In Silico testing and validation of Cardiovascular Implantable devices

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

In-silico trial impact assessment framework

Document describing the conceptual framework for the insilico trial impact assessment

Project handbook

Reference document indicating standards for project management internal communication meetings and reporting

Impact analysis on clinical and preclinical trials

Report describing the results of the impact assessment of cardiovascular in-silico methods on clinical and preclinical trials

Socio-economic impact report

Report describing the socio-economic impact from the perspective of patients, the healthcare system and society as a whole

Communication channels and materials

Document reporting setup, features and audience data relevant to the project communication channels, as well as produced C&D materials.

Project presentation

Document presenting project rationale mission goals and expected outcomes in common language to be used as base for the launch of initial press releases and production of preliminary communication materials

Validated constitutive models of the vessel wall

Report on constitutive model validation

Quality assurance guidelines

Reference document with procedures and best practices to guarantee quality of reporting

Constitutive vessel model

Simplified vessel model describing the homogeneous behavior of the vessel once in contact with the device

Self-assessment plan

Reference document indicating specific goals and key performance indicators for selfassessment of WP activities

Report on 3D finite element simulation

Report on the results of 3D simulations for a subset of patients.

Devices approval experience report

White paper on best practice on regulatory approval supported by in-silico methods.

First version of the simulation models

A document that describes the selection of the first version of simulation models for virtual cohort generation and the installation of models within the computing framework for the parallel simulation of multiple patient datasets

Reduced order model

Description of the reduced order model implemented in a prototype

Sensitivity and uncertainty quantification toolbox

A report that demonstrates the proofofprinciple of the application of uncertainty quantification and sensitivity analysis to both use cases

Dissemination events

Document reporting all public conferences, workshops and seminars attended or organised throughout the project to disseminate project results and engage stakeholders.

System requirements

Document describing the defined technical requirements for the adaptation and extension of the cloudbased infrastructure its integration structure and workflow elements

Guidelines for documentation

Providing guidelines for documentation of reports for hemodynamic studies of TAVI in medical device submissions

Data management plan

Document describing how data will be acquired processed and stored in compliance with privacy and security obligations

Communication and dissemination strategy plan

Document describing the overall project strategy for communication and dissemination including analysis of primary and secondary audiences envisaged strategies and preliminarily produced materials

Regulatory feedback report (2)

Report incorporating feedback from the third round up with regulatory authorities on SOPs, virtual cohort generation, device effect simulation and translation into the clinical setting.

Definition of model output

A document with definition of the outputs of interests their correlations and their joint probability density functions for each of the two insilico clinical trials in WP9

Industry and market impact report

Report describing the effect of the use of virtual cohorts on medical devices manufacturers within their ecosystem as well as on the medical device market

Conceptual framework report

Report describing the conceptual framework that illustrates all effect channels that the use of virtual cohorts and computer simulations may have

Enhanced constitutive vessel model

Report on development and parameterization of enhanced constitutive vessel models of the pulmonary artery and aortic sinus.

First version of the definition of the input space

A document that elaborates on how the available data templates are converted to a first definition of the input space ie based on expert opinion

Kick-off meeting report

Report on topics issues and outcomes of the project kickoff meeting

Regulatory feedback report (1)

Report incorporating feedback from the first and second round up with regulatory authorities on SOPs, virtual cohort generation, device effect simulation and translation into the clinical setting.

Uncertainty quantification and re-definition of input space

A document describing how the input space can be redefined based on the results of a sensitivity analysis and it can reduce the output uncertainty for both use cases

SOPs for data acquisition for in-silico models

Providing standards and workflow for preclinical and clinical data acquisition.

Fast device deployment model

Modelling of the fast device deployment process implemented in a prototype.

Specification of data-processing requirements

A protocol specifying imaging modality settings (resolutions, quality measures, formats) for TAVI and PAPS.

Specification and quantification of synthetic boundary conditions

An elaboration of specification for synthetic boundary condition generation (standards, quality measures, formats).

SOPs for data processing for in-silico models

Describing procedures and workflows for the processing of preclinical (in vitro, in vivo) and clinical data (imaging, sensor data) for generating virtual cohorts.

Specification and quantification of subject-specific data-based boundary conditions

An elaboration of specification describing formats and resolution of clinical imaging and sensor data used for simulations with subject-specific boundary conditions.

SOPs for in-silico analysis of TAVI

Providing standard protocols for performing CFD and FSI simulation as well as PIV measurements of TAVI in medical device submissions

SOPs for virtual cohorts generation and validation

Describing procedures for optimal virtual cohort generation and validation.

IGA model

IGA based model for 3D device deployment simulation

Uncertainty quantification for input data

Tools, parameters and methods for quantification of clinical data used as boundary conditions for simulations and for validation.

SOPs for validation of in-silico models

Providing standard protocols for multi-level validation of in-silico models

Validated virtual cohorts for in-silico trials

Accurate validated virtual cohorts will be delivered for both use cases.

