The Energetics and Habitat of Metabolic Origin

Información del proyecto

EcolMetabOrigin

Identificador del acuerdo de subvención: 101018894

DOI

10.3030/101018894

Fecha de la firma de la CE 1 Mayo 2021

Fecha de inicio 1 Noviembre 2021

Fecha de finalización 31 Octubre 2026

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 490 000,00

Aportación de la UE

€ 2 490 000,00

Coordinado por

HEINRICH-HEINE-UNIVERSITAET DUESSELDORF
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (28)

ATP requirements for growth reveal the bioenergetic impact of mitochondrial symbiosis

Autores: William F. Martin
Publicado en: Biochimica et Biophysica Acta (BBA) - Bioenergetics, Edición 1866, 2025, Página(s) 149564, ISSN 0005-2728
Editor: Elsevier BV
DOI: 10.1016/j.bbabio.2025.149564

Serpentinization as the source of energy, electrons, organics, catalysts, nutrients and pH gradients for the origin of LUCA and life

Autores: Schwander L, Brabender M, Mrnjavac N, Wimmer JLE, Preiner M, Martin WF
Publicado en: Frontiers in Microbiology, Edición 14, 2023, Página(s) 1257597, ISSN 1664-302X
Editor: Frontiers Media
DOI: 10.3389/fmicb.2023.1257597

GTP before ATP: The energy currency at the origin of genes

Autores: Natalia Mrnjavac, William F. Martin
Publicado en: Biochimica et Biophysica Acta (BBA) - Bioenergetics, Edición 1866, 2024, Página(s) 149514, ISSN 0005-2728
Editor: Elsevier BV
DOI: 10.1016/j.bbabio.2024.149514

Gene Duplications Are At Least 50 Times Less Frequent than Gene Transfers in Prokaryotic Genomes

Autores: Fernando D K Tria, William F Martin
Publicado en: Genome Biology and Evolution, Edición 13/10, 2021, ISSN 1759-6653
Editor: Oxford University Press
DOI: 10.1093/gbe/evab224

Ambient temperature CO2 fixation to pyruvate and subsequently to citramalate over iron and nickel nanoparticles

Autores: Beyazay T, Belthle KS, Farès C, Preiner M, Moran J, Martin WF, Tüysüz H
Publicado en: Nature Communications, Edición 14, 2023, Página(s) 570, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-36088-w

Synergistic Effects of Silica‐Supported Iron−Cobalt Catalysts for CO₂ Reduction to Prebiotic Organics

Autores: Kendra S. Belthle, William F. Martin, Harun Tüysüz
Publicado en: ChemCatChem, Edición 16, 2024, ISSN 1867-3880
Editor: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/cctc.202301218

Narrowing gaps between Earth and life

Autores: Martin WF
Publicado en: Proc Natl Acad Sci USA, 2022, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2216017119

Conversion of pyridoxal to pyridoxamine with <scp>NH</scp>₃ and <scp>H</scp>₂ on nickel generates a protometabolic nitrogen shuttle under serpentinizing conditions

Autores: Manon Laura Schlikker, Max Brabender, Loraine Schwander, Carolina Garcia Garcia, Maximillian Burmeister, Sabine Metzger, Joseph Moran, William F. Martin
Publicado en: The FEBS Journal, 2024, ISSN 1742-464X
Editor: Blackwell Publishing Inc.
DOI: 10.1111/febs.17357

Pyrophosphate and Irreversibility in Evolution, or why PPi Is Not an Energy Currency and why Nature Chose Triphosphates

Autores: Jessica L. E. Wimmer, Karl Kleinermanns, William F. Martin
Publicado en: Frontiers in Microbiology, Edición 12, 2021, ISSN 1664-302X
Editor: Frontiers Media
DOI: 10.3389/fmicb.2021.759359

The ancestral mitotic state: Closed orthomitosis with intranuclear spindles in the syncytial last eukaryotic common ancestor.

