Individual and Collective Migration of the Immune Cellular System

3D collagen migration patterns reveal a SMAD3-dependent and TGF-β1-independent mechanism of recruitment for tumour-associated fibroblasts in lung adenocarcinoma

Autores: Yago Juste-Lanas, Natalia Díaz-Valdivia, Alejandro Llorente, Rafael Ikemori, Alejandro Bernardo, Marselina Arshakyan, Carlos Borau, Josep Ramírez, José Carlos Ruffinelli, Ernest Nadal, Noemí Reguart, José M. García-Aznar & Jordi Alcaraz
Publicado en: British Journal of Cancer, 2022, ISSN 0007-0920
Editor: Nature Publishing Group
DOI: 10.1038/s41416-022-02093-x

Tumour growth: An approach to calibrate parameters of a multiphase porous media model based on in vitro observations of Neuroblastoma spheroid growth in a hydrogel microenvironment

Autores: Silvia Hervas-Raluy, Barbara Wirthl, Pedro E. Guerrero, Gil Robalo Rei, Jonas Nitzler, Esther Coronado, Jaime Font de Mora Sainz, Bernhard A. Schrefler, Maria Jose Gomez-Benito, Jose Manuel Garcia-Aznar, Wolfgang A. Wall
Publicado en: Computers in Biology and Medicine, 2023, ISSN 0010-4825
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2023.106895

Hydrocolloids of Egg White and Gelatin as a Platform for Hydrogel-Based Tissue Engineering

Autores: Pele, K.G.; Amaveda, H.; Mora, M.; Marcuello, C.; Lostao, A.; Alamán-Díez, P.; Pérez-Huertas, S.; Ángeles Pérez, M.; García-Aznar, J.M.; García-Gareta, E.
Publicado en: Gels, 2023, ISSN 2310-2861
Editor: MDPI
DOI: 10.3390/gels9060505

CAR-T cells are more affected than T lymphocytes by mechanical constraints: A microfluidic-based approach

Autores: Jack Zhang-Zhou, Nieves Movilla Meno, Carmen Oate Salafranca, Maria Jose Gomez-Benito, Pedro Enrique Guerrero, Julian Pardo Jimeno, Jose Manuel Garca-Aznar
Publicado en: Life Sciences, Edición 363, 2025, Página(s) 123335, ISSN 0024-3205
Editor: Elsevier BV
DOI: 10.1016/j.lfs.2024.123335

A 3D multi-agent-based model for lumen morphogenesis: the role of the biophysical properties of the extracellular matrix

Autores: Daniel Camacho-Gómez; José Manuel García-Aznar; María José Gómez-Benito
Publicado en: ENGINEERING WITH COMPUTERS, Edición 1, 2022, ISSN 0177-0667
Editor: Springer Verlag
DOI: 10.1007/s00366-022-01654-1

A mechanistic protrusive-based model for 3D cell migration

Autores: Merino Casallo, F.; Gómez Benito, M. J.; Martínez Cantín, R.; García Aznar, J. M.
Publicado en: European Journal of Cell Biology, Edición 1, 2022, ISSN 0171-9335
Editor: Elsevier BV
DOI: 10.1016/j.ejcb.2022.151255

Polydopamine Interfacial Coating for Stable Tumor-on-a-Chip Models: Application for Pancreatic Ductal Adenocarcinoma

Autores: Soraya Hernández-Hatibi, Pedro Enrique Guerrero, José Manuel García-Aznar, Elena García-Gareta
Publicado en: Biomacromolecules, Edición 25, 2024, Página(s) 5169-5180, ISSN 1525-7797
Editor: American Chemical Society
DOI: 10.1021/acs.biomac.4c00551

Decellularization of tumours: A new frontier in tissue engineering

Autores: García Gareta, E.; Pérez, M. Á.; García Aznar, J. M.
Publicado en: Journal of Tissue Engineering, Edición 1, 2022, ISSN 2041-7314
Editor: Sage Journals
DOI: 10.1177/20417314221091682

Exploring the potential of Physics-Informed Neural Networks to extract vascularization data from DCE-MRI in the presence of diffusion

Autores: Sainz de Mena, D.; Pérez, M. A. ; García-Aznar, J. M.
Publicado en: MEDICAL ENGINEERING & PHYSICS, 2024, ISSN 1350-4533
Editor: Elsevier BV
DOI: 10.1016/j.medengphy.2023.104092

Borrelia burgdorferi modulates the physical forces and immunity signaling in endothelial cells

Autores: Aparicio Yuste, Raúl; Muenkel, Marie; Axarlis, Konstantinos; Gómez Benito, María J.; Reuss, Annalena; Blacker, Grace; Tal, Michal Caspi; Kraiczy, Peter; Bastounis, Effie E.
Publicado en: iSCIENCE, 2022, ISSN 2589-0042
Editor: CellPress
DOI: 10.1016/j.isci.2022.104793

Mechanotherapy as an alternative for cancer treatment

Autores: JM. Garcia-Aznar
Publicado en: Physics of Life Reviews, Edición 5, 2023, ISSN 1571-0645
Editor: Elsevier BV
DOI: 10.1016/j.plrev.2023.10.007