Pubblicazioni

A statistical shape model of the porcine and human pulmonary artery for evaluation of medical devices

Autori: Jan Brüning
Pubblicato in: 2023
Editore: ESB2023
DOI: 10.5281/zenodo.8164649

SIMCor. Deliverable 7.2 - Definition of model templates (TUE, M9)

Autori: Huberts, Wouter
Pubblicato in: 2021
Editore: OpenAIRE
DOI: 10.5281/zenodo.6146528

SIMCor. Deliverable 7.4 - Sensitivity and uncertainty quantification toolbox (TUE, M15)

Autori: Huberts, Wouter
Pubblicato in: 2022
Editore: N/A
DOI: 10.5281/zenodo.7036217

SIMCor. Deliverable 1.3: Project handbook (LYN, M4)

Autori: Anna Rizzo
Pubblicato in: NO JOURNAL TITLE, 2021
Editore: OpenAire
DOI: 10.5281/zenodo.4750993

SIMCor. Deliverable 4.5 - SOPs for in-silico analysis of TAVI (IIB, M24)

Autori: Stiehm, Michael; Borowski, Finja; Oldenburg, Jan; Lavezzo, Valentina; Brüning, Jan; Lesage, Raphaëlle; Seger, Axel; Rizzo, Anna.
Pubblicato in: 2024
Editore: OpenAIRE
DOI: 10.5281/zenodo.10931583

SIMCor. Deliverable 6.1 - Data processing requirements (CHA, M4)

Autori: Brüning, Jan
Pubblicato in: 2021
Editore: OpenAIRE
DOI: 10.5281/zenodo.5094742

SIMCor. Deliverable 8.3 - Constitutive vessel model (TUG, M20)

Autori: Rolf-Pissarczyk, Malte; Terzano, Michele.
Pubblicato in: 2024
Editore: OpenAIRE
DOI: 10.5281/zenodo.10560205

SIMCor. Deliverable 9.6 - Devices approval experience report (BIO, M39)

Autori: Romberg, Jan; Srikantharajah, Kagithiri; Brüning, Jan; Rangarajan, Janaki Raman
Pubblicato in: Numero 3, 2024
Editore: Open Aire
DOI: 10.5281/zenodo.13987334

SIMCor. Deliverable 4.2 - Standard operating procedures for data processing for in-silico models (CHA, M12)

Autori: Bruning, Jan; Krüger, Nina; Goubergrits, Leonid; Lesage, Raphaëlle; Huberts, Wouter; Schievano, Silvia
Pubblicato in: 2021
Editore: OpenAIRE
DOI: 10.5281/zenodo.6150519

From Engineering Metrics to Clinical Endpoints

Autori: Andreas Arndt
Pubblicato in: 2023
Editore: ESB2023
DOI: 10.5281/zenodo.8164674

SIMCor. Deliverable 2.3 - Communication channels and materials (LYN, M42)

Autori: Reale, Gaia; Rizzo, Anna
Pubblicato in: Numero 2, 2024
Editore: Open Aire
DOI: 10.5281/zenodo.13987155

Deliverable 2.6 - Regulatory feedback report (2) (VPH, M40)

Autori: Lesage, Raphaëlle; Rangarajan, Janaki Raman; geris, liesbet; Brüning, Jan; Rizzo, Anna
Pubblicato in: Numero 3, 2024
Editore: Open Aire
DOI: 10.5281/zenodo.13987311

Virtual cohort generation and validation

Autori: Wouter Huberts
Pubblicato in: 2023
Editore: ESB2023
DOI: 10.5281/zenodo.8164594

SIMCor. Deliverable 3.2 - Data management plan (LYN, M6)

Autori: Rizzo, Anna
Pubblicato in: 2021
Editore: OpenAIRE
DOI: 10.5281/zenodo.5095494

SIMCor. Leaflet

Autori: Rizzo, Anna; Servidio, Stefania
Pubblicato in: Numero 2, 2022
Editore: N/A
DOI: 10.5281/zenodo.6151181

SIMCor. Deliverable 7.8 - Validated virtual cohorts for in-silico trials (TUE, CHA)

Autori: Huberts, Wouter; Verstraeten, Sabine; Brüning, Jan
Pubblicato in: Numero 3, 2023
Editore: Zenodo
DOI: 10.5281/zenodo.10670423

SIMCor. Deliverable 4.3 - SOPs for virtual cohorts generation and validation (TUE, M36)

Autori: Huberts, Wouter; Verstraeten, Sabine; Lesage, Raphaëlle; Raman Rangarajan, Janaki; Cracanel, Alex; Moradi, Hamed; Van Driel, Marloes; Brüning, Jan; Goubergrits, Leonid.
Pubblicato in: 2024
Editore: OpenAIRE
DOI: 10.5281/zenodo.10930897

SIMCor. Deliverable 8.6 - Report on 3D finite element simulations (PHI, M24)

Autori: Spanjaards, Michelle; Lavezzo, Valentina.
Pubblicato in: 2024
Editore: OpenAIRE
DOI: 10.5281/zenodo.10931349

SIMCor. Deliverable 2.1 - Project presentation (LYN, M1)

Autori: Rizzo, Anna
Pubblicato in: 2021
Editore: OpenAIRE
DOI: 10.5281/zenodo.4644534

SIMCor. Deliverable 3.1 - System requirements (UTBV, M6)

