Life-long cross-generational priming of the hypothalamus for obesity

Información del proyecto

FOODFORLIFE

Identificador del acuerdo de subvención: 101021016

DOI

10.3030/101021016

Fecha de la firma de la CE 10 Julio 2021

Fecha de inicio 1 Enero 2022

Fecha de finalización 31 Diciembre 2026

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 498 960,00

Aportación de la UE

€ 2 498 960,00

Coordinado por

MEDIZINISCHE UNIVERSITAET WIEN
Austria

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Open Research Data Pilot (1)

Data Management Plan (DMP)

Participation in the Open Research Data Pilot Data Management Plan

Publicaciones

Peer reviewed articles (14)

A hydrophobic groove in secretagogin allows for alternate interactions with SNAP-25 and syntaxin-4 in endocrine tissues

Autores: Edit Szodorai, Zsofia Hevesi, Ludwig Wagner, Tomas G. M. Hökfelt, Tibor Harkany, Robert Schnell
Publicado en: Proceedings of the National Academy of Sciences, Edición 121, 2024, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2309211121

A brainstem–hypothalamus neuronal circuit reduces feeding upon heat exposure

Autores: Marco Benevento, Alán Alpár, Anna Gundacker, Leila Afjehi, Kira Balueva, Zsofia Hevesi, János Hanics, Sabah Rehman, Daniela D. Pollak, Gert Lubec, Peer Wulff, Vincent Prevot, Tamas L. Horvath, Tibor Harkany
Publicado en: Nature, Edición 628, 2024, Página(s) 826-834, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-024-07232-3

Brain-wide mapping of efferent projections of glutamatergic (Onecut3+ ) neurons in the lateral mouse hypothalamus

Autores: Zupančič M, Tretiakov E, Máté Z, Erdélyi F, Szabó G, Clotman F, Hökfelt T, Harkany T, Keimpema E.
Publicado en: Acta Physiol (Oxf)., Edición e13973, 2023, ISSN 1748-1716
Editor: Wiley
DOI: 10.1111/apha.13973

Neuronal diversity of neuropeptide signaling, including galanin, in the mouse locus coeruleus

Autores: Caramia M, Romanov RA, Sideromenos S, Hevesi Z, Zhao M, Krasniakova M, Xu ZD, Harkany T, Hökfelt TGM.
Publicado en: Proceedings of the National Academy of Sciences USA, Edición e2222095120, 2023, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2222095120

A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology

Autores: Petersen J, Englmaier L, Artemov AV, Poverennaya I, Mahmoud R, Bouderlique T, Tesarova M, Deviatiiarov R, Szilvásy-Szabó A, Akkuratov EE, Pajuelo Reguera D, Zeberg H, Kaucka M, Kastriti ME, Krivanek J, Radaszkiewicz T, Gömöryová K, Knauth S, Potesil D, Zdrahal Z, Ganji RS, Grabowski A, Buhl ME, Zikmund T, Kavkova M, Axelson H, Lindgren D, Kramann R, Kuppe C, Erdélyi F, Máté Z, Szabó G, Ko
Publicado en: Nature Communications, Edición 3092, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-38663-7

Adverse effects of gestational ω-3 and ω-6 polyunsaturated fatty acid imbalance on the programming of fetal brain development

Autores: Cinquina V, Keimpema E, Pollak DD, Harkany T.
Publicado en: Journal of Neuroendocrinology, Edición 2023 Jul 5. doi: 10.1111/jne.13320., 2023, ISSN 1365-2826
Editor: Wiley
DOI: 10.1111/jne.13320

Preclinical Establishment of a Divalent Vaccine against SARS-CoV-2

Autores: Zsofia Hevesi, Daniela Anna Gerges, Sebastian Kapps, Raimundo Freire, Sophie Schmidt, Daniela D. Pollak, Klaus Schmetterer, Tobias Frey, Rita Lang, Wolfgang Winnicki, Alice Schmidt, Tibor Harkany, Ludwig Wagner
Publicado en: Vaccines, Edición 10, 2024, Página(s) 516, ISSN 2076-393X
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines10040516

A hypothalamic pathway for Augmentor α-controlled body weight regulation

Autores: Ahmed M, Kaur N, Cheng Q, Shanabrough M, Tretiakov EO, Harkany T, Horvath TL, Schlessinger J.
Publicado en: Proc Natl Acad Sci USA, Edición 119/16, 2022, ISSN 1091-6490
Editor: National Academy of Science
DOI: 10.1073/pnas.2200476119

Transient expression of the neuropeptide galanin modulates peripheral‑to‑central connectivity in the somatosensory thalamus during whisker development in mice

Autores: Zsofia Hevesi, Joanne Bakker, Evgenii O. Tretiakov, Csaba Adori, Anika Raabgrund, Swapnali S. Barde, Martino Caramia, Thomas Krausgruber, Sabrina Ladstätter, Christoph Bock, Tomas Hökfelt, Tibor Harkany
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-47054-5

Grabbing neuropeptide signals in the brain

Autores: Roman A. Romanov, Tibor Harkany
Publicado en: Science, Edición 382, 2024, Página(s) 764-765, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.adl1788

A hypothalamic dopamine locus for psychostimulant-induced hyperlocomotion in mice

