Individual and Collective Migration of the Immune Cellular System

Project Information

ICoMICS

Grant agreement ID: 101018587

DOI

10.3030/101018587

EC signature date 20 June 2021

Start date 1 January 2022

End date 31 December 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 494 662,00

EU contribution

€ 2 494 662,00

Coordinated by

UNIVERSIDAD DE ZARAGOZA
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (18)

3D collagen migration patterns reveal a SMAD3-dependent and TGF-β1-independent mechanism of recruitment for tumour-associated fibroblasts in lung adenocarcinoma

Author(s): Yago Juste-Lanas, Natalia Díaz-Valdivia, Alejandro Llorente, Rafael Ikemori, Alejandro Bernardo, Marselina Arshakyan, Carlos Borau, Josep Ramírez, José Carlos Ruffinelli, Ernest Nadal, Noemí Reguart, José M. García-Aznar & Jordi Alcaraz
Published in: British Journal of Cancer, 2022, ISSN 0007-0920
Publisher: Nature Publishing Group
DOI: 10.1038/s41416-022-02093-x

Tumour growth: An approach to calibrate parameters of a multiphase porous media model based on in vitro observations of Neuroblastoma spheroid growth in a hydrogel microenvironment

Author(s): Silvia Hervas-Raluy, Barbara Wirthl, Pedro E. Guerrero, Gil Robalo Rei, Jonas Nitzler, Esther Coronado, Jaime Font de Mora Sainz, Bernhard A. Schrefler, Maria Jose Gomez-Benito, Jose Manuel Garcia-Aznar, Wolfgang A. Wall
Published in: Computers in Biology and Medicine, 2023, ISSN 0010-4825
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2023.106895

Hydrocolloids of Egg White and Gelatin as a Platform for Hydrogel-Based Tissue Engineering

Author(s): Pele, K.G.; Amaveda, H.; Mora, M.; Marcuello, C.; Lostao, A.; Alamán-Díez, P.; Pérez-Huertas, S.; Ángeles Pérez, M.; García-Aznar, J.M.; García-Gareta, E.
Published in: Gels, 2023, ISSN 2310-2861
Publisher: MDPI
DOI: 10.3390/gels9060505

CAR-T cells are more affected than T lymphocytes by mechanical constraints: A microfluidic-based approach

Author(s): Jack Zhang-Zhou, Nieves Movilla Meno, Carmen Oate Salafranca, Maria Jose Gomez-Benito, Pedro Enrique Guerrero, Julian Pardo Jimeno, Jose Manuel Garca-Aznar
Published in: Life Sciences, Issue 363, 2025, Page(s) 123335, ISSN 0024-3205
Publisher: Elsevier BV
DOI: 10.1016/j.lfs.2024.123335

A 3D multi-agent-based model for lumen morphogenesis: the role of the biophysical properties of the extracellular matrix

Author(s): Daniel Camacho-Gómez; José Manuel García-Aznar; María José Gómez-Benito
Published in: ENGINEERING WITH COMPUTERS, Issue 1, 2022, ISSN 0177-0667
Publisher: Springer Verlag
DOI: 10.1007/s00366-022-01654-1

A mechanistic protrusive-based model for 3D cell migration

Author(s): Merino Casallo, F.; Gómez Benito, M. J.; Martínez Cantín, R.; García Aznar, J. M.
Published in: European Journal of Cell Biology, Issue 1, 2022, ISSN 0171-9335
Publisher: Elsevier BV
DOI: 10.1016/j.ejcb.2022.151255

Polydopamine Interfacial Coating for Stable Tumor-on-a-Chip Models: Application for Pancreatic Ductal Adenocarcinoma

Author(s): Soraya Hernández-Hatibi, Pedro Enrique Guerrero, José Manuel García-Aznar, Elena García-Gareta
Published in: Biomacromolecules, Issue 25, 2024, Page(s) 5169-5180, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.4c00551

Decellularization of tumours: A new frontier in tissue engineering

Author(s): García Gareta, E.; Pérez, M. Á.; García Aznar, J. M.
Published in: Journal of Tissue Engineering, Issue 1, 2022, ISSN 2041-7314
Publisher: Sage Journals
DOI: 10.1177/20417314221091682

Exploring the potential of Physics-Informed Neural Networks to extract vascularization data from DCE-MRI in the presence of diffusion

Author(s): Sainz de Mena, D.; Pérez, M. A. ; García-Aznar, J. M.
Published in: MEDICAL ENGINEERING & PHYSICS, 2024, ISSN 1350-4533
Publisher: Elsevier BV
DOI: 10.1016/j.medengphy.2023.104092

Borrelia burgdorferi modulates the physical forces and immunity signaling in endothelial cells

Author(s): Aparicio Yuste, Raúl; Muenkel, Marie; Axarlis, Konstantinos; Gómez Benito, María J.; Reuss, Annalena; Blacker, Grace; Tal, Michal Caspi; Kraiczy, Peter; Bastounis, Effie E.
Published in: iSCIENCE, 2022, ISSN 2589-0042
Publisher: CellPress
DOI: 10.1016/j.isci.2022.104793

Mechanotherapy as an alternative for cancer treatment

Author(s): JM. Garcia-Aznar
Published in: Physics of Life Reviews, Issue 5, 2023, ISSN 1571-0645
Publisher: Elsevier BV
DOI: 10.1016/j.plrev.2023.10.007

