CBASS: Life, Death and cyclic nucleotides

Project Information

CBASS

Grant agreement ID: 101018608

DOI

10.3030/101018608

EC signature date 15 July 2021

Start date 1 August 2021

End date 31 January 2027

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 785 866,00

EU contribution

€ 1 785 866,00

Coordinated by

THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (15)

Antiviral signaling by a cyclic nucleotide activated CRISPR protease

Author(s): Christophe Marcel Joseph Rouillon, Niels Schneberger, Haotian Chi, Katja Blumenstock, Stefano Da Vela, Katrin Ackermann, Jonas Moecking, Martin F. Peter, Wolfgang Boenigk, Reinhard Seifert, Bela Ernest Bode, Jonathan L. Schmid-Burgk, Dmitri Svergun, Matthias Geyer, Malcolm F. White, Gregor Hageluken
Published in: Nature, 2023, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-05571-7

SAM-AMP lyases in type III CRISPR defence

Author(s): Haotian Chi, Stephen McMahon, Lukas Daniel-Pedersen, Shirley Graham, Tracey M Gloster, Malcolm F White
Published in: Nucleic Acids Research, Issue 53, 2025, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkaf655

Activation of Csm6 ribonuclease by cyclic nucleotide binding: in an emergency, twist to open

Author(s): Stuart McQuarrie; Januka S Athukoralage; Stephen A McMahon; Shirley Graham; Katrin Ackermann; Bela E Bode; Malcolm F White; Tracey M Gloster
Published in: Nucleic Acids Research, 2023, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkad739

Structure and mechanism of the broad spectrum CRISPR-associated ring nuclease Crn4

Author(s): Haotian Chi, Ville Hoikkala, Stephen McMahon, Shirley Graham, Tracey Gloster, Malcolm F. White
Published in: Nature Communications, Issue 17, 2026, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-025-67607-6

Cyclic nucleotide signaling in phage defense and counter-defense

Author(s): Januka S. Athukoralage and Malcolm F. White
Published in: Annual Reviews in Virology, Issue 9, 2022, Page(s) 451-468, ISSN 2327-056X
Publisher: Annual Reviews
DOI: 10.1146/annurev-virology-100120-010228

A viral SAVED protein with ring nuclease activity degrades the CRISPR second messenger cA4

Author(s): Marta Orzechowski, Ville Hoikkala, Haotian Chi, Stephen McMahon, Tracey Gloster, Malcolm F White
Published in: Biochemical Journal, Issue 482, 2025, Page(s) 1707-1719, ISSN 0264-6021
Publisher: Portland Press, Ltd.
DOI: 10.1042/bcj20253271

Structure of the Saccharolobus solfataricus type III-D CRISPR effector

Author(s): Giuseppe Cannone, Dmytro Kompaniiets, Shirley Graham, Malcolm F White, Laura Spagnolo
Published in: Current Research in Structural Biology, Issue 5, 2023, Page(s) 100098, ISSN 2665-928X
Publisher: Elsevier
DOI: 10.1016/j.crstbi.2023.100098

CRISPR antiphage defence mediated by the cyclic nucleotide-binding membrane protein Csx23

Author(s): Sabine Grüschow, Stuart McQuarrie, Katrin Ackermann, Stephen McMahon, Bela E Bode, Tracey M Gloster, Malcolm F White
Published in: Nucleic Acids Research, Issue 52, 2024, Page(s) 2761-2775, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkae167

Bioinformatic analysis of type III CRISPR systems reveals key properties and new effector families

Author(s): Ville Hoikkala, Shirley Graham, Malcolm F White
Published in: Nucleic Acids Research, Issue 52, 2024, Page(s) 7129-7141, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkae462

Reversible conjugation of a CBASS nucleotide cyclase regulates bacterial immune response to phage infection

Author(s): Larissa Krüger, Laura Gaskell-Mew, Shirley Graham, Sally Shirran, Robert Hertel, Malcolm F. White
Published in: Nature Microbiology, Issue 9, 2024, Page(s) 1579-1592, ISSN 2058-5276
Publisher: Springer Nature
DOI: 10.1038/s41564-024-01670-5

Cas10 based 7SL-sRNA diagnostic for the detection of active trypanosomosis

Author(s): Sabine Grüschow, Pieter C. Steketee, Edith Paxton, Keith R. Matthews, Liam J. Morrison, Malcolm F. White, Finn Grey
Published in: PLOS Neglected Tropical Diseases, Issue 19, 2025, Page(s) e0012937, ISSN 1935-2735
Publisher: Public Library of Science (PLoS)
DOI: 10.1371/journal.pntd.0012937

Diversity and abundance of ring nucleases in type III CRISPR-Cas loci

Author(s): Ville Hoikkala, Haotian Chi, Sabine Grüschow, Shirley Graham, Malcolm F White
Published in: Philosophical Transactions of the Royal Society B: Biological Sciences, Issue 380, 2025, ISSN 0962-8436
Publisher: Royal Society of London
DOI: 10.1098/rstb.2024.0084

Cyclic nucleotide-induced helical structure activates a TIR immune effector

Author(s): Gaëlle Hogrel, Abbie Guild, Shirley Graham, Hannah Rickman, Sabine Grüschow, Quentin Bertrand, Laura Spagnolo, Malcolm F. White
Published in: Nature, Issue 608, 2022, Page(s) 808-812, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-05070-9

Antiviral Type III CRISPR signalling via conjugation of ATP and AdoMet

Author(s): Haotian Chi; Ville Hoikkala; Sabine Grüschow; Shirley Graham; Sally Shirran; Malcolm F White
Published in: Nature, 2023, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1101/2023.06.26.546636

RNA processing by the CRISPR-associated NYN ribonuclease

Author(s): Haotian Chi, Malcolm F. White
Published in: Biochemical Journal, Issue 481, 2024, Page(s) 793-804, ISSN 0264-6021
Publisher: Portland Press, Ltd.
DOI: 10.1042/bcj20240151