Deliverables
Document describing the conceptual framework for the insilico trial impact assessment
Project handbookReference document indicating standards for project management internal communication meetings and reporting
Project presentationDocument presenting project rationale mission goals and expected outcomes in common language to be used as base for the launch of initial press releases and production of preliminary communication materials
Validated constitutive models of the vessel wallReport on constitutive model validation
Quality assurance guidelinesReference document with procedures and best practices to guarantee quality of reporting
Constitutive vessel modelSimplified vessel model describing the homogeneous behavior of the vessel once in contact with the device
Self-assessment planReference document indicating specific goals and key performance indicators for selfassessment of WP activities
Report on 3D finite element simulationReport on the results of 3D simulations for a subset of patients.
First version of the simulation modelsA document that describes the selection of the first version of simulation models for virtual cohort generation and the installation of models within the computing framework for the parallel simulation of multiple patient datasets
Reduced order modelDescription of the reduced order model implemented in a prototype
Sensitivity and uncertainty quantification toolboxA report that demonstrates the proofofprinciple of the application of uncertainty quantification and sensitivity analysis to both use cases
System requirementsDocument describing the defined technical requirements for the adaptation and extension of the cloudbased infrastructure its integration structure and workflow elements
Guidelines for documentationProviding guidelines for documentation of reports for hemodynamic studies of TAVI in medical device submissions
Data management planDocument describing how data will be acquired processed and stored in compliance with privacy and security obligations
Communication and dissemination strategy planDocument describing the overall project strategy for communication and dissemination including analysis of primary and secondary audiences envisaged strategies and preliminarily produced materials
Definition of model outputA document with definition of the outputs of interests their correlations and their joint probability density functions for each of the two insilico clinical trials in WP9
Conceptual framework reportReport describing the conceptual framework that illustrates all effect channels that the use of virtual cohorts and computer simulations may have
Enhanced constitutive vessel modelReport on development and parameterization of enhanced constitutive vessel models of the pulmonary artery and aortic sinus.
First version of the definition of the input spaceA document that elaborates on how the available data templates are converted to a first definition of the input space ie based on expert opinion
Kick-off meeting reportReport on topics issues and outcomes of the project kickoff meeting
Regulatory feedback report (1)Report incorporating feedback from the first and second round up with regulatory authorities on SOPs, virtual cohort generation, device effect simulation and translation into the clinical setting.
Uncertainty quantification and re-definition of input spaceA document describing how the input space can be redefined based on the results of a sensitivity analysis and it can reduce the output uncertainty for both use cases
Providing standards and workflow for preclinical and clinical data acquisition.
Fast device deployment modelModelling of the fast device deployment process implemented in a prototype.
Specification of data-processing requirementsA protocol specifying imaging modality settings (resolutions, quality measures, formats) for TAVI and PAPS.
Specification and quantification of synthetic boundary conditionsAn elaboration of specification for synthetic boundary condition generation (standards, quality measures, formats).
SOPs for data processing for in-silico modelsDescribing procedures and workflows for the processing of preclinical (in vitro, in vivo) and clinical data (imaging, sensor data) for generating virtual cohorts.
Specification and quantification of subject-specific data-based boundary conditionsAn elaboration of specification describing formats and resolution of clinical imaging and sensor data used for simulations with subject-specific boundary conditions.
SOPs for in-silico analysis of TAVIProviding standard protocols for performing CFD and FSI simulation as well as PIV measurements of TAVI in medical device submissions
SOPs for virtual cohorts generation and validationDescribing procedures for optimal virtual cohort generation and validation.
IGA modelIGA based model for 3D device deployment simulation
Uncertainty quantification for input dataTools, parameters and methods for quantification of clinical data used as boundary conditions for simulations and for validation.
SOPs for validation of in-silico modelsProviding standard protocols for multi-level validation of in-silico models
Accurate validated virtual cohorts will be delivered for both use cases.