Collagen-Laponite Nanoclay Hydrogels for Tumor Spheroid Growth

Author(s): Pilar Alamán-Díez, Carlos Borau, Pedro Enrique Guerrero, Hippolyte Amaveda, Mario Mora, José María Fraile, Elena García-Gareta, José Manuel García-Aznar, María Ángeles Pérez
Published in: BIOMACROMOLECULES, 2023, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.3c00257

A hybrid physics-based and data-driven framework for cellular biological systems: Application to the morphogenesis of organoids

Author(s): Camacho-Gomez D, Sorzabal-Bellido I, Ortiz-de-Solorzano C, Garcia-Aznar JM, Gomez-Benito MJ.
Published in: iScience, 2023, ISSN 2589-0042
Publisher: Cell Press
DOI: 10.1016/j.isci.2023.107164

An agent-based method to estimate 3D cell migration trajectories from 2D measurements: Quantifying and comparing T vs CAR-T 3D cell migration

Author(s): Daniel Camacho-Gomez, Nieves Movilla, Carlos Borau, Alejandro Martin, Carmen Oñate Salafranca, Julian Pardo, Maria Jose Gomez-Benito, Jose Manuel Garcia-Aznar
Published in: Computer Methods and Programs in Biomedicine, Issue 255, 2024, Page(s) 108331, ISSN 0169-2607
Publisher: Elsevier BV
DOI: 10.1016/j.cmpb.2024.108331

Hybrid computational models of multicellular tumour growth considering glucose metabolism

Author(s): Gonçalves, Inês G.; García-Aznar, José Manuel
Published in: Computational and Structural Biotechnology Journal, Issue 1, 2023, ISSN 2001-0370
Publisher: Research Networks
DOI: 10.1016/j.csbj.2023.01.044

Physico-chemical characterization of the tumour microenvironment of pancreatic ductal adenocarcinoma

Author(s): García-Gareta, E.; Calderón Villalba, A.; Alamán-Díez, P.; Gracia Costa, C.; Guerrero, P.E.; Mur, C.; Rueda Flores, A.; Olivera Jurjo, N.; Sancho, P.; Pérez, M.A.; García-Aznar, J.M.
Published in: European Journal of Cell Biology, 2024, ISSN 0171-9335
Publisher: Elsevier BV
DOI: 10.1016/j.ejcb.2024.151396

A Mutation in Mouse MT-ATP6 Gene Induces Respiration Defects and Opposed Effects on the Cell Tumorigenic Phenotype

Author(s): Raquel Moreno-Loshuertos; Nieves Movilla; Joaquín Marco-Brualla; Ruth Soler-Agesta; Patricia Ferreira; José Antonio Enríquez; Patricio Fernández-Silva
Published in: International Journal of Molecular Sciences, Issue 4, 2023, Page(s) Volume 24; Issue 2; Pages: 1300, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24021300

Computational modelling of the mechanical behaviour of protein-based hydrogels

Author(s): Ángela Pérez-Benito, Carla Huerta-López, Jorge Alegre-Cebollada, José Manuel García-Aznar, Silvia Hervas-Raluy
Published in: Journal of the Mechanical Behavior of Biomedical Materials, 2023, ISSN 1751-6161
Publisher: Elsevier BV
DOI: 10.1016/j.jmbbm.2023.105661

Conference proceedings (3)

Pilar Alamán - Collagen-nanoclay hydrogels for stiffness enhancement of the extracellular matrix: the effect on spheroid growth

Author(s): Pilar Alamán
Published in: Jornada de Jóvenes Investigadores e Investigadoras del I3A, Issue 3, 2023, ISSN 2341-4790
Publisher: Universidad de Zaragoza
DOI: 10.26754/jjii3a.20239524

Quantification of T-cell Migration in Confined and 3D Conditions

Author(s): Jack Zhang Zhou; Nieves Movilla Meno; Carmen Oñate Salafranca; Pedro Enrique Guerrero Barrado; Julián Pardo Jimeno; José Manuel García Aznar
Published in: Jornada de Jóvenes Investigadores e Investigadoras del I3A, Issue 2, 2023, ISSN 2341-4790
Publisher: Universidad de Zaragoza
DOI: 10.26754/jjii3a.20239048

Application of Copper-Based NPs for Cancer Therapy in 3D Microfluidic-Based Cell Culture Model.

Author(s): Guerrero Lopez, P., García Peiró, J. I., Hornos Adán, F., Hueso, J. L., García Aznar, J. M., Santamaría, J.
Published in: Jornada De Jóvenes Investigadores Del I3A, 11., 2023, ISSN 2341-4790
Publisher: Universidad de Zaragoza
DOI: 10.26754/jjii3a.20239038

Non-peer reviewed articles (1)

PhysiCOOL: A generalized framework for model Calibration and Optimization Of modeLing projects

Author(s): Inês G. Gonçalves, David A. Hormuth,Sandhya Prabhakaran, Caleb M. Phillips, José Manuel García-Aznar
Published in: Gigabyte, Issue 5, 2023, ISSN 2709-4715
Publisher: GigaScience Press
DOI: 10.46471/gigabyte.77