"Targeting the ""untargetable"" by merging biological and chemical compound libraries"

Project Information

TARGET

Grant agreement ID: 101020521

DOI

10.3030/101020521

EC signature date 22 May 2021

Start date 1 January 2022

End date 31 December 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 239 500,00

EU contribution

€ 2 239 500,00

Coordinated by

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (5)

Solid-phase peptide synthesis in 384-well plates

Author(s): Mischa Schüttel, Edward Will, Gontran Sangouard, Anne Zarda, Sevan Habeshian, Alexander L. Nielsen, Christian Heinis
Published in: Journal of Peptide Science, Issue Volume 30, Issue 4, 2024, ISSN 1075-2617
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/psc.3555

Solid-phase peptide synthesis on disulfide-linker resin followed by reductive release affords pure thiol-functionalized peptides

Author(s): Zsolt Bognar; Ganesh K. Mothukuri; Alexander L. Nielsen; Manuel L. Merz; Peter M. F. Pânzar; Christian Heinis
Published in: Organic & Biomolecular Chemistry, Issue Volume 20, issue 29, 2022, Page(s) 5699-5703, ISSN 1477-0520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2ob00910b

Large Libraries of Structurally Diverse Macrocycles Suitable for Membrane Permeation

Author(s): Alexander Lund Nielsen Zsolt Bognar Ganesh K. Mothukuri Anne Zarda Mischa Schüttel, Manuel L. Merz Xinjian Ji Edward J. Will Monica Chinellato Christian R. O. Bartling Kristian Strømgaard Laura Cendron Alessandro Angelini Christian Heinis
Published in: Angewandte Chemie International Edition, 2024, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202400350

De novo development of small cyclicpeptides that are orally bioavailable

Author(s): Manuel L. Merz, Sevan Habeshian, Bo Li, Jean-Alexandre G. L. David, Alexander L. Nielsen, Xinjian Ji, Khaled Il Khwildy, Maury M. Duany Benitez, Phoukham Phothirath, Christian Heinis
Published in: Nature Chemical Biology, 2023, ISSN 0000-0000
Publisher: Nature
DOI: 10.1038/s41589-023-01496-y

Cyclic Peptides for Drug Development

Author(s): Xinjian Ji; Alexander L. Nielsen; Christian Heinis
Published in: Angewandte Chemie International, Issue 1, 2024, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202308251