Autores: Bremer N, Tria FDK, Skejo J, Martin WF
Publicado en: Genome Biology and Evolution, 2023, ISSN 1759-6653
Editor: Oxford University Press
DOI: 10.1093/gbe/evad016

A prebiotic Krebs cycle analog generates amino acids with H2 and NH3 over nickel

Autores: Kaur H, Rauscher SA, Werner E, Song Y, Yi J, Kazöne W, Martin WF, Tüysüz H, Moran J
Publicado en: Chem, Edición 10, 2024, Página(s) 1-13, ISSN 2451-9294
Editor: Cell Press
DOI: 10.1016/j.chempr.2024.02.001

Direct synthesis of formamide from CO2 and H2O with nickel–iron nitride heterostructures under mild hydrothermal conditions

Autores: Beyazay T, Martin WF, Tüysüz H
Publicado en: Journal of the American Chemical Society, Edición 145, 2023, Página(s) 19768–19779, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.3c05412

Ancestral state reconstructions trace mitochondria but not phagocytosis to the last eukaryotic common ancestor

Autores: Bremer N, Tria FDK, Skejo J, Garg SG, Martin WF
Publicado en: Genome Biology and Evolution, 2022, ISSN 1759-6653
Editor: Oxford University Press
DOI: 10.1093/gbe/evac079

Chemiosmotic ATP synthesis by minimal protocells

Autores: Fanchen Yu, Jinbo Fei, Yi Jia, Tonghui Wang, William F. Martin, Junbai Li
Publicado en: Cell Reports Physical Science, Edición 6, 2025, Página(s) 102461, ISSN 2666-3864
Editor: Elsevier BV
DOI: 10.1016/j.xcrp.2025.102461

Ferredoxin reduction by hydrogen with iron functions as an evolutionary precursor of flavin-based electron bifurcation

Autores: Brabender M, Henriques Pereira DP, Mrnjavac N, Schlikker ML, Kimura Z-I, Sucharitakul J, Kleinermanns K, Tüysüz H, Buckel W, Preiner M, Martin WF
Publicado en: Proceedings of the National Academy of Sciences of the United States of America, Edición 121, 2024, Página(s) e2318969121, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2318969121

Archaeal pseudomurein and bacterial murein cell wall biosynthesis share a common evolutionary ancestry

Autores: Bishwa P. Subedi, William F. Martin, Vincenzo Carbone, Eduardus C. Duin, Bryan Cronin, Julia Sauter, Linley R. Schofield, Andrew J. Sutherland-Smith, Ron S. Ronimus
Publicado en: FEMS Microbes, 2021, ISSN 2633-6685
Editor: Oxford University Press
DOI: 10.1093/femsmc/xtab012

Cryptic diversity of cellulose-degrading gut bacteria in industrialized humans

Autores: Moraïs S, Winkler S, Zorea A, Levin L, Nagies FSP, Kapust N, Lamed E, Artan-Furman A, Bolam DN, Yadav MP, Bayer EA, Martin WF, Mizrahi I
Publicado en: Science, 2024, Página(s) eadj9223, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.adj9223

The Moon-forming impact and the autotrophic origin of life

Autores: Mrnjavac N, Wimmer JLE, Brabender M, Schwander L, Martin WF
Publicado en: ChemPlusChem, 2023, Página(s) e202300270, ISSN 2192-6506
Editor: Wiley-VCH Verlag
DOI: 10.1002/cplu.202300270

Chemical Antiquity in Metabolism

Autores: Natalia Mrnjavac, Loraine Schwander, Max Brabender, William F. Martin
Publicado en: Accounts of Chemical Research, Edición 57, 2024, Página(s) 2267-2278, ISSN 0001-4842
Editor: American Chemical Society
DOI: 10.1021/acs.accounts.4c00226

The radical impact of oxygen on prokaryotic evolution—enzyme inhibition first, uninhibited essential biosyntheses second, aerobic respiration third