Publications
Author(s):
Pjotr Hilhorst
Published in:
NO JOURNAL TITLE, Issue 5, 2022
Publisher:
Zenodo
DOI:
10.5281/zenodo.7225277
Author(s):
Jan Brüning
Published in:
2023
Publisher:
ESB2023
DOI:
10.5281/zenodo.8164649
Author(s):
Huberts, Wouter
Published in:
2021
Publisher:
OpenAIRE
DOI:
10.5281/zenodo.6146528
Author(s):
Huberts, Wouter
Published in:
2022
Publisher:
N/A
DOI:
10.5281/zenodo.7036217
Author(s):
Anna Rizzo
Published in:
NA, Issue NA, 2021, Page(s) NA
Publisher:
NA
DOI:
10.5281/zenodo.4750993
Author(s):
Brüning, Jan
Published in:
2021
Publisher:
OpenAIRE
DOI:
10.5281/zenodo.5094742
Author(s):
Bruning, Jan; Krüger, Nina; Goubergrits, Leonid; Lesage, Raphaëlle; Huberts, Wouter; Schievano, Silvia
Published in:
2021
Publisher:
OpenAIRE
DOI:
10.5281/zenodo.6150519
Author(s):
Andreas Arndt
Published in:
2023
Publisher:
ESB2023
DOI:
10.5281/zenodo.8164674
Author(s):
Wouter Huberts
Published in:
2023
Publisher:
ESB2023
DOI:
10.5281/zenodo.8164594
Author(s):
Rizzo, Anna
Published in:
2021
Publisher:
OpenAIRE
DOI:
10.5281/zenodo.5095494
Author(s):
Rizzo, Anna; Servidio, Stefania
Published in:
Issue 2, 2022
Publisher:
N/A
DOI:
10.5281/zenodo.6151181
Author(s):
Huberts, Wouter; Verstraeten, Sabine; Brüning, Jan
Published in:
Issue 3, 2023
Publisher:
Zenodo
DOI:
10.5281/zenodo.10670423
Author(s):
Rizzo, Anna
Published in:
2021
Publisher:
OpenAIRE
DOI:
10.5281/zenodo.4644534
Author(s):
Rizzo, Anna
Published in:
2021
Publisher:
OpenAIRE
DOI:
10.5281/zenodo.4664231
Author(s):
De Maldè, Mirko
Published in:
2021
Publisher:
OpenAIRE
DOI:
10.5281/zenodo.4644568
Author(s):
Goubergrits, Leonid; Kruger, Nina; Bruning, Jan
Published in:
2022
Publisher:
N/A
DOI:
10.5281/zenodo.7105663
Author(s):
Anna Rizzo
Published in:
2021
Publisher:
OpenAIRE
DOI:
10.5281/zenodo.4750992
Author(s):
Huberts, Wouter
Published in:
2021
Publisher:
OpenAIRE
DOI:
10.5281/zenodo.6074807
Author(s):
Schievano, Silvia; Capelli, Claudio; Bruning, Jan; Lesage, Raphaelle; Ohmann, Christian; Panagiotopoulou, Maria; Montgomery Liljeroth, Ebba; Staument, Bernard
Published in:
2022
Publisher:
N/A
DOI:
10.5281/zenodo.7041346
Author(s):
Raphaëlle; Michiel; Silvia; Ine; Claudio; Giulia; Martina; Roberta; Goran
Published in:
NA, Issue NA, 2022, Page(s) NA
Publisher:
VPH Institute
DOI:
10.5281/zenodo.7974392
Author(s):
Huberts, Wouter
Published in:
2021
Publisher:
OpenAIRE
DOI:
10.5281/zenodo.6150326
Author(s):
Pablo E. Verde
Published in:
2023
Publisher:
ESB2023
DOI:
10.5281/zenodo.8164661
Author(s):
De Maldè, Mirko
Published in:
2021
Publisher:
OpenAIRE
