Death Receptors as Integrators of Stress-induced inflammation

Project Information

DESTRESS

Grant agreement ID: 101020534

DOI

10.3030/101020534

EC signature date 13 August 2021

Start date 1 October 2021

End date 30 September 2027

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 499 386,25

EU contribution

€ 2 499 386,25

Coordinated by

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (7)

Discriminating Between Apoptosis, Necrosis, Necroptosis, and Ferroptosis by Microscopy and Flow Cytometry

Author(s): Aoife Costigan; Emilie Hollville; Seamus J. Martin
Published in: Current Protocols in Immunology, Issue 2, 2023, Page(s) 1-31, ISSN 2691-1299
Publisher: WILEY
DOI: 10.1002/cpz1.951

IL-1α and IL-36 Family Cytokines Can Undergo Processing and Activation by Diverse Allergen-Associated Proteases

Author(s): Valentina Frezza, Zaneta Najda, Pavel Davidovich, Graeme P. Sullivan, Seamus J. Martin
Published in: Frontiers in Immunology, Issue 13, 2022, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2022.879029

Myeloid cell-derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement

Author(s): Graeme P Sullivan 1, Pavel Davidovich , Natalia Muñoz-Wolf 2 3 , Ross W Ward 2 , Yasmina E Hernandez Santana 4 , Danielle M Clancy 1 , Aoife Gorman 2 , Zaneta Najda 1 , Boris Turk 5 , Patrick T Walsh 4 5 , Ed C Lavelle 2 , Seamus J Martin 1
Published in: Science Immunology, Issue 7, 2022, Page(s) 1-15, ISSN 2470-9468
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciimmunol.ade5728

cFLIPL acts as a suppressor of TRAIL- and Fas-initiated inflammation by inhibiting assembly of caspase-8/FADD/RIPK1 NF-κB-activating complexes

Author(s): Davidovich, P., Higgins, C.A., Najda, Z., Longley, D.B. and Martin S.J.
Published in: Cell Reports, Issue 42, 2023, Page(s) 1-17, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2023.113476

IL-1 family cytokines serve as 'activity recognition receptors' for aberrant protease activity indicative of danger

Author(s): Seamus J, Martin; Valentina, Frezza; Pavel, Davidovich; Zaneta, Najda; Danielle M, Clancy
Published in: Cytokine, Issue 157, 155935, 2022, Page(s) 1-10, ISSN 1043-4666
Publisher: Academic Press
DOI: 10.1016/j.cyto.2022.155935

Endothelial IL-36 receptor activation promotes vascular stability to limit pathological microvessel permeability in the CNS

Author(s): Erin Fahey, Lucia Celkova, Valentina Frezza, Graeme P. Sullivan, Kieran Byrne, Avril Watson, Yasmina E. Hernandez-Santana, Kieva Byrne, Rachel Dalton, Hande Efe-Cicek, Jeffrey O’Callaghan, Conor Delaney, Ema Ozaki, Patrick T. Walsh, Seamus J. Martin, Matthew Campbell, Sarah L. Doyle
Published in: Cell Reports, Issue 44, 2026, Page(s) 116549, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2025.116549

Unleashing dendritic cell-mediated tumor clearance by targeting Bcl-2

Author(s): Seamus J. Martin
Published in: Trends in Immunology, Issue 11, 2023, Page(s) 871-873, ISSN 1471-4906
Publisher: Elsevier BV
DOI: 10.1016/j.it.2023.09.007