Autores: Natalia Mrnjavac, Falk S. P. Nagies, Jessica L. E. Wimmer, Nils Kapust, Michael R. Knopp, Katharina Trost, Luca Modjewski, Nico Bremer, Marek Mentel, Mauro Degli Esposti, Itzhak Mizrahi, John F. Allen, William F. Martin
Publicado en: FEBS Letters, Edición 598, 2024, Página(s) 1692-1714, ISSN 0014-5793
Editor: Elsevier BV
DOI: 10.1002/1873-3468.14906

Evidence for corrin biosynthesis in the last universal common ancestor

Autores: Luca D. Modjewski, Val Karavaeva, Natalia Mrnjavac, Michael Knopp, William F. Martin, Filipa L. Sousa
Publicado en: The FEBS Journal, Edición 292, 2025, Página(s) 827-850, ISSN 1742-464X
Editor: Blackwell Publishing Inc.
DOI: 10.1111/febs.17367

Role of geochemical protoenzymes (geozymes) in primordial metabolism: specific abiotic hydride transfer by metals to the biological redox cofactor NAD+

Autores: Delfina P. Henriques Pereira, Jana Leethaus, Tugce Beyazay, Andrey do Nascimento Vieira, Karl Kleinermanns, Harun Tüysüz, William F. Martin, Martina Preiner
Publicado en: The FEBS Journal, Edición 289, 2022, Página(s) 3148-3162, ISSN 1742-464X
Editor: Blackwell Publishing Inc.
DOI: 10.1111/febs.16329

Realistic Gene Transfer to Gene Duplication Ratios Identify Different Roots in the Bacterial Phylogeny Using a Tree Reconciliation Method.

Autores: Nico Bremer; Michael Knopp; William F. Martin; Fernando D. K. Tria
Publicado en: Life; Volume 12; Edición 7; Pages: 995, Edición 1, 2022, ISSN 2075-1729
Editor: MDPI AG
DOI: 10.3390/life12070995

The early evolution of the glycolytic pathway from autotrophic origins to glycogen and back

Autores: Luca D Modjewski, Ulrike Johnsen, Peter Schönheit, William F Martin
Publicado en: FEMS Microbiology Reviews, Edición 49, 2025, ISSN 1574-6976
Editor: Oxford University Press (OUP)
DOI: 10.1093/femsre/fuaf049

Three enzymes governed the rise of O2 on Earth

Autores: Natalia Mrnjavac, Mauro Degli Esposti, Itzhak Mizrahi, William F. Martin, John F. Allen
Publicado en: Biochimica et Biophysica Acta (BBA) - Bioenergetics, Edición 1865, 2024, Página(s) 149495, ISSN 0005-2728
Editor: Elsevier BV
DOI: 10.1016/j.bbabio.2024.149495

Surprising effects of differential loss in genome evolution: the last-one-out

Autores: Nico Bremer, William F Martin, Mike Steel
Publicado en: FEMS Microbiology Letters, Edición 372, 2025, ISSN 1574-6968
Editor: Oxford University Press (OUP)
DOI: 10.1093/femsle/fnaf051

Energy at Origins: Favorable Thermodynamics of Biosynthetic Reactions in the Last Universal Common Ancestor (LUCA)

Autores: Jessica L. E. Wimmer; Joana C. Xavier; Andrey d. N. Vieira; Delfina P. H. Pereira; Jacqueline Leidner; Filipa L. Sousa; Karl Kleinermanns; Martina Preiner; William F. Martin
Publicado en: Frontiers in Microbiology, Edición 1, 2021, ISSN 1664-302X
Editor: Frontiers Media
DOI: 10.3389/fmicb.2021.793664

A universal and constant rate of gene content change traces pangenome flux to LUCA

Autores: Katharina Trost, Michael R Knopp, Jessica L E Wimmer, Fernando D K Tria, William F Martin
Publicado en: FEMS Microbiology Letters, Edición 371, 2024, ISSN 1574-6968
Editor: Oxford University Press
DOI: 10.1093/femsle/fnae068