Life-long cross-generational priming of the hypothalamus for obesity

Project Information

FOODFORLIFE

Grant agreement ID: 101021016

DOI

10.3030/101021016

EC signature date 10 July 2021

Start date 1 January 2022

End date 31 December 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 498 960,00

EU contribution

€ 2 498 960,00

Coordinated by

MEDIZINISCHE UNIVERSITAET WIEN
Austria

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan (DMP)

Participation in the Open Research Data Pilot Data Management Plan

Publications

Peer reviewed articles (14)

A hydrophobic groove in secretagogin allows for alternate interactions with SNAP-25 and syntaxin-4 in endocrine tissues

Author(s): Edit Szodorai, Zsofia Hevesi, Ludwig Wagner, Tomas G. M. Hökfelt, Tibor Harkany, Robert Schnell
Published in: Proceedings of the National Academy of Sciences, Issue 121, 2024, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2309211121

A brainstem–hypothalamus neuronal circuit reduces feeding upon heat exposure

Author(s): Marco Benevento, Alán Alpár, Anna Gundacker, Leila Afjehi, Kira Balueva, Zsofia Hevesi, János Hanics, Sabah Rehman, Daniela D. Pollak, Gert Lubec, Peer Wulff, Vincent Prevot, Tamas L. Horvath, Tibor Harkany
Published in: Nature, Issue 628, 2024, Page(s) 826-834, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-024-07232-3

Brain-wide mapping of efferent projections of glutamatergic (Onecut3+ ) neurons in the lateral mouse hypothalamus

Author(s): Zupančič M, Tretiakov E, Máté Z, Erdélyi F, Szabó G, Clotman F, Hökfelt T, Harkany T, Keimpema E.
Published in: Acta Physiol (Oxf)., Issue e13973, 2023, ISSN 1748-1716
Publisher: Wiley
DOI: 10.1111/apha.13973

Neuronal diversity of neuropeptide signaling, including galanin, in the mouse locus coeruleus

Author(s): Caramia M, Romanov RA, Sideromenos S, Hevesi Z, Zhao M, Krasniakova M, Xu ZD, Harkany T, Hökfelt TGM.
Published in: Proceedings of the National Academy of Sciences USA, Issue e2222095120, 2023, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2222095120

A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology

Author(s): Petersen J, Englmaier L, Artemov AV, Poverennaya I, Mahmoud R, Bouderlique T, Tesarova M, Deviatiiarov R, Szilvásy-Szabó A, Akkuratov EE, Pajuelo Reguera D, Zeberg H, Kaucka M, Kastriti ME, Krivanek J, Radaszkiewicz T, Gömöryová K, Knauth S, Potesil D, Zdrahal Z, Ganji RS, Grabowski A, Buhl ME, Zikmund T, Kavkova M, Axelson H, Lindgren D, Kramann R, Kuppe C, Erdélyi F, Máté Z, Szabó G, Ko
Published in: Nature Communications, Issue 3092, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-38663-7

Adverse effects of gestational ω-3 and ω-6 polyunsaturated fatty acid imbalance on the programming of fetal brain development

Author(s): Cinquina V, Keimpema E, Pollak DD, Harkany T.
Published in: Journal of Neuroendocrinology, Issue 2023 Jul 5. doi: 10.1111/jne.13320., 2023, ISSN 1365-2826
Publisher: Wiley
DOI: 10.1111/jne.13320

Preclinical Establishment of a Divalent Vaccine against SARS-CoV-2

Author(s): Zsofia Hevesi, Daniela Anna Gerges, Sebastian Kapps, Raimundo Freire, Sophie Schmidt, Daniela D. Pollak, Klaus Schmetterer, Tobias Frey, Rita Lang, Wolfgang Winnicki, Alice Schmidt, Tibor Harkany, Ludwig Wagner
Published in: Vaccines, Issue 10, 2024, Page(s) 516, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines10040516

A hypothalamic pathway for Augmentor α-controlled body weight regulation

Author(s): Ahmed M, Kaur N, Cheng Q, Shanabrough M, Tretiakov EO, Harkany T, Horvath TL, Schlessinger J.
Published in: Proc Natl Acad Sci USA, Issue 119/16, 2022, ISSN 1091-6490
Publisher: National Academy of Science
DOI: 10.1073/pnas.2200476119

Transient expression of the neuropeptide galanin modulates peripheral‑to‑central connectivity in the somatosensory thalamus during whisker development in mice

Author(s): Zsofia Hevesi, Joanne Bakker, Evgenii O. Tretiakov, Csaba Adori, Anika Raabgrund, Swapnali S. Barde, Martino Caramia, Thomas Krausgruber, Sabrina Ladstätter, Christoph Bock, Tomas Hökfelt, Tibor Harkany
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-47054-5

Grabbing neuropeptide signals in the brain

Author(s): Roman A. Romanov, Tibor Harkany
Published in: Science, Issue 382, 2024, Page(s) 764-765, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.adl1788

A hypothalamic dopamine locus for psychostimulant-induced hyperlocomotion in mice

Author(s): Korchynska S, Rebernik P, Pende M, Boi L, Alpár A, Tasan R, Becker K, Balueva K, Saghafi S, Wulff P, Horvath TL, Fisone G, Dodt HU, Hökfelt T, Harkany T, Romanov RA.
Published in: Nature Communication, Issue 13, 2022, Page(s) 1-16, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-33584-3