Autori: Cracanel, Răzvan Alexandru; Demeter, Robert; Itu, Lucian Mihai
Pubblicato in: 2021
Editore: OpenAIRE
DOI: 10.5281/zenodo.10555913

SIMCor. Deliverable 2.2 - Communication and dissemination strategy plan (LYN, M2)

Autori: Rizzo, Anna
Pubblicato in: 2021
Editore: OpenAIRE
DOI: 10.5281/zenodo.4664231

SIMCor. Deliverable 1.2 - Kick-off meeting report (LYN, M2)

Autori: De Maldè, Mirko
Pubblicato in: 2021
Editore: OpenAIRE
DOI: 10.5281/zenodo.4644568

SIMCor. Deiverable 6.3 - Uncertainty quantification for input data (CHA, M21)

Autori: Goubergrits, Leonid; Kruger, Nina; Bruning, Jan
Pubblicato in: 2022
Editore: N/A
DOI: 10.5281/zenodo.7105663

SIMCor. Deliverable 1.3 - Project handbook (LYN, M4)

Autori: Anna Rizzo
Pubblicato in: 2021
Editore: OpenAIRE
DOI: 10.5281/zenodo.4750992

SIMCor. Deliverable 4.3 - SOPs for virtual cohorts generation and validation (TUE, M36)

Autori: Huberts, Wouter; Verstraeten, Sabine; Lesage, Raphaëlle; Rangarajan, Janaki Raman; Cracanel, Alex; Moradi, Hamed; Van Driel, Marloes; Brüning, Jan; Goubergrits, Leonid
Pubblicato in: Numero 2, 2023
Editore: OpenAire
DOI: 10.5281/zenodo.10930896

SIMCor. Deliverable 2.4 - Dissemination events (LYN, M42)

Autori: Rizzo, Anna
Pubblicato in: Numero 5, 2024
Editore: Open Aire
DOI: 10.5281/zenodo.13987197

SIMCor. Deliverable 7.1 - Definition of model output (TUE, M6)

Autori: Huberts, Wouter
Pubblicato in: 2021
Editore: OpenAIRE
DOI: 10.5281/zenodo.6074807

SIMCor. Deliverable 4.6 - SOPs for validation of in silico models (BIO, IIB, CHA, M36)

Autori: Arndt, Andreas; Romberg, Jan; Stiem, Michael; Borowski, Finja; Supp, Laura; Oldenburg, Jan; Brüning, Jan; Goubergrits, Leonid.
Pubblicato in: 2024
Editore: OpenAIRE
DOI: 10.5281/zenodo.10654506

SIMCor. Deliverable 8.7 - Reduced-order model (PHI, M30)

Autori: Spanjaards, Michelle; Divi, Sai; Verhoosel, Clemens; Lavezzo, Valentina.
Pubblicato in: 2024
Editore: OpenAIRE
DOI: 10.5281/zenodo.10931283

SIMCor. Deliverable 8.8 - Fast-to-evaluate TAVI model based on multi-patch NURBS (TUE, M28)

Autori: Divi, Sai; Verhoosel, Clemens
Pubblicato in: 2024
Editore: OpenAIRE
DOI: 10.5281/zenodo.10931226

SIMCor. Deliverable 4.1 - SOPs for data acquisition for in-silico models (UCL, M18)

Autori: Schievano, Silvia; Capelli, Claudio; Bruning, Jan; Lesage, Raphaelle; Ohmann, Christian; Panagiotopoulou, Maria; Montgomery Liljeroth, Ebba; Staument, Bernard
Pubblicato in: 2022
Editore: N/A
DOI: 10.5281/zenodo.7041346

Mapping the use of computer modelling and simulation in clinics

Autori: Raphaëlle; Michiel; Silvia; Ine; Claudio; Giulia; Martina; Roberta; Goran
Pubblicato in: 2022
Editore: OpenAIRE
DOI: 10.5281/zenodo.7974392

SIMCor. Deliverable 6.4 - Specification and quantification of subject-specific data-based boundary conditions (CHA, M24)

Autori: Goubergrits, Leonid; Brüning, Jan.
Pubblicato in: 2024
Editore: OpenAIRE
DOI: 10.5281/zenodo.10931548

SIMCor. Deliverable 2.5 - Regulatory feedback report (1) (VPH, M19)

Autori: Raphaëlle Lesage, Liesbet Geris
Pubblicato in: 2024
Editore: OpenAIRE
DOI: 10.5281/zenodo.10931642

SIMCor. Deliverable 9.1 - Constitutive vessel model (TUG, M27)

Autori: Rolf-Pissarczyk, Malte; Terzano, Michele
Pubblicato in: 2024
Editore: OpenAIRE
DOI: 10.5281/zenodo.10931075

SIMCor. Deliverable 7.3 - First version of the definition of the input space (TUE, M12)

Autori: Huberts, Wouter
Pubblicato in: 2021
Editore: OpenAIRE
DOI: 10.5281/zenodo.6150326

SIMCor. Deliverable 6.5 - Specification and quantification of synthetic boundary conditions (CHA, M30)

Autori: Goubergrits, Leonid; Brüning, Jan.
Pubblicato in: 2024
Editore: OpenAIRE
DOI: 10.5281/zenodo.10931503

