"Targeting the ""untargetable"" by merging biological and chemical compound libraries"

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Solid-phase peptide synthesis in 384-well plates

Autores: Mischa Schüttel, Edward Will, Gontran Sangouard, Anne Zarda, Sevan Habeshian, Alexander L. Nielsen, Christian Heinis
Publicado en: Journal of Peptide Science, 2024, ISSN 1075-2617
Editor: John Wiley & Sons Inc.
DOI: 10.1002/psc.3555

Solid-phase peptide synthesis on disulfide-linker resin followed by reductive release affords pure thiol-functionalized peptides

Autores: Zsolt Bognar; Ganesh K. Mothukuri; Alexander L. Nielsen; Manuel L. Merz; Peter M. F. Pânzar; Christian Heinis
Publicado en: Organic & Biomolecular Chemistry, Edición Volume 20, issue 29, 2022, Página(s) 5699-5703, ISSN 1477-0520
Editor: Royal Society of Chemistry
DOI: 10.1039/d2ob00910b

Large Libraries of Structurally Diverse Macrocycles Suitable for Membrane Permeation

Autores: Alexander Lund Nielsen Zsolt Bognar Ganesh K. Mothukuri Anne Zarda Mischa Schüttel, Manuel L. Merz Xinjian Ji Edward J. Will Monica Chinellato Christian R. O. Bartling Kristian Strømgaard Laura Cendron Alessandro Angelini Christian Heinis
Publicado en: Angewandte Chemie International Edition, 2024, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202400350

De novo development of small cyclicpeptides that are orally bioavailable

Autores: Manuel L. Merz, Sevan Habeshian, Bo Li, Jean-Alexandre G. L. David, Alexander L. Nielsen, Xinjian Ji, Khaled Il Khwildy, Maury M. Duany Benitez, Phoukham Phothirath, Christian Heinis
Publicado en: Nature Chemical Biology, 2023, ISSN 0000-0000
Editor: Nature
DOI: 10.1038/s41589-023-01496-y

Cyclic Peptides for Drug Development

Autores: Xinjian Ji; Alexander L. Nielsen; Christian Heinis
Publicado en: Angewandte Chemie International, Edición 1, 2024, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202308251

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