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Sexual dimorphIsM in renal PrOgenitors to explain gender- Specificity In kidney physiOlogy aNd diseases

Project description

The role of gender in kidney homeostasis and disease

Compared to males, females seem to be protected from kidney diseases including kidney cancer. This sexual dimorphism offers females an advantage against the age-related decline in renal function, which is the main cause of kidney disease. The EU-funded SIMPOSION project is working on the hypothesis that oestrogen signalling in renal progenitors supports their survival and self-renewal. Researchers will also test the rationale that the higher incidence of kidney cancer in males can be explained by lower renal progenitor numbers and a higher proliferation rate. Moreover, this sex hormone renal progenitor axis will be studied under the prism of pregnancy.

Host institution

UNIVERSITA DEGLI STUDI DI FIRENZE
Net EU contribution
€ 2 167 456,25
Address
Piazza San Marco 4
50121 Florence
Italy

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Region
Centro (IT) Toscana Firenze
Activity type
Higher or Secondary Education Establishments
Other funding
€ 2 167 456,25

Beneficiaries (2)

UNIVERSITA DEGLI STUDI DI FIRENZE
Italy
Net EU contribution
€ 2 167 456,25
Address
Piazza San Marco 4
50121 Florence

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Region
Centro (IT) Toscana Firenze
Activity type
Higher or Secondary Education Establishments
Other funding
€ 2 167 456,25
AARHUS UNIVERSITET
Denmark
Net EU contribution
€ 129 443,75
Address
Nordre Ringgade 1
8000 Aarhus C

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Region
Danmark Midtjylland Østjylland
Activity type
Higher or Secondary Education Establishments
Other funding
€ 129 443,75