Autores: Korchynska S, Rebernik P, Pende M, Boi L, Alpár A, Tasan R, Becker K, Balueva K, Saghafi S, Wulff P, Horvath TL, Fisone G, Dodt HU, Hökfelt T, Harkany T, Romanov RA.
Publicado en: Nature Communication, Edición 13, 2022, Página(s) 1-16, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-33584-3

Disrupted Cacna1c gene expression perturbs spontaneous Ca2+ activity causing abnormal brain development and increased anxiety

Autores: Smedler E, Louhivuori L, Romanov RA, Masini D, Dehnisch Ellström I, Wang C, Caramia M, West Z, Zhang S, Rebellato P, Malmersjö S, Brusini I, Kanatani S, Fisone G, Harkany T, Uhlén P.
Publicado en: Proc Natl Acad Sci U S A., Edición 119/7, 2022, ISSN 1091-6490
Editor: National Academy of Science
DOI: 10.1073/pnas.210876811

Disrupted <i>Cacna1c</i> gene expression perturbs spontaneous Ca ²⁺ activity causing abnormal brain development and increased anxiety

Autores: Erik Smedler, Lauri Louhivuori, Roman A. Romanov, Débora Masini, Ivar Dehnisch Ellström, Chungliang Wang, Martino Caramia, Zoe West, Songbai Zhang, Paola Rebellato, Seth Malmersjö, Irene Brusini, Shigeaki Kanatani, Gilberto Fisone, Tibor Harkany, Per Uhlén
Publicado en: Proceedings of the National Academy of Sciences, Edición 119, 2022, Página(s) e2108768119, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2108768119

Ontogenetic rules for the molecular diversification of hypothalamic neurons

Autores: Benevento M, Hökfelt T, Harkany T.
Publicado en: Nat Rev Neursosci, Edición 23, 611–627, 2022, Página(s) 611–627, ISSN 1471-003X
Editor: Nature Publishing Group
DOI: 10.1038/s41583-022-00615-3

Non-peer reviewed articles (5)

Regional redistribution of CB1 cannabinoid receptors in human foetal brains with Down's syndrome and their functional modifications in Ts65Dn+/+ mice.

Autores: Patthy Á, Hanics J, Zachar G, Kovács GG, Harkany T, Alpár A.
Publicado en: Neuropathology and applied Neurobiology, Edición 49/1, 2023, ISSN 0000-0000
Editor: Wiley
DOI: 10.1111/nan.12887

Neuroglia: Function and Pathology by Alexei Verkhratsky and Arthur M. Butt.

Autores: Harkany, T and Hökfelt, T
Publicado en: Acta Physiol (Oxf)., Edición 2023 Aug 22:e14033, 2023, ISSN 1748-1716
Editor: Wiley
DOI: 10.1111/apha.14033

An accessory prefrontal cortex-thalamus circuit sculpts maternal behavior in virgin female mice

Autores: Glat M, Gundacker A, Cuenca Rico L, Czuczu B, Ben-Simon Y, Harkany T, Pollak DD.
Publicado en: The EMBO Journal, Edición 41/24, 2022, ISSN 1460-2075
Editor: European Molecular Biology Organization (EMBO)
DOI: 10.15252/embj.2022111648

Gestational immune activation disrupts hypothalamic neurocircuits of maternal care behavior

Autores: Zambon A, Rico LC, Herman M, Gundacker A, Telalovic A, Hartenberger LM, Kuehn R, Romanov RA, Hussaini SA, Harkany T, Pollak DD.
Publicado en: Mol Psychiatry, Edición 17, 2022, Página(s) 1-15, ISSN 1476-5578
Editor: Molecular Psychiatry
DOI: 10.1038/s41380-022-01602-x

Resident Astrocytes can Limit Injury to Developing Hippocampal Neurons upon THC Exposure.

Autores: Krassnitzer M, Boisvert B, Beiersdorf J, Harkany T, Keimpema E.
Publicado en: Neurochem Res., Edición 48, 2022, Página(s) 1242-1253, ISSN 0000-0000
Editor: Springer Verlag
DOI: 10.1007/s11064-022-03836-1

Other (2)

Molecularly stratified hypothalamic astrocytes are cellular foci for obesity

Autores: Evgenii Tretiakov, Luis Varela, Jasna Jarc, Patrick Rebernik, Sylvia Newbold, Erik Keimpema, Alexei Verkhratsky, Tamas L. Horvath, Roman A. Romanov, Tibor Harkany
Publicado en: Research square, Edición rs.3.rs-3748581, 2024, Página(s) rs.3.rs-3748581
Editor: Springer Nature
DOI: 10.21203/rs.3.rs-3748581/v1

Crucial neuroprotective roles of the metabolite BH4 in dopaminergic neurons

Autores: Shane J F Cronin, Weonjin Yu, Ashley Hale, Simon Licht-Mayer, Mark J Crabtree, Joanna A Korecka, Evgenii O Tretiakov, Marco Sealey-Cardona, Mate Somlyay, Masahiro Onji, Meilin An, Jesse D Fox, Bruna Lenfers Turnes, Carlos Gomez-Diaz, Débora da Luz Scheffer, Domagoj Cikes, Vanja Nagy, Adelheid Weidinger, Alexandra Wolf, Harald Reither, Antoine Chabloz, Anoop Kavirayani, Shuan Rao, Nick Andrews, Al
Publicado en: BioRxiv, Edición 2023.05.08.539795, 2023, Página(s) 2023.05.08.539795
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.05.08.539795