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Tissue Cytokines at the Nexus of Immune Cell-Cardiac Stromal Cell Interaction

Project description

Tissue cytokines are at the centre of immune cell-driven inflammation in myocarditis

Myocarditis is an acute inflammatory heart disease caused by the body’s immune system in response to an infection or other triggers. Recent studies identified cross-reactive CD4+ T cells as central players in the inflammatory cardiomyopathy pathogenesis, in which activation is controlled by the tissue cytokines of the transforming growth factor-beta superfamily. The goal of the EU-funded CardiacStroma project is to decipher the molecular pathways that control the interaction of immune cells with stromal cells in the cardiac tissue during inflammation reaction. The project will identify novel targets for the treatment of myocarditis and inflammatory cardiomyopathy, validate antibodies that ameliorate cardiac inflammation, and provide a comprehensive analysis of the cellular and molecular changes during cardiac inflammation.

Host institution

KANTONSSPITAL ST. GALLEN
Net EU contribution
€ 2 424 000,00
Address
Rorschacherstrasse 95
9007 St. Gallen
Switzerland

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Region
Schweiz/Suisse/Svizzera Ostschweiz St. Gallen
Activity type
Research Organisations
Other funding
€ 0,00

Beneficiaries (1)

KANTONSSPITAL ST. GALLEN
Switzerland
Net EU contribution
€ 2 424 000,00
Address
Rorschacherstrasse 95
9007 St. Gallen

See on map

Region
Schweiz/Suisse/Svizzera Ostschweiz St. Gallen
Activity type
Research Organisations
Other funding
€ 0,00