DOI:
10.5281/zenodo.5095412
Author(s):
Huberts, Wouter; Stiehm, Michael; Borowsky, Finja; Oldeburg, Jan
Published in:
2022
Publisher:
N/A
DOI:
10.5281/zenodo.7041286
Author(s):
Sabine Verstraeten; Frans van de Vosse; Wouter Huberts
Published in:
2023
Publisher:
ESB2023
DOI:
10.5281/zenodo.8164617
Author(s):
Stiehm, Michael; Brüning, Jan; Lesage, Raphaëlle; Czypionka, Thomas; Oldenburg, Jan; Huberts, Wouter; Rolf-Pissarczyk, Malte; Luther; Torsten; Staumont, Bernard; Geris, Liesbet
Published in:
2021
Publisher:
OpenAIRE
DOI:
10.5281/zenodo.6150904
Author(s):
De Maldè, Mirko
Published in:
2021
Publisher:
OpenAIRE
DOI:
10.5281/zenodo.5095487
Author(s):
Aydin, Burç; Ohmann, Christian
Published in:
2021
Publisher:
OpenAIRE
DOI:
10.5281/zenodo.6353627
Author(s):
Michelle Spanjaards, Finja Borowski, Laura Supp, René Ubachs, Valentina Lavezzo & Olaf van der Sluis
Published in:
Biomechanics and Modeling in Mechanobiology, 2024, ISSN 1617-7940
Publisher:
Springer
DOI:
10.1007/s10237-024-01816-8
Author(s):
Burç Aydin, Eanna Kiely, Christian Ohmann
Published in:
Journal of the Society of Clinical Data Management, Issue Volume 3, Issue 3 2023, Fall 2023, 2023, ISSN 2694-1473
Publisher:
Society of clinical data management
DOI:
10.47912/jscdm.230
Author(s):
Leonid Goubergrits, Marie Schafstedde, Nikola Cesarovic, Angelika Szengel, Boris Schmitt, Moritz Wiegand, Jan Romberg 4, Andreas Arndt 4, Titus Kuehne 1,2 & Jan Brüning 1,2*
Published in:
Scientific reports, 2023, ISSN 2045-2322
Publisher:
Nature Publishing Group
DOI:
10.1038/s41598-023-47532-8
Author(s):
Oldenburg, Jan, Borowski, Finja, Kaule, Sebastian, Schmitz, Klaus-Peter, Öner, Alper and Stiehm, Michael.
Published in:
tm - Technisches Messen, 2023, ISSN 2196-7113
Publisher:
Oldenbourg Wissenschaftsverlag
DOI:
10.1515/teme-2022-0116
Author(s):
Finja Borowski, Robert Ott, Jan Oldenburg, Sebastian Kaule, Alper Öner, Klaus-Peter
Schmitz, Michael Stiehm
Published in:
Current Directions in Biomedical Engineering, Issue vol. 8, no. 2, 2022, Page(s) 512-515, ISSN 2364-5504
Publisher:
De Gruyter
DOI:
10.1515/cdbme-2022-1131
Author(s):
Oldenburg, Jan, Borowski, Finja, Schmitz, Klaus-Peter and Stiehm, Michael.
Published in:
Current Directions in Biomedical Engineering, Issue vol. 8, no. 2, 2022, Page(s) 741-744, ISSN 2364-5504
Publisher:
De Gruyter
DOI:
10.1515/cdbme-2022-1189
Author(s):
Lesage, R., Van Oudheusden, M., Schievano, S., Van Hoyweghen, I., Geris, L., Capelli, C.
Published in:
Frontiers in Medical Technology, 2023, ISSN 2673-3129
Publisher:
Frontiers Media S.A.
