufacturing Hospitals

Data management plan

Publications

Elaborating the potential of Artificial Intelligence in automated CAR-T cell manufacturing

Auteurs: Niklas Bäckel, Tamás Kis, David F. Nettleton, Joseph R. Egan, John J. L. Jacobs, Dennis Grunert, Robert H. Schmitt
Publié dans: Frontiers in Molecular Medicine, 2023
Éditeur: Frontiers
DOI: 10.3389/fmmed.2023.1250508

How can digitalisation and AI improve CAR-T cell manufacturing?

Auteurs: Simon Hort
Publié dans: Advanced Therapies Europe 2023, 2023
Éditeur: Fraunhofer Publica
DOI: 10.24406/publica-2433

Process Development and Manufacturing: Impact Of Xeno-Free And Serum Free Medium Formulations For Car-T Cell Manufacturing

Auteurs: P. Silva Couto, P. Springuel, Q.A. Rafiq
Publié dans: 2023
Éditeur: Elsevier
DOI: 10.1016/s1465-3249(23)00527-3

AIDPATH - Modular Approach to AI-Enabled CAR-T Cell Manufacturing

Auteurs: Erkens, Frederik
Publié dans: Numéro 1, 2022
Éditeur: International Forum on Cell Manufacturing & Engineeing 2022
DOI: 10.24406/publica-574

Optimising Perfusion Parameters Using Quality By Design For The Intensified Production Of Car T Cells In A Single-Use Automated Stirred-Tank Bioreactor

Auteurs: P. Springuel, T. Hood, F. Slingsby, N. Bevan, W. Geis, V. Sandner, T. Schmidberger, J. Hengst, N. Dianat, Q.A. Rafiq
Publié dans: 2023
Éditeur: Elsevier
DOI: 10.1016/s1465-3249(23)00528-5

How can digitalization and automation enable large-scale application of CAR-T cell therapies?

Auteurs: Frederik Erkens
Publié dans: 2023
Éditeur: Fraunhofer publica
DOI: 10.24406/publica-2040

Trust in and Acceptance of Artificial Intelligence Applications in Medicine: Mixed Methods Study

Auteurs: Daria Shevtsova 1, 2 Author Orcid Image ; Anam Ahmed 1 Author Orcid Image ; Iris W A Boot 1 Author Orcid Image ; Carmen Sanges 3 Author Orcid Image ; Michael Hudecek 3 Author Orcid Image ; John J L Jacobs 4 Author Orcid Image ; Simon Hort 5 Author Orcid Image ; Hubertus J M Vrijhoef 1 Author Orcid Image
Publié dans: JMIR Human Factors, 2024, ISSN 2292-9495
Éditeur: JMIR Publications
DOI: 10.2196/47031

Smart Sensor Control and Monitoring of an Automated Cell Expansion Process

Auteurs: David F. Nettleton; Núria Marí-Buyé; Helena Marti-Soler; Joseph R. Egan; Simon Hort; David Horna; Miquel Costa; Elia Vallejo Benítez-Cano; Stephen Goldrick; Qasim A. Rafiq; Niels König; Robert H. Schmitt; Aldo R. Reyes
Publié dans: Sensors, 2023, ISSN 1424-8220
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s23249676

Toward Rapid, Widely Available Autologous CAR-T Cell Therapy – Artificial Intelligence and Automation Enabling the Smart Manufacturing Hospital

Auteurs: Hort S, Herbst L, Bäckel N, Erkens F, Niessing B, Frye M, König N, Papantoniou I, Hudecek M, Jacobs JJL and Schmitt RH
Publié dans: Frontiers in Medicine, 2022, ISSN 2296-858X
Éditeur: Frontiers Media
DOI: 10.3389/fmed.2022.913287

Towards Automated Car-T Cell Manufacturing - Keeping up with Technological Advancement

Auteurs: Laura Herbst
Publié dans: 2023
Éditeur: Fraunhofer publica
DOI: 10.1016/s1465-3249(22)00437-6

Digital transformation of CAR-T cell therapy – challenges and potential for Industry 4.0

Auteurs: Simon Hort , Carmen Sanges , John J.L. Jacobs , Michael Hudecek , Robert H. Schmitt
Publié dans: Procedia CIRP International Conference on Manufacturing Systems 2023, Numéro 120, 2023, ISSN 2212-8271
Éditeur: Elsevier BV
DOI: 10.1016/j.procir.2023.09.121

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