Patient-based clinical trials

Autori: Pablo E. Verde
Pubblicato in: 2023
Editore: ESB2023
DOI: 10.5281/zenodo.8164661

SIMCor. Deliverable 1.5 – Quality assurance guidelines (LYN, M8)

Autori: De Maldè, Mirko
Pubblicato in: 2021
Editore: OpenAIRE
DOI: 10.5281/zenodo.5095412

SIMCor. Deliverable 7.5 - Uncertainty quantification and re-definition of input space (TUE, M18)

Autori: Huberts, Wouter; Stiehm, Michael; Borowsky, Finja; Oldeburg, Jan
Pubblicato in: 2022
Editore: N/A
DOI: 10.5281/zenodo.7041286

Virtual cohort generation of aortic valve stenosis geometries

Autori: Sabine Verstraeten; Frans van de Vosse; Wouter Huberts
Pubblicato in: 2023
Editore: ESB2023
DOI: 10.5281/zenodo.8164617

SIMCor. Deliverable 8.4 - Validated constitutive models of the vessel wall (TUG, M26)

Autori: Rolf-Pissarczyk, Malte; Terzano, Michele.
Pubblicato in: 2024
Editore: OpenAIRE
DOI: 10.5281/zenodo.10931406

SIMCor. Deliverable 4.4 - Guidelines for documentation (IIB, M12)

Autori: Stiehm, Michael; Brüning, Jan; Lesage, Raphaëlle; Czypionka, Thomas; Oldenburg, Jan; Huberts, Wouter; Rolf-Pissarczyk, Malte; Luther; Torsten; Staumont, Bernard; Geris, Liesbet
Pubblicato in: 2021
Editore: OpenAIRE
DOI: 10.5281/zenodo.6150904

SIMCor. Deliverable 1.4 - Self-assessment plan (LYN, M6)

Autori: De Maldè, Mirko
Pubblicato in: 2021
Editore: OpenAIRE
DOI: 10.5281/zenodo.5095487

SIMCor. Deliverable 8.5 - Fast device deployment model (CHA, M24)

Autori: Walczak, Lars.
Pubblicato in: 2024
Editore: OpenAIRE
DOI: 10.5281/zenodo.10931379

SIMCor. Deliverable 10.1 - In-silico trial impact assessment framework (ECRIN, M12)

Autori: Aydin, Burç; Ohmann, Christian
Pubblicato in: 2021
Editore: OpenAIRE
DOI: 10.5281/zenodo.6353627

Hemodynamics of an implanted pressure sensor in porcine and human pulmonary artery

Autori: Goubergrits, Leonid; Yevtushenko, Pavlo; Schlief, Adriano; Romberg, Jan; Kuehne, Titus; Arndt, Andreas; Bruening, Jan
Pubblicato in: VPH 2024 Conference abstracts, Numero 1, 2024
Editore: VHP Institute
DOI: 10.5281/zenodo.13759976

Pre-operative risk assessment of paravalvular leakage using a computational TAVI deployment model

Autori: Spanjaards, M., Ubachs, R., Lavezzo, V., Van der Sluis, O
Pubblicato in: 28th Annual Conference of the European Society of Biomechanics (ESB2023), 2023
Editore: European Society of Biomechanics

Potential of using shell elements methods in FSI simulations of pulmonary arteries

Autori: Moradi, H., van de Vosse, F., Huberts, W
Pubblicato in: 28th Annual Conference of the European Society of Biomechanics (ESB2023), 2023
Editore: European Society of Biomechanics

Inter-species differences in pulmonary artery morphometry and hemodynamics

Autori: Brüning, J., Krüger, N., Yevtushenko, P., Goubergrits, L.
Pubblicato in: 28th Annual Conference of the European Society of Biomechanics (ESB2023), Numero 3, 2023
Editore: European Society of Biomechanics

Measurement of Steady Flow through a Transcatheter Aortic Valve Replacement by means of Particle Image Velocimetry

Autori: Jan Oldenburg, Finja Borowski, Sebastian Kaule, Alper Öner, Klaus-Peter Schmitz and Michael Stiehm
Pubblicato in: 2022
Editore: German Society for Laser Anemometry (GALA) Annual Conference

Identification of the most influential factors on pulmonary artery hemodynamics using variance-based sensitivity analysis

Autori: Moradi, Hamed; Van de Vosse, Frans; Huberts, Wouter
Pubblicato in: VPH2022 Abstract Book, Numero 5, 2022
Editore: VPH Institute
DOI: 10.5281/zenodo.7488716

A conceptual framework to evaluate the socioeconomic impact of in-silico models for implantable medical devices

Autori: Thomas Czypionka, Siegfried Eisenberg, Markus Kraus, Miriam Reiss, David Rösler
Pubblicato in: European health Management Association (EHMA) 2023 Abstract Book, 2023, Pagina/e 328-329
Editore: European health Management Association (EHMA)

Validation of a Synthetic Cohort of Aortic Stenosis Patients

Autori: Brüning, Jan; Yevtushenko, Pavlo; Goubergrits, Leonid
Pubblicato in: VPH2022 Abstract Book, Numero 1, 2022
Editore: VPH Institute
DOI: 10.5281/zenodo.7488850

Inform design of a pulmonary artery pressure sensor using virtual cohorts

Autori: Brüning, Jan; Schlief, Adriano; Yevtushenko, Pavlo; Romberg, Jan; Arndt, Andreas; Goubergrits, Leonid
Pubblicato in: VPH 2024 Conference abstracts, Numero 1, 2024
Editore: VPH Institute
DOI: 10.5281/zenodo.13759869

In-silico enhanced chronic animal experiment to investigate cardiovascular implantable devices.

