Death Receptors as Integrators of Stress-induced inflammation

Project Information

DESTRESS

Grant agreement ID: 101020534

DOI 10.3030/101020534

EC signature date 13 August 2021

Start date 1 October 2021

End date 30 September 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 499 386,25

EU contribution € 2 499 386,25

Coordinated by

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland

Publications

Peer reviewed articles (5)

Discriminating Between Apoptosis, Necrosis, Necroptosis, and Ferroptosis by Microscopy and Flow Cytometry

Author(s): Aoife Costigan; Emilie Hollville; Seamus J. Martin
Published in: Current Protocols in Immunology, Issue 2, 2023, Page(s) 1-31, ISSN 2691-1299
Publisher: WILEY
DOI: 10.1002/cpz1.951

Myeloid cell-derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement

Author(s): Graeme P Sullivan 1, Pavel Davidovich , Natalia Muñoz-Wolf 2 3 , Ross W Ward 2 , Yasmina E Hernandez Santana 4 , Danielle M Clancy 1 , Aoife Gorman 2 , Zaneta Najda 1 , Boris Turk 5 , Patrick T Walsh 4 5 , Ed C Lavelle 2 , Seamus J Martin 1
Published in: Science Immunology, Issue 7, 2022, Page(s) 1-15, ISSN 2470-9468
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciimmunol.ade5728

cFLIPL acts as a suppressor of TRAIL- and Fas-initiated inflammation by inhibiting assembly of caspase-8/FADD/RIPK1 NF-κB-activating complexes

Author(s): Davidovich, P., Higgins, C.A., Najda, Z., Longley, D.B. and Martin S.J.
Published in: Cell Reports, Issue 42, 2023, Page(s) 1-17, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2023.113476

IL-1 family cytokines serve as 'activity recognition receptors' for aberrant protease activity indicative of danger

Author(s): Seamus J, Martin; Valentina, Frezza; Pavel, Davidovich; Zaneta, Najda; Danielle M, Clancy
Published in: Cytokine, Issue 157, 155935, 2022, Page(s) 1-10, ISSN 1043-4666
Publisher: Academic Press
DOI: 10.1016/j.cyto.2022.155935

Unleashing dendritic cell-mediated tumor clearance by targeting Bcl-2

Author(s): Seamus J. Martin
Published in: Trends in Immunology, Issue 11, 2023, Page(s) 871-873, ISSN 1471-4906
Publisher: Elsevier BV
DOI: 10.1016/j.it.2023.09.007