Tissue cytokines are at the centre of immune cell-driven inflammation in myocarditis
Myocarditis is an acute inflammatory heart disease caused by the body’s immune system in response to an infection or other triggers. Recent studies identified cross-reactive CD4+ T cells as central players in the inflammatory cardiomyopathy pathogenesis, in which activation is controlled by the tissue cytokines of the transforming growth factor-beta superfamily. The goal of the EU-funded CardiacStroma project is to decipher the molecular pathways that control the interaction of immune cells with stromal cells in the cardiac tissue during inflammation reaction. The project will identify novel targets for the treatment of myocarditis and inflammatory cardiomyopathy, validate antibodies that ameliorate cardiac inflammation, and provide a comprehensive analysis of the cellular and molecular changes during cardiac inflammation.
Fields of science
Funding SchemeERC-ADG - Advanced Grant
9007 St. Gallen
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