Autori: Brüning, J., Schlief, A., Yevtushenko, P., Romberg, J., Arndt, A., Goubergrits, L.
Pubblicato in: 29th Congress of the European Society of Biomechanics (ESB 2024), 30 June – 3 July 2024, 2024
Editore: 29th Congress of the European Society of Biomechanics (ESB 2024)

In-silico enhanced animal experiments for evaluation of cardiovascular implantable devices

A fluid-structure interaction approach to distinguish between true and pseudo-severe aortic stenosis.

Autori: Verstraeten, S., Hoeijmakers, M., van de Vosse, F., Huberts, W.
Pubblicato in: 19th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering (CMBBE 2024), 30 July – 1 August 2024., 2024
Editore: 19th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering (CMBBE 2024)

Unveiling the relation between aortic shape and calcification in population with aortic stenosis: Towards better management of TAVI patients

Autori: Sivera, Raphael; Montgomery-Liljeroth, Ebba; Cook, Andrew; Schievano, Silvia; Patel, Kush; Capelli, Claudio
Pubblicato in: VPH 2024 Conference abstracts, Numero 1, 2024
Editore: VPH Institute
DOI: 10.5281/zenodo.13756920

Deep Learning Based Detection of Collateral Circulation in Coronary Angiographies

Autori: Cosmin-Andrei Hatfaludi; Daniel Bunescu; Costin Florian Ciuşdel; Alex Serban; Karl Böse; Marc Oppel; Stephanie Schröder; Christopher Seehase; Harald F. Langer; Jeanette Erdmann; Henry Nording; Lucian Mihai Itu
Pubblicato in: Crossref, Numero 7, 2022
Editore: Institute of Electrical and Electronic Engineers
DOI: 10.1109/cbms58004.2023.00337

Non-parametric statistical shape modelling for in silico trials of TAVI

Autori: Verstraeten, Sabine; Suasso de Lima de Prado, Damián; Hoeijmakers, Martijn; Van de Vosse, Frans; Huberts, Wouter
Pubblicato in: VPH2022 Abstract Book, Numero 2, 2022
Editore: VPH Institute
DOI: 10.5281/zenodo.7488786

Virtual cohort generation for in silico trials of transcatheter aortic valve implantation

Autori: Verstraeten, S., Hoeijmakers, M., van de Vosse, F., Huberts, W.
Pubblicato in: 28th Annual Conference of the European Society of Biomechanics (ESB2023), 2023
Editore: European Society of Biomechanics

Computer modelling and simulation in clinics: Longitudinal mapping of usage and clinician's trust in in silico medicine

Autori: Van Horenbeeck, Zita; Lesage, Raphaëlle; Platonov, Artem; Contin, Martina; van Oudheusden, Michiel; Lievevrouw, Elisa; Staumont, Bernard; Rangarajan, Janaki Raman; Schievano, Silvia; Van Hoyweghen, Ine; Capelli, Claudio; Geris, Liesbet
Pubblicato in: VPH 2024 Conference abstracts, Numero 1, 2024
Editore: VPH Institute
DOI: 10.5281/zenodo.13760055

The socioeconomic impact of in-silico methods for implantable medical devices: a conceptual framework

Autori: David Roesler, Thomas Czypionka, Siegfried Eisenberg, Markus Kraus, Miriam Reiss
Pubblicato in: EHMA 2024 ABSTRACT BOOK, 2024, Pagina/e 108
Editore: European Health Management Association (EHMA)

Sensitivity analysis of an one-dimensional pulse wave propagation model with correlated input

Autori: Hilhorst, Pjotr; Quicken, Sjeng; Van de Vosse, Frans; Huberts, Wouter
Pubblicato in: VPH2022 Abstract Book, Numero 4, 2022
Editore: VPH Institute
DOI: 10.5281/zenodo.7488829

A fluid-structure interaction simulation framework to distinguish between true and pseudo-severe aortic stenosis.

