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In Silico testing and validation of Cardiovascular Implantable devices


In-silico trial impact assessment framework

Document describing the conceptual framework for the insilico trial impact assessment

Project handbook

Reference document indicating standards for project management internal communication meetings and reporting

Project presentation

Document presenting project rationale mission goals and expected outcomes in common language to be used as base for the launch of initial press releases and production of preliminary communication materials

Quality assurance guidelines

Reference document with procedures and best practices to guarantee quality of reporting

Constitutive vessel model

Simplified vessel model describing the homogeneous behavior of the vessel once in contact with the device

Self-assessment plan

Reference document indicating specific goals and key performance indicators for selfassessment of WP activities

First version of the simulation models

A document that describes the selection of the first version of simulation models for virtual cohort generation and the installation of models within the computing framework for the parallel simulation of multiple patient datasets

Sensitivity and uncertainty quantification toolbox

A report that demonstrates the proofofprinciple of the application of uncertainty quantification and sensitivity analysis to both use cases

System requirements

Document describing the defined technical requirements for the adaptation and extension of the cloudbased infrastructure its integration structure and workflow elements

Guidelines for documentation

Providing guidelines for documentation of reports for hemodynamic studies of TAVI in medical device submissions

Data management plan

Document describing how data will be acquired processed and stored in compliance with privacy and security obligations

Communication and dissemination strategy plan

Document describing the overall project strategy for communication and dissemination including analysis of primary and secondary audiences envisaged strategies and preliminarily produced materials

Definition of model output

A document with definition of the outputs of interests their correlations and their joint probability density functions for each of the two insilico clinical trials in WP9

Conceptual framework report

Report describing the conceptual framework that illustrates all effect channels that the use of virtual cohorts and computer simulations may have

First version of the definition of the input space

A document that elaborates on how the available data templates are converted to a first definition of the input space ie based on expert opinion

Kick-off meeting report

Report on topics issues and outcomes of the project kickoff meeting

Uncertainty quantification and re-definition of input space

A document describing how the input space can be redefined based on the results of a sensitivity analysis and it can reduce the output uncertainty for both use cases


Geometry aware physics informed neural network surrogate for solving Navier–Stokes equation (GAPINN)

Autoren: Jan Oldenburg; Finja Borowski; Alper Öner; Klaus-Peter Schmitz; Michael Stiehm
Veröffentlicht in: Advanced Modeling and Simulation in Engineering Sciences, 9, 2022, ISSN 2213-7467
Herausgeber: Springer Open
DOI: 10.1186/s40323-022-00221-z

Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibility

Autoren: Flora T. Musuamba,Ine Skottheim Rusten,Raphaëlle Lesage,Giulia Russo,Roberta Bursi,Luca Emili,Gaby Wangorsch,Efthymios Manolis,Kristin E. Karlsson,Alexander Kulesza,Eulalie Courcelles,Jean-Pierre Boissel,Cécile F. Rousseau,Emmanuelle M. Voisin,Rossana Alessandrello,Nuno Curado,Enrico Dall’ara,Blanca Rodriguez,Francesco Pappalardo, Liesbet Geris.
Veröffentlicht in: CPT: Pharmacometrics & Systems Pharmacology, 10 (8), 2021, Page(s) 804-825, ISSN 2163-8306
Herausgeber: Nature Publishing Group
DOI: 10.1002/psp4.12669

Cascaded neural network-based CT image processing for aortic root analysis

Autoren: Nina Krüger; Alexander Meyer; Lennart Tautz; Markus Hüllebrand; Isaac Wamala; Marius Pullig; Markus Kofler; Jörg Kempfert; Simon Sündermann; Volkmar Falk; Anja Hennemuth
Veröffentlicht in: International Journal of Computer Assisted Radiology and Surgery, 17 (3), 17, 2022, Page(s) 507–519, ISSN 1861-6410
Herausgeber: Springer Verlag
DOI: 10.1007/s11548-021-02554-3


SIMCor - Demo of TAVI deployment simulations using the virtual geometries and a high-fidelity model

Autoren: Spanjaards, Michelle; Huberts, Wouter
Veröffentlicht in: Zenodo

SIMCor - Clinically driven Virtual Cohort Generator for aortic valve geometries

Autoren: Huberts, Wouter; Verstraeten, Sabine
Veröffentlicht in: Zenodo

SIMCor - Demo of the Virtual Research Environment (VRE)

Autoren: Huberts, Wouter; Cracanel, Alexandru
Veröffentlicht in: Zenodo

SIMCor - Demo of fast-to-evaluate surrogate models used for device implantation

Autoren: Divi, Sai; Huberts, Wouter
Veröffentlicht in: Zenodo

2021 VPHi clinical community survey

Autoren: Claudio Capelli; Liesbet Geris; Raphaëlle Lesage; Martina Contin; VPHi Board of Directors
Veröffentlicht in: Zenodo


VPHi-clinical-community-survey: data & R notebooks for statistical analysis

Autoren: Raphaelle Lesage; Claudio Capelli; Liesbet Geris; Michiel Van Oudheusden
DOI:; 10.5281/zenodo.7704491
Herausgeber: Zenodo