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Pinpointing novel molecular and cellular functions generated by retroelement onco-exaptation

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Antibodies against endogenous retroviruses promote lung cancer immunotherapy (opens in new window)

Author(s): Kevin W Ng, Jesse Boumelha, Katey S S Enfield, Jorge Almagro, Hongui Cha, Oriol Pich, Takahiro Karasaki, David A Moore, Roberto Salgado, Monica Sivakumar, George Young, Miriam Molina-Arcas, Sophie de Carné Trécesson, Panayiotis Anastasiou, Annika Fendler, Lewis Au, Scott T C Shepherd, Carlos Martínez-Ruiz, Clare Puttick, James R M Black, Thomas B K Watkins, Hyemin Kim, Seohee Shim, Nikhil Faulk
Published in: Nature, 2023, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-023-05771-9

Evolution of antiviral host defenses against a backdrop of endogenous retroelements (opens in new window)

Author(s): George Kassiotis, Jonathan P. Stoye
Published in: Science, Issue 389, 2025, Page(s) 588-593, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.adx4379

Retroelement co-option disrupts the cancer transcriptional programme (opens in new window)

Author(s): Jane Loong, Rachael Thompson, Callum Hall, Laura Doglio, Judith Pape, Tobias Plowman, George Kassiotis
Published in: Genome Medicine, Issue 17, 2025, ISSN 1756-994X
Publisher: BioMed Central
DOI: 10.1186/s13073-025-01479-9

Antibodies against endogenous retroviruses (opens in new window)

Author(s): Mihaela Chisca, Jean‐David Larouche, Qi Xing, George Kassiotis
Published in: Immunological Reviews, Issue 328, 2024, Page(s) 300-313, ISSN 0105-2896
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/imr.13378

Primate retroelement exonization and sexually dimorphic <i>IL13RA1</i> transcription tune type 2 immune responses (opens in new window)

Author(s): Tobias Plowman, Tom Hofland, Callum Hall, Rachael Thompson, Judith Pape, Kevin W. Ng, Laura Doglio, George Kassiotis
Published in: Science Immunology, Issue 10, 2025, ISSN 2470-9468
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciimmunol.adr1105

Human endogenous retrovirus onco-exaptation counters cancer cell senescence through Calbindin

Author(s): Jan Attig, Judith Pape, Laura Doglio, Anastasiya Kazachenka, Eleonora Ottina, George R Young, Katey Ss Enfield, Iker Valle Aramburu, Kevin W Ng, Nikhil Faulkner, William Bolland, Venizelos Papayannopoulos, Charles Swanton, George Kassiotis
Published in: J Clin Invest, 2023, ISSN 0021-9738
Publisher: American Society for Clinical Investigation

Tracking Nongenetic Evolution from Primary to Metastatic ccRCC: TRACERx Renal (opens in new window)

Author(s): Ángel Fernández-Sanromán, Annika Fendler, Benjy J.Y. Tan, Anne-Laure Cattin, Charlotte Spencer, Rachael Thompson, Lewis Au, Irene Lobon, Husayn Ahmed Pallikonda, Alice Martin, Fiona Byrne, Antonia Franz, Anna Mikolajczak, Haseeb Rahman, Zayd Tippu, Scott T.C. Shepherd, Hugang Feng, Daqi Deng, Andrew Rowan, Lisa Pickering, Andrew J.S. Furness, Kate Young, David Nicol, Sarah Maria Rudman, Tim O
Published in: Cancer Discovery, Issue 15, 2025, Page(s) 530-552, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-24-0499

The transcriptional landscape of endogenous retroelements delineates esophageal adenocarcinoma subtypes (opens in new window)

Author(s): Anastasiya Kazachenka; Jane Hc Loong; Jan Attig; George R Young; Piyali Ganguli; Ginny Devonshire; Nicola Grehan; Rebecca C Fitzgerald; Paul A W Edwards; Nicola Grehan; Barbara Nutzinger; Elwira Fidziukiewicz; Aisling M Redmond; Sujath Abbas; Adam Freeman; Elizabeth C Smyth; Maria O’Donovan; Ahmad Miremadi; Shalini Malhotra; Monika Tripathi; Calvin Cheah; Hannah Coles; Connor Flint; Matthew Eldr
Published in: NAR Cancer, 2023, ISSN 2632-8674
Publisher: Oxford University Press
DOI: 10.1093/narcan/zcad040

The Immunological Conundrum of Endogenous Retroelements

Author(s): George Kassiotis
Published in: Annu Rev Immunol, 2023, ISSN 0732-0582
Publisher: Annual Reviews, Inc.

Evolution of a melanoma that escapes allogeneic rejection (opens in new window)

Author(s): Ahmed Rokan, Mariana O. Diniz, Jose I. de las Heras, Callum Hall, Somaya Noorsaeed, Clare L. Bennett, Maria Secrier, George Kassiotis, Ariberto Fassati
Published in: Cell Reports, Issue 44, 2025, Page(s) 116288, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2025.116288

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