Project description
The role of gender in kidney homeostasis and disease
Compared to males, females seem to be protected from kidney diseases including kidney cancer. This sexual dimorphism offers females an advantage against the age-related decline in renal function, which is the main cause of kidney disease. The EU-funded SIMPOSION project is working on the hypothesis that oestrogen signalling in renal progenitors supports their survival and self-renewal. Researchers will also test the rationale that the higher incidence of kidney cancer in males can be explained by lower renal progenitor numbers and a higher proliferation rate. Moreover, this sex hormone renal progenitor axis will be studied under the prism of pregnancy.
Fields of science
- medical and health sciencesclinical medicineobstetricsfetal medicine
- medical and health sciencesmedical biotechnologycells technologiesstem cells
- medical and health sciencesclinical medicineoncology
- medical and health sciencesbasic medicinephysiology
- medical and health sciencesclinical medicinenephrologykidney diseases
Programme(s)
Topic(s)
Funding Scheme
ERC-ADG - Advanced GrantHost institution
UNIVERSITA DEGLI STUDI DI FIRENZE
Net EU contribution
€ 2 167 456,25
Address
Piazza San Marco 4
50121 Florence
Italy
50121 Florence
Italy
See on map
Region
Centro (IT) Toscana Firenze
Activity type
Higher or Secondary Education Establishments
Other funding
€ 2 167 456,25
Beneficiaries (2)
UNIVERSITA DEGLI STUDI DI FIRENZE
Italy
Net EU contribution
€ 2 167 456,25
Address
Piazza San Marco 4
50121 Florence
50121 Florence
See on map
Region
Centro (IT) Toscana Firenze
Activity type
Higher or Secondary Education Establishments
Other funding
€ 2 167 456,25
AARHUS UNIVERSITET
Denmark
Net EU contribution
€ 129 443,75
Address
Nordre Ringgade 1
8000 Aarhus C
8000 Aarhus C
See on map
Region
Danmark Midtjylland Østjylland
Activity type
Higher or Secondary Education Establishments
Other funding
€ 129 443,75