Disrupted Cacna1c gene expression perturbs spontaneous Ca2+ activity causing abnormal brain development and increased anxiety

Author(s): Smedler E, Louhivuori L, Romanov RA, Masini D, Dehnisch Ellström I, Wang C, Caramia M, West Z, Zhang S, Rebellato P, Malmersjö S, Brusini I, Kanatani S, Fisone G, Harkany T, Uhlén P.
Published in: Proc Natl Acad Sci U S A., Issue 119/7, 2022, ISSN 1091-6490
Publisher: National Academy of Science
DOI: 10.1073/pnas.210876811

Disrupted <i>Cacna1c</i> gene expression perturbs spontaneous Ca ²⁺ activity causing abnormal brain development and increased anxiety

Author(s): Erik Smedler, Lauri Louhivuori, Roman A. Romanov, Débora Masini, Ivar Dehnisch Ellström, Chungliang Wang, Martino Caramia, Zoe West, Songbai Zhang, Paola Rebellato, Seth Malmersjö, Irene Brusini, Shigeaki Kanatani, Gilberto Fisone, Tibor Harkany, Per Uhlén
Published in: Proceedings of the National Academy of Sciences, Issue 119, 2022, Page(s) e2108768119, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2108768119

Ontogenetic rules for the molecular diversification of hypothalamic neurons

Author(s): Benevento M, Hökfelt T, Harkany T.
Published in: Nat Rev Neursosci, Issue 23, 611–627, 2022, Page(s) 611–627, ISSN 1471-003X
Publisher: Nature Publishing Group
DOI: 10.1038/s41583-022-00615-3

Non-peer reviewed articles (5)

Regional redistribution of CB1 cannabinoid receptors in human foetal brains with Down's syndrome and their functional modifications in Ts65Dn+/+ mice.

Author(s): Patthy Á, Hanics J, Zachar G, Kovács GG, Harkany T, Alpár A.
Published in: Neuropathology and applied Neurobiology, Issue 49/1, 2023, ISSN 0000-0000
Publisher: Wiley
DOI: 10.1111/nan.12887

Neuroglia: Function and Pathology by Alexei Verkhratsky and Arthur M. Butt.

Author(s): Harkany, T and Hökfelt, T
Published in: Acta Physiol (Oxf)., Issue 2023 Aug 22:e14033, 2023, ISSN 1748-1716
Publisher: Wiley
DOI: 10.1111/apha.14033

An accessory prefrontal cortex-thalamus circuit sculpts maternal behavior in virgin female mice

Author(s): Glat M, Gundacker A, Cuenca Rico L, Czuczu B, Ben-Simon Y, Harkany T, Pollak DD.
Published in: The EMBO Journal, Issue 41/24, 2022, ISSN 1460-2075
Publisher: European Molecular Biology Organization (EMBO)
DOI: 10.15252/embj.2022111648

Gestational immune activation disrupts hypothalamic neurocircuits of maternal care behavior

Author(s): Zambon A, Rico LC, Herman M, Gundacker A, Telalovic A, Hartenberger LM, Kuehn R, Romanov RA, Hussaini SA, Harkany T, Pollak DD.
Published in: Mol Psychiatry, Issue 17, 2022, Page(s) 1-15, ISSN 1476-5578
Publisher: Molecular Psychiatry
DOI: 10.1038/s41380-022-01602-x

Resident Astrocytes can Limit Injury to Developing Hippocampal Neurons upon THC Exposure.

Author(s): Krassnitzer M, Boisvert B, Beiersdorf J, Harkany T, Keimpema E.
Published in: Neurochem Res., Issue 48, 2022, Page(s) 1242-1253, ISSN 0000-0000
Publisher: Springer Verlag
DOI: 10.1007/s11064-022-03836-1

Other (2)

Molecularly stratified hypothalamic astrocytes are cellular foci for obesity

Author(s): Evgenii Tretiakov, Luis Varela, Jasna Jarc, Patrick Rebernik, Sylvia Newbold, Erik Keimpema, Alexei Verkhratsky, Tamas L. Horvath, Roman A. Romanov, Tibor Harkany
Published in: Research square, Issue rs.3.rs-3748581, 2024, Page(s) rs.3.rs-3748581
Publisher: Springer Nature
DOI: 10.21203/rs.3.rs-3748581/v1

Crucial neuroprotective roles of the metabolite BH4 in dopaminergic neurons

Author(s): Shane J F Cronin, Weonjin Yu, Ashley Hale, Simon Licht-Mayer, Mark J Crabtree, Joanna A Korecka, Evgenii O Tretiakov, Marco Sealey-Cardona, Mate Somlyay, Masahiro Onji, Meilin An, Jesse D Fox, Bruna Lenfers Turnes, Carlos Gomez-Diaz, Débora da Luz Scheffer, Domagoj Cikes, Vanja Nagy, Adelheid Weidinger, Alexandra Wolf, Harald Reither, Antoine Chabloz, Anoop Kavirayani, Shuan Rao, Nick Andrews, Al
Published in: BioRxiv, Issue 2023.05.08.539795, 2023, Page(s) 2023.05.08.539795
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.05.08.539795