DOI:
10.3389/fmedt.2023.1125524
Author(s):
Jan Oldenburg; Finja Borowski; Alper Öner; Klaus-Peter Schmitz; Michael Stiehm
Published in:
Advanced Modeling and Simulation in Engineering Sciences, Issue 9, 2022, ISSN 2213-7467
Publisher:
Springer Open
DOI:
10.1186/s40323-022-00221-z
Author(s):
Pjotr L. J. Hilhorst, Sjeng Quicken, Frans N. van de Vosse, Wouter Huberts
Published in:
International Journal for Numerical Methods in Biomedical Engineering, 2023, ISSN 2040-7947
Publisher:
Wiley Online LIbrary
DOI:
10.1002/cnm.3797
Author(s):
Robin Willems, Lex Verberne, Olaf van der Sluis, Clemens V. Verhoosel
Published in:
Computer Methods in Applied Mechanics and Engineering, Issue 425, 2024, Page(s) 116958, ISSN 0045-7825
Publisher:
Elsevier BV
DOI:
10.1016/j.cma.2024.116958
Author(s):
Jan Brüning, Pavlo Yevtushenko, Adriano Schlief, Tobias Jochum, Livia van Gijzen, Sonja Meine, Jan Romberg, Titus Kuehne, Andreas Arndt, Leonid Goubergrits
Published in:
Frontiers in Cardiovascular Medicine, 2023, ISSN 2297-055X
Publisher:
Frontiers
DOI:
10.3389/fcvm.2023.1193209
Author(s):
Stein K.F. Stoter, Sai C. Divi, E. Harald van Brummelen, Mats G. Larson, Frits de Prenter, Clemens V. Verhoosel
Published in:
Computer Methods in Applied Mechanics and Engineering, Issue Volume 412, 1 July 2023, 2023, Page(s) 116074, ISSN 0045-7825
Publisher:
Elsevier BV
DOI:
10.1016/j.cma.2023.116074
Author(s):
Matei, T. I., Popescu, A. B., Nita, C. I., Ciusdel, C. F., & Itu, L. M.
Published in:
Studies in Informatics and Control, Issue 32(4), 2023, Page(s) 49-58, ISSN 1220-1766
Publisher:
National Institute for R & D in Informatics
Author(s):
Finja Borowski, Sebastian Kaule, Jan Oldenburg, Klaus-Peter Schmitz, Alper Öner and
Michael Stiehm
Published in:
tm - Technisches Messen, 2023, ISSN 2196-7113
Publisher:
Oldenbourg Wissenschaftsverlag
DOI:
10.1515/teme-2022-0100
Author(s):
Flora T. Musuamba,Ine Skottheim Rusten,Raphaëlle Lesage,Giulia Russo,Roberta Bursi,Luca Emili,Gaby Wangorsch,Efthymios Manolis,Kristin E. Karlsson,Alexander Kulesza,Eulalie Courcelles,Jean-Pierre Boissel,Cécile F. Rousseau,Emmanuelle M. Voisin,Rossana Alessandrello,Nuno Curado,Enrico Dall’ara,Blanca Rodriguez,Francesco Pappalardo, Liesbet Geris.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, Issue 10 (8), 2021, Page(s) 804-825, ISSN 2163-8306
Publisher:
Nature Publishing Group
DOI:
10.1002/psp4.12669
Author(s):
Nina Krüger; Alexander Meyer; Lennart Tautz; Markus Hüllebrand; Isaac Wamala; Marius Pullig; Markus Kofler; Jörg Kempfert; Simon Sündermann; Volkmar Falk; Anja Hennemuth
Published in:
International Journal of Computer Assisted Radiology and Surgery, 17 (3), Issue 17, 2022, Page(s) 507–519, ISSN 1861-6410
Publisher:
Springer Verlag
DOI:
10.1007/s11548-021-02554-3
Author(s):
Spanjaards, M., Ubachs, R., Lavezzo, V., Van der Sluis, O
Published in:
28th Annual Conference of the European Society of Biomechanics (ESB2023), 2023
Publisher:
European Society of Biomechanics
Author(s):
Moradi, H., van de Vosse, F., Huberts, W
Published in:
28th Annual Conference of the European Society of Biomechanics (ESB2023), 2023
Publisher:
European Society of Biomechanics
Author(s):
Brüning, J., Krüger, N., Yevtushenko, P., Goubergrits, L.
