Project description DEENESFRITPL A closer look at simple eyes Every aspect of vision is diverse. For instance, simple eyes in extant animals show a remarkable diversity of form and function. The ERC-funded PROTOEYE project will look into how nervous systems across the animal kingdom interpret light cues. It will use cutting-edge light and electron microscopy to reconstruct the eyes and the entire nervous system of several marine plankton animals. The focus of this curiosity-driven project will be to dissect the neuronal bases of light-driven behaviours in marine animals. In addition to increasing our understanding of the evolution of animal vision, the findings will shed light on the general principles of sensory system evolution and our understanding of the origin and evolution of eyes and visual circuits. Show the project objective Hide the project objective Objective Complex animal eyes evolved many times independently from simpler forms. As already suggested by Darwin, the path to vision may have led from non-directional to directional light sensing and then to low-resolution spatial vision. Simple eyes in extant animals show a remarkable diversity of form and function and may hold the key to the origin of eyes and vision. We do not know why this diversity evolved when the organisms all respond to the same physical cue. Although we have a detailed molecular-centric view of eye evolution across animals, we lack corresponding knowledge of the physical mechanics and neuronal circuits coordinating the responses. PROTOEYE will study the diversity of simple non-visual and visual eyes and map the phase space of light-guided behaviours across animals. This will inform general principles of sensory system evolution and our understanding of the origin and evolution of eyes and visual circuits. The project will build on our long-term expertise in neural circuits and mechanistic photo-biology. We will study a range of aquatic invertebrates with distinct behavioural strategies, unified by the presence of simple eyes and non-visual photoreceptors. Instead of looking at eyes in isolation, we will investigate light responses from a whole-organism perspective focusing on circuits, behaviour and the biophysics of motion. In order to obtain entire neuronal circuits driving photic behaviours, we will use whole-body serial electron microscopy and connectomics. With laser ablation, we will explore strategies of light-seeking or light-avoidance behaviours. In high-throughput behavioural assays we will test navigation strategies and sensitivities to different wavelengths. With high-speed imaging and flow tracing, we will investigate how animal movement is shaped by light. This comparative and multi-disciplinary project will chart the functional diversity of simple eyes and provide a new framework for understanding the evolution of animal vision. Fields of science natural sciencesbiological sciencesevolutionary biologynatural sciencesphysical sciencesopticsmicroscopyelectron microscopy Keywords eye evolution neural circuits marine larvae light-regulated behaviour photoreceptors microswimmers biophysics ciliated larvae connectomics Programme(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Topic(s) ERC-2020-ADG - ERC ADVANCED GRANT Call for proposal ERC-2020-ADG See other projects for this call Funding Scheme ERC-ADG - Advanced Grant Coordinator RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG Net EU contribution € 3 021 059,21 Address Seminarstrasse 2 69117 Heidelberg Germany See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Beneficiaries (2) Sort alphabetically Sort by Net EU contribution Expand all Collapse all RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG Germany Net EU contribution € 3 021 059,21 Address Seminarstrasse 2 69117 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 THE UNIVERSITY OF EXETER Participation ended United Kingdom Net EU contribution € 132 859,79 Address The queen's drive northcote house EX4 4QJ Exeter See on map Region South West (England) Devon Devon CC Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