Autori: Verstraeten, S., Hoeijmakers, M., van de Vosse, F., Huberts, W.
Pubblicato in: 29th Congress of the European Society of Biomechanics (ESB 2024), 30 June – 3 July 2024., 2024
Editore: 29th Congress of the European Society of Biomechanics (ESB 2024)

Assessment of Thrombogenic Potential of Prosthetic Heart Valves based on Particle Image Velocimetry Measurements

Autori: Finja Borowski, Jan Oldenburg, Sebastian Kaule, Klaus-Peter Schmitz, Alper Öner, Michael Stiehm1
Pubblicato in: 2022
Editore: German Society for Laser Anemometry (GALA) Annual Meeting

Computer modelling and simulation in clinics: mapping usage and opinions for advancing in silico medicine

Autori: Raphaelle Lesage; Michiel Van Oudheusden; Martina Contin; Silvia Schievano; Liesbet Geris; Claudio Capelli
Pubblicato in: VPH2022 Abstract Book, Numero 3, 2022
Editore: VPH Institute
DOI: 10.5281/zenodo.7437507

An in silico medicine info kit for effective stakeholder engagement

Autori: Contin, Martina; Davide Montesarchio, Davide; Van Horenbeeck, Zita; Lesage, Raphaelle; Platonov, Artem; Stanic, Goran; De Michele, Roberta; Rangarajan, Janaki Raman; Geris, Liesbet
Pubblicato in: VPH 2024 Conference abstracts, Numero 1, 2024
Editore: VPH Institute
DOI: 10.5281/zenodo.13760091

A conceptual framework to evaluate the socioeconomic impact of in-silico models for implantable medical devices

Autori: Thomas Czypionka, Siegfried Eisenberg, Markus Kraus, Miriam Reiss, David Rösler
Pubblicato in: Austrian Health Economics Association (ATHEA) 2023 Book of abstracts, 2023, Pagina/e 29-30
Editore: Austrian Health Economics Association (ATHEA) 2023

A fast-to-evaluate model to inform device design decisions for pulmonary artery pressure sensors.

Autori: Schlief, A., Goubergrits, L., Brüning, J.
Pubblicato in: 29th Congress of the European Society of Biomechanics (ESB 2024), 30 June – 3 July 2024., 2024
Editore: 29th Congress of the European Society of Biomechanics (ESB 2024)

Virtual cohort generation for in silico trials of transcatheter aortic valve implantation

Autori: Verstraeten, Sabine; Thissen, Doris; Hoeijmakers, Martijn; van de Vosse, Frans; Huberts, Wouter
Pubblicato in: VPH 2024 Conference abstracts, Numero 1, 2024
Editore: VPH Institute
DOI: 10.5281/zenodo.13756771

A fast in silico model for preoperative risk assessment of paravalvular leakage

Autori: Michelle Spanjaards, Finja Borowski, Laura Supp, René Ubachs, Valentina Lavezzo & Olaf van der Sluis
Pubblicato in: Biomechanics and Modeling in Mechanobiology, 2024, ISSN 1617-7940
Editore: Springer
DOI: 10.1007/s10237-024-01816-8

A conceptual framework to evaluate the socioeconomic impact of in-silico models for implantable medical devices

Autori: Siegfried Eisenberg, Miriam Reiss, Thomas Czypionka, Markus Kraus, David Rösler
Pubblicato in: Population Medicine, Numero 5, 2023, ISSN 2654-1459
Editore: 17th World Congress on Public Health
DOI: 10.18332/popmed/164681

Feasibility Assessment of Using CDISC Data Standards for in vivo and in silico Medical Device Trials

Autori: Burç Aydin, Eanna Kiely, Christian Ohmann
Pubblicato in: Journal of the Society of Clinical Data Management, Numero Volume 3, Numero 3 2023, Fall 2023, 2023, ISSN 2694-1473
Editore: Society of clinical data management
DOI: 10.47912/jscdm.230

CT‑based comparison of porcine, ovine, and human pulmonary arterial morphometry

Autori: Leonid Goubergrits, Marie Schafstedde, Nikola Cesarovic, Angelika Szengel, Boris Schmitt, Moritz Wiegand, Jan Romberg 4, Andreas Arndt 4, Titus Kuehne 1,2 & Jan Brüning 1,2*
Pubblicato in: Scientific reports, 2023, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-023-47532-8

Quantification of noncircular stent expansion after TAVR into a pathological annulus and its impact on paravalvular leakage

Autori: Finja Borowski, Sebastian Kaule, Jan Oldenburg, Alper Öner, Klaus-Peter Schmitz, Michael Stiehm
Pubblicato in: Current Directions in Biomedical Engineering, Numero 7, 2022, Pagina/e 597-600, ISSN 2364-5504
Editore: Walter de Gruyter GmbH
DOI: 10.1515/cdbme-2021-2152

Analysis on the effects of hypo-attenuated leaflet thickening on the hemodynamics of transcatheter aortic valve prostheses by means of particle image velocimetry

Autori: Oldenburg, Jan, Borowski, Finja, Kaule, Sebastian, Schmitz, Klaus-Peter, Öner, Alper and Stiehm, Michael.
Pubblicato in: tm - Technisches Messen, 2023, ISSN 2196-7113
Editore: Oldenbourg Wissenschaftsverlag
DOI: 10.1515/teme-2022-0116

Validation of a Fluid Structure Interaction Model for TAVR using Particle Image Velocimetry

Autori: Finja Borowski, Robert Ott, Jan Oldenburg, Sebastian Kaule, Alper Öner, Klaus-Peter Schmitz, Michael Stiehm
Pubblicato in: Current Directions in Biomedical Engineering, Numero vol. 8, no. 2, 2022, Pagina/e 512-515, ISSN 2364-5504
Editore: De Gruyter
DOI: 10.1515/cdbme-2022-1131

