Project description
Retroelements and cancer evolution
Nearly 50 % of the human genome consists of mobile genetic elements that are thought to have emerged from the integration of retroelement genomes. Although these are believed to confer novel functions and a host fitness advantage, they may also have an oncogenic role. The EU-funded RETROFIT project aims to detect and quantify the transcription of endogenous retroelements and decipher their participation in the cancer transcriptome. Researchers will identify retroelements that have a potential impact on overall cancer survival rates or that respond to immunotherapy. RETROFIT is expected to unveil novel targets for the design of cancer treatments.
Fields of science
Programme(s)
Topic(s)
Funding Scheme
ERC-ADG - Advanced Grant
Host institution
THE FRANCIS CRICK INSTITUTE LIMITED
Net EU contribution
€ 2 483 691,00
Address
1 Midland Road
NW1 1AT London
United Kingdom
NW1 1AT London
United Kingdom
See on map
Region
London Inner London — West Camden and City of London
Activity type
Research Organisations
Other funding
€ 0,00
Beneficiaries (1)
THE FRANCIS CRICK INSTITUTE LIMITED
United Kingdom
Net EU contribution
€ 2 483 691,00
Address
1 Midland Road
NW1 1AT London
NW1 1AT London
See on map
Region
London Inner London — West Camden and City of London
Activity type
Research Organisations
Other funding
€ 0,00