Collagen-Laponite Nanoclay Hydrogels for Tumor Spheroid Growth

Autores: Pilar Alamán-Díez, Carlos Borau, Pedro Enrique Guerrero, Hippolyte Amaveda, Mario Mora, José María Fraile, Elena García-Gareta, José Manuel García-Aznar, María Ángeles Pérez
Publicado en: BIOMACROMOLECULES, 2023, ISSN 1525-7797
Editor: American Chemical Society
DOI: 10.1021/acs.biomac.3c00257

A hybrid physics-based and data-driven framework for cellular biological systems: Application to the morphogenesis of organoids

Autores: Camacho-Gomez D, Sorzabal-Bellido I, Ortiz-de-Solorzano C, Garcia-Aznar JM, Gomez-Benito MJ.
Publicado en: iScience, 2023, ISSN 2589-0042
Editor: Cell Press
DOI: 10.1016/j.isci.2023.107164

An agent-based method to estimate 3D cell migration trajectories from 2D measurements: Quantifying and comparing T vs CAR-T 3D cell migration

Autores: Daniel Camacho-Gomez, Nieves Movilla, Carlos Borau, Alejandro Martin, Carmen Oñate Salafranca, Julian Pardo, Maria Jose Gomez-Benito, Jose Manuel Garcia-Aznar
Publicado en: Computer Methods and Programs in Biomedicine, Edición 255, 2024, Página(s) 108331, ISSN 0169-2607
Editor: Elsevier BV
DOI: 10.1016/j.cmpb.2024.108331

Hybrid computational models of multicellular tumour growth considering glucose metabolism

Autores: Gonçalves, Inês G.; García-Aznar, José Manuel
Publicado en: Computational and Structural Biotechnology Journal, Edición 1, 2023, ISSN 2001-0370
Editor: Research Networks
DOI: 10.1016/j.csbj.2023.01.044

Physico-chemical characterization of the tumour microenvironment of pancreatic ductal adenocarcinoma

Autores: García-Gareta, E.; Calderón Villalba, A.; Alamán-Díez, P.; Gracia Costa, C.; Guerrero, P.E.; Mur, C.; Rueda Flores, A.; Olivera Jurjo, N.; Sancho, P.; Pérez, M.A.; García-Aznar, J.M.
Publicado en: European Journal of Cell Biology, 2024, ISSN 0171-9335
Editor: Elsevier BV
DOI: 10.1016/j.ejcb.2024.151396

A Mutation in Mouse MT-ATP6 Gene Induces Respiration Defects and Opposed Effects on the Cell Tumorigenic Phenotype

Autores: Raquel Moreno-Loshuertos; Nieves Movilla; Joaquín Marco-Brualla; Ruth Soler-Agesta; Patricia Ferreira; José Antonio Enríquez; Patricio Fernández-Silva
Publicado en: International Journal of Molecular Sciences, Edición 4, 2023, Página(s) Volume 24; Edición 2; Pages: 1300, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24021300

Computational modelling of the mechanical behaviour of protein-based hydrogels

Autores: Ángela Pérez-Benito, Carla Huerta-López, Jorge Alegre-Cebollada, José Manuel García-Aznar, Silvia Hervas-Raluy
Publicado en: Journal of the Mechanical Behavior of Biomedical Materials, 2023, ISSN 1751-6161
Editor: Elsevier BV
DOI: 10.1016/j.jmbbm.2023.105661

Pilar Alamán - Collagen-nanoclay hydrogels for stiffness enhancement of the extracellular matrix: the effect on spheroid growth

Autores: Pilar Alamán
Publicado en: Jornada de Jóvenes Investigadores e Investigadoras del I3A, Edición 3, 2023, ISSN 2341-4790
Editor: Universidad de Zaragoza
DOI: 10.26754/jjii3a.20239524

Quantification of T-cell Migration in Confined and 3D Conditions

Autores: Jack Zhang Zhou; Nieves Movilla Meno; Carmen Oñate Salafranca; Pedro Enrique Guerrero Barrado; Julián Pardo Jimeno; José Manuel García Aznar
Publicado en: Jornada de Jóvenes Investigadores e Investigadoras del I3A, Edición 2, 2023, ISSN 2341-4790
Editor: Universidad de Zaragoza
DOI: 10.26754/jjii3a.20239048

Application of Copper-Based NPs for Cancer Therapy in 3D Microfluidic-Based Cell Culture Model.

Autores: Guerrero Lopez, P., García Peiró, J. I., Hornos Adán, F., Hueso, J. L., García Aznar, J. M., Santamaría, J.
Publicado en: Jornada De Jóvenes Investigadores Del I3A, 11., 2023, ISSN 2341-4790
Editor: Universidad de Zaragoza
DOI: 10.26754/jjii3a.20239038

PhysiCOOL: A generalized framework for model Calibration and Optimization Of modeLing projects

Autores: Inês G. Gonçalves, David A. Hormuth,Sandhya Prabhakaran, Caleb M. Phillips, José Manuel García-Aznar
Publicado en: Gigabyte, 2023, ISSN 2709-4715
Editor: GigaScience Press
DOI: 10.46471/gigabyte.77

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