In silico model to assess thrombosis risk of TAVR with hemodynamic predictors using fluid structure interaction

Autori: Finja Borowski, Sebastian Kaule, Jan Oldenburg, Alper Öner, Klaus-Peter Schmitz, Michael Stiehm
Pubblicato in: Current Directions in Biomedical Engineering, Numero 9, 2023, Pagina/e 499-502, ISSN 2364-5504
Editore: Walter de Gruyter GmbH
DOI: 10.1515/cdbme-2023-1125

Computation of flow through TAVI device by means of physics informed neural networks

Autori: Oldenburg, Jan, Borowski, Finja, Schmitz, Klaus-Peter and Stiehm, Michael.
Pubblicato in: Current Directions in Biomedical Engineering, Numero vol. 8, no. 2, 2022, Pagina/e 741-744, ISSN 2364-5504
Editore: De Gruyter
DOI: 10.1515/cdbme-2022-1189

Mapping the use of computational modelling and simulation in clinics: A survey

Autori: Lesage, R., Van Oudheusden, M., Schievano, S., Van Hoyweghen, I., Geris, L., Capelli, C.
Pubblicato in: Frontiers in Medical Technology, 2023, ISSN 2673-3129
Editore: Frontiers Media S.A.
DOI: 10.3389/fmedt.2023.1125524

Geometry aware physics informed neural network surrogate for solving Navier–Stokes equation (GAPINN)

Autori: Jan Oldenburg; Finja Borowski; Alper Öner; Klaus-Peter Schmitz; Michael Stiehm
Pubblicato in: Advanced Modeling and Simulation in Engineering Sciences, Numero 9, 2022, ISSN 2213-7467
Editore: Springer Open
DOI: 10.1186/s40323-022-00221-z

Efficient sensitivity analysis for biomechanical models with correlated inputs

Autori: Pjotr L. J. Hilhorst, Sjeng Quicken, Frans N. van de Vosse, Wouter Huberts
Pubblicato in: International Journal for Numerical Methods in Biomedical Engineering, 2023, ISSN 2040-7947
Editore: Wiley Online LIbrary
DOI: 10.1002/cnm.3797

Echocardiogram-based ventricular isogeometric cardiac analysis using multi-patch fitted NURBS

Autori: Robin Willems, Lex Verberne, Olaf van der Sluis, Clemens V. Verhoosel
Pubblicato in: Computer Methods in Applied Mechanics and Engineering, Numero 425, 2024, Pagina/e 116958, ISSN 0045-7825
Editore: Elsevier BV
DOI: 10.1016/j.cma.2024.116958

In-silico enhanced animal study of pulmonary artery pressure sensors: assessing hemodynamics using computational fluid dynamics

Autori: Jan Brüning, Pavlo Yevtushenko, Adriano Schlief, Tobias Jochum, Livia van Gijzen, Sonja Meine, Jan Romberg, Titus Kuehne, Andreas Arndt, Leonid Goubergrits
Pubblicato in: Frontiers in Cardiovascular Medicine, 2023, ISSN 2297-055X
Editore: Frontiers
DOI: 10.3389/fcvm.2023.1193209

Critical time-step size analysis and mass scaling by ghost-penalty forimmersogeometric explicit dynamics

Autori: Stein K.F. Stoter, Sai C. Divi, E. Harald van Brummelen, Mats G. Larson, Frits de Prenter, Clemens V. Verhoosel
Pubblicato in: Computer Methods in Applied Mechanics and Engineering, Numero Volume 412, 1 July 2023, 2023, Pagina/e 116074, ISSN 0045-7825
Editore: Elsevier BV
DOI: 10.1016/j.cma.2023.116074

Assessment of the functional severity of coronary lesions from optical coherence tomography based on ensembled learning

Autori: Irina-Andra Tache, Cosmin-Andrei Hatfaludi, Andrei Puiu, Lucian Mihai Itu, Nicoleta-Monica Popa-Fotea, Lucian Calmac, Alexandru Scafa-Udriste
Pubblicato in: BioMedical Engineering OnLine, Numero 22, 2023, ISSN 1475-925X
Editore: BioMed Central
DOI: 10.1186/s12938-023-01192-x

CFD-based synthetic data generation for machine learning based pressure drop assessment in aortic stenosis

Autori: Matei, T. I., Popescu, A. B., Nita, C. I., Ciusdel, C. F., & Itu, L. M.
Pubblicato in: Studies in Informatics and Control, Numero 32(4), 2023, Pagina/e 49-58, ISSN 1220-1766
Editore: National Institute for R & D in Informatics

Analysis of thrombosis risk of commissural misaligned transcatheter aortic valve prostheses using particle image velocimetry

Autori: Finja Borowski, Sebastian Kaule, Jan Oldenburg, Klaus-Peter Schmitz, Alper Öner and Michael Stiehm
Pubblicato in: tm - Technisches Messen, 2023, ISSN 2196-7113
Editore: Oldenbourg Wissenschaftsverlag
DOI: 10.1515/teme-2022-0100

Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibility

Autori: Flora T. Musuamba,Ine Skottheim Rusten,Raphaëlle Lesage,Giulia Russo,Roberta Bursi,Luca Emili,Gaby Wangorsch,Efthymios Manolis,Kristin E. Karlsson,Alexander Kulesza,Eulalie Courcelles,Jean-Pierre Boissel,Cécile F. Rousseau,Emmanuelle M. Voisin,Rossana Alessandrello,Nuno Curado,Enrico Dall’ara,Blanca Rodriguez,Francesco Pappalardo, Liesbet Geris.
Pubblicato in: CPT: Pharmacometrics & Systems Pharmacology, Numero 10 (8), 2021, Pagina/e 804-825, ISSN 2163-8306
Editore: Nature Publishing Group
DOI: 10.1002/psp4.12669

Cascaded neural network-based CT image processing for aortic root analysis

Autori: Nina Krüger; Alexander Meyer; Lennart Tautz; Markus Hüllebrand; Isaac Wamala; Marius Pullig; Markus Kofler; Jörg Kempfert; Simon Sündermann; Volkmar Falk; Anja Hennemuth
Pubblicato in: International Journal of Computer Assisted Radiology and Surgery, 17 (3), Numero 17, 2022, Pagina/e 507–519, ISSN 1861-6410
Editore: Springer Verlag
DOI: 10.1007/s11548-021-02554-3

A reparameterization-invariant Bayesian framework for uncertainty estimation and calibration of simple materials

Autori: Maximilian P. Wollner, Malte Rolf-Pissarczyk, Gerhard A. Holzapfel
Pubblicato in: Computational Mechanics, 2025, ISSN 0178-7675
Editore: Springer Verlag
DOI: 10.1007/s00466-024-02573-2

Comparison of steady-state and transient flow measurements for the characterization of paravalvular leakage of transcatheter-aortic valve prostheses

Autori: Sebastian Kaule, Michael Stiehm, Stefan Siewert, Alper Öner, Klaus-Peter Schmitz, Finja Borowksi
Pubblicato in: Current Directions in Biomedical Engineering, Numero 9, 2023, Pagina/e 503-506, ISSN 2364-5504
Editore: Walter de Gruyter GmbH
DOI: 10.1515/cdbme-2023-1126

The socioeconomic impact of in-silico models for implantable medical devices: a conceptual framework

Autori: S Eisenberg, T Czypionka, M Kraus, M Reiss, D Rösler
Pubblicato in: European Journal of Public Health, Numero 33, 2023, ISSN 1101-1262
Editore: Oxford University Press
DOI: 10.1093/eurpub/ckad160.576

An open source statistical web application for validation and analysis of virtual cohorts

Autori: Christian Ohmann, Takoua Khorchani, Alexandru Cracanel, Jan Brüning, Pablo Emilio Verde
Pubblicato in: Scientific Reports, Numero 15, 2025, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-025-99720-3

Influence of TAVR-dilatation concepts on hydrodynamic properties under pulsatile flow

Autori: Sebastian Kaule, Michael Stiehm, Stefan Siewert, Alper Öner, Klaus-Peter Schmitz
Pubblicato in: Current Directions in Biomedical Engineering, Numero 10, 2024, Pagina/e 365-368, ISSN 2364-5504
Editore: Walter de Gruyter GmbH
DOI: 10.1515/cdbme-2024-2089

A numerical study to investigate the impact of cell size of self-expanding aortic valve stents on paravalvular leakage

Autori: Finja Borowski, Laura Supp, Jan Oldenburg, Sebastian Kaule, Alper Öner, Klaus-Peter Schmitz, Michael Stiehm
Pubblicato in: Current Directions in Biomedical Engineering, Numero 10, 2024, Pagina/e 107-110, ISSN 2364-5504
Editore: Walter de Gruyter GmbH
DOI: 10.1515/cdbme-2024-2026

Augmentation of experimentally obtained flow fields by means of Physics Informed Neural Networks (PINN) demonstrated on aneurysm flow

Autori: Jan Oldenburg, Finja Borowski, Wiebke Wollenberg, Alper Öner, Klaus-Peter Schmitz, Michael Stiehm
Pubblicato in: Current Directions in Biomedical Engineering, Numero 9, 2023, Pagina/e 519-523, ISSN 2364-5504
Editore: De Gruyter
DOI: 10.1515/cdbme-2023-1130

Generation of synthetic aortic valve stenosis geometries for in silico trials

Autori: Sabine Verstraeten, Martijn Hoeijmakers, Pim Tonino, Jan Brüning, Claudio Capelli, Frans van de Vosse, Wouter Huberts
Pubblicato in: Numerical Methods in Biomedical Engineering, 2023, ISSN 2040-7939
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cnm.3778

Scan-based immersed isogeometric flow analysis

Autori: Verhoosel, Clemens V.; van Brummelen, E. Harald; Divi, Sai C.; de Prenter, Frits
Pubblicato in: Frontiers in Computational Fluid-Structure Interaction and Flow Simulation: Research from Lead Investigators under 40 - 2022, edited by Tayfun Tezduyar, 2022, Springer Nature Switzerland AG, Numero 1, 2022, ISSN 2331-8422
Editore: Forntiers
DOI: 10.48550/arxiv.2208.14994

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