Published in:
28th Annual Conference of the European Society of Biomechanics (ESB2023), 2023
Publisher:
European Society of Biomechanics
Author(s):
Jan Oldenburg, Finja Borowski, Sebastian Kaule, Alper Öner, Klaus-Peter Schmitz and Michael Stiehm
Published in:
2022
Publisher:
German Society for Laser Anemometry (GALA) Annual Conference
Author(s):
Moradi, Hamed; Van de Vosse, Frans; Huberts, Wouter
Published in:
VPH2022 Abstract Book, Issue 5, 2022
Publisher:
VPH Institute
DOI:
10.5281/zenodo.7488716
Author(s):
Brüning, Jan; Yevtushenko, Pavlo; Goubergrits, Leonid
Published in:
VPH2022 Abstract Book, Issue 1, 2022
Publisher:
VPH Institute
DOI:
10.5281/zenodo.7488850
Author(s):
Cosmin-Andrei Hatfaludi; Daniel Bunescu; Costin Florian Ciuşdel; Alex Serban; Karl Böse; Marc Oppel; Stephanie Schröder; Christopher Seehase; Harald F. Langer; Jeanette Erdmann; Henry Nording; Lucian Mihai Itu
Published in:
Crossref, Issue 7, 2022
Publisher:
Institute of Electrical and Electronic Engineers
DOI:
10.1109/cbms58004.2023.00337
Author(s):
Verstraeten, Sabine; Suasso de Lima de Prado, Damián; Hoeijmakers, Martijn; Van de Vosse, Frans; Huberts, Wouter
Published in:
VPH2022 Abstract Book, Issue 2, 2022
Publisher:
VPH Institute
DOI:
10.5281/zenodo.7488786
Author(s):
Verstraeten, S., Hoeijmakers, M., van de Vosse, F., Huberts, W.
Published in:
28th Annual Conference of the European Society of Biomechanics (ESB2023), 2023
Publisher:
European Society of Biomechanics
Author(s):
Hilhorst, Pjotr; Quicken, Sjeng; Van de Vosse, Frans; Huberts, Wouter
Published in:
VPH2022 Abstract Book, Issue 4, 2022
Publisher:
VPH Institute
DOI:
10.5281/zenodo.7488829
Author(s):
Finja Borowski, Jan Oldenburg, Sebastian Kaule, Klaus-Peter Schmitz, Alper Öner, Michael Stiehm1
Published in:
2022
Publisher:
German Society for Laser Anemometry (GALA) Annual Meeting
Author(s):
Raphaelle Lesage; Michiel Van Oudheusden; Martina Contin; Silvia Schievano; Liesbet Geris; Claudio Capelli
Published in:
VPH2022 Abstract Book, Issue 3, 2022
Publisher:
VPH Institute
DOI:
10.5281/zenodo.7437507
Author(s):
Sabine Verstraeten, Martijn Hoeijmakers, Pim Tonino, Jan Brüning, Claudio Capelli, Frans van de Vosse, Wouter Huberts
Published in:
Numerical Methods in Biomedical Engineering, 2023, ISSN 2040-7939
Publisher:
John Wiley & Sons Ltd.
DOI:
10.1002/cnm.3778
Author(s):
Verhoosel, Clemens V.; van Brummelen, E. Harald; Divi, Sai C.; de Prenter, Frits
Published in:
Frontiers in Computational Fluid-Structure Interaction and Flow Simulation: Research from Lead Investigators under 40 - 2022, edited by Tayfun Tezduyar, 2022, Springer Nature Switzerland AG, Issue 1, 2022, ISSN 2331-8422
Publisher:
Forntiers
DOI:
10.48550/arxiv.2208.14994
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