Project description DEENESFRITPL Preventing dementia in the early stages of development Dementia, the most severe expression of cognitive impairment, currently affects nearly 50 million individuals worldwide. It has been shown that non-pharmacological interventions seem to have a positive impact on the onset of cognitive decline and dementia related risk factors. The EU-funded LETHE project aims to provide a data-driven risk factor prediction model for older individuals at risk of cognitive decline building upon big data analysis of observational and longitudinal intervention datasets from four European clinical centres. It will establish novel digital biomarkers for early detection of risk factors based on unobtrusive ICT-based passive and active monitoring. The aim of the project is a digital ICT-based preventive lifestyle intervention through individualised profiling, personalised recommendations, feedback and support. Show the project objective Hide the project objective Objective As the world's population increases in age, the number of people living with dementia grows. Dementia has long been considered to be neither preventable nor treatable, but while the underlying illnesses are not curable, today we know that the disease course might be modifiable with good preventive interventions at an early time point. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) showed a positive effect after a 2-year intervention targeting several lifestyles and vascular risk factors simultaneously. LETHE will go beyond and provide a data-driven risk factor prediction model for older individuals at risk of cognitive decline building upon big data analysis of cross-sectional observational and longitudinal intervention datasets from 4 clinical centers in Europe including the 11- years analysis of FINGER. LETHE will establish novel digital biomarkers, for early detection of risk factors, based on unobtrusive ICT-based passive and active monitoring. The aim is to establish a digital-enabled intervention for cognitive decline prevention based on the evolution of a successful protocol (FINGER) evolving into an ICT based preventive lifestyle intervention through individualized profiling, personalized recommendations, feedback and support (FINGER 2.0) well targeted on a population stratified by cost-effective biological biomarkers. The LETHE solution will be tested in a feasibility study validating the achieved improvements. A successful LETHE project could lead to a more personalized risk factor prevention for persons with beginning cognitive decline, thereby empowering people to an active and healthy lifestyle. Expansions of prevention trials on large scale by an automatized roll out of a multimodal intervention approach, reaching out to large populations, could save future costs on expensive traditional interventions and confer benefits for the wider society. Fields of science natural sciencescomputer and information sciencesdata sciencebig datamedical and health sciencesbasic medicineneurologydementianatural sciencescomputer and information sciencesartificial intelligencemachine learning Keywords data-driven prediction model cognitive decline dementia risk factors lifestyle intervention Programme(s) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme H2020-EU.3.1.4.2. - Individual awareness and empowerment for self-management of health Topic(s) SC1-DTH-02-2020 - Personalised early risk prediction, prevention and intervention based on Artificial Intelligence and Big Data technologies Call for proposal H2020-SC1-DTH-2018-2020 See other projects for this call Sub call H2020-SC1-DTH-2020-1 Funding Scheme RIA - Research and Innovation action Coordinator FH JOANNEUM GESELLSCHAFT MBH Net EU contribution € 642 000,00 Address Alte poststrasse 149 8020 Graz Austria See on map Region Südösterreich Steiermark Graz Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (14) Sort alphabetically Sort by Net EU contribution Expand all Collapse all MEDIZINISCHE UNIVERSITAET WIEN Austria Net EU contribution € 502 317,50 Address Spitalgasse 23 1090 Wien See on map Region Ostösterreich Wien Wien Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITA DEGLI STUDI DI PERUGIA Italy Net EU contribution € 408 750,00 Address Piazza dell universita 1 06123 Perugia See on map Region Centro (IT) Umbria Perugia Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 KAROLINSKA INSTITUTET Sweden Net EU contribution € 481 262,49 Address Nobels vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 TERVEYDEN JA HYVINVOINNIN LAITOS Finland Net EU contribution € 750 625,00 Address Mannerheimintie 166 00271 Helsinki See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ALZHEIMER EUROPE Luxembourg Net EU contribution € 222 500,00 Address Rue dicks 14 1417 Luxembourg See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Luxembourg Luxembourg Luxembourg Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 IDRYMA TECHNOLOGIAS KAI EREVNAS Greece Net EU contribution € 495 000,00 Address N plastira str 100 70013 Irakleio See on map Region Νησιά Αιγαίου Κρήτη Ηράκλειο Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITEIT MAASTRICHT Netherlands Net EU contribution € 287 022,50 Address Minderbroedersberg 4 6200 MD Maastricht See on map Region Zuid-Nederland Limburg (NL) Zuid-Limburg Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 KAASA SOLUTION GMBH Germany Net EU contribution € 347 500,00 Address Flinger strasse 11 40213 Dusseldorf See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Nordrhein-Westfalen Düsseldorf Düsseldorf, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 I2GROW INNOVATION TO GROW SRL Italy Net EU contribution € 288 706,25 Address Via andrea appiani 12 20121 Milano See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Nord-Ovest Lombardia Milano Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 STICHTING EGI Netherlands Net EU contribution € 339 500,00 Address Science park 140 1098 XG Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Other Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 EXTRA RED SRL Italy Net EU contribution € 305 875,00 Address Via salvo d'acquisto 40/p 56025 Pontedera See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Centro (IT) Toscana Pisa Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 INFOTREND INNOVATIONS COMPANY LIMITED Cyprus Net EU contribution € 328 750,00 Address Demonaktos street 13 1017 Lefkosia See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Κύπρος Κύπρος Κύπρος Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 COMBINOSTICS OY Finland Net EU contribution € 387 580,00 Address Hatanpään valtatie 24 33100 Tampere See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Manner-Suomi Länsi-Suomi Pirkanmaa Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 THE LISBON COUNCIL FOR ECONOMIC COMPETITIVENESS ASBL Belgium Net EU contribution € 212 500,00 Address Rue de la loi 155 residence palace ipc 1040 Bruxelles / brussel See on map